HUE029264T2 - Pyrazolo-triazine derivatives are selective cyclin-dependent kinase inhibitors - Google Patents
Pyrazolo-triazine derivatives are selective cyclin-dependent kinase inhibitors Download PDFInfo
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- HUE029264T2 HUE029264T2 HUE13707008A HUE13707008A HUE029264T2 HU E029264 T2 HUE029264 T2 HU E029264T2 HU E13707008 A HUE13707008 A HU E13707008A HU E13707008 A HUE13707008 A HU E13707008A HU E029264 T2 HUE029264 T2 HU E029264T2
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EP12157751.4A EP2634190A1 (en) | 2012-03-01 | 2012-03-01 | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors |
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UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
GB201403093D0 (en) | 2014-02-21 | 2014-04-09 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
ES2702951T3 (es) | 2014-04-04 | 2019-03-06 | Syros Pharmaceuticals Inc | Inhibidores de quinasas dependientes de ciclina 7 (cdk7) |
EP3129371B1 (en) * | 2014-04-05 | 2020-07-29 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
AU2015337607B2 (en) | 2014-10-31 | 2020-04-09 | Ube Corporation | Substituted dihydropyrrolopyrazole compound |
CA2978170C (en) * | 2015-03-09 | 2024-02-27 | Aurigene Discovery Technologies Limited | Pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives as cdk inhibitors |
US10273252B2 (en) | 2015-06-15 | 2019-04-30 | Ube Industries, Ltd. | Substituted dihydropyrrolopyrazole derivative |
WO2016206999A1 (en) * | 2015-06-24 | 2016-12-29 | Apodemus Ab | Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy |
SI3432916T1 (sl) | 2016-09-13 | 2020-01-31 | Allergan, Inc. | Stabilizirani ne-protein klostridijski toksin sestavki |
CN106432249B (zh) * | 2016-09-30 | 2018-12-04 | 陕西科技大学 | 一类吡咯并[2,1-f][1,2,4]三嗪母核化合物的合成及其医药用途 |
WO2019032720A1 (en) | 2017-08-09 | 2019-02-14 | Sanford Burnham Prebys Medical Discovery Institute | APELIN RECEPTOR AGONISTS AND METHODS OF USE |
GB201715194D0 (en) | 2017-09-20 | 2017-11-01 | Carrick Therapeutics Ltd | Compounds and their therapeutic use |
US11649238B2 (en) | 2018-01-17 | 2023-05-16 | Glaxosmithkline Intellectual Property Development Limited | Substituted pyrazolo[1,5-a]pyrimidines as PI4K inhibitors |
IL277770B2 (en) * | 2018-04-11 | 2024-01-01 | Qurient Co Ltd | Pyrazolo-triazine and/or pyrazolo-pyrimidine derivatives as selective inhibitor of cyclin dependent kinase |
WO2019197546A1 (en) * | 2018-04-11 | 2019-10-17 | Qurient Co., Ltd. | Pharmaceutically active pyrazolo-triazine and/or pyrazolo-pyrimidine derivatives |
WO2020051689A1 (en) * | 2018-09-12 | 2020-03-19 | The Governing Council Of The University Of Toronto | Compounds and methods for treating nematode infections |
US11517568B2 (en) | 2018-09-12 | 2022-12-06 | The Governing Council Of The University Of Toronto | Compounds and methods for treating nematode infections |
IL282737B2 (en) | 2018-11-01 | 2025-05-01 | Syros Pharmaceuticals Inc | Cyclin-dependent kinase 7 (CDK7) inhibitors |
US12304913B2 (en) | 2018-11-14 | 2025-05-20 | Ube Industries, Ltd. | Dihydropyrrolopyrazole derivative |
CN110101703B (zh) * | 2019-05-06 | 2021-06-11 | 暨南大学 | Cdk7抑制剂在制备溃疡性结肠炎或结肠癌药物的应用 |
RU2713152C1 (ru) * | 2019-08-30 | 2020-02-04 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Алтайский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ лечения хронической аллергической крапивницы на фоне описторхоза |
TW202146416A (zh) * | 2019-12-11 | 2021-12-16 | 德商拜耳廠股份有限公司 | 吡唑并三𠯤 |
GB201918541D0 (en) * | 2019-12-16 | 2020-01-29 | Carrick Therapeutics Ltd | Therapeutic compounds and their use |
CN110950871B (zh) * | 2019-12-25 | 2022-05-17 | 陕西师范大学 | 2-取代-4-芳氨基吡唑并三嗪衍生物及制备抗肿瘤药物的应用 |
CN116964061A (zh) * | 2020-12-21 | 2023-10-27 | 詹森药业有限公司 | 作为细胞周期蛋白依赖性激酶7(cdk7)抑制剂的三环嘧啶 |
EP4305040A1 (en) * | 2021-03-09 | 2024-01-17 | JANSSEN Pharmaceutica NV | Tricyclic pyridines as cyclin-dependent kinase 7 (cdk7) inhibitors |
US20250042903A1 (en) * | 2021-06-17 | 2025-02-06 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Triazine inhibitors of cyclin-dependent kinases |
WO2023001061A1 (en) * | 2021-07-17 | 2023-01-26 | Jingrui Biopharma Co., Ltd. | Cdk7 selective inhibitors as anticancer agents |
US20240327397A1 (en) | 2021-07-29 | 2024-10-03 | Syngenta Crop Protection Ag | Pesticidally Active Fused Bicyclic Heteroaromatic Compounds |
JP2024541474A (ja) * | 2021-11-23 | 2024-11-08 | オリゲニス ゲーエムベーハー | Cdk9阻害剤として有用なピラゾロトリアジン誘導体 |
CN114181217B (zh) * | 2022-01-10 | 2022-12-27 | 陕西师范大学 | 吡唑并[1,5-a][1,3,5]三嗪衍生物及其盐和在制备抗癌药物中的应用 |
WO2023175173A1 (en) * | 2022-03-18 | 2023-09-21 | Qurient Co., Ltd. | Cdk7 inhibitors for antiviral treatment |
WO2024175024A1 (zh) * | 2023-02-21 | 2024-08-29 | 杭州德睿智药科技有限公司 | 作为CDKs抑制剂的新型并杂环类新化合物及其应用 |
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US615968A (en) | 1898-12-13 | Apparatus for treating ores | ||
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US7119200B2 (en) * | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
PE20051128A1 (es) | 2004-02-25 | 2006-01-16 | Schering Corp | Pirazolotriazinas como inhibidores de quinasa |
CZ302122B6 (cs) * | 2009-01-28 | 2010-10-20 | Univerzita Palackého v Olomouci | Substituované deriváty 6-(2-aminobenzylamino)purinu, jejich použití jako léciva a prípravky tyto slouceniny obsahující |
FR2943058B1 (fr) * | 2009-03-11 | 2011-06-03 | Centre Nat Rech Scient | Derives de pyrazolo°1,5-a!-1,3,5-triazines, leur preparation et leur application en therapeutique. |
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EP2820020A1 (en) | 2015-01-07 |
IL234183A (en) | 2016-11-30 |
MX2014010494A (es) | 2015-04-08 |
CN104350054A (zh) | 2015-02-11 |
KR20140131994A (ko) | 2014-11-14 |
WO2013128028A8 (en) | 2014-10-02 |
WO2013128028A1 (en) | 2013-09-06 |
BR112014021189B1 (pt) | 2022-08-16 |
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