WO2000021909A3 - Selecting codes to be used for encoding combinatorial libraries - Google Patents

Selecting codes to be used for encoding combinatorial libraries Download PDF

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Publication number
WO2000021909A3
WO2000021909A3 PCT/US1999/023444 US9923444W WO0021909A3 WO 2000021909 A3 WO2000021909 A3 WO 2000021909A3 US 9923444 W US9923444 W US 9923444W WO 0021909 A3 WO0021909 A3 WO 0021909A3
Authority
WO
WIPO (PCT)
Prior art keywords
codes
synthesis
tags
criterion
combinatorial libraries
Prior art date
Application number
PCT/US1999/023444
Other languages
French (fr)
Other versions
WO2000021909A2 (en
Inventor
Lawrence Wayne Dillard
James Andrew Connelly
John J Baldwin
Eric George Horlbeck
Gregory L Kirk
Giorgio Lauri
Original Assignee
Pharmacopeia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacopeia Inc filed Critical Pharmacopeia Inc
Priority to AU62959/99A priority Critical patent/AU6295999A/en
Priority to EP99950264A priority patent/EP1119530A2/en
Publication of WO2000021909A2 publication Critical patent/WO2000021909A2/en
Publication of WO2000021909A3 publication Critical patent/WO2000021909A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00542—Alphanumeric characters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)

Abstract

Codes to be used for encoding combinatorial libraries are selectively chosen based on one or more predefined function or criterion. In particular, a subset of N possible codes is selected based on some criterion. In one example, the codes are binary codes, and each code represents the tags used during a particular stage of synthesis of members of a combinatorial library. The tags define the reaction condition used during that particular stage of synthesis. In one embodiment, the predefined criterion ensures that each code includes more than one tag. This helps eliminate ambiguity during a decoding process in which the tags are identified to determine the reaction history during synthesis.
PCT/US1999/023444 1998-10-09 1999-10-07 Selecting codes to be used for encoding combinatorial libraries WO2000021909A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU62959/99A AU6295999A (en) 1998-10-09 1999-10-07 Selecting codes to be used for encoding combinatorial libraries
EP99950264A EP1119530A2 (en) 1998-10-09 1999-10-07 Selecting codes to be used for encoding combinatorial libraries

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16942698A 1998-10-09 1998-10-09
US09/169,426 1998-10-09

Publications (2)

Publication Number Publication Date
WO2000021909A2 WO2000021909A2 (en) 2000-04-20
WO2000021909A3 true WO2000021909A3 (en) 2001-01-04

Family

ID=22615638

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/023444 WO2000021909A2 (en) 1998-10-09 1999-10-07 Selecting codes to be used for encoding combinatorial libraries

Country Status (3)

Country Link
EP (1) EP1119530A2 (en)
AU (1) AU6295999A (en)
WO (1) WO2000021909A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932992B2 (en) 2001-06-20 2015-01-13 Nuevolution A/S Templated molecules and methods for using such molecules
US9096951B2 (en) 2003-02-21 2015-08-04 Nuevolution A/S Method for producing second-generation library
US9109248B2 (en) 2002-10-30 2015-08-18 Nuevolution A/S Method for the synthesis of a bifunctional complex
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2186897B1 (en) 2002-03-15 2016-02-17 Nuevolution A/S An improved method for synthesising templated molecules
WO2004013070A2 (en) 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
CA2539890A1 (en) 2002-09-27 2004-04-08 Carlsberg A/S Spatially encoded polymer matrix
DE602004019764D1 (en) 2003-03-20 2009-04-16 Nuevolution As LIGATION-RELATED CODING OF SMALL MOLECULES
WO2005026387A1 (en) 2003-09-18 2005-03-24 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
DE602005017370D1 (en) 2004-03-22 2009-12-10 Nuevolution As LIGATION CODING USING OLIGONUCLEOTIDE COMPONENTS
CA2832672A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995028640A1 (en) * 1994-04-13 1995-10-26 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995028640A1 (en) * 1994-04-13 1995-10-26 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BALDWIN J J ET AL: "SYNTHESIS OF A SMALL MOLECULE COMBINATORIAL LIBRARY ENCODED WITH MOLECULAR TAGS", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, vol. 117, no. 20, 1995, pages 5588 - 5589, XP000652265, ISSN: 0002-7863 *
CHABALA J C ET AL: "BINARY ENCODED SMALL-MOLECULE LIBRARIES IN DRUG DISCOVERY AND OPTIMIZATION", PERSPECTIVES IN DRUG DISCOVERY AND DESIGN,XX,ESCOM SCIENCE PUBLISHERS BV, vol. 2, 1994, pages 305 - 318, XP000654519, ISSN: 0928-2866 *
LEBL M. ET AL.: "One-bead-one-structure combinatorial libraries", BIOPOLYMERS (PEPTIDE SCIENCE), vol. 37, 1995, pages 177 - 198, XP000929745 *
OHLMEYER M H J ET AL: "COMPLEX SYNTHETIC CHEMICAL LIBRARIES INDEXED WITH MOLECULAR TAGS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 90, 1 December 1993 (1993-12-01), pages 10922 - 10926, XP000652270, ISSN: 0027-8424 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932992B2 (en) 2001-06-20 2015-01-13 Nuevolution A/S Templated molecules and methods for using such molecules
US9109248B2 (en) 2002-10-30 2015-08-18 Nuevolution A/S Method for the synthesis of a bifunctional complex
US9284600B2 (en) 2002-10-30 2016-03-15 Neuvolution A/S Method for the synthesis of a bifunctional complex
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US9096951B2 (en) 2003-02-21 2015-08-04 Nuevolution A/S Method for producing second-generation library
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries

Also Published As

Publication number Publication date
WO2000021909A2 (en) 2000-04-20
AU6295999A (en) 2000-05-01
EP1119530A2 (en) 2001-08-01

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