HU9500952D0 - Complex combinatorial chemical libraries encoded with tags - Google Patents

Complex combinatorial chemical libraries encoded with tags

Info

Publication number
HU9500952D0
HU9500952D0 HU9500952A HU9500952A HU9500952D0 HU 9500952 D0 HU9500952 D0 HU 9500952D0 HU 9500952 A HU9500952 A HU 9500952A HU 9500952 A HU9500952 A HU 9500952A HU 9500952 D0 HU9500952 D0 HU 9500952D0
Authority
HU
Hungary
Prior art keywords
define
tags
choice
particle
stage
Prior art date
Application number
HU9500952A
Other languages
English (en)
Other versions
HUT72495A (en
Inventor
W Clark Still
Michael Ohlmeyer
Michael Wigler
Lawrence Dillard
John Reader
Original Assignee
Univ Columbia
Cold Spring Harbor Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002144637A priority Critical patent/CA2144637A1/en
Application filed by Univ Columbia, Cold Spring Harbor Lab filed Critical Univ Columbia
Publication of HU9500952D0 publication Critical patent/HU9500952D0/hu
Publication of HUT72495A publication Critical patent/HUT72495A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Record Information Processing For Printing (AREA)
HU9500952A 1992-09-18 1993-10-01 Complex combinatorial chemical libraries encoded with tags HUT72495A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002144637A CA2144637A1 (en) 1992-09-18 1992-09-18 Production of glyoxylic acid by oxidizing glycolic acid in the presence of immobilized glycolate oxidase and catalase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95537192A 1992-10-01 1992-10-01
US1394893A 1993-02-04 1993-02-04

Publications (2)

Publication Number Publication Date
HU9500952D0 true HU9500952D0 (en) 1995-05-29
HUT72495A HUT72495A (en) 1996-05-28

Family

ID=26685452

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9500952A HUT72495A (en) 1992-09-18 1993-10-01 Complex combinatorial chemical libraries encoded with tags

Country Status (14)

Country Link
EP (1) EP0665897B1 (hu)
JP (1) JPH08506175A (hu)
KR (1) KR100310939B1 (hu)
AT (1) ATE244769T1 (hu)
AU (1) AU686579B2 (hu)
CA (1) CA2143848C (hu)
DE (1) DE69333087T2 (hu)
DK (1) DK0665897T3 (hu)
ES (1) ES2204910T3 (hu)
HU (1) HUT72495A (hu)
IL (1) IL107166A (hu)
NO (1) NO951230L (hu)
PT (1) PT665897E (hu)
WO (1) WO1994008051A1 (hu)

Families Citing this family (203)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688941A (en) * 1990-07-27 1997-11-18 Isis Pharmaceuticals, Inc. Methods of making conjugated 4' desmethyl nucleoside analog compounds
US5998603A (en) 1994-09-29 1999-12-07 Isis Pharmaceuticals, Inc. 4'-desmethyl nucleoside analogs, and oligomers thereof
US5608046A (en) * 1990-07-27 1997-03-04 Isis Pharmaceuticals, Inc. Conjugated 4'-desmethyl nucleoside analog compounds
US5646123A (en) * 1991-06-10 1997-07-08 Alberta Research Council Time dependent administration of oligosaccharide glycosides related to blood group determinants having a type I or type II core structure in reducing inflammation in a sensitized mammal arising form exposure to an antigen
EP0604552B1 (en) * 1991-09-18 1997-02-12 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5639603A (en) * 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
AU5827294A (en) * 1992-12-11 1994-07-04 Chiron Corporation Synthesis of encoded polymers
DK1310510T3 (da) * 1993-05-27 2007-09-24 Aventis Pharma Inc Topologisk adsilte, kodede biblioteker med fast fase
US5840485A (en) * 1993-05-27 1998-11-24 Selectide Corporation Topologically segregated, encoded solid phase libraries
US5789385A (en) * 1993-06-16 1998-08-04 Glycomed Incorporated Sialyl Lewisx mimetics containing phenyl backbones
US5837689A (en) * 1993-06-16 1998-11-17 Glycomed Incorporated Sialyl lewis-x mimetics containing naphthyl backbones
IL106106A0 (en) * 1993-06-22 1993-10-20 Interpharm Lab Ltd Library of polymeric molecules and its preparation
US6087186A (en) * 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US5503805A (en) * 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US6165778A (en) * 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
US6828427B1 (en) 1994-01-11 2004-12-07 Isis Pharmaceuticals, Inc. Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same
US6184389B1 (en) 1994-01-11 2001-02-06 Isis Pharmaceuticals, Inc. Combinatorial libraries having aminodiol monomer subunits
JPH09510442A (ja) * 1994-03-11 1997-10-21 ファーマコペイア，インコーポレイテッド スルホンアミド誘導体及びそれらの使用
US6790965B1 (en) 1994-05-06 2004-09-14 Pharmacopeia Drug Discovery, Inc. Combinatorial dihydrobenzopyran library
JPH10500112A (ja) * 1994-05-06 1998-01-06 ファーマコピーア，インコーポレイテッド 組合せ ジヒドロベンゾピラン ライブラリー
US5856083A (en) * 1994-05-06 1999-01-05 Pharmacopeia, Inc. Lawn assay for compounds that affect enzyme activity or bind to target molecules
DE69513178T2 (de) * 1994-07-22 2000-08-31 Zeneca Ltd., London Verfahren zur sichtung einer bibliothek von chemischen verbindungen
US5939268A (en) * 1994-07-26 1999-08-17 The Scripps Research Institute Combinatorial libraries of molecules and methods for producing same
US5846719A (en) * 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US5604097A (en) * 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5695934A (en) * 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
EP0804460A1 (en) * 1995-01-20 1997-11-05 Molecumetics, Ltd. Conformationally constrained reverse-turn library and methods relating thereto
GB9502225D0 (en) * 1995-02-04 1995-03-22 Zeneca Ltd Method
EP0817787A4 (en) 1995-03-27 2000-09-13 Isis Pharmaceuticals Inc NITROGEN MACROCYCLIC COMPOUNDS
WO1996030392A1 (en) * 1995-03-28 1996-10-03 Novartis Ag Process for the production of combinatorial compound libraries
US5801175A (en) 1995-04-07 1998-09-01 Schering Corporation Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
US5925562A (en) * 1995-04-25 1999-07-20 Irori Remotely programmable matrices with memories
US6284459B1 (en) 1995-04-25 2001-09-04 Discovery Partners International Solid support matrices with memories and combinatorial libraries therefrom
US6100026A (en) * 1995-04-25 2000-08-08 Irori Matrices with memories and uses thereof
US5961923A (en) * 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
WO1996033972A1 (en) * 1995-04-28 1996-10-31 Glaxo Group Limited Methods for synthesizing diverse collections of pyridines, pyrimidines, 1,4-dihydro derivatives thereof, and piperidine derivatives
AU5987696A (en) * 1995-06-07 1996-12-30 Zymogenetics Inc. Combinatorial non-peptide libraries
JPH11509086A (ja) * 1995-06-21 1999-08-17 マーテック・バイオサイエンシズ・コーポレイション 標識生化学化合物の組合わせライブラリーとその作成方法
WO1997001560A1 (en) * 1995-06-29 1997-01-16 Pharmacopeia, Inc. Combinatorial 1,4-benzodiazepin-2,5-dione library
GB9515070D0 (en) * 1995-07-22 1995-09-20 Zeneca Ltd Label
GB9517661D0 (en) * 1995-08-30 1995-11-01 Smithkline Beecham Plc Novel compounds
US5886186A (en) * 1995-10-25 1999-03-23 Versicor, Inc. Synthesis of substituted N-heteroaromatic compounds and methods of use thereof
US5605616A (en) * 1995-11-06 1997-02-25 Versicor, Inc. Reversible charge-based sequestration on solid support
US5846839A (en) * 1995-12-22 1998-12-08 Glaxo Group Limited Methods for hard-tagging an encoded synthetic library
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
WO1997027325A2 (en) * 1996-01-23 1997-07-31 Rapigene, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6312893B1 (en) 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
US5766963A (en) * 1996-01-26 1998-06-16 Pharmacopeia, Inc. Combination hydroxypropylamine library
US5649576A (en) * 1996-02-26 1997-07-22 Pharmacopeia, Inc. Partitioning device
US5880972A (en) * 1996-02-26 1999-03-09 Pharmacopeia, Inc. Method and apparatus for generating and representing combinatorial chemistry libraries
GB2326152B (en) * 1996-03-07 2000-06-28 Imperial College A composite for combinatorial organic synthesis
GB9604858D0 (en) * 1996-03-07 1996-05-08 Imperial College A composite
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US5792431A (en) * 1996-05-30 1998-08-11 Smithkline Beecham Corporation Multi-reactor synthesizer and method for combinatorial chemistry
US6077954A (en) 1996-08-01 2000-06-20 Isis Pharmaceuticals, Inc. Substituted heterocyclic compounds
US6355490B1 (en) 1996-09-13 2002-03-12 Jill Edie Hochlowski Attached tags for use in combinatorial chemistry synthesis
US5798035A (en) * 1996-10-03 1998-08-25 Pharmacopeia, Inc. High throughput solid phase chemical synthesis utilizing thin cylindrical reaction vessels useable for biological assay
US5780241A (en) * 1996-11-05 1998-07-14 Isis Pharmaceuticals, Inc. Complex chemical libraries
JP2001508050A (ja) * 1996-12-18 2001-06-19 イーライ・リリー・アンド・カンパニー ヒドロフロキノリンライブラリーを作製するためのコンビネーション法
US6004823A (en) * 1997-05-07 1999-12-21 Smithkline Beecham Corporation Compounds
US5908960A (en) * 1997-05-07 1999-06-01 Smithkline Beecham Corporation Compounds
US6037340A (en) * 1997-05-28 2000-03-14 Cadus Pharmaceutical Corporation Synthesis and use of thiophene- and pyrrole-based heteroaromatic compounds
US6376670B1 (en) 1997-06-19 2002-04-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
JP2002505689A (ja) 1997-06-19 2002-02-19 セプレイコー インコーポレイテッド キノリン−インドール抗菌剤、それらに関する用途及び組成物
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6207679B1 (en) 1997-06-19 2001-03-27 Sepracor, Inc. Antimicrobial agents uses and compositions related thereto
US6750344B1 (en) 1997-09-05 2004-06-15 Isis Pharmaceuticals, Inc. Amine compounds and combinatorial libraries comprising same
US6168913B1 (en) 1997-10-14 2001-01-02 Abbott Laboratories Coding combinatorial libraries with fluorine tags
AUPP032897A0 (en) * 1997-11-12 1997-12-04 University Of Queensland, The Oligomer libraries
US7964192B1 (en) 1997-12-02 2011-06-21 Janssen Alzheimer Immunotherapy Prevention and treatment of amyloidgenic disease
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
WO1999028290A1 (en) 1997-12-03 1999-06-10 Massachusetts Institute Of Technology Synthesis of oligoarylamines, and uses and reagents related thereto
GB9814259D0 (en) * 1998-07-02 1998-09-02 Univ Hertfordshire Improvements to the fabrication and method of use of coded particles in the field of combinatorial chemistry
US6642062B2 (en) * 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
US6291516B1 (en) 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
AU4698600A (en) 1999-05-05 2000-11-17 Ut-Battelle, Llc Method and apparatus for combinatorial chemistry
US7396905B1 (en) 1999-05-21 2008-07-08 Mckeon Frank Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
UA81216C2 (en) 1999-06-01 2007-12-25 Prevention and treatment of amyloid disease
WO2000077519A1 (en) * 1999-06-15 2000-12-21 Aventis Pharmaceuticals Products Inc. Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
NO994873D0 (no) 1999-10-06 1999-10-06 Sinvent As Metode for syntese og analyse av kombinatoriske kjemibiblioteker
ATE483970T1 (de) 2000-02-08 2010-10-15 Sangamo Biosciences Inc Zellen zur entdeckung von medikamenten
EP1265641A2 (en) 2000-02-22 2002-12-18 Biostream, Inc. Imaging agents for diagnosis of parkinson's disease
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US6613798B1 (en) 2000-03-30 2003-09-02 Curis, Inc. Small organic molecule regulators of cell proliferation
US6683108B1 (en) 2000-03-30 2004-01-27 Curis, Inc. Agonists of hedgehog signaling pathways and uses related thereto
US7115653B2 (en) 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
US8852937B2 (en) 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
US6511808B2 (en) 2000-04-28 2003-01-28 Sangamo Biosciences, Inc. Methods for designing exogenous regulatory molecules
EP1276860B1 (en) 2000-04-28 2007-09-26 Sangamo Biosciences Inc. Databases of regulatory sequences; methods of making and using same
WO2001084148A2 (en) 2000-04-28 2001-11-08 Sangamo Biosciences, Inc. Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
US7923542B2 (en) 2000-04-28 2011-04-12 Sangamo Biosciences, Inc. Libraries of regulatory sequences, methods of making and using same
US20020064802A1 (en) 2000-04-28 2002-05-30 Eva Raschke Methods for binding an exogenous molecule to cellular chromatin
EP1287364B1 (en) 2000-04-29 2008-10-22 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
WO2001093892A1 (en) 2000-06-08 2001-12-13 The Center For Blood Research, Inc. Methods and compositions for inhibiting immunoglobulin-mediated__reperfusion injury
US6576472B1 (en) 2000-07-26 2003-06-10 Smithkline Beecham Corporation Chemical constructs for solution phase chemistry
US6584411B1 (en) 2000-07-26 2003-06-24 Smithkline Beecham Corporation Methods to facilitate the calculation of yields of reaction products
US6908732B2 (en) 2000-10-13 2005-06-21 President & Fellows Of Harvard College Compounds and methods for regulating cell differentiation
US7378280B2 (en) 2000-11-16 2008-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
JP4057422B2 (ja) * 2001-01-25 2008-03-05 プレシジョン・システム・サイエンス株式会社 微小物識別装置およびその識別方法
AU2002258100B2 (en) 2001-03-02 2007-03-01 University Of Western Ontario Polymer precursors of radiolabeled compounds, and methods of making and using the same
DE10117274B4 (de) * 2001-04-06 2005-03-03 Hte Ag The High Throughput Experimentation Company Verfahren zur Analyse und Archivierung von wenigstens einer Materialbibliothek
EP1390340B1 (en) 2001-04-24 2017-03-01 Massachusetts Institute Of Technology Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
WO2002100172A1 (en) 2001-06-11 2002-12-19 Xenoport, Inc. Administration of agents via the pept-2 transporter
WO2004001042A2 (en) * 2002-06-20 2003-12-31 Nuevolution A/S Microarrays displaying encoded molecules
WO2002102820A1 (en) 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
US6974665B2 (en) 2001-09-06 2005-12-13 University Of Nebraska In situ screening to optimize variables in organic reactions
US20050065205A1 (en) 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
ES2559764T3 (es) 2002-03-11 2016-02-15 Molecular Insight Pharmaceuticals, Inc. Complejos de tecnecio-dipiridina, y métodos de uso de los mismos
ATE414769T1 (de) 2002-03-15 2008-12-15 Nuevolution As Eine verbesserte methode zur synthese von matritzenabhängigen molekülen
EP1496905B1 (en) 2002-04-22 2008-08-13 Johns Hopkins University School of Medicine Modulators of hedgehog signaling pathways, compositions and uses related thereto
AU2003228793B2 (en) 2002-04-30 2008-01-03 Trustees Of Tufts College Smart Pro-Drugs of Serine Protease Inhibitors
HUP0202212A2 (hu) * 2002-07-10 2004-04-28 Comgenex Rt. Új kombinatorikus fehérjemarker molekulakönyvtárak, eljárás azok előállítására és alkalmazására
AU2003247266A1 (en) 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
ES2640279T3 (es) 2002-10-30 2017-11-02 Nuevolution A/S Procedimiento para la síntesis de un complejo bifuncional
US8506959B2 (en) 2002-11-01 2013-08-13 Neotope Biosciences Limited Prevention and treatment of synucleinopathic and amyloidogenic disease
TW200509968A (en) 2002-11-01 2005-03-16 Elan Pharm Inc Prevention and treatment of synucleinopathic disease
EP2583958B1 (en) 2002-12-09 2016-08-10 Massachusetts Institute of Technology (MIT) Ligands for metals and improved metal-catalyzed processes based thereon
EP1756277B1 (en) 2002-12-19 2009-12-02 Nuevolution A/S Quasirandom structure and function guided synthesis methods
ZA200505782B (en) 2003-02-01 2006-09-27 Neuralab Ltd Active immunization to generate antibodies to soluble A-beta
US20070026397A1 (en) 2003-02-21 2007-02-01 Nuevolution A/S Method for producing second-generation library
WO2005019819A1 (en) 2003-08-20 2005-03-03 Biosite, Inc. Methods and compositions for measuring biologically active natriuretic peptides and for improving their therapeutic potential
CN100536926C (zh) 2003-05-02 2009-09-09 西安大略省大学 合成放射性药物中连接至甲锡烷基聚合物的辅基
US20050014932A1 (en) 2003-05-15 2005-01-20 Iogenetics, Llc Targeted biocides
US7358331B2 (en) 2003-05-19 2008-04-15 Elan Pharmaceuticals, Inc. Truncated fragments of alpha-synuclein in Lewy body disease
PT1633189T (pt) 2003-05-19 2017-10-04 Prothena Biosciences Ltd Fragmentos truncados de alfa-sinucleína em doença com corpos de lewy
US8153410B2 (en) 2003-07-07 2012-04-10 Fox Chase Cancer Center Alternate morpheein forms of allosteric proteins as a target for the development of bioactive molecules
US20060162014A1 (en) 2003-07-07 2006-07-20 Jaffe Eileen K Alternate morpheeins of allosteric proteins as a target for the development of bioactive molecules
EP1670939B1 (en) 2003-09-18 2009-11-04 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
JP4696079B2 (ja) 2003-12-17 2011-06-08 ヤンセン アルツハイマー イミュノセラピー Ａβ免疫原性ペプチド担体結合物およびそれの製造方法
US20070134762A1 (en) 2003-12-17 2007-06-14 Arumugham Rasappa G Immunogenic peptide carrier conjugates and methods of producing same
ATE413393T1 (de) * 2003-12-20 2008-11-15 Merck Patent Gmbh 2-(hetero-)aryl substituierte tetrahydrochinolinderivate
WO2005082425A1 (en) 2004-02-24 2005-09-09 The General Hospital Corporation Catalytic radiofluorination
ATE498010T1 (de) 2004-03-01 2011-02-15 Immune Disease Inst Inc Natürliche igm-antikörper und inhibitoren davon
TW201207390A (en) 2004-05-18 2012-02-16 Brni Neurosciences Inst Method for screening agent for antidepressant activity
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
US7342093B2 (en) 2004-07-23 2008-03-11 University Of Massachusetts Compounds that inhibit Hsp90 protein-protein interactions with IAP proteins
US7572600B2 (en) 2004-08-04 2009-08-11 Chemocentryx, Inc. Enzymatic activities in chemokine-mediated inflammation
MX2007001679A (es) 2004-08-09 2007-05-23 Elan Pharm Inc Prevencion y tratamiento de la enfermedad sinucleinopatica y amiloidogenica.
AU2006214320C1 (en) 2005-02-14 2012-07-05 University Of Iowa Research Foundation Methods and reagents for treatment and diagnosis of age-related macular degeneration
SG171690A1 (en) 2005-03-22 2011-06-29 Harvard College Treatment of protein degradation disorders
AU2006244074B2 (en) 2005-05-09 2012-12-13 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
CA2617003A1 (en) 2005-07-29 2007-02-08 Blanchette Rockefeller Neurosciences Institute Use of a pkc activator, alone or combined with a pkc inhibitor to enhance long term memory
US8193328B2 (en) 2005-09-08 2012-06-05 Philadelphia Health & Education Corporation Identification of modulators of serine protease inhibitor Kazal and their use as anti-cancer and anti-viral agents
WO2007044396A2 (en) 2005-10-04 2007-04-19 The Research Foundation Of State University Of New York Fibronectin polypeptides and methods of use
EP1957644B1 (en) 2005-12-01 2010-12-01 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
MX2008010462A (es) 2006-02-14 2009-04-17 Harvard College Inhibidores de histona desacetilasa.
EP1991247B1 (en) 2006-02-14 2015-10-14 President and Fellows of Harvard College Bifunctional histone deacetylase inhibitors
JP5497431B2 (ja) 2006-05-03 2014-05-21 プレジデント アンド フェローズ オブ ハーバード カレッジ ヒストンデアセチラーゼおよびチューブリンデアセチラーゼ阻害剤
EP3050562A1 (en) 2006-05-22 2016-08-03 The Board of Trustees of the Leland Stanford Junior University Pharmacological treatment of cognitive impairment using gabaa receptor antagonists
JP2009538924A (ja) 2006-06-01 2009-11-12 エラン ファーマシューティカルズ，インコーポレイテッド Ａｐｐの神経活性断片
EP3042668B1 (en) 2006-06-07 2018-09-19 The Board of Trustees of the Leland Stanford Junior University Anti-leukocyte recruitment therapy for the treatment of seizures and epilepsy
US20100297102A1 (en) 2006-06-22 2010-11-25 Hannah Monyer Serotonin 5-ht3a receptors in treatment of neurological and psychiatric disorders
AU2007287024A1 (en) 2006-08-24 2008-02-28 Surface Logix, Inc. Pharmacokinetically improved compounds
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
KR20090120480A (ko) 2007-02-09 2009-11-24 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 허혈/뇌졸중-유도된 기억 장애 및 뇌 손상에 대한 브리오스타틴, 브리오로그 및 기타 관련된 물질의 치료학적 효과
EP2121000B1 (en) 2007-02-09 2015-09-23 Blanchette Rockefeller Neurosciences, Institute Therapeutic effects of bryostatins, bryologs, and other related substances on head trauma-induced memory impairment and brain injury
PL2118300T3 (pl) 2007-02-23 2015-11-30 Prothena Biosciences Ltd Zapobieganie i leczenie synukleinopatii i amyloidozy
HUE043966T2 (hu) 2007-02-23 2019-09-30 Prothena Biosciences Ltd Szinukleinopátiás és amiloidogén betegség megelõzése és kezelése
EP2167111A4 (en) 2007-06-14 2010-06-09 Univ New York State Res Found POLYPEPTIDES AND METHOD OF USE
EP2192916A4 (en) 2007-08-23 2012-04-04 Univ Leland Stanford Junior MODULATION OF SYNAPTOGENESIS
WO2009078799A1 (en) 2007-12-17 2009-06-25 Marfl Ab New vaccine for the treatment of mycobacterium related disorders
EP2237803B1 (en) 2007-12-28 2015-07-01 Prothena Biosciences Limited Treatment and prophylaxis of amyloidosis
CA2713423A1 (en) 2008-01-18 2009-07-23 North Carolina State University Peptides and methods of use as therapeutics and screening agents
US8440716B2 (en) 2008-07-23 2013-05-14 President And Fellows Of Harvard College Deacetylase inhibitors and uses thereof
WO2010021415A1 (en) 2008-08-18 2010-02-25 Seoul National University Industry Foundation Method for controlling cancer metastasis or cancer cell migration by modulating the cellular level of lysyl trna synthetase
SG173627A1 (en) 2009-02-13 2011-09-29 Chem Inc X Methods of creating and screening dna-encoded libraries
HUE033661T2 (hu) 2009-02-16 2017-12-28 Cerenis Therapeutics Holding Sa Apolipoprotein A-l mimetikumok
JP6059014B2 (ja) 2009-06-19 2017-01-11 アリゾナ ボード オブ リージェンツ ア ボディー コーポレート アクティング オン ビハーフ オブ アリゾナ ステイト ユニバーシティＡＲＩＺＯＮＡ ＢＯＡＲＤ ＯＦ ＲＥＧＥＮＴＳ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ ａｃｔｉｎｇ ｏｎ ｂｅｈａｌｆ ｏｆ ＡＲＩＺＯＮＡ ＳＴＡＴＥ ＵＮＩＶＥＲＳＩＴＹ 試料の構成成分の検出において使用されるデバイスを製造する方法およびペプチドアレイ
US8716344B2 (en) 2009-08-11 2014-05-06 President And Fellows Of Harvard College Class- and isoform-specific HDAC inhibitors and uses thereof
WO2011091435A2 (en) 2010-01-25 2011-07-28 Mount Sinai School Of Medicine Methods of treating liver disease
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
WO2012162514A2 (en) 2011-05-26 2012-11-29 Regents Of The University Of Michigan Epigenetic co-repressors of the gamma-globin gene and methods of using same
BR112014005205A2 (pt) 2011-09-07 2017-03-21 X-Chem Inc métodos para etiquetar bibliotecas codificadas com dna
JP6166263B2 (ja) 2011-09-22 2017-07-19 メディシナル バイオコンバージェンス リサーチ センター ロイシンｔＲＮＡ合成酵素の新規用途（ＮｏｖｅｌｕｓｅｏｆｌｅｕｃｙｌｔＲＮＡｓｙｎｔｈｅｔａｓｅ）
EP2748307A4 (en) 2011-09-23 2015-08-19 Univ Louisville Res Found METHODS AND COMPOSITIONS FOR CELL EXPANSION AND GRAFT ENHANCEMENT
KR101398079B1 (ko) 2011-10-10 2014-05-27 재단법인 의약바이오컨버젼스연구단 글리실-티알엔에이 합성효소 및 캐드헤린을 이용한 암 예방 또는 치료제의 스크리닝 방법
WO2013078138A1 (en) 2011-11-21 2013-05-30 OSI Pharmaceuticals, LLC Proton nmr spectroscopy for biochemical screening
IL236633B (en) 2012-07-13 2022-07-01 X Chem Inc DNA-encoded libraries containing a conjugate containing conjugated oligonucleotide links
US9517223B2 (en) 2012-08-07 2016-12-13 The General Hospital Corporation Methods to treat neurodegenerative diseases
US9970932B2 (en) 2013-03-15 2018-05-15 Arizona Board Of Regents On Behalf Of Arizona State University Non-covalent patterned chemical features and use thereof in MALDI-based quality control
WO2014145123A2 (en) 2013-03-15 2014-09-18 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State Unversity Peptide array quality control
WO2016040895A1 (en) 2014-09-12 2016-03-17 xxTHE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Wnt signaling agonist molecules
US10196613B2 (en) 2014-12-19 2019-02-05 Regeneron Pharmaceuticals, Inc. Stem cells for modeling type 2 diabetes
US10758886B2 (en) 2015-09-14 2020-09-01 Arizona Board Of Regents On Behalf Of Arizona State University Conditioned surfaces for in situ molecular array synthesis
US11186641B2 (en) 2016-03-17 2021-11-30 Oslo Universitetssykehus Hf Fusion proteins targeting tumour associated macrophages for treating cancer
WO2017197158A1 (en) 2016-05-11 2017-11-16 Leuvas Therapeutics Blockade of tim-1 pathways and p-selectin pathways in treatment of neuroinflammatory degenerative disease
WO2017208210A1 (en) 2016-06-03 2017-12-07 Prothena Biosciences Limited Anti-mcam antibodies and associated methods of use
CA3028975A1 (en) 2016-06-20 2017-12-28 Healthtell Inc. Methods for diagnosis and treatment of autoimmune diseases
AU2017281039A1 (en) 2016-06-20 2019-01-24 Healthtell Inc. Methods for differential diagnosis of autoimmune diseases
PT3482210T (pt) 2016-07-06 2021-07-28 Prothena Biosciences Ltd Ensaio para detetar alfa-sinucleína total e fosforilada s129
US10548302B2 (en) 2016-07-29 2020-02-04 Regeneron Pharmaceuticals, Inc. Fibrillin-1 mutations for modeling neonatal progeroid syndrome with congenital lipodystrophy
EP3526346A1 (en) 2016-10-12 2019-08-21 Janssen Biotech, Inc. Methods for screening for modulators of gdf15-like biological activity
US11371990B2 (en) 2016-11-11 2022-06-28 Cowper Sciences Inc. Methods for identifying candidate biomarkers
US20200150109A1 (en) 2017-05-05 2020-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Microtubule-targeting drugs as immune checkpoint inhibitors and methods of screening novel immune checkpoint inhibitors for the treatment of cancers and infectious diseases
JP7370252B2 (ja) 2017-05-30 2023-10-27 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 神経炎症性疾患の治療
WO2019094735A1 (en) 2017-11-10 2019-05-16 Regeneron Pharmaceuticals, Inc. Non-human animals comprising slc30a8 mutation and methods of use
US20210396761A1 (en) 2018-07-20 2021-12-23 Aicuris Gmbh & Co. Kg Methods for screening and identifying agents that inhibit or modulate the nuclear egress complex of herpesviruses
JP2022526429A (ja) 2019-04-10 2022-05-24 ザ ユニバーシティ オブ ユタ リサーチ ファウンデイション Ａｍｄの処置のためのｈｔｒａ１調節

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631211A (en) * 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4755558A (en) * 1986-05-30 1988-07-05 Beckman Instruments, Inc. Using internal marker
EP0427745A4 (en) * 1988-07-14 1992-11-25 Baylor College Of Medicine Solid phase assembly and reconstruction of biopolymers
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
EP0604552B1 (en) * 1991-09-18 1997-02-12 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers
US5677195A (en) * 1991-11-22 1997-10-14 Affymax Technologies N.V. Combinatorial strategies for polymer synthesis
AU3816993A (en) * 1992-03-19 1993-10-21 Regents Of The University Of California, The Multiple tag labeling method for DNA sequencing
US5573905A (en) * 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5541061A (en) * 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
HUT65477A (en) * 1992-05-21 1994-06-28 Recsei Method for complex purification of communal and industrial waste water and apparatus therefor
US5565324A (en) * 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags

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