HU228775B1 - 6-(Dimetilamino-metil)-1-fenil-ciklohexán vegyületek felhasználása vizeletinkontinencia kezelésére és ezeket tartalmazó gyógyszerkészítmények - Google Patents
6-(Dimetilamino-metil)-1-fenil-ciklohexán vegyületek felhasználása vizeletinkontinencia kezelésére és ezeket tartalmazó gyógyszerkészítmények Download PDFInfo
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- HU228775B1 HU228775B1 HU0303046A HUP0303046A HU228775B1 HU 228775 B1 HU228775 B1 HU 228775B1 HU 0303046 A HU0303046 A HU 0303046A HU P0303046 A HUP0303046 A HU P0303046A HU 228775 B1 HU228775 B1 HU 228775B1
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- HU
- Hungary
- Prior art keywords
- hydrogen
- fluoro
- hydroxy
- alkyl
- chloro
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- 206010046543 Urinary incontinence Diseases 0.000 title claims description 25
- 239000008194 pharmaceutical composition Substances 0.000 title description 14
- BDPAJJIAIBKWER-UHFFFAOYSA-N n,n-dimethyl-1-(2-phenylcyclohexyl)methanamine Chemical class CN(C)CC1CCCCC1C1=CC=CC=C1 BDPAJJIAIBKWER-UHFFFAOYSA-N 0.000 title description 2
- -1 hydroxy, difluoromethyl Chemical group 0.000 claims description 74
- 229910052739 hydrogen Inorganic materials 0.000 claims description 71
- 239000001257 hydrogen Substances 0.000 claims description 70
- 150000001875 compounds Chemical class 0.000 claims description 42
- 125000001153 fluoro group Chemical group F* 0.000 claims description 39
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 38
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 36
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 34
- 125000000217 alkyl group Chemical group 0.000 claims description 34
- 229920006395 saturated elastomer Polymers 0.000 claims description 33
- 150000002431 hydrogen Chemical class 0.000 claims description 32
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 27
- 239000003814 drug Substances 0.000 claims description 22
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
- 229910052801 chlorine Inorganic materials 0.000 claims description 15
- 229910052731 fluorine Inorganic materials 0.000 claims description 15
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 15
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 14
- 150000003839 salts Chemical class 0.000 claims description 12
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 10
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- 239000011737 fluorine Substances 0.000 claims description 10
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
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- 239000004480 active ingredient Substances 0.000 claims description 7
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims description 7
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- 125000003545 alkoxy group Chemical group 0.000 claims description 6
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 6
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- 125000001544 thienyl group Chemical group 0.000 claims description 5
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 4
- 125000002572 propoxy group Chemical group [*]OC([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 3
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- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
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- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 2
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- JJWSNOOGIUMOEE-UHFFFAOYSA-N Monomethylmercury Chemical compound [Hg]C JJWSNOOGIUMOEE-UHFFFAOYSA-N 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10059411A DE10059411A1 (de) | 2000-11-30 | 2000-11-30 | Verwendung von 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz |
| PCT/EP2001/013909 WO2002043712A2 (de) | 2000-11-30 | 2001-11-28 | Verwendung von 6-dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur therapie der harninkontinenz |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0303046A2 HUP0303046A2 (hu) | 2003-12-29 |
| HUP0303046A3 HUP0303046A3 (en) | 2007-03-28 |
| HU228775B1 true HU228775B1 (hu) | 2013-05-28 |
Family
ID=7665209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0303046A HU228775B1 (hu) | 2000-11-30 | 2001-11-28 | 6-(Dimetilamino-metil)-1-fenil-ciklohexán vegyületek felhasználása vizeletinkontinencia kezelésére és ezeket tartalmazó gyógyszerkészítmények |
Country Status (28)
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|---|---|
| US (1) | US6908944B2 (ru) |
| EP (1) | EP1337246B1 (ru) |
| JP (1) | JP4287143B2 (ru) |
| KR (1) | KR100827217B1 (ru) |
| CN (1) | CN1321634C (ru) |
| AT (1) | ATE320797T1 (ru) |
| AU (2) | AU2002233209B9 (ru) |
| BR (1) | BR0115880A (ru) |
| CA (1) | CA2430279C (ru) |
| CY (1) | CY1105317T1 (ru) |
| CZ (1) | CZ304062B6 (ru) |
| DE (2) | DE10059411A1 (ru) |
| DK (1) | DK1337246T3 (ru) |
| EC (1) | ECSP034636A (ru) |
| ES (1) | ES2260306T3 (ru) |
| HK (1) | HK1058621A1 (ru) |
| HU (1) | HU228775B1 (ru) |
| IL (2) | IL156169A0 (ru) |
| MX (1) | MXPA03004711A (ru) |
| NO (1) | NO333953B1 (ru) |
| NZ (1) | NZ526605A (ru) |
| PL (1) | PL204346B1 (ru) |
| PT (1) | PT1337246E (ru) |
| RU (1) | RU2280444C2 (ru) |
| SI (1) | SI1337246T1 (ru) |
| SK (1) | SK287701B6 (ru) |
| WO (1) | WO2002043712A2 (ru) |
| ZA (1) | ZA200305001B (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2815691B1 (fr) * | 2000-10-20 | 2003-08-15 | Valois Sa | Bille de clapet |
| DE10059413A1 (de) * | 2000-11-30 | 2002-06-20 | Gruenenthal Gmbh | Verwendung von substituierten 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz |
| US20050182131A1 (en) * | 2002-07-19 | 2005-08-18 | Gruenenthal Gmbh | 1-Phenyl-2-dimethylaminomethyl cyclohexane compounds and therapies for depressive symptoms, pain and incontinence |
| DE10233048A1 (de) * | 2002-07-19 | 2004-01-29 | Grünenthal GmbH | Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken |
| SI1685829T1 (sl) * | 2002-11-22 | 2008-08-31 | Gruenenthal Gmbh | Uporaba (1RS,3RS,6RS)-6-dimetilaminometil-1- (3-metoksi-fenil)-cikloheksan-1, 3-diola za zdravljenje vnetne bolečine |
| DE10356362A1 (de) * | 2003-11-28 | 2005-06-23 | Grünenthal GmbH | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen |
| US20090104266A1 (en) * | 2005-09-15 | 2009-04-23 | Tobias Jung | 3-(2-dimethylaminomethylcy clohexyl)phenol retard formulation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR955065A (ru) * | 1947-01-13 | 1950-01-07 | ||
| DE19525137C2 (de) * | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
| WO1998046216A1 (fr) * | 1997-04-11 | 1998-10-22 | Nippon Shinyaku Co., Ltd. | Traitements des mictions frequentes et de l'incontinence urinaire |
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2000
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