HRP960267B1 - Novel crystal form of anhydrous 7-(/1'alpha, 5'alpha, 6'alpha/-6-amino-3-azabicyclo/3.1.0/hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt - Google Patents
Novel crystal form of anhydrous 7-(/1'alpha, 5'alpha, 6'alpha/-6-amino-3-azabicyclo/3.1.0/hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid saltInfo
- Publication number
- HRP960267B1 HRP960267B1 HR960267A HRP960267A HRP960267B1 HR P960267 B1 HRP960267 B1 HR P960267B1 HR 960267 A HR960267 A HR 960267A HR P960267 A HRP960267 A HR P960267A HR P960267 B1 HRP960267 B1 HR P960267B1
- Authority
- HR
- Croatia
- Prior art keywords
- alpha
- naphthyridine
- azabicyclo
- difluorophenyl
- hex
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1995/007211 WO1996039406A1 (en) | 1995-06-06 | 1995-06-06 | NOVEL CRYSTAL FORM OF ANHYDROUS 7-([1α, 5α, 6α]-6-AMINO-3-AZABICYCLO[3.1.0]HEX-3-YL)-6-FLUORO-1-(2,4-DIFLUOROPHENYL)-1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID, METHANESULFONIC ACID SALT |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP960267A2 HRP960267A2 (en) | 1997-08-31 |
HRP960267B1 true HRP960267B1 (en) | 2000-06-30 |
Family
ID=39431076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR960267A HRP960267B1 (en) | 1995-06-06 | 1996-06-06 | Novel crystal form of anhydrous 7-(/1'alpha, 5'alpha, 6'alpha/-6-amino-3-azabicyclo/3.1.0/hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt |
Country Status (38)
Country | Link |
---|---|
US (1) | US5763454A (sl) |
EP (1) | EP0789697B1 (sl) |
JP (1) | JP3145715B2 (sl) |
KR (1) | KR100191989B1 (sl) |
CN (1) | CN1055474C (sl) |
AR (1) | AR002753A1 (sl) |
AU (1) | AU703634B2 (sl) |
BG (1) | BG62443B1 (sl) |
BR (1) | BR9602630A (sl) |
CA (1) | CA2223404C (sl) |
CZ (1) | CZ285878B6 (sl) |
DE (1) | DE69503066T2 (sl) |
DK (1) | DK0789697T3 (sl) |
DZ (1) | DZ2046A1 (sl) |
ES (1) | ES2117426T3 (sl) |
FI (1) | FI974441A0 (sl) |
HR (1) | HRP960267B1 (sl) |
HU (1) | HUP9601540A3 (sl) |
IL (1) | IL118488A (sl) |
IS (1) | IS4351A (sl) |
LV (1) | LV11619B (sl) |
MA (1) | MA23892A1 (sl) |
NO (1) | NO305599B1 (sl) |
NZ (1) | NZ286735A (sl) |
OA (1) | OA10293A (sl) |
PE (1) | PE38097A1 (sl) |
PL (1) | PL314604A1 (sl) |
RU (1) | RU2125571C1 (sl) |
SG (1) | SG54339A1 (sl) |
SI (1) | SI9600185A (sl) |
SK (1) | SK280535B6 (sl) |
TN (1) | TNSN96084A1 (sl) |
TW (2) | TW580389B (sl) |
UA (1) | UA44718C2 (sl) |
UY (1) | UY25459A1 (sl) |
WO (1) | WO1996039406A1 (sl) |
YU (1) | YU34596A (sl) |
ZA (1) | ZA964647B (sl) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA24500A1 (fr) | 1997-03-21 | 1998-10-01 | Lg Life Sciences Ltd | Derive du sel d'acide carboxylique de naphthyridine . |
US20020032216A1 (en) | 1997-03-21 | 2002-03-14 | Lg Chemical Ltd. | Salt of naphthyridine carboxylic acid derivative |
HN1998000106A (es) | 1997-08-01 | 1999-01-08 | Pfizer Prod Inc | Composiciones parenterales de alatroflaxacino |
DE19800214A1 (de) * | 1998-01-06 | 1999-07-15 | Knoll Ag | Verfahren zur Herstellung von Doxazosin-Mcsylat in einer als Form A bezeichneten Kristallmodifikation und ein Zwischenprodukt dafür |
US7019142B2 (en) * | 1998-01-16 | 2006-03-28 | Pfizer Inc. | Process for preparing naphthyridones and intermediates |
GB9818258D0 (en) * | 1998-08-21 | 1998-10-14 | Pfizer Ltd | Antifungal compositions |
HN1999000141A (es) * | 1998-09-03 | 2000-06-19 | Pfizer Prod Inc | Procedimiento para preparar sales de trovafloxacina de adicion de acidos. |
GB9820405D0 (en) * | 1998-09-18 | 1998-11-11 | Smithkline Beecham Plc | Process |
ES2164520B1 (es) | 1999-03-16 | 2003-04-01 | Medichem Sa | "procedimiento de obtencion del polimorfo a del mesilato de doxazosina" |
US6239141B1 (en) | 1999-06-04 | 2001-05-29 | Pfizer Inc. | Trovafloxacin oral suspensions |
GB9920917D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel process |
GB9920919D0 (en) | 1999-09-03 | 1999-11-10 | Sb Pharmco Inc | Novel compound |
US6657061B2 (en) | 2001-06-29 | 2003-12-02 | Grayson Walker Stowell | Polymorphic forms of 6-[4-1(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6660864B2 (en) | 2001-06-29 | 2003-12-09 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6388080B1 (en) | 2001-06-29 | 2002-05-14 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6531603B1 (en) | 2001-06-29 | 2003-03-11 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6596871B2 (en) | 2001-06-29 | 2003-07-22 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
US6573382B2 (en) | 2001-06-29 | 2003-06-03 | Grayson Walker Stowell | Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone |
KR100517638B1 (ko) | 2002-04-08 | 2005-09-28 | 주식회사 엘지생명과학 | 게미플록사신 산염의 새로운 제조방법 |
CN102512364A (zh) * | 2011-12-30 | 2012-06-27 | 天津市嵩锐医药科技有限公司 | 一种供注射用的甲磺酸阿拉曲伐沙星药物组合物 |
TWI608970B (zh) * | 2013-01-11 | 2017-12-21 | 參天製藥股份有限公司 | 內塞和具備該內塞的液體收容容器、以及注口的前端構造和具備該構造的液體收容容器 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5164402A (en) * | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
PL166381B1 (pl) * | 1989-08-16 | 1995-05-31 | Pfizer | Sposób wytwarzania nowych podstawionych kwasów 7-azabicyklochinolonokarboksylowych PL PL PL PL |
KR100221386B1 (ko) * | 1994-01-18 | 1999-09-15 | 디. 제이. 우드, 스피겔 알렌 제이 | 나프티리돈카복실산 염의 제조방법 및 중간체 |
GB2289674A (en) * | 1994-05-23 | 1995-11-29 | Pfizer | Antibacterial naphthyridine |
-
1995
- 1995-06-06 CA CA002223404A patent/CA2223404C/en not_active Expired - Fee Related
- 1995-06-06 JP JP50037497A patent/JP3145715B2/ja not_active Expired - Fee Related
- 1995-06-06 DK DK95922240T patent/DK0789697T3/da active
- 1995-06-06 WO PCT/US1995/007211 patent/WO1996039406A1/en active IP Right Grant
- 1995-06-06 EP EP95922240A patent/EP0789697B1/en not_active Expired - Lifetime
- 1995-06-06 US US08/849,300 patent/US5763454A/en not_active Expired - Fee Related
- 1995-06-06 DE DE69503066T patent/DE69503066T2/de not_active Expired - Fee Related
- 1995-06-06 SK SK719-96A patent/SK280535B6/sk unknown
- 1995-06-06 ES ES95922240T patent/ES2117426T3/es not_active Expired - Lifetime
-
1996
- 1996-05-13 TW TW089107609A patent/TW580389B/zh not_active IP Right Cessation
- 1996-05-13 TW TW085105632A patent/TW403751B/zh not_active IP Right Cessation
- 1996-05-29 CN CN96110060A patent/CN1055474C/zh not_active Expired - Fee Related
- 1996-05-30 IL IL11848896A patent/IL118488A/en not_active IP Right Cessation
- 1996-05-31 AR ARP960102817A patent/AR002753A1/es unknown
- 1996-06-03 IS IS4351A patent/IS4351A/is unknown
- 1996-06-04 LV LVP-96-172A patent/LV11619B/en unknown
- 1996-06-04 BR BR9602630A patent/BR9602630A/pt not_active Application Discontinuation
- 1996-06-04 PL PL96314604A patent/PL314604A1/xx unknown
- 1996-06-04 UA UA96062190A patent/UA44718C2/uk unknown
- 1996-06-05 YU YU34596A patent/YU34596A/sh unknown
- 1996-06-05 MA MA24262A patent/MA23892A1/fr unknown
- 1996-06-05 DZ DZ960090A patent/DZ2046A1/fr active
- 1996-06-05 TN TNTNSN96084A patent/TNSN96084A1/fr unknown
- 1996-06-05 ZA ZA9604647A patent/ZA964647B/xx unknown
- 1996-06-05 RU RU96111026A patent/RU2125571C1/ru not_active IP Right Cessation
- 1996-06-05 KR KR1019960020171A patent/KR100191989B1/ko not_active IP Right Cessation
- 1996-06-05 SG SG1996009972A patent/SG54339A1/en unknown
- 1996-06-05 NO NO962321A patent/NO305599B1/no not_active IP Right Cessation
- 1996-06-05 HU HU9601540A patent/HUP9601540A3/hu unknown
- 1996-06-05 BG BG100639A patent/BG62443B1/bg unknown
- 1996-06-05 NZ NZ286735A patent/NZ286735A/en unknown
- 1996-06-05 AU AU54749/96A patent/AU703634B2/en not_active Ceased
- 1996-06-05 CZ CZ961625A patent/CZ285878B6/cs not_active IP Right Cessation
- 1996-06-06 PE PE1996000421A patent/PE38097A1/es not_active Application Discontinuation
- 1996-06-06 OA OA60835A patent/OA10293A/fr unknown
- 1996-06-06 SI SI9600185A patent/SI9600185A/sl not_active IP Right Cessation
- 1996-06-06 HR HR960267A patent/HRP960267B1/xx not_active IP Right Cessation
-
1997
- 1997-12-05 FI FI974441A patent/FI974441A0/fi unknown
-
1999
- 1999-04-06 UY UY25459A patent/UY25459A1/es not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP960267B1 (en) | Novel crystal form of anhydrous 7-(/1'alpha, 5'alpha, 6'alpha/-6-amino-3-azabicyclo/3.1.0/hex-3-yl)-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt | |
AP9600817A0 (en) | Novel cryatal form of anhydrous 7-( [1A,5A,6A]-6-amino3-3-azabicyclo [3.1.0.] hex-3-yl) -6-fluro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt. | |
GB8709448D0 (en) | Heterobicyclic quinoline derivatives | |
ZA928300B (en) | 2-ethyl 1h-Imidazo(4,5-c)quinolin-4-amines. | |
FI913510A0 (fi) | Menetelmä terapeuttisesti käyttökelpoisten, raseemisten tai optisesti aktiivisten pyrido/1,2-a/pyratsiinien valmistamiseksi | |
ITTO920676A0 (it) | Procedimento per la produzione di poli acido lattico | |
IT1307267B1 (it) | Procedimento di rafforzamento di attivita' antitumorale di farmacigrezzi, composizione contenente un farmaco grezzo rafforzante | |
NO170330C (no) | Fremgangsmaate for fremstilling av vesentlig optisk rent monohydrat av s-(-)-propyl-2',6'-pipekoloksylididhydroklorid | |
FI885622A (fi) | Menetelmä 7 -/(Z)-2-(5-amino-1,2,4-tiadiatsol-3-yyli)-2-metoksi-iminoasetamido/-3-(1-imidatso/1,2-b/-pyridatsinium)metyyli-3-kefeemi-4-karboksylaatti-hydrokloridin kiteiden valmistamiseksi | |
IT1226548B (it) | Benzazepine 3-sostituite ad attivita' farmaceutica | |
ES2003828A6 (es) | Mejoras introducidas en el objeto de la patente principal n 552684 por un procedimiento para la obtencion de derivados 4 1 (5,6,7,8-tetrahidropirido(2,3-d)pirimidin-6-il-alquil-2 benzoil de acido l-glutamico | |
IL142695A0 (en) | Crystal modification b of 8-cyano-1-cyclopropyl-7-(1s,6s,-2, 8-diazabicyclo [4.3.0] nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid | |
AP9600851A0 (en) | Novel crystal form of anhydrous 7-(1A,5A,6A) -6- amino-3- azabicyclo(3.1.0)hex-3-YL) -6- fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo1,8-naphthyridine S-3-carboxylic acid methanesulfonic acid salt | |
ATE167478T1 (de) | Kristallform von wasserfreien 7-((1a,5a,6a)-6- amino-3-azabicyclo (3.1.0.) hex-3-yl)-6-fluoro-1- (2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8- naphthyridin-carbonsäure methanesulfonsäure salz | |
HK1045158A1 (en) | Crystal modification d of 8-cyano-1-cyclopropyl-7-(1s, 6s, 2,8-diazabicyclo-(4.3.0.)nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid | |
HK1042704A1 (en) | Semi-hydrochloride of 8-cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo Ä4.3.0Ünonan-8-yl)-6-fluoro-1,4-dihydro -4-oxo-3- quinoline carboxylic acid. | |
IL142696A0 (en) | Crystal modification a of 8-cyano-1-cyclopropyl-7-(1s,6s,-2, 8-diazabicyclo [4.3.0] nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid | |
KR950700295A (ko) | 키랄 에틸(5-아미노-1,2-디히드로-2-메틸-3-페닐피리도[3,4-b]피라진-7-일)카르바메이트의 제조방법(Process for Preparing Chiral Ethyl(5-Amino-1,2-Dihydro-2-Methyl-3-Phenylpyrido[3,4-b]Pyrazin-7-yl(Carbamate) | |
EP0276805A3 (en) | Substituted 3-phenyl-7h-thiazoloû3,2-b¨û1,2,4¨triazin-7-ones, processes for their preparation, medicaments containing them and their use as well as some of the intermediates obtained during the preparation of said compounds | |
EP0330468A3 (en) | Use of heterocyclic derivatives as kappa-opioid receptor agonists in the treatment of cerebral ischaemia | |
PL299530A1 (en) | Novel derivative of pyrido [3,2-3]-1,2-thiazine system | |
YU106787A (en) | Process for obtaining monohydrate of optically pure s-(-)-1-propyl-2',6'pipecoloxylidid chlorinehydrate | |
SI1105390T1 (sl) | Derivati imidazo/1,2-a/piridina za zdravljenje gastrointestinalnih bolezni | |
GB8809176D0 (en) | Pyrido(3 4-b)indole derivatives & process for their preparation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
A1OB | Publication of a patent application | ||
B1PR | Patent granted | ||
ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20030415 Year of fee payment: 8 |
|
PBON | Lapse due to non-payment of renewal fee |
Effective date: 20040607 |