HRP960307A2 - Novel peptides derived from human heat shock protein 60 for treatment of diabetes - preparations, methods and kits - Google Patents
Novel peptides derived from human heat shock protein 60 for treatment of diabetes - preparations, methods and kits Download PDFInfo
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- HRP960307A2 HRP960307A2 HR114407A HRP960307A HRP960307A2 HR P960307 A2 HRP960307 A2 HR P960307A2 HR 114407 A HR114407 A HR 114407A HR P960307 A HRP960307 A HR P960307A HR P960307 A2 HRP960307 A2 HR P960307A2
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- peptide
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- hsp60
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- 238000005516 engineering process Methods 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 230000014101 glucose homeostasis Effects 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000006058 immune tolerance Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 230000017307 interleukin-4 production Effects 0.000 description 1
- ZCYVEMRRCGMTRW-YPZZEJLDSA-N iodine-125 Chemical group [125I] ZCYVEMRRCGMTRW-YPZZEJLDSA-N 0.000 description 1
- 229940044173 iodine-125 Drugs 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000001821 langerhans cell Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 229940054269 sodium pyruvate Drugs 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
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- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000563 toxic property Toxicity 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
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- 229960005486 vaccine Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11440795A IL114407A0 (en) | 1995-06-30 | 1995-06-30 | Novel peptides and pharmaceutical compositions comprising them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP960307A2 true HRP960307A2 (en) | 1998-04-30 |
Family
ID=11067704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR114407A HRP960307A2 (en) | 1995-06-30 | 1996-07-01 | Novel peptides derived from human heat shock protein 60 for treatment of diabetes - preparations, methods and kits |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6682897B1 (zh) |
| EP (1) | EP0845943B1 (zh) |
| KR (1) | KR100454554B1 (zh) |
| CN (1) | CN1102598C (zh) |
| AR (1) | AR003446A1 (zh) |
| AT (1) | ATE290315T1 (zh) |
| AU (1) | AU710882B2 (zh) |
| CA (1) | CA2225675C (zh) |
| CZ (1) | CZ295110B6 (zh) |
| DE (1) | DE69634438T2 (zh) |
| DK (1) | DK0845943T3 (zh) |
| ES (1) | ES2239770T3 (zh) |
| HR (1) | HRP960307A2 (zh) |
| HU (1) | HUP9901688A3 (zh) |
| IL (2) | IL114407A0 (zh) |
| NO (1) | NO320715B1 (zh) |
| UY (1) | UY24270A1 (zh) |
| WO (1) | WO1997001959A1 (zh) |
| ZA (1) | ZA965565B (zh) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6488933B2 (en) | 1995-07-05 | 2002-12-03 | Yeda Research And Development Co. Ltd. | Preparations for the treatment of T cell mediated diseases |
| DE69724619T2 (de) * | 1996-05-14 | 2004-07-01 | Winnacker, Ernst-Ludwig, Prof. | Chaperone, die prionproteine binden und zwischen den isoformen prpc und prpsc unterscheiden können |
| US5993803A (en) * | 1996-08-30 | 1999-11-30 | Yeda Research And Development Co., Ltd. | Method of reducing the severity of host vs graft reaction by down-regulating hsp60 autoimmunity |
| JP2004501061A (ja) * | 1999-12-15 | 2004-01-15 | ペプトル・リミテツド | 熱ショックタンパク質６０のフラグメントおよびアンタゴニスト |
| CA2420499A1 (en) * | 2000-08-25 | 2002-02-28 | Yeda Research And Development Co. Ltd. | Methods of treatment or prevention of autoimmune diseases with cpg-containing polynucleotide |
| WO2003063759A2 (en) | 2002-01-31 | 2003-08-07 | Peptor Ltd. | Hsp peptides and analogs for modulation of immune responses via antigen presenting cells |
| AU2003209623A1 (en) * | 2002-02-19 | 2003-09-09 | Yeda Research And Development Co. Ltd. | Dual-effect ligands comprising anti-inflammatory hsp peptide epitopes for immunomodulation |
| ES2433915T3 (es) | 2002-05-21 | 2013-12-13 | Irun R. Cohen | Vacunas de ADN que codifican proteínas de choque térmico |
| WO2004098489A2 (en) * | 2003-05-12 | 2004-11-18 | Peptor Ltd. | Compositions and methods for modulation of specific epitopes of hsp60 |
| US20090202618A1 (en) * | 2003-11-24 | 2009-08-13 | Yeda Research & Development Co. Ltd | Dna vaccines encoding hsp60 peptide fragments for treating autoimmune diseases |
| AU2005207891B2 (en) | 2004-01-28 | 2010-04-01 | Andromeda Biotech Ltd. | Hsp therapy in conjunction with a low antigenicity diet |
| WO2006072946A2 (en) | 2005-01-04 | 2006-07-13 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Hsp60, hsp60 peptides and t cell vaccines for immunomodulation |
| CU23701A1 (es) | 2008-12-29 | 2011-09-21 | Ct Ingenieria Genetica Biotech | Método de tratamiento de enfermedades inflamatorias intestinales y diabetes tipo i |
| WO2011096756A2 (ko) * | 2010-02-04 | 2011-08-11 | 이화여자대학교 산학협력단 | 비정상적 세포 증식 억제용 약제학적 조성물 |
| ITCO20120007A1 (it) * | 2012-02-21 | 2013-08-22 | Nuovo Pignone Srl | Dispositivo di filtraggio dell'aria in ingresso per un impianto |
| WO2013128453A1 (en) | 2012-03-01 | 2013-09-06 | Yeda Research And Development Co. Ltd. | Regeneration of islet beta cells by hsp60 derived peptides |
| CN104244967A (zh) | 2012-03-01 | 2014-12-24 | 耶达研究与发展有限公司 | 用于抑制和治疗非自身免疫性糖尿病的Hsp60衍生肽和肽类似物 |
| WO2017189988A1 (en) * | 2016-04-29 | 2017-11-02 | Araim Pharmaceuticals, Inc. | Tissue protective peptides for preventing and treating diseases and disorders associated with tissue damage |
| CN111035755B (zh) * | 2020-01-08 | 2023-04-14 | 中国医学科学院医学生物学研究所 | 一种1型糖尿病疫苗及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5242823A (en) * | 1986-03-07 | 1993-09-07 | International Genetic Engineering, Inc. | Cloning of the 38kd Mycoplasma hyorhinis regression-associated antigen |
| US4976958A (en) * | 1987-02-26 | 1990-12-11 | Scripps Clinic And Research Foundation | Mycobacterial recombinants and peptides |
| US5114844A (en) * | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
-
1995
- 1995-06-30 IL IL11440795A patent/IL114407A0/xx unknown
-
1996
- 1996-06-28 UY UY24270A patent/UY24270A1/es unknown
- 1996-07-01 CA CA2225675A patent/CA2225675C/en not_active Expired - Lifetime
- 1996-07-01 HU HU9901688A patent/HUP9901688A3/hu not_active Application Discontinuation
- 1996-07-01 DE DE69634438T patent/DE69634438T2/de not_active Expired - Lifetime
- 1996-07-01 ZA ZA9605565A patent/ZA965565B/xx unknown
- 1996-07-01 WO PCT/US1996/011375 patent/WO1997001959A1/en active IP Right Grant
- 1996-07-01 IL IL12275796A patent/IL122757A/en not_active IP Right Cessation
- 1996-07-01 HR HR114407A patent/HRP960307A2/hr not_active Application Discontinuation
- 1996-07-01 DK DK96924372T patent/DK0845943T3/da active
- 1996-07-01 CN CN96196403A patent/CN1102598C/zh not_active Expired - Lifetime
- 1996-07-01 ES ES96924372T patent/ES2239770T3/es not_active Expired - Lifetime
- 1996-07-01 CZ CZ19974117A patent/CZ295110B6/cs not_active IP Right Cessation
- 1996-07-01 KR KR1019970709962A patent/KR100454554B1/ko not_active IP Right Cessation
- 1996-07-01 EP EP96924372A patent/EP0845943B1/en not_active Expired - Lifetime
- 1996-07-01 AT AT96924372T patent/ATE290315T1/de active
- 1996-07-01 AU AU64845/96A patent/AU710882B2/en not_active Expired
- 1996-07-01 AR ARP960103410A patent/AR003446A1/es not_active Application Discontinuation
-
1997
- 1997-12-29 NO NO19976094A patent/NO320715B1/no not_active IP Right Cessation
-
2000
- 2000-07-11 US US09/613,743 patent/US6682897B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997001959A1 (en) | 1997-01-23 |
| DE69634438T2 (de) | 2006-02-09 |
| AU6484596A (en) | 1997-02-05 |
| IL114407A0 (en) | 1995-10-31 |
| IL122757A (en) | 2001-07-24 |
| EP0845943A4 (en) | 2002-04-10 |
| KR100454554B1 (ko) | 2005-04-06 |
| CN1193889A (zh) | 1998-09-23 |
| CA2225675C (en) | 2010-09-21 |
| EP0845943A1 (en) | 1998-06-10 |
| NO976094L (no) | 1998-02-02 |
| DE69634438D1 (de) | 2005-04-14 |
| IL122757A0 (en) | 1998-08-16 |
| JP3955627B2 (ja) | 2007-08-08 |
| CN1102598C (zh) | 2003-03-05 |
| NO320715B1 (no) | 2006-01-23 |
| AU710882B2 (en) | 1999-09-30 |
| HUP9901688A3 (en) | 1999-12-28 |
| CZ295110B6 (cs) | 2005-05-18 |
| AR003446A1 (es) | 1998-08-05 |
| CZ411797A3 (cs) | 1998-06-17 |
| EP0845943B1 (en) | 2005-03-09 |
| KR19990028640A (ko) | 1999-04-15 |
| ATE290315T1 (de) | 2005-03-15 |
| ZA965565B (en) | 1997-02-26 |
| ES2239770T3 (es) | 2005-10-01 |
| US6682897B1 (en) | 2004-01-27 |
| HUP9901688A2 (hu) | 1999-09-28 |
| DK0845943T3 (da) | 2005-07-11 |
| UY24270A1 (es) | 2000-12-29 |
| JPH11509196A (ja) | 1999-08-17 |
| CA2225675A1 (en) | 1997-01-23 |
| MX9800191A (es) | 1998-05-31 |
| NO976094D0 (no) | 1997-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ODBC | Application rejected |