HU192232B - Process for producing 9-alpha,11-alpha epoxy-steroides and pharmaceutical compositions containing them - Google Patents
Process for producing 9-alpha,11-alpha epoxy-steroides and pharmaceutical compositions containing them Download PDFInfo
- Publication number
- HU192232B HU192232B HU852433A HU243385A HU192232B HU 192232 B HU192232 B HU 192232B HU 852433 A HU852433 A HU 852433A HU 243385 A HU243385 A HU 243385A HU 192232 B HU192232 B HU 192232B
- Authority
- HU
- Hungary
- Prior art keywords
- formula
- compound
- epoxy
- unsaturated
- acid
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 26
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 49
- 238000002360 preparation method Methods 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 12
- 239000002934 diuretic Substances 0.000 claims description 10
- 150000003431 steroids Chemical class 0.000 claims description 9
- 239000004593 Epoxy Substances 0.000 claims description 8
- 230000001882 diuretic effect Effects 0.000 claims description 7
- 239000003792 electrolyte Substances 0.000 claims description 7
- 238000006735 epoxidation reaction Methods 0.000 claims description 7
- KOUKXHPPRFNWPP-UHFFFAOYSA-N pyrazine-2,5-dicarboxylic acid;hydrate Chemical compound O.OC(=O)C1=CN=C(C(O)=O)C=N1 KOUKXHPPRFNWPP-UHFFFAOYSA-N 0.000 claims description 7
- 239000005977 Ethylene Substances 0.000 claims description 6
- 125000004980 cyclopropylene group Chemical group 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 4
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- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 3
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- 206010020571 Hyperaldosteronism Diseases 0.000 abstract description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH300984 | 1984-06-21 | ||
| CH464684 | 1984-09-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT38367A HUT38367A (en) | 1986-05-28 |
| HU192232B true HU192232B (en) | 1987-05-28 |
Family
ID=25691934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU852433A HU192232B (en) | 1984-06-21 | 1985-06-20 | Process for producing 9-alpha,11-alpha epoxy-steroides and pharmaceutical compositions containing them |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4670551A (en, 2012) |
| EP (1) | EP0165902B1 (en, 2012) |
| AR (2) | AR242036A1 (en, 2012) |
| AU (1) | AU582754B2 (en, 2012) |
| CA (1) | CA1239388A (en, 2012) |
| DE (1) | DE3569540D1 (en, 2012) |
| DK (1) | DK173854B1 (en, 2012) |
| ES (2) | ES8704967A1 (en, 2012) |
| FI (1) | FI83225C (en, 2012) |
| GR (1) | GR851499B (en, 2012) |
| HU (1) | HU192232B (en, 2012) |
| IE (1) | IE58050B1 (en, 2012) |
| IL (1) | IL75569A (en, 2012) |
| NO (1) | NO165496C (en, 2012) |
| NZ (1) | NZ212492A (en, 2012) |
| PT (1) | PT80663B (en, 2012) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100384866C (zh) | 1995-12-11 | 2008-04-30 | G·D·瑟尔公司 | 制备7α-羧基9,11-环氧甾族化合物的方法和其中使用的中间体以及烯双键环氧化作用的一般方法 |
| EP1148061B1 (en) * | 1996-12-11 | 2007-10-17 | G.D. Searle LLC. | Epoxidation process |
| BR9714510A (pt) * | 1996-12-11 | 2000-11-28 | Searle & Co | Processo e preparo de esteróides de 9,11-époxi e intermediários úteis dos mesmos |
| US6887991B1 (en) | 1996-12-11 | 2005-05-03 | G. D. Searle & Company | Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein |
| ATE473759T1 (de) | 1998-05-22 | 2010-07-15 | Univ Leland Stanford Junior | Bifunktionelle moleküle sowie darauf basierende therapien. |
| PL371128A1 (en) | 2001-12-12 | 2005-06-13 | Pharmacia Corporation | Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists |
| US7235655B2 (en) | 2002-03-22 | 2007-06-26 | Pharmacia & Upjohn Company | Processes to prepare eplerenone |
| DK1889198T3 (da) | 2005-04-28 | 2015-02-09 | Proteus Digital Health Inc | Farma-informatiksystem |
| WO2007025780A2 (en) * | 2005-09-02 | 2007-03-08 | Recordati Ireland Limited | Aldosterone receptor antagonists |
| US9062126B2 (en) | 2005-09-16 | 2015-06-23 | Raptor Pharmaceuticals Inc. | Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof |
| NZ616673A (en) | 2009-02-20 | 2014-08-29 | To Bbb Holding B V | Glutathione-based drug delivery system |
| MX2011011833A (es) | 2009-05-06 | 2012-01-27 | Lab Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de partículas de fosfato de calcio-agente activo y métodos para utilizar las mismas. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3013012A (en) * | 1960-12-22 | 1961-12-12 | Searle & Co | Alkanoylthio-17alpha-carboxyethyl-17beta-hydroxyandrosten-3-one lactones |
| US3095412A (en) * | 1961-12-19 | 1963-06-25 | Searle & Co | 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs |
| GB1041534A (en) * | 1963-04-24 | 1966-09-07 | Merck & Co Inc | 20-spiroxane compounds |
| DE2652761C2 (de) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| FI77669C (fi) * | 1983-04-13 | 1989-04-10 | Ciba Geigy Ag | 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat. |
| ATE51233T1 (de) * | 1983-08-17 | 1990-04-15 | Schering Ag | 7-alpha-substituierte 3-oxo-17alpha-pregn-4-en21.17-carbolactone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate. |
-
1985
- 1985-06-13 US US06/744,444 patent/US4670551A/en not_active Expired - Fee Related
- 1985-06-17 EP EP85810277A patent/EP0165902B1/de not_active Expired
- 1985-06-17 DE DE8585810277T patent/DE3569540D1/de not_active Expired
- 1985-06-19 PT PT80663A patent/PT80663B/pt not_active IP Right Cessation
- 1985-06-19 CA CA000484418A patent/CA1239388A/en not_active Expired
- 1985-06-19 FI FI852430A patent/FI83225C/fi not_active IP Right Cessation
- 1985-06-19 GR GR851499A patent/GR851499B/el unknown
- 1985-06-19 IL IL75569A patent/IL75569A/xx not_active IP Right Cessation
- 1985-06-20 NO NO852501A patent/NO165496C/no unknown
- 1985-06-20 IE IE153585A patent/IE58050B1/en not_active IP Right Cessation
- 1985-06-20 DK DK198502800A patent/DK173854B1/da not_active IP Right Cessation
- 1985-06-20 NZ NZ212492A patent/NZ212492A/xx unknown
- 1985-06-20 HU HU852433A patent/HU192232B/hu not_active IP Right Cessation
- 1985-06-20 ES ES544387A patent/ES8704967A1/es not_active Expired
- 1985-06-21 AR AR85300773A patent/AR242036A1/es active
- 1985-06-21 AU AU43971/85A patent/AU582754B2/en not_active Ceased
-
1986
- 1986-10-01 ES ES557112A patent/ES8707737A1/es not_active Expired
-
1989
- 1989-07-31 AR AR89314546A patent/AR245731A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| IE58050B1 (en) | 1993-06-16 |
| PT80663B (en) | 1987-05-08 |
| DE3569540D1 (en) | 1989-05-24 |
| FI83225C (fi) | 1991-06-10 |
| EP0165902A2 (de) | 1985-12-27 |
| NZ212492A (en) | 1989-02-24 |
| EP0165902B1 (de) | 1989-04-19 |
| IE851535L (en) | 1985-12-21 |
| AR245731A1 (es) | 1994-02-28 |
| FI83225B (fi) | 1991-02-28 |
| IL75569A (en) | 1989-03-31 |
| NO165496C (no) | 1991-02-20 |
| DK280085D0 (da) | 1985-06-20 |
| NO165496B (no) | 1990-11-12 |
| US4670551A (en) | 1987-06-02 |
| ES557112A0 (es) | 1987-08-16 |
| AU4397185A (en) | 1986-01-02 |
| DK280085A (da) | 1985-12-22 |
| ES8704967A1 (es) | 1987-04-16 |
| DK173854B1 (da) | 2001-12-27 |
| NO852501L (no) | 1985-12-23 |
| GR851499B (en, 2012) | 1985-11-25 |
| HUT38367A (en) | 1986-05-28 |
| FI852430L (fi) | 1985-12-22 |
| AU582754B2 (en) | 1989-04-13 |
| PT80663A (en) | 1985-07-01 |
| AR242036A1 (es) | 1993-02-26 |
| FI852430A0 (fi) | 1985-06-19 |
| IL75569A0 (en) | 1985-10-31 |
| EP0165902A3 (en) | 1986-10-22 |
| CA1239388A (en) | 1988-07-19 |
| ES544387A0 (es) | 1987-04-16 |
| ES8707737A1 (es) | 1987-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HPC4 | Succession in title of patentee |
Owner name: NOVARTIS AG, CH |
|
| HMM4 | Cancellation of final prot. due to non-payment of fee |