WO2000021909A3 - Selecting codes to be used for encoding combinatorial libraries - Google Patents

Selecting codes to be used for encoding combinatorial libraries Download PDF

Info

Publication number
WO2000021909A3
WO2000021909A3 PCT/US1999/023444 US9923444W WO0021909A3 WO 2000021909 A3 WO2000021909 A3 WO 2000021909A3 US 9923444 W US9923444 W US 9923444W WO 0021909 A3 WO0021909 A3 WO 0021909A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
codes
used
synthesis
tags
criterion
Prior art date
Application number
PCT/US1999/023444
Other languages
French (fr)
Other versions
WO2000021909A2 (en )
Inventor
John J Baldwin
James Andrew Connelly
Lawrence Wayne Dillard
Eric George Horlbeck
Gregory L Kirk
Giorgio Lauri
Original Assignee
Pharmacopeia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL CHEMISTRY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
    • C40B70/00Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00542Alphanumeric characters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • B01J2219/00689Automatic using computers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00695Synthesis control routines, e.g. using computer programs

Abstract

Codes to be used for encoding combinatorial libraries are selectively chosen based on one or more predefined function or criterion. In particular, a subset of N possible codes is selected based on some criterion. In one example, the codes are binary codes, and each code represents the tags used during a particular stage of synthesis of members of a combinatorial library. The tags define the reaction condition used during that particular stage of synthesis. In one embodiment, the predefined criterion ensures that each code includes more than one tag. This helps eliminate ambiguity during a decoding process in which the tags are identified to determine the reaction history during synthesis.
PCT/US1999/023444 1998-10-09 1999-10-07 Selecting codes to be used for encoding combinatorial libraries WO2000021909A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US16942698 true 1998-10-09 1998-10-09
US09/169,426 1998-10-09

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU6295999A AU6295999A (en) 1998-10-09 1999-10-07 Selecting codes to be used for encoding combinatorial libraries
EP19990950264 EP1119530A2 (en) 1998-10-09 1999-10-07 Selecting codes to be used for encoding combinatorial libraries

Publications (2)

Publication Number Publication Date
WO2000021909A2 true WO2000021909A2 (en) 2000-04-20
WO2000021909A3 true true WO2000021909A3 (en) 2001-01-04

Family

ID=22615638

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/023444 WO2000021909A3 (en) 1998-10-09 1999-10-07 Selecting codes to be used for encoding combinatorial libraries

Country Status (2)

Country Link
EP (1) EP1119530A2 (en)
WO (1) WO2000021909A3 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932992B2 (en) 2001-06-20 2015-01-13 Nuevolution A/S Templated molecules and methods for using such molecules
US9096951B2 (en) 2003-02-21 2015-08-04 Nuevolution A/S Method for producing second-generation library
US9109248B2 (en) 2002-10-30 2015-08-18 Nuevolution A/S Method for the synthesis of a bifunctional complex
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101006177B (en) 2002-03-15 2011-10-12 纽韦卢森公司 An improved method for synthesising templated molecules
CA2539890A1 (en) 2002-09-27 2004-04-08 Carlsberg A/S Spatially encoded polymer matrix
US7915201B2 (en) 2003-03-20 2011-03-29 Nuevolution A/S Ligational encoding of small molecules
DE602005017370D1 (en) 2004-03-22 2009-12-10 Nuevolution As Ligation coding using of oligonucleotide building

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995028640A1 (en) * 1994-04-13 1995-10-26 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995028640A1 (en) * 1994-04-13 1995-10-26 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BALDWIN J J ET AL: "SYNTHESIS OF A SMALL MOLECULE COMBINATORIAL LIBRARY ENCODED WITH MOLECULAR TAGS", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, vol. 117, no. 20, 1995, pages 5588 - 5589, XP000652265, ISSN: 0002-7863 *
CHABALA J C ET AL: "BINARY ENCODED SMALL-MOLECULE LIBRARIES IN DRUG DISCOVERY AND OPTIMIZATION", PERSPECTIVES IN DRUG DISCOVERY AND DESIGN,XX,ESCOM SCIENCE PUBLISHERS BV, vol. 2, 1994, pages 305 - 318, XP000654519, ISSN: 0928-2866 *
LEBL M. ET AL.: "One-bead-one-structure combinatorial libraries", BIOPOLYMERS (PEPTIDE SCIENCE), vol. 37, 1995, pages 177 - 198, XP000929745 *
OHLMEYER M H J ET AL: "COMPLEX SYNTHETIC CHEMICAL LIBRARIES INDEXED WITH MOLECULAR TAGS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA,US,NATIONAL ACADEMY OF SCIENCE. WASHINGTON, vol. 90, 1 December 1993 (1993-12-01), pages 10922 - 10926, XP000652270, ISSN: 0027-8424 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932992B2 (en) 2001-06-20 2015-01-13 Nuevolution A/S Templated molecules and methods for using such molecules
US9109248B2 (en) 2002-10-30 2015-08-18 Nuevolution A/S Method for the synthesis of a bifunctional complex
US9284600B2 (en) 2002-10-30 2016-03-15 Neuvolution A/S Method for the synthesis of a bifunctional complex
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US9096951B2 (en) 2003-02-21 2015-08-04 Nuevolution A/S Method for producing second-generation library
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries

Also Published As

Publication number Publication date Type
EP1119530A2 (en) 2001-08-01 application
WO2000021909A2 (en) 2000-04-20 application

Similar Documents

Publication Publication Date Title
US5606313A (en) Low power addressable data communication device and method
US6049633A (en) Adaptive arithmetic codec method and apparatus
EP0285419A2 (en) Access control equipment
US5365530A (en) Error-correction encoding and decoding system
US5382955A (en) Error tolerant thermometer-to-binary encoder
US5608739A (en) Apparatus and method for error detection and correction in radio frequency identification device
US20030019929A1 (en) Methods and apparatuses to identify devices
JPS6444499A (en) Forecast encoding system for voice
US7486172B2 (en) Enhanced identification protocol for RFID systems
WO1995014289A3 (en) Identification/authentication coding method and apparatus
WO2003043346A1 (en) Image encoding method, image decoding method, image encoder, image decode, program, computer data signal, and image transmission system
JPH07235879A (en) Header detector and decoder using it
Battail Does information theory explain biological evolution?
EP0236017A2 (en) Synchronizing signal decoding
WO1993005502A1 (en) Error protection for multimode speech coders
US7237178B1 (en) Marking unreliable symbols in a hard disk drive read back signal
WO2003096608A1 (en) Data transmission method and data transmission device
US6877090B2 (en) Branch predictor suitable for multi-processing microprocessor
US6794999B1 (en) Resilient parameterized prefix codes for adaptive coding
JPS63237628A (en) System for codeing vehicle multiplex transmission system
JPH02304611A (en) Wireless keyboard
US4743744A (en) Bar code reader
US20050094784A1 (en) System and method of using variable pulses for symbology
Kamijo et al. Invisible barcode with optimized error correction
JPH10322222A (en) Variable length coding and decoding method and system therefor

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

WWE Wipo information: entry into national phase

Ref document number: 1999950264

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1999950264

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWW Wipo information: withdrawn in national office

Ref document number: 1999950264

Country of ref document: EP