HRP950478B1 - METHOD FOR THE PREPARATION OF 3-HYDROXY-5-(2-(DIMETHYLAMINO)-ETHYL)-2,3-DIHYDRO-4-(METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5h)-ONE AND USE OF THE PRODUCT FOR MAKING PHARMACEUTICALLY ACTIVE COMPOUNDS - Google Patents

METHOD FOR THE PREPARATION OF 3-HYDROXY-5-(2-(DIMETHYLAMINO)-ETHYL)-2,3-DIHYDRO-4-(METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5h)-ONE AND USE OF THE PRODUCT FOR MAKING PHARMACEUTICALLY ACTIVE COMPOUNDS

Info

Publication number
HRP950478B1
HRP950478B1 HR94114643.3A HRP950478A HRP950478B1 HR P950478 B1 HRP950478 B1 HR P950478B1 HR P950478 A HRP950478 A HR P950478A HR P950478 B1 HRP950478 B1 HR P950478B1
Authority
HR
Croatia
Prior art keywords
active compounds
pharmaceutically active
product
benzothiazepin
methoxyphenyl
Prior art date
Application number
HR94114643.3A
Other languages
English (en)
Inventor
Martti Hytoenen
Original Assignee
Martti Hytoenen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Martti Hytoenen filed Critical Martti Hytoenen
Publication of HRP950478A2 publication Critical patent/HRP950478A2/hr
Publication of HRP950478B1 publication Critical patent/HRP950478B1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D281/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02Seven-membered rings
    • C07D281/04Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR94114643.3A 1994-09-16 1995-09-15 METHOD FOR THE PREPARATION OF 3-HYDROXY-5-(2-(DIMETHYLAMINO)-ETHYL)-2,3-DIHYDRO-4-(METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5h)-ONE AND USE OF THE PRODUCT FOR MAKING PHARMACEUTICALLY ACTIVE COMPOUNDS HRP950478B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP94114643A EP0702009B1 (en) 1994-09-16 1994-09-16 Method for the preparation of pharmaceutically active benzothiazepine derivatives

Publications (2)

Publication Number Publication Date
HRP950478A2 HRP950478A2 (en) 1997-06-30
HRP950478B1 true HRP950478B1 (en) 1999-10-31

Family

ID=8216292

Family Applications (1)

Application Number Title Priority Date Filing Date
HR94114643.3A HRP950478B1 (en) 1994-09-16 1995-09-15 METHOD FOR THE PREPARATION OF 3-HYDROXY-5-(2-(DIMETHYLAMINO)-ETHYL)-2,3-DIHYDRO-4-(METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5h)-ONE AND USE OF THE PRODUCT FOR MAKING PHARMACEUTICALLY ACTIVE COMPOUNDS

Country Status (20)

Country Link
US (1) US5663332A (cs)
EP (1) EP0702009B1 (cs)
JP (1) JPH08269026A (cs)
AT (1) ATE167858T1 (cs)
BA (1) BA95040A (cs)
CA (1) CA2158223A1 (cs)
CZ (1) CZ290970B6 (cs)
DE (1) DE69411387T2 (cs)
DK (1) DK0702009T3 (cs)
EE (1) EE03565B1 (cs)
ES (1) ES2118292T3 (cs)
HR (1) HRP950478B1 (cs)
HU (1) HU220610B1 (cs)
IL (1) IL115275A (cs)
LV (1) LV11324B (cs)
PL (1) PL310495A1 (cs)
RU (1) RU2141957C1 (cs)
SK (1) SK281219B6 (cs)
YU (1) YU60395A (cs)
ZA (1) ZA957703B (cs)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038429A1 (en) * 1995-06-01 1996-12-05 Acic (Canada) Inc. Method for the manufacture of benzothiazepine derivatives
IL123352A0 (en) 1997-02-27 1998-09-24 Tanabe Seiyaku Co Process for preparing an optically active trans-3-substituted glycidic acid ester
DE102004010830A1 (de) * 2004-02-27 2005-09-15 Bioagency Ag Neue 1,4-Benzooxazepane oder 1,4-Benzothiazepane und Derivate
CN103304514B (zh) * 2013-06-28 2014-09-17 天津梅花医药有限公司 一种稳定性好的盐酸地尔硫卓化合物及药物组合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3562257A (en) * 1967-10-28 1971-02-09 Tanabe Seiyaku Co Benzothiazepine derivatives
JPS5899471A (ja) * 1981-12-07 1983-06-13 Tanabe Seiyaku Co Ltd ベンゾチアゼピン誘導体の新規製造法
IT1175814B (it) * 1984-03-09 1987-07-15 Luso Farmaco Inst Resine solfoniche ad attivita' terapeutica,loro preparazione e composizioni farmaceutiche che le contengono
JPS63275572A (ja) * 1987-05-01 1988-11-14 Tanabe Seiyaku Co Ltd 1,5−ベンゾチアゼピン誘導体
FR2624117B1 (fr) * 1987-12-08 1991-02-22 Synthelabo Derives de hydroxy-3 (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique
FR2630109B1 (fr) * 1988-04-19 1991-11-29 Synthelabo Derives de ((n-(amino-2 oxo-2 ethyl)methylamino)-2 ethyl)-5 hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique
US5002942A (en) * 1988-07-25 1991-03-26 Sankyo Company, Limited 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders
FR2653122B1 (fr) * 1989-10-17 1994-04-15 Synthelabo Derives de 5-[2-[[2-amino-2-oxoethyl]methylamino]ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5(5h)-benzothiazepine-4-one, leur preparation et leur application en therapeutique.
IT1240686B (it) * 1990-04-27 1993-12-17 Luso Farmaco Inst Derivati 1,5-benzotiazepinonici, loro preparazione e uso farmaceutico
IT1244878B (it) * 1990-12-11 1994-09-12 Lusochimica Spa Processo per la preparazione del (+)-cis-3-(acetossi)-5-!2-( dimetilammino)etil!-2,3-diidro-2-(4-metossifenil)-1,5-benzotiazepin- 4-(5h)-one cloridrato

Also Published As

Publication number Publication date
SK114195A3 (en) 1996-06-05
DE69411387T2 (de) 1999-02-25
BA95040A (bs) 1998-12-28
DK0702009T3 (da) 1999-02-01
IL115275A (en) 2000-06-01
SK281219B6 (sk) 2001-01-18
RU2141957C1 (ru) 1999-11-27
CZ290970B6 (cs) 2002-11-13
ES2118292T3 (es) 1998-09-16
EP0702009A1 (en) 1996-03-20
PL310495A1 (en) 1996-03-18
IL115275A0 (en) 1995-12-31
LV11324A (lv) 1996-06-20
HRP950478A2 (en) 1997-06-30
EE03565B1 (et) 2001-12-17
DE69411387D1 (de) 1998-08-06
ZA957703B (en) 1996-04-24
HU220610B1 (hu) 2002-03-28
CZ237295A3 (en) 1996-04-17
ATE167858T1 (de) 1998-07-15
LV11324B (en) 1996-10-20
EE9500050A (et) 1996-04-15
US5663332A (en) 1997-09-02
CA2158223A1 (en) 1996-03-17
HUT76924A (hu) 1998-01-28
HU9502710D0 (en) 1995-11-28
YU60395A (sh) 1998-09-18
JPH08269026A (ja) 1996-10-15
EP0702009B1 (en) 1998-07-01

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