HUE027445T2 - 1H-indazol-3-karboxamid-vegyületek alkalmazása glikogén-szintáz kináz 3-béta inhibitorként - Google Patents
1H-indazol-3-karboxamid-vegyületek alkalmazása glikogén-szintáz kináz 3-béta inhibitorként Download PDFInfo
- Publication number
- HUE027445T2 HUE027445T2 HUE13703799A HUE13703799A HUE027445T2 HU E027445 T2 HUE027445 T2 HU E027445T2 HU E13703799 A HUE13703799 A HU E13703799A HU E13703799 A HUE13703799 A HU E13703799A HU E027445 T2 HUE027445 T2 HU E027445T2
- Authority
- HU
- Hungary
- Prior art keywords
- disorders
- group
- methyl
- compound
- gsk
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (5)
- ^ $ V ν' í V j £ f!4411/DK EP 2 Sí? 301 B1 1 H“®áa^E3-k^b0xai»Iá~vegyildel: alkalmazása, glikogétt-szlMaz Mnéz 3-beta inhibitorokként SZABADALMI IDÉMYFON' ΓΟΚ L A (1) Utalásos képlett 1 II-lödazol-S-kmlxjxamM vegyuletekPl ahol 1¾ M Eís'azoBos vagy Milösbözo, és jetetésife bEffögeaBlota' balogénaiom; M szénaíomos slkllcsöpörk Mi szénaiomos alkemlesopott* 2M széaatomns alkmilesopett «agy 1 szénatomos alkoxtcsoport, adott estbe» szuhsztlttAéYgy vagy több.. a Lőve#azS eso|?oAbő| .'kiválasztott szubsztituenssei: hatogénaiora, |MtpxÍ~, ~NH?, és 1-3 sxénaíomos alkoxkspport;; karbodkiusos vagy heterociklusos akiás vagy aromlá,: 3-12 tagú gyűrű, mely adott esetben egy vagy több, a hálögérmtom, bidroxi-, 1-i Szinátötnos alktE, 1-6 szioátomöS alkoxi, -1¾¾ -0(0)01-1, - 0(0)01.¾ és ~€<ö)N.RjR2 csoportból választott sxtÉsziiMéhssel lehet szubszfcllva; Y jelentése egy kötés, ]~6 szénatomos aikiL, 2-í szénatomos alkeml-yagy 2-i Sziftatoxaes alkínilcsopori, adott esetben egy vagy több, a hálogénatom, hidroxil*, -MBy, is 1 »3 szénatomos aikoxlesoport csoportból válasziótt szúbsztítaenssel. szttbsxtiéllvat Rí> 3-12 tagú karbodfeteos vagy betetödMttsos,alifás vagy aromás* 341 szénatomos gyűrű, mely egy vagy több, a halogétiatom, hidroxíl-, miro-, dano-, -CPj, 1-6 sxénatomos alkoxi-. benziloxl-J-4 szendomps . alkik, 2-4 szénatomos alkesi~, és |~4 szénaiomos alklni!-, ~MliSÖ2Ci%, -S02NH2, -Z-€(0)0H, -Z-C(0)0Ri és ~ZC(0)NRsR2 “aWljeteiese o-kÖí# vagy 1-3 szénatomos alkilcsoport - csoportból kiválasztott s^íbsztltuepssel van sznbsztltuálva; t:j és R> f&ggetienQlhidrogénatomot» 14 szénatótüos alktiesoporiot, alkeniesoponot, 24 szénatomos alkioilesöportót, vágj? frnjtesopmtet jelem; és 0 vegytó(^; eílbga#ató szerves és szervetlen savakkal és bázisokkal képezett sddielps sói; θ$Κ>·3β szabályozatlan aktivitása vagy iúlexptésszlója mül kialakuló, az (I) inzbllm rezisztaocia betegségek; pl); Marödegener&Civ beíepégefe; (ili) baognlat zavarok; (iv) skizofrén zavarok; (v) rákos betegségek; (vi) gyulladás, (vlxj kábítószerrel való visszaélés betegségek; és (vili) epilepsziák kezelésében való alkalmazásra, 2, iíi“indazöl»3"karbözamid az 1, igénypont szerinti alkataiazásra, attól az említett iinzulin-reziszteaeia betegségek a 24ípüSü diabétesz, X szindróma, eünzottság, és polielsztás péteiészek szindróma: csoportból vannak, kiválasztva, 3, tltdadazöl44arboxs.mid az L igénypont szerinti alkalmazásra, ahol az említett oeuxodegeneradv betegségek a FarkinsookónAlzheirner kór, Huntington kór, és spmális nemrrdegenerauv betegségek csoportból vannak kiválasztva.
- 4, IHÓRdazobB-karboxamid: a 3. igénypont szerinti alkateazásm5: áboi az említeti neürodépneratív betegségek az amiotrófiás laterális szklerézls, sciemzls mnlbplex, geánm iZömsörvadás és gerincvelő sérülés következtében létrejött aeareiegeaeráeld csoportból vadnak kiválasztva. 5.1 l:frí«dazob3»karbóxamid: az 1, igénypont szmánti alkalmazásra, abol az említett hangulat zavarok a bipoláris zavarok és a depresszív zavarok csoportból vannak kiválasztva, 6. ÍH^Iiáazol“3“k8rÍáxaiai4i m $« %É$|aPRt szerinti alkalmazásra, abol az említett bipoláris zavarok a bipoláris I zavar, bipoláris II zavar, ciklusos elmeállapot és másként meg nem határozható bipoláris zavarok (BD-NOS) csoportból vannak kiválasztva, ?x. ilddadazoi-B-'karboxamid m S, igénypont szerinti alkalmazásra, aboi az említett depressziós renrfellenességek a major depressz.lv zavar (MDD), aiipusos depresszió (AD), melmikoiikas depresszió, pszkhoíibus major depressziós zavar (FMD), katalán depresszió, szülés utáni depresszió (PPD}, szezonális affektív zavar (SAÖ), dysthymla, és másként meg nem katározbaró depressziós rendellenességek (DDdsIöS) csoportból vannak kiválasztva, ÜL ÍlÍ-Índazoh3--karboxamid az i. igénypont szerinti alkalmazásra, abol a visszaélési rendeléPésségek a pszíehostinudánsokkál váló visszaélés következtében kialakult rendeilénésségek közül vannak kiválasztva.
- 9, I ax 1, Igéin pont szerinti aMmaMsm, ahól m. említett sMtófés zavarok a paranoid skizofrénia, rendezetlen Sklxöiénia* katatőn skizoitori;*, egyszerű skizofrénia* rezíiuáits tósoMiiák és diíferenetilsiaP skizofrénia esöporlból vannak kiválasztva, 10, Í||é|kia2ölO»lÉif|^8iöíd az 1,: Igénypont szeriig. ^φψφ^, aM, m eialtett rákos betegségek a prosztata, hasnyábrsirigy, petefészek és vastagbehyégMI rák* és MLL-társait lenkémla csoporiboi vannak kiválasztva,
- 11. Gyógyszerkészítmény, mely legalább egy l:. Igénypont szerinti (I) állalános képlett Végyüktet* a· mák győgyásxatiiag elfogadható szérves vagy szervetlen savval vagy bázissal képezett sóját* vágy egy észter ptodrugjáí, IsdeplátÉ) egy inert, gyógyászátilág elfogadható exeipienst fártaltPáz, CISKtóp szabályozaiaa aktivitása vagy túiexpréssziója miatt kialakuló, az (1} inzuiirnrezisztancsa betegségek, mint 2-típusú diabétesz* X»szindróma< elhizottság* és poücisztás petelsszek szindróma; ;||i| neurodegenemllv betegségek* mint Parkinson kór* Alzheimer kér*, inntingion kór* és spináik petnodegeoerativ feeíepégek; iiangnlát zavarok* ndnt bi poláris zavarok és depressziós zavarók; (ív) skizofrén zavarok; (v) rákos bóiégsépk* mint prosztata,/hasnyálmirigy, petefészek, vastagbél-végbél rak és MLiU társnlilébkémia; (vl) gyűl ládán, (kdi) kábítészerfel való visszaélés betegségek; és (yifi) epilepsziát kezelésében való afkaftnazásM,
- 12. Az aiábbl IH-miazoí'ó-karbóáamlá vegyölemfe -H-{iid2,4-diklörbe.!iziI)"piperid.Ín-4"ilj~meíllÍ"5'ntetoxitóli4ndazoltó)'karbosaroid, és
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12156298 | 2012-02-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE027445T2 true HUE027445T2 (hu) | 2016-09-28 |
Family
ID=47710141
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE13703799A HUE027445T2 (hu) | 2012-02-21 | 2013-02-08 | 1H-indazol-3-karboxamid-vegyületek alkalmazása glikogén-szintáz kináz 3-béta inhibitorként |
Country Status (27)
Country | Link |
---|---|
US (2) | US9163013B2 (hu) |
EP (1) | EP2817301B1 (hu) |
JP (1) | JP6285873B2 (hu) |
KR (1) | KR102101702B1 (hu) |
CN (1) | CN104080781B (hu) |
AR (1) | AR090085A1 (hu) |
AU (1) | AU2013224313B2 (hu) |
BR (1) | BR112014018657B1 (hu) |
CA (1) | CA2860466C (hu) |
CY (1) | CY1117467T1 (hu) |
DK (1) | DK2817301T3 (hu) |
EA (1) | EA026952B1 (hu) |
ES (1) | ES2564033T3 (hu) |
GE (1) | GEP201606552B (hu) |
HK (1) | HK1203931A1 (hu) |
HR (1) | HRP20160124T1 (hu) |
HU (1) | HUE027445T2 (hu) |
IL (1) | IL233825A (hu) |
MX (1) | MX351288B (hu) |
PL (1) | PL2817301T3 (hu) |
PT (1) | PT2817301E (hu) |
RS (1) | RS54539B1 (hu) |
SG (2) | SG10201701171TA (hu) |
SI (1) | SI2817301T1 (hu) |
SM (1) | SMT201600054B (hu) |
UA (1) | UA113189C2 (hu) |
WO (1) | WO2013124169A1 (hu) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2564033T3 (es) * | 2012-02-21 | 2016-03-17 | Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A. | Utilización de compuestos de 1H-indazol-3-carboxamida como inhibidores de la glucógeno sintasa cinasa 3 beta |
EP3190889B1 (en) | 2014-09-03 | 2021-11-17 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
CN107709314A (zh) | 2015-06-11 | 2018-02-16 | 巴斯利尔药物国际股份公司 | 外排泵抑制剂及其治疗性用途 |
WO2017093157A1 (en) * | 2015-11-30 | 2017-06-08 | Basilea Pharmaceutica Ag | Piperidine, pyrrolidine and 2-oxo-1,3-oxazinane derivatives as inhibitors of bacterial efflux-pumps for the treatment of microbial infections |
RU2018145734A (ru) * | 2016-06-08 | 2020-07-14 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Химические соединения в качестве ингибиторов atf4 пути |
CN112135821B (zh) * | 2018-05-07 | 2024-05-31 | 方济各安吉利克化学联合股份有限公司 | 作为糖原合酶激酶3β抑制剂的1H-吲唑-3-甲酰胺化合物 |
AU2019339355A1 (en) | 2018-09-13 | 2021-05-13 | Bristol-Myers Squibb Company | Indazole carboxamides as kinase inhibitors |
CN117186027B (zh) * | 2023-09-11 | 2024-04-19 | 上海蓝木化工有限公司 | 一种糖原合酶激酶-3抑制剂及其制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ257545A (en) | 1992-11-05 | 1997-01-29 | Smithkline Beecham Plc | Heterocyclic (especially piperidine) derivatives and pharmaceutical compositions |
EP0829474B1 (en) | 1995-05-31 | 2003-04-09 | Nisshin Seifun Group Inc. | Indazole derivatives having monocyclic amino group |
IT1291569B1 (it) * | 1997-04-15 | 1999-01-11 | Angelini Ricerche Spa | Indazolammidi come agenti serotoninergici |
GB0218625D0 (en) | 2002-08-10 | 2002-09-18 | Astex Technology Ltd | Pharmaceutical compounds |
ITMI20030287A1 (it) | 2003-02-18 | 2004-08-19 | Acraf | Indazolammidi dotate di attivita' analgesica metodo, per |
ITMI20030972A1 (it) | 2003-05-15 | 2004-11-16 | Acraf | Indazolo dotato di attivita' analgesica, metodo per prepararlo e composizione farmaceutica che lo comprende. |
UA99927C2 (uk) | 2007-11-12 | 2012-10-25 | Ацьенде Кимике Риуните Анджелини Франческо А.Чи.Р.А.Ф. С.П.А. | Медикамент, який є активним при невропатичному болі |
TW201040191A (en) | 2009-03-27 | 2010-11-16 | Abbott Gmbh & Co Kg | Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors |
US7947728B1 (en) * | 2009-11-11 | 2011-05-24 | Hoffmann-La Roche Inc. | Indole and indazole analogs as glycogen synthase activators |
BR112014018655B1 (pt) | 2012-02-21 | 2022-02-08 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A | Composto de 1h-indazol-3-carboxamida, e, composição farmacêutica |
ES2564033T3 (es) * | 2012-02-21 | 2016-03-17 | Aziende Chimiche Riunite Angelini Francesco - A.C.R.A.F. - S.P.A. | Utilización de compuestos de 1H-indazol-3-carboxamida como inhibidores de la glucógeno sintasa cinasa 3 beta |
-
2013
- 2013-02-08 ES ES13703799.0T patent/ES2564033T3/es active Active
- 2013-02-08 DK DK13703799.0T patent/DK2817301T3/en active
- 2013-02-08 WO PCT/EP2013/052523 patent/WO2013124169A1/en active Application Filing
- 2013-02-08 SG SG10201701171TA patent/SG10201701171TA/en unknown
- 2013-02-08 AU AU2013224313A patent/AU2013224313B2/en not_active Ceased
- 2013-02-08 CN CN201380007410.2A patent/CN104080781B/zh not_active Expired - Fee Related
- 2013-02-08 JP JP2014556994A patent/JP6285873B2/ja active Active
- 2013-02-08 MX MX2014009298A patent/MX351288B/es active IP Right Grant
- 2013-02-08 KR KR1020147022709A patent/KR102101702B1/ko active IP Right Grant
- 2013-02-08 CA CA2860466A patent/CA2860466C/en active Active
- 2013-02-08 PL PL13703799T patent/PL2817301T3/pl unknown
- 2013-02-08 EA EA201491448A patent/EA026952B1/ru unknown
- 2013-02-08 EP EP13703799.0A patent/EP2817301B1/en active Active
- 2013-02-08 SI SI201330133T patent/SI2817301T1/sl unknown
- 2013-02-08 RS RS20160091A patent/RS54539B1/en unknown
- 2013-02-08 US US14/373,393 patent/US9163013B2/en active Active
- 2013-02-08 SG SG11201403788VA patent/SG11201403788VA/en unknown
- 2013-02-08 GE GEAP201313572A patent/GEP201606552B/en unknown
- 2013-02-08 BR BR112014018657-0A patent/BR112014018657B1/pt not_active IP Right Cessation
- 2013-02-08 HU HUE13703799A patent/HUE027445T2/hu unknown
- 2013-02-08 PT PT137037990T patent/PT2817301E/pt unknown
- 2013-02-19 AR ARP130100501A patent/AR090085A1/es unknown
- 2013-08-02 UA UAA201407125A patent/UA113189C2/uk unknown
-
2014
- 2014-07-27 IL IL233825A patent/IL233825A/en active IP Right Grant
-
2015
- 2015-05-06 HK HK15104325.1A patent/HK1203931A1/zh not_active IP Right Cessation
- 2015-08-13 US US14/825,261 patent/US9700551B2/en active Active
-
2016
- 2016-02-03 HR HRP20160124TT patent/HRP20160124T1/hr unknown
- 2016-02-23 SM SM201600054T patent/SMT201600054B/xx unknown
- 2016-03-15 CY CY20161100218T patent/CY1117467T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2017258187B2 (en) | Isoquinolin-3-yl carboxamides and preparation and use thereof | |
AU2013224313B2 (en) | Use of 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors | |
US9242977B2 (en) | Trk-inhibiting compound | |
AU2013224302B2 (en) | 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors | |
US11472795B2 (en) | 1H-indazole-3-carboxamide compounds as glycogen synthase kinase 3 beta inhibitors |