HU194849B - Process for preparing n-/2-///5-(dimethylamino)-methyl-2-furanyl/-methyl/thio/-ethyl/-n'-methyl-2-nitro-1,1-ethene-diamine - Google Patents

Process for preparing n-/2-///5-(dimethylamino)-methyl-2-furanyl/-methyl/thio/-ethyl/-n'-methyl-2-nitro-1,1-ethene-diamine Download PDF

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Publication number
HU194849B
HU194849B HU831827A HU182783A HU194849B HU 194849 B HU194849 B HU 194849B HU 831827 A HU831827 A HU 831827A HU 182783 A HU182783 A HU 182783A HU 194849 B HU194849 B HU 194849B
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HU
Hungary
Prior art keywords
methyl
nitro
formula
dimethylamino
thio
Prior art date
Application number
HU831827A
Other languages
English (en)
Hungarian (hu)
Inventor
Kikelj Alenka Hribar
Janko Zmitek
Jolanda Lah
Original Assignee
Lek Tovarna Farmacevtskih
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Tovarna Farmacevtskih filed Critical Lek Tovarna Farmacevtskih
Publication of HU194849B publication Critical patent/HU194849B/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Es wird ein neues Verfahren zur Herstellung von N-(2-(((5-(Dimethylamino)-methyl-2-furanyl)methyl)thio)aethyl)-N'-methyl-2-nitro-1,1-aethendiamin (Ranitidin) der Formel I und seinen physiologisch vertraeglichen Saeureadditionssalzen beschrieben, bei welchem 2-(((5-(Dimethylamino)methyl-2-furanyl)methyl)thio)aethanaminder Formel II mit 1-Nitro-3-methyl-ketenimin der Formel CH tief3-N=C=CHNO tief2 zur gewuenschten Verbindung umgesetzt wird. 1-Nitro-3-methyl-ketenimin wird "in situ" durch Umsetzung von 1-Methylthio-1-methylamino-2-nitroaethen der Formel III in einem polaren organischen Loesungsmittel, wie Methanol oder Acetonitril, mit der Loesung eines Schwermetallsalzes, wie AgNO tief3, CuCl, in demselben Loesungsmittel in Anwesenheit von einem Protonenakzeptor, wie Triaethylamin, bei Raumtemperatur gebildet. Ranitidin ist ein wertvolles Arzneimittel in der Behandlung von Ulkus-Krankheiten. Wegen des sehr einfachen Reaktionsverlaufs und der ausserordentlich kurzen Reaktionszeit ist das Verfahren hervorragend fuer den industriellen Massstab geeignet.
HU831827A 1982-11-22 1983-05-24 Process for preparing n-/2-///5-(dimethylamino)-methyl-2-furanyl/-methyl/thio/-ethyl/-n'-methyl-2-nitro-1,1-ethene-diamine HU194849B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU2608/82A YU42819B (en) 1982-11-22 1982-11-22 Process for preparing n-/2-///5-(dimethyl-amino)-methyl-2-furanyl/methyl/thio/ethyl-n'-methyl-2-nitro-1,1-ethene diamine

Publications (1)

Publication Number Publication Date
HU194849B true HU194849B (en) 1988-03-28

Family

ID=25558386

Family Applications (1)

Application Number Title Priority Date Filing Date
HU831827A HU194849B (en) 1982-11-22 1983-05-24 Process for preparing n-/2-///5-(dimethylamino)-methyl-2-furanyl/-methyl/thio/-ethyl/-n'-methyl-2-nitro-1,1-ethene-diamine

Country Status (12)

Country Link
KR (1) KR870000165B1 (de)
AT (1) AT386200B (de)
CA (1) CA1178289A (de)
CS (1) CS237339B2 (de)
DD (1) DD209830A5 (de)
ES (1) ES523235A0 (de)
FI (1) FI832246L (de)
HU (1) HU194849B (de)
PL (1) PL242065A1 (de)
PT (1) PT76760B (de)
SU (1) SU1194277A3 (de)
YU (1) YU42819B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU207308B (en) * 1990-11-09 1993-03-29 Richter Gedeon Vegyeszet Process for producing 1- /2-/5-/dimethyl-amino-methyl/-2-/furyl-methyl-thio/-ethyl//- -amino-1-/methyl-amino-2-nitro-ethylene
HU210849B (en) * 1990-11-09 1995-08-28 Richter Gedeon Vegyeszet Process for preparing furil derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
PT72320B (en) * 1980-01-08 1982-07-23 Glaxo Group Ltd Process for preparation of a furan derivative
ES8300325A1 (es) * 1981-05-02 1982-11-01 Especialidades Farmaco Terape Procedimiento para la obtencion de un compuesto derivado delalcohol furfurilico

Also Published As

Publication number Publication date
CA1178289A (en) 1984-11-20
PT76760B (en) 1986-01-14
ES8500925A1 (es) 1984-11-16
CS380183A2 (en) 1984-12-14
SU1194277A3 (ru) 1985-11-23
ATA177783A (de) 1987-12-15
YU260882A (en) 1984-10-31
AT386200B (de) 1988-07-11
PL242065A1 (en) 1984-07-30
ES523235A0 (es) 1984-11-16
FI832246L (fi) 1984-05-23
FI832246A0 (fi) 1983-06-20
DD209830A5 (de) 1984-05-23
PT76760A (en) 1983-06-01
KR870000165B1 (ko) 1987-02-13
KR840007089A (ko) 1984-12-05
YU42819B (en) 1988-12-31
CS237339B2 (en) 1985-07-16

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee