HUE027577T2 - Morfolinil-benzotriazol alkalmazása rákterápiában - Google Patents
Morfolinil-benzotriazol alkalmazása rákterápiában Download PDFInfo
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- HUE027577T2 HUE027577T2 HUE12783121A HUE12783121A HUE027577T2 HU E027577 T2 HUE027577 T2 HU E027577T2 HU E12783121 A HUE12783121 A HU E12783121A HU E12783121 A HUE12783121 A HU E12783121A HU E027577 T2 HUE027577 T2 HU E027577T2
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Classifications
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
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Claims (10)
- of sucmse, potato starch, talc, uagaeanth and dye. Example Ci: Canutes 2 kg oísctive cmnposPd According tot i&feiteMiksi were imrodotx'd into hard gelatins capsules ára m&-ventional manner :œ such a way that each capsule contained 2ü rng of active compound according to the imm~ don. Campte B; Ampoules .A solution of 1 kg of active compound according to the invention in 60 t of bidisdlled water was sterile-filiered, Ptinsfemed into smpordes, lyephdised |pi^sten3&^dté^âad^te$.:aaà5r sterile conditions. Each ampoule contained i 0 mg of active compoand ^cording to ine invention. 14 g of active compound according to the invention were dissolved in 101: of isotonic NaCI solution, and the solution was transfcned into standard commercial spray vessels with pump médiaitisat. The solution could he Sjjfapdinto tmm& of nose. One spray shot fappnnc 0:. 3 M) coftepondsd: in a dose of approx. 0. Id mg. Szahadalnu igénypontok 1. (í) képleté vegyüîetek.,·ΥΝ «hol 'ïf jelentése Hét* vagy Ar; R^, R:i Jelentése egymástól logge; IcnülY vagy OY. vagy együtt jelentősök -OtCH^)»·; R4 jelentése A vagy (€H;í)söA; L jdeutém -CE'Elegyes kötés, -<€Η2}ιΓ, -CH(Hal)··, -C<ifa]}r, -(CH^hCHtOY)·, -(01,),.00-, - {ch^mh-* -{mi&mm'T-i -mcű*, -iybcû-», .-a®-co-, «sör, -c(-*nr% -c^ncnk WWúr; -CYíCNK -€Y(Ö-{CH^.CN}-< -CYCBcf}· vagy-CYtOdCHAJleí>: Y jelentése ff vagy A: A jelentése nem: #%.ró vagy elágazó, I -10 Λβ Ä, Ad, egymástól föggetfcnül, i -y H atom he-lyeitesíivc lőhet Hal-ial; Cye jeleméss gy%lls, ;3:-·7 scépatomos nihil,: ahol, egyahbi&l iaggétienűh i-4 M-aín-m helyettesítve lehet Hal-lal; Ar jelentése inni, amely ssubscdlaálatian vagy « k&veikczők hármclyikéveí: ngys^erssen vagy kétszeresen szuhsatitoált: (C)l2),OY. R4, (OI^OE4, COOY, NY2, T1YG0Y ésYagyCN; Klet*' jelentésé íssöö- vagjr: fefeMssosv 2-Sí szettatotrtos és 1-41% 0- étvágy :$·» atöbuít lartalmg^ Mtetoanl, amely Msei sssöfeszälöHsösH vttgy mom> vagy diszubssztUuáit a következők bármelyiketek: ίί,Μο^ΟΥ, Cyc, Mer és.· vagy CN: H*r: jelentése tnonooklusos, telített, 2-7sxénmmms és 1-4 M, O és'vagy S atomot tano-mazo nvtefocrklus, amely lehet szobszumálatiaa vagy Λ -vas taoobsznbsztlbkR; Hal jelentése F, Cí, Bt vagy 1; na értéke ö, 1 vagy 2; és n, p értéke egyt&fcíöi Siggeáéati Ö, 1,2,3,4 vagy Y és/vagy Bziolégiáasaí: elibgadhátö: sói iantomejjet ésAltgy sxiesöolälaöstt^ beleértve: etek bármilyen arányá keverékeit,
- 2. At 1. igénypont szerinti vegyüieíek, ahol R! jelentése Hét'. 3, A* 1, vagy 2, igéítyisörstszseisb vegyáfefóki Äés R·* jéléstése egymástéi: %gt4ie=&íl Y vagy ÖY. 4 Az 1 -3. igétryjxtniok bármelyike »zertttii vegyűietek, ahol L jelentése -CRrR -.
- 5, Az 1-4. ígénygösttök bármelyike saertsíi vegyültek, ahol Hét* jelentése motto- vagy bicikinsox, 2-8 rnëmmm és Ί4 Μ, O és/vagy S »krn^m^smé^mmi méy leket sznbsztiinsisskstt vagy a következőik bármelyikével motto- vagy öisasÉssrattnáR: Hal tCHjX-OY, A és/vagy O.
- 6, Az 1, igénypont szénát!, {IAj aiképletü vegyülitek,«Λ) ahol Rl jelextíéSe Hek vagy A.y; R" jelentése Y vagy OY; RJ jelentése OY vagy A; R'\ fV jelentése együtt -0-(CH;..tS!··; L jeiestesevCR^R5-;: Y jelentése H vagy A; A teleniésesej» elágazó vagy elágazó, 1 -ő szértaíomos alksl, ahol egymástól löggetlsalll 1 -5 H Mim helyettesítve leltet Hal-M; Ar Jelentése fettlí amely SAibsztítaálatkít vagy a következők bármelyikével: moms- vagy diszttbszíiíöM: Httl éx/vagy (CH:)pOY: Héti5 íeletítése ttmno· vagy bfeiklssok 24 szénáiét« és 10 N, Oésévagy S atomot íMálinazó ihéiéimril, améiy jebét sznbsztltaâlsîktt vágy a következők bfenelyikével mono- vagy fcateibsSite Ä1,. (CH^GY, A ásAíágy ~Ö; Hal jelentése F, Cl, Br vagy 1; és Xi, P értéke egymástól íuggetlenöl 0, 1,2,5 vagy 4, ivvagy ßzÄgMSäs eíf^aáfeai& séi, íastomertsi étvágy M^úmmm^h Sértve ezek; Mxrösfeí amsyú keverékeit.
- 7. Az I , igé&yppgf sxeníUi. fîB;? alkértieiü vegySí&*éfcahol V lekötése H vagy A; À jsierítése srern eilágssé vagy elapad, l-6- mmmmm: sfcl »bit ppi «ggetisiiSJ 7-3 H ákmhh iye-sesnvv: kép B&klal; Hé# jeleméi & kdveteS csoportiből válasz »«(«Ä m4$ sltelilrti W i^feák Man» Kikével tnono vlsgy dissuKssll&kilk Hal. (OH^CIk, A é$*yagy --0::i Hal jelentése F, Cl. Br vagy I; és p értéke 0; I vagy 2, és/vágy iïmùàgkfean eifpgsááaíé sói, Mufeme^ei é^vsgy s^efaptsarsesyek Beleértve e^à-hàmBps^. mmfû keverékeit, S. Az 1-7. igéaypirtrtük BariSeiyíké sxertâïfi vegyelek amely à 1#vétked esppertM vstesgtotfcés/vagy fiziokSgîâsax* -elfogadható- Ä, ísus-omejjei és/vagy sete^feaerjej, beleértve esek bármilyen aráévá, keverékeit.
- 9, Eljárás az L. igásypostt szeíiaíi (]j képiéit veí^tfelek es/vagy fíxielógíásías dfogaábaté sói, fógíöiö«rjsi és/vagy satereoíaömesjes előállítására, amely reagábaa foglalja az slábhs lépéseket: (a) (II) képleté yggySlel: Mgá&alása(Ï1) vagy (V) képlete vegyiMeíieláhol R\ L és m jielesiése se 1 ígéovpoöífesa megáíiott «sállá! &a (!) képleté vegyük·;!: előállítása,ähol Εν Lys nrfeleptóse m ig#s}^ondjan megélő«, és adott «selbes ($$ szg) képleté 'véstetek, bádsa vagy ssy|a »égávi áliÉhÉ®
- 18, Az I-&. igénypontok bárnteiyike szemtl yegyÁrek ós/vágy ||S$e%iftsan élfegadbatö söi,: taxgnbterjei étvágy szte^oixQSíojei belesítvv ssgÉ bármilyen arányé .3^é*É?Üí .alkalmazása sminfirmisâ^ pmÄfeWxöjs« előnyösen PINK., kblbnöses előnyösen DNS-PK mmm gátlására.
- 11. Az 1-8. igénypontok bármelyike sssánti vegyétek és/vagv fiziológiásán elí^adkaio sói, Ondomerjói ««Ángy sztereoizomerjet beleértve esék: biknntyen arányé keverékeit alkslrnasfea rákos sejtek szenzsdzálására rákellenes szer és/vagy ionizáló srsgárzássat szemfem
- 12. Gyógyszerek, sxneiyek Míaknazásk íeplább egy. 1-g. Mmrelylse tsæBna&^gySîtetet ászvagy fiziológiása® elfogadható sipí, táutömetfáí és/vagy szfereoizomerpt betelve ezek bármilyen: arányé keverékeit 1$, Gytlgyászaíi ikésztüoéay, amely bstoáfiysgkéni az Î-8, ígénypoolok £&$$$&# -«egyÖM ésí'vggy feiológiásm eifhpdh&tő sói. tanlosnsgei és/vggy szteeoizoiseriei, befofeá bögrékéit, hátásös rïi&myisègé; tamlnrpza, gyágyászaíilag: tolerálható sogéémysgokkal együtt, legalább egy räkelleireg szerrel koibbinációbao,
- 14. Az 1-8. igénypopok bármelyike szefmE vegffetek és/vttgy ;Szíol%iá«ao elfogadható sói, tame-rnerjei ésivagy ázítsvoizetnsíjei, beleértve: ezek bármilyen arányé keveíékeit, rák, főmérők, rneiasztázlsofc èsAagy angiogenezis-rendeleoessógek megdőzóséhen, feezelôsebsa ésfoagy gédgíossbibjpk szabályozásában íMénó alkalmazásra, nidioíeráplával ésfvagy legalább egy rákellenes szerrel egyiltl
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DE102011118830A DE102011118830A1 (de) | 2011-11-18 | 2011-11-18 | Morpholinylbenzotriazine |
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US (1) | US9187469B2 (hu) |
EP (1) | EP2780332B1 (hu) |
JP (1) | JP6096792B2 (hu) |
KR (1) | KR20140097391A (hu) |
CN (1) | CN103930408B (hu) |
AU (1) | AU2012339196B2 (hu) |
BR (1) | BR112014011805A2 (hu) |
CA (1) | CA2856103C (hu) |
DE (1) | DE102011118830A1 (hu) |
DK (1) | DK2780332T3 (hu) |
EA (1) | EA201400595A1 (hu) |
ES (1) | ES2572605T3 (hu) |
HK (1) | HK1199875A1 (hu) |
HR (1) | HRP20160495T1 (hu) |
HU (1) | HUE027577T2 (hu) |
IL (1) | IL232577A (hu) |
IN (1) | IN2014KN01287A (hu) |
MX (1) | MX2014005838A (hu) |
PL (1) | PL2780332T3 (hu) |
RS (1) | RS54768B1 (hu) |
SG (1) | SG11201402206YA (hu) |
SI (1) | SI2780332T1 (hu) |
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PT2841428T (pt) | 2012-04-24 | 2018-11-29 | Vertex Pharma | Inibidores de adn-pk |
EP3985003B1 (en) | 2013-03-12 | 2023-08-09 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
DE102013008118A1 (de) | 2013-05-11 | 2014-11-13 | Merck Patent Gmbh | Arylchinazoline |
CN105814036B (zh) | 2013-10-17 | 2018-10-26 | 沃泰克斯药物股份有限公司 | 作为dna-pk抑制剂的共晶 |
KR20190062485A (ko) | 2016-09-27 | 2019-06-05 | 버텍스 파마슈티칼스 인코포레이티드 | Dna-손상제 및 dna-pk 저해제의 조합을 사용한 암 치료 방법 |
CN107793373B (zh) * | 2017-10-31 | 2019-09-17 | 广西师范大学 | 2-取代苯并三嗪酮衍生物及其制备方法 |
EA202091708A1 (ru) * | 2018-01-17 | 2020-11-10 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы днк-пк |
WO2021083936A1 (en) | 2019-11-01 | 2021-05-06 | Syngenta Crop Protection Ag | Pesticidally active fused bicyclic heteroaromatic compounds |
WO2022268648A1 (en) | 2021-06-24 | 2022-12-29 | Syngenta Crop Protection Ag | 2-[3-[1 [(quinazolin-4-yl)amino]ethyl]pyrazin-2-yl]thiazole-5-carbonitrile derivatives and similar compounds as pesticides |
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AU4972900A (en) | 1999-04-08 | 2000-11-14 | Arch Development Corporation | Use of anti-vegf antibody to enhance radiation in cancer therapy |
AU2001288432A1 (en) * | 2000-09-01 | 2002-03-22 | Icos Corporation | Materials and methods to potentiate cancer treatment |
US7291733B2 (en) * | 2003-10-10 | 2007-11-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted tricyclic heterocycles and their uses |
CN101230045B (zh) * | 2008-02-14 | 2013-04-10 | 沈阳药科大学 | 芳环并三嗪类衍生物及其应用 |
SG183855A1 (en) * | 2010-03-16 | 2012-10-30 | Merck Patent Gmbh | Morpholinylquinazolines |
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MX2014005838A (es) | 2014-07-30 |
DK2780332T3 (en) | 2016-05-30 |
JP6096792B2 (ja) | 2017-03-15 |
RS54768B1 (sr) | 2016-10-31 |
ES2572605T3 (es) | 2016-06-01 |
CN103930408A (zh) | 2014-07-16 |
ZA201404438B (en) | 2015-12-23 |
SG11201402206YA (en) | 2014-11-27 |
KR20140097391A (ko) | 2014-08-06 |
AU2012339196B2 (en) | 2017-04-27 |
US9187469B2 (en) | 2015-11-17 |
JP2015502926A (ja) | 2015-01-29 |
HK1199875A1 (en) | 2015-07-24 |
IN2014KN01287A (hu) | 2015-10-16 |
HRP20160495T1 (hr) | 2016-06-03 |
CA2856103A1 (en) | 2013-05-23 |
EP2780332A1 (de) | 2014-09-24 |
PL2780332T3 (pl) | 2016-07-29 |
CN103930408B (zh) | 2016-09-07 |
EP2780332B1 (de) | 2016-02-24 |
DE102011118830A1 (de) | 2013-05-23 |
IL232577A0 (en) | 2014-06-30 |
WO2013072015A1 (de) | 2013-05-23 |
EA201400595A1 (ru) | 2014-11-28 |
US20140275072A1 (en) | 2014-09-18 |
SI2780332T1 (sl) | 2016-06-30 |
AU2012339196A1 (en) | 2014-07-03 |
CA2856103C (en) | 2020-08-25 |
BR112014011805A2 (pt) | 2017-05-16 |
IL232577A (en) | 2017-05-29 |
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