FI83225C - Foerfarande foer framstaellning av terapeutiskt verkande 9 ,11 -epoxisteroider. - Google Patents
Foerfarande foer framstaellning av terapeutiskt verkande 9 ,11 -epoxisteroider. Download PDFInfo
- Publication number
- FI83225C FI83225C FI852430A FI852430A FI83225C FI 83225 C FI83225 C FI 83225C FI 852430 A FI852430 A FI 852430A FI 852430 A FI852430 A FI 852430A FI 83225 C FI83225 C FI 83225C
- Authority
- FI
- Finland
- Prior art keywords
- solution
- epoxy
- acid
- water
- methylene
- Prior art date
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- 238000000034 method Methods 0.000 title claims description 19
- 238000002360 preparation method Methods 0.000 title claims description 11
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- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 108010017796 epoxidase Proteins 0.000 claims 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C07J71/0015—Oxiranes at position 9(11)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH300984 | 1984-06-21 | ||
| CH300984 | 1984-06-21 | ||
| CH464684 | 1984-09-28 | ||
| CH464684 | 1984-09-28 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI852430A0 FI852430A0 (fi) | 1985-06-19 |
| FI852430L FI852430L (fi) | 1985-12-22 |
| FI83225B FI83225B (fi) | 1991-02-28 |
| FI83225C true FI83225C (fi) | 1991-06-10 |
Family
ID=25691934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI852430A FI83225C (fi) | 1984-06-21 | 1985-06-19 | Foerfarande foer framstaellning av terapeutiskt verkande 9 ,11 -epoxisteroider. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4670551A (en, 2012) |
| EP (1) | EP0165902B1 (en, 2012) |
| AR (2) | AR242036A1 (en, 2012) |
| AU (1) | AU582754B2 (en, 2012) |
| CA (1) | CA1239388A (en, 2012) |
| DE (1) | DE3569540D1 (en, 2012) |
| DK (1) | DK173854B1 (en, 2012) |
| ES (2) | ES8704967A1 (en, 2012) |
| FI (1) | FI83225C (en, 2012) |
| GR (1) | GR851499B (en, 2012) |
| HU (1) | HU192232B (en, 2012) |
| IE (1) | IE58050B1 (en, 2012) |
| IL (1) | IL75569A (en, 2012) |
| NO (1) | NO165496C (en, 2012) |
| NZ (1) | NZ212492A (en, 2012) |
| PT (1) | PT80663B (en, 2012) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100384866C (zh) | 1995-12-11 | 2008-04-30 | G·D·瑟尔公司 | 制备7α-羧基9,11-环氧甾族化合物的方法和其中使用的中间体以及烯双键环氧化作用的一般方法 |
| EP1148061B1 (en) * | 1996-12-11 | 2007-10-17 | G.D. Searle LLC. | Epoxidation process |
| BR9714510A (pt) * | 1996-12-11 | 2000-11-28 | Searle & Co | Processo e preparo de esteróides de 9,11-époxi e intermediários úteis dos mesmos |
| US6887991B1 (en) | 1996-12-11 | 2005-05-03 | G. D. Searle & Company | Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein |
| ATE473759T1 (de) | 1998-05-22 | 2010-07-15 | Univ Leland Stanford Junior | Bifunktionelle moleküle sowie darauf basierende therapien. |
| PL371128A1 (en) | 2001-12-12 | 2005-06-13 | Pharmacia Corporation | Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists |
| US7235655B2 (en) | 2002-03-22 | 2007-06-26 | Pharmacia & Upjohn Company | Processes to prepare eplerenone |
| DK1889198T3 (da) | 2005-04-28 | 2015-02-09 | Proteus Digital Health Inc | Farma-informatiksystem |
| WO2007025780A2 (en) * | 2005-09-02 | 2007-03-08 | Recordati Ireland Limited | Aldosterone receptor antagonists |
| US9062126B2 (en) | 2005-09-16 | 2015-06-23 | Raptor Pharmaceuticals Inc. | Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof |
| NZ616673A (en) | 2009-02-20 | 2014-08-29 | To Bbb Holding B V | Glutathione-based drug delivery system |
| MX2011011833A (es) | 2009-05-06 | 2012-01-27 | Lab Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de partículas de fosfato de calcio-agente activo y métodos para utilizar las mismas. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3013012A (en) * | 1960-12-22 | 1961-12-12 | Searle & Co | Alkanoylthio-17alpha-carboxyethyl-17beta-hydroxyandrosten-3-one lactones |
| US3095412A (en) * | 1961-12-19 | 1963-06-25 | Searle & Co | 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs |
| GB1041534A (en) * | 1963-04-24 | 1966-09-07 | Merck & Co Inc | 20-spiroxane compounds |
| DE2652761C2 (de) * | 1976-11-16 | 1985-11-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| FI77669C (fi) * | 1983-04-13 | 1989-04-10 | Ciba Geigy Ag | 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat. |
| ATE51233T1 (de) * | 1983-08-17 | 1990-04-15 | Schering Ag | 7-alpha-substituierte 3-oxo-17alpha-pregn-4-en21.17-carbolactone, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate. |
-
1985
- 1985-06-13 US US06/744,444 patent/US4670551A/en not_active Expired - Fee Related
- 1985-06-17 EP EP85810277A patent/EP0165902B1/de not_active Expired
- 1985-06-17 DE DE8585810277T patent/DE3569540D1/de not_active Expired
- 1985-06-19 PT PT80663A patent/PT80663B/pt not_active IP Right Cessation
- 1985-06-19 CA CA000484418A patent/CA1239388A/en not_active Expired
- 1985-06-19 FI FI852430A patent/FI83225C/fi not_active IP Right Cessation
- 1985-06-19 GR GR851499A patent/GR851499B/el unknown
- 1985-06-19 IL IL75569A patent/IL75569A/xx not_active IP Right Cessation
- 1985-06-20 NO NO852501A patent/NO165496C/no unknown
- 1985-06-20 IE IE153585A patent/IE58050B1/en not_active IP Right Cessation
- 1985-06-20 DK DK198502800A patent/DK173854B1/da not_active IP Right Cessation
- 1985-06-20 NZ NZ212492A patent/NZ212492A/xx unknown
- 1985-06-20 HU HU852433A patent/HU192232B/hu not_active IP Right Cessation
- 1985-06-20 ES ES544387A patent/ES8704967A1/es not_active Expired
- 1985-06-21 AR AR85300773A patent/AR242036A1/es active
- 1985-06-21 AU AU43971/85A patent/AU582754B2/en not_active Ceased
-
1986
- 1986-10-01 ES ES557112A patent/ES8707737A1/es not_active Expired
-
1989
- 1989-07-31 AR AR89314546A patent/AR245731A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| IE58050B1 (en) | 1993-06-16 |
| PT80663B (en) | 1987-05-08 |
| DE3569540D1 (en) | 1989-05-24 |
| EP0165902A2 (de) | 1985-12-27 |
| NZ212492A (en) | 1989-02-24 |
| EP0165902B1 (de) | 1989-04-19 |
| IE851535L (en) | 1985-12-21 |
| AR245731A1 (es) | 1994-02-28 |
| FI83225B (fi) | 1991-02-28 |
| IL75569A (en) | 1989-03-31 |
| NO165496C (no) | 1991-02-20 |
| DK280085D0 (da) | 1985-06-20 |
| NO165496B (no) | 1990-11-12 |
| US4670551A (en) | 1987-06-02 |
| ES557112A0 (es) | 1987-08-16 |
| AU4397185A (en) | 1986-01-02 |
| DK280085A (da) | 1985-12-22 |
| ES8704967A1 (es) | 1987-04-16 |
| DK173854B1 (da) | 2001-12-27 |
| NO852501L (no) | 1985-12-23 |
| GR851499B (en, 2012) | 1985-11-25 |
| HUT38367A (en) | 1986-05-28 |
| FI852430L (fi) | 1985-12-22 |
| AU582754B2 (en) | 1989-04-13 |
| PT80663A (en) | 1985-07-01 |
| AR242036A1 (es) | 1993-02-26 |
| FI852430A0 (fi) | 1985-06-19 |
| IL75569A0 (en) | 1985-10-31 |
| HU192232B (en) | 1987-05-28 |
| EP0165902A3 (en) | 1986-10-22 |
| CA1239388A (en) | 1988-07-19 |
| ES544387A0 (es) | 1987-04-16 |
| ES8707737A1 (es) | 1987-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Transfer of assignment of patent |
Owner name: NOVARTIS AG |
|
| MM | Patent lapsed |
Owner name: NOVARTIS AG |