HRP931158B1 - Beads having a core coated with an antifungal and a polymer - Google Patents

Beads having a core coated with an antifungal and a polymer

Info

Publication number
HRP931158B1
HRP931158B1 HR92202664.6A HRP931158A HRP931158B1 HR P931158 B1 HRP931158 B1 HR P931158B1 HR P931158 A HRP931158 A HR P931158A HR P931158 B1 HRP931158 B1 HR P931158B1
Authority
HR
Croatia
Prior art keywords
antifungal
beads
polymer
core coated
coated
Prior art date
Application number
HR92202664.6A
Other languages
English (en)
Inventor
Paul M V Gilis
Conde Valentin F V De
Roger P G Vandecruys
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8210890&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP931158(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HRP931158A2 publication Critical patent/HRP931158A2/xx
Publication of HRP931158B1 publication Critical patent/HRP931158B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HR92202664.6A 1992-09-03 1993-09-02 Beads having a core coated with an antifungal and a polymer HRP931158B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92202664 1992-09-03

Publications (2)

Publication Number Publication Date
HRP931158A2 HRP931158A2 (en) 1995-06-30
HRP931158B1 true HRP931158B1 (en) 1999-02-28

Family

ID=8210890

Family Applications (1)

Application Number Title Priority Date Filing Date
HR92202664.6A HRP931158B1 (en) 1992-09-03 1993-09-02 Beads having a core coated with an antifungal and a polymer

Country Status (33)

Country Link
US (1) US5633015A (fr)
EP (1) EP0658103B1 (fr)
JP (1) JP2865869B2 (fr)
KR (1) KR0151893B1 (fr)
CN (1) CN1034714C (fr)
AP (1) AP444A (fr)
AT (1) ATE145327T1 (fr)
AU (1) AU665867B2 (fr)
CA (1) CA2142848C (fr)
CY (1) CY2105B1 (fr)
CZ (1) CZ283403B6 (fr)
DE (1) DE69306119T2 (fr)
DK (1) DK0658103T3 (fr)
ES (1) ES2097536T3 (fr)
FI (1) FI112437B (fr)
GR (1) GR3022198T3 (fr)
HK (1) HK1006000A1 (fr)
HR (1) HRP931158B1 (fr)
HU (1) HU220614B1 (fr)
IL (1) IL106871A (fr)
MX (1) MX9305438A (fr)
MY (1) MY109369A (fr)
NO (1) NO307953B1 (fr)
NZ (1) NZ255379A (fr)
OA (1) OA10130A (fr)
PH (1) PH30929A (fr)
PL (2) PL172676B1 (fr)
RU (1) RU2125445C1 (fr)
SG (1) SG48801A1 (fr)
SI (1) SI9300461B (fr)
TW (1) TW376322B (fr)
WO (1) WO1994005263A1 (fr)
ZA (1) ZA936493B (fr)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9325445D0 (en) 1993-12-13 1994-02-16 Cortecs Ltd Pharmaceutical formulations
CN1183715A (zh) 1995-05-09 1998-06-03 科洛康有限公司 适合药物基质静电包衣的粉末包衣物质
US7008668B2 (en) 1995-05-09 2006-03-07 Phoqus Pharmaceuticals Limited Powder coating composition for electrostatic coating of pharmaceutical substrates
US5750147A (en) * 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
HU227745B1 (en) * 1996-05-20 2012-02-28 Janssen Pharmaceutica Nv Antifungal compositions containing itraconazole
US5846971A (en) * 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
JP2000514059A (ja) * 1996-06-28 2000-10-24 シェーリング コーポレイション トリアゾール抗真菌化合物を含む経口組成物
GB9623634D0 (en) 1996-11-13 1997-01-08 Bpsi Holdings Inc Method and apparatus for the coating of substrates for pharmaceutical use
FR2758459B1 (fr) 1997-01-17 1999-05-07 Pharma Pass Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation
BR9806174A (pt) * 1997-03-26 1999-10-19 Janssen Pharmaceutica Nv Péletes tendo um núcleo revestido com um antifúngico e um polìmero
KR19990001564A (ko) * 1997-06-16 1999-01-15 유충식 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제
DE69808670T2 (de) * 1997-12-31 2003-07-03 Choongwae Pharma Corp., Seoul/Soul Herstellungsverfahren und zusammensetzung einer oralen zubereitung von itraconazol
KR100514330B1 (ko) * 1997-12-31 2006-02-17 주식회사 중외제약 난용성 약물을 함유하는 코팅정
DE19808634A1 (de) * 1998-02-24 1999-08-26 Schering Ag Mantel für eine pharmazeutische Zusammensetzung
UA65607C2 (uk) 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
TR200002217T2 (tr) 1998-07-17 2001-02-21 Janssen Pharmaceutica N.V. Bir mantar ilacı ve bir polimer ile kaplanmış bir çekirdeğe sahip taneler.
ES2157731B1 (es) * 1998-07-21 2002-05-01 Liconsa Liberacion Controlada Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
JP2003531099A (ja) 1999-03-24 2003-10-21 エフ エム シー コーポレーション 改良された水溶解度をもつ医薬製剤
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US20060034937A1 (en) * 1999-11-23 2006-02-16 Mahesh Patel Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US20030180352A1 (en) * 1999-11-23 2003-09-25 Patel Mahesh V. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
KR100694667B1 (ko) * 1999-12-08 2007-03-14 동아제약주식회사 생체내이용률 향상과 개인간 및 개인내 흡수 편차를감소시킨 이트라코나졸 함유 항진균성 제제
JP5159012B2 (ja) * 1999-12-23 2013-03-06 メイン・ファ−マ・インタ−ナショナル・プロプライエタリ−・リミテッド 不良溶解性の薬物に対する改良された医薬組成物
CN101385732A (zh) * 2000-02-29 2009-03-18 布里斯托尔-迈尔斯斯奎布公司 低剂量艾替开韦制剂及其应用
US6551608B2 (en) * 2000-03-06 2003-04-22 Porex Technologies Corporation Porous plastic media with antiviral or antimicrobial properties and processes for making the same
US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6673373B2 (en) * 2001-02-01 2004-01-06 Carlsbad Technology Inc. Antifungal formulation and the methods for manufacturing and using the same
US6663897B2 (en) * 2001-02-06 2003-12-16 Dsm Ip Assets B.V. Oral itraconazole formulations and methods of making the same
CN100369904C (zh) 2001-02-14 2008-02-20 泰博特克药品有限公司 2-(取代-氨基)-苯并噻唑磺酰胺hiv蛋白酶抑制剂
AR035819A1 (es) 2001-04-09 2004-07-14 Tibotec Pharm Ltd 2-(amino sustituido)-benzoxazol sulfonamidas, inhibidoras de la proteasa del hiv, composiciones farmaceuticas que comprenden dichos compuestos, metodo in vitro para inhibir la replicacion retroviral y uso de dichos compuestos en la fabricacion de medicamentos
PT1387842E (pt) 2001-05-11 2009-07-20 Tibotec Pharm Ltd 2-aminobenzoxazolsulfonamidas inibidoras de largo espectro da protease hiv
US20030070584A1 (en) * 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
AU4061702A (en) * 2001-05-15 2003-04-03 Mcneil-Ppc, Inc. Dip coating compositions containing starch or dextrin
KR100438485B1 (ko) * 2001-08-13 2004-07-09 한국디디에스제약 주식회사 아졸류 항진균제의 약제학적 조성물
US8071133B2 (en) 2001-08-20 2011-12-06 Stiefel Laboratories, Inc. Oral dosage forms of water insoluble drugs and methods of making the same
US8309118B2 (en) * 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
CA2363376A1 (fr) * 2001-11-16 2003-05-16 Bernard Charles Sherman Compositions pharmaceutiques solides, comprenant de l'itraconazole, destinees a l'administration orale
EP1463502B1 (fr) 2001-12-21 2011-07-13 Tibotec Pharmaceuticals Phenyle heterocyclique substitue a large spectre contenant des inhibiteurs de la sulfonamide protease vih
US7078526B2 (en) * 2002-05-31 2006-07-18 Transform Pharmaceuticals, Inc. CIS-itraconazole crystalline forms and related processes, pharmaceutical compositions and methods
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US7446107B2 (en) * 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
US7790905B2 (en) * 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
CA2477923C (fr) * 2002-03-01 2021-02-23 University Of South Florida Phases solides multicomposants contentant au moins un principe pharmaceutiquement actif
MY142238A (en) 2002-03-12 2010-11-15 Tibotec Pharm Ltd Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
SI1517899T1 (sl) 2002-05-17 2008-02-29 Tibotec Pharm Ltd Substituirani benzoksazol sulfonamidi sirokega spektra, ki so HIV proteazni inhibitorji
US20070059356A1 (en) * 2002-05-31 2007-03-15 Almarsson Oern Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
MXPA05000232A (es) * 2002-06-21 2005-06-17 Transform Pharmaceuticals Inc Composiciones farmaceuticas con disolucion mejorada.
EP1542728A4 (fr) * 2002-07-22 2005-09-21 Nanohybrid Co Ltd Hybride d'itraconazole, cyclosporine ou carvedilol avec un silicate en couches et son procede de preparation
US7429619B2 (en) * 2002-08-02 2008-09-30 Mcneil Consumer Healthcare Polyacrylic film forming compositions
KR100994759B1 (ko) 2002-08-14 2010-11-16 티보텍 파마슈티컬즈 광역스펙트럼의 치환된 옥신돌 설폰아미드 ｈｉｖ프로테아제 저해제
US20040086567A1 (en) * 2002-10-30 2004-05-06 Pawan Seth Bioequivalent composition of itraconazole and a hydrophilic polymer
AU2002352938B8 (en) 2002-11-26 2009-10-08 The University Of Chicago Materials and methods for preventing and treating microbe-mediated epithelial disorders
US8183290B2 (en) * 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
EP1438960B2 (fr) * 2003-01-14 2012-12-19 Acino Pharma AG Composition sous la forme d'une dispersion solide comprenant de l'itraconazole et un polymer hydrophilique dont la biodisponibilité est améliorée
DK1438961T4 (da) † 2003-01-14 2014-11-17 Acino Pharma Ag Bioækvivalent sammensætning af itraconazol dispergeret i en hydrofil polymer
FR2852607B1 (fr) * 2003-03-20 2006-07-14 Procede de fabrication de microspheres de sucre de petite taille, les microspheres susceptibles d'etre obtenues par ce procede et leurs applications
WO2005023242A1 (fr) 2003-09-11 2005-03-17 Tibotec Pharmaceuticals Ltd. Inhibiteurs de la penetration du virus vih
US20050074494A1 (en) * 2003-10-06 2005-04-07 Xiu-Xiu Cheng Itraconazole immediate release formulation
US20050118265A1 (en) * 2003-11-28 2005-06-02 Anandi Krishnan Antifungal oral dosage forms and the methods for preparation
US9247765B2 (en) 2004-01-14 2016-02-02 Omniactive Health Technologies Limited Stable beadlets of lipophilic nutrients
US20050249799A1 (en) * 2004-03-03 2005-11-10 Spherics, Inc. Polymeric drug delivery system for hydrophobic drugs
AR048650A1 (es) 2004-05-04 2006-05-10 Tibotec Pharm Ltd Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
AU2005244121B2 (en) 2004-05-07 2012-01-19 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
JP4879889B2 (ja) 2004-05-17 2012-02-22 テイボテク・フアーマシユーチカルズ・リミテツド ４−置換−１，５−ジヒドロ−ピリド［３，２−ｂ］インドール−２−オン
CN1976930B (zh) 2004-05-17 2011-01-19 泰博特克药品有限公司 用作抗感染药物的6,7,8,9-取代的1-苯基-1,5-二氢吡啶并(3,2-b)吲哚-2-酮
EA012330B1 (ru) 2004-05-17 2009-08-28 Тиботек Фармасьютикалз Лтд. 1-ГЕТЕРОЦИКЛИЛ-1,5-ДИГИДРОПИРИДО[3,2-b]ИНДОЛ-2-ОНЫ
WO2006026504A2 (fr) * 2004-08-27 2006-03-09 Spherics, Inc. Formulations orales mucoadhesives de medicaments a permeabilite et solubilite elevees
US20060045865A1 (en) * 2004-08-27 2006-03-02 Spherics, Inc. Controlled regional oral delivery
US20100297251A1 (en) * 2004-09-01 2010-11-25 Board Of Regents, The University Of Texas System Encapsulated particles for enteric release
US20100297248A1 (en) * 2004-09-01 2010-11-25 Board Of Regents, The University Of Texas System Encapsulated particles for amorphous stability enhancement
US20060045822A1 (en) 2004-09-01 2006-03-02 Board Of Regents, The University Of Texas System Plasma polymerization for encapsulating particles
FR2883179B1 (fr) 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
TW200710091A (en) 2005-04-11 2007-03-16 Tibotec Pharm Ltd (1,10B-dihydro-2-(aminoalkyl-phenyl)-5H-pyrazolo [1,5-c][1,3]benzoxazin-5-yl)phenyl methanone derivatives as HIV viral replication inhibitors
JP2009502258A (ja) * 2005-07-21 2009-01-29 ノミール・メディカル・テクノロジーズ・インコーポレーテッド 標的部位の生物学的汚染物質のレベルを下げる方法
US20070148240A1 (en) * 2005-12-23 2007-06-28 Fang-Yu Lee Oral formulation containing itraconazole and methods for manufacturing and using the same
WO2007113290A1 (fr) 2006-04-03 2007-10-11 Tibotec Pharmaceuticals Ltd. 3,4-dihydro-imidazo[4,5-b]pyridin-5-ones inhibant le vih
CN101091725A (zh) * 2006-06-23 2007-12-26 天津天士力制药股份有限公司 一种中药颗粒及其制备方法
US20100151035A1 (en) * 2007-03-13 2010-06-17 Sandoz Ag Pharmaceutical compositions of poorly soluble drugs
CN101283984B (zh) * 2007-04-12 2010-05-26 永胜药品工业股份有限公司 高生物使用率的经杀真菌剂和聚合物涂覆的核心微粒状物
US7314641B1 (en) 2007-04-18 2008-01-01 Everest Pharm. Industrial Co., Ltd. High-bioavailability particle coated with fungicide and polymer
JP2008280254A (ja) * 2007-05-08 2008-11-20 Everest Pharm Industrial Co Ltd 生体に使用される比率が高い、殺菌剤と重合物を塗粧してる核心微粒状物
EP2224923A4 (fr) 2007-11-28 2013-05-15 Sequoia Pharmaceuticals Inc Compositions et procédés destinés à l'inhibition du cytochrome p450 2d6
US8906647B2 (en) 2008-02-21 2014-12-09 Sequoia Pharmaceuticals, Inc. Diamide inhibitors of cytochrome P450
WO2009114834A2 (fr) 2008-03-13 2009-09-17 Board Of Regents, The University Of Texas System Particules à fonctionnalisation covalente pour la synthèse de nouveaux matériaux composites
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
SG174658A1 (en) 2010-04-01 2011-10-28 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
BR112013015085A8 (pt) * 2010-12-16 2018-04-03 Univ Texas Composição farmacêutica, método para preparar uma composição, e, uso de composição
US8940763B2 (en) 2011-05-10 2015-01-27 Theravida, Inc. Combinations of solifenacin and salivary stimulants for the treatment of overactive bladder
WO2013192566A1 (fr) 2012-06-21 2013-12-27 Mayne Pharma International Pty. Ltd. Compositions et formes galéniques d'itraconazole et leurs procédés d'utilisation
CN103948911B (zh) * 2014-04-23 2016-04-20 深圳市健元医药科技有限公司 一种棘白菌素类抗真菌药物缓释微球制剂及其制备方法
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
WO2016033549A2 (fr) 2014-08-28 2016-03-03 Lipocine Inc. Compositions de (17-ss)-3-oxoandrost-4-èn-17-yl tridécanoate et leurs procédés de préparation et d'utilisation
AU2016388308B2 (en) 2016-01-20 2022-08-04 Theravida, Inc. Methods and compositions for treating hyperhidrosis
EP3544614A4 (fr) 2016-11-28 2020-08-05 Lipocine Inc. Traitement oral à base d'undécanoate de testostérone

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
US4916134A (en) * 1987-03-25 1990-04-10 Janssen Pharmacuetica N.V. 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones
US4855326A (en) * 1987-04-20 1989-08-08 Fuisz Pharmaceutical Ltd. Rapidly dissoluble medicinal dosage unit and method of manufacture
JPH01165520A (ja) * 1987-12-23 1989-06-29 Shin Etsu Chem Co Ltd 持続性製剤およびその製造方法
US5049374A (en) * 1989-11-28 1991-09-17 Dansereau Richard J Oral (coated bead) dosage form for sodium iodide I-131
US5213811A (en) * 1991-09-13 1993-05-25 Sterling Drug Inc. Oral sustained-release drug compositions

Also Published As

Publication number Publication date
FI950975A (fi) 1995-03-02
GR3022198T3 (en) 1997-03-31
HU9500642D0 (en) 1995-04-28
SI9300461B (en) 2001-12-31
SI9300461A (en) 1994-03-31
PH30929A (en) 1997-12-23
OA10130A (en) 1996-12-18
WO1994005263A1 (fr) 1994-03-17
AP9300563A0 (en) 1993-10-31
MX9305438A (es) 1994-03-31
IL106871A (en) 1998-02-22
CN1034714C (zh) 1997-04-30
JP2865869B2 (ja) 1999-03-08
US5633015A (en) 1997-05-27
SG48801A1 (en) 1998-05-18
RU2125445C1 (ru) 1999-01-27
FI112437B (fi) 2003-12-15
CA2142848A1 (fr) 1994-03-17
CA2142848C (fr) 1999-11-16
HUT70419A (en) 1995-10-30
JPH08501092A (ja) 1996-02-06
HU220614B1 (hu) 2002-03-28
AU4954693A (en) 1994-03-29
EP0658103B1 (fr) 1996-11-20
PL172676B1 (pl) 1997-11-28
ES2097536T3 (es) 1997-04-01
NZ255379A (en) 1996-06-25
DK0658103T3 (da) 1996-12-09
IL106871A0 (en) 1993-12-28
MY109369A (en) 1997-01-31
AU665867B2 (en) 1996-01-18
TW376322B (en) 1999-12-11
NO307953B1 (no) 2000-06-26
KR0151893B1 (ko) 1998-10-15
ATE145327T1 (de) 1996-12-15
HK1006000A1 (en) 1999-02-05
DE69306119T2 (de) 1997-03-13
AP444A (en) 1996-01-19
CN1088432A (zh) 1994-06-29
CZ283403B6 (cs) 1998-04-15
PL307791A1 (en) 1995-06-26
NO950829D0 (no) 1995-03-02
PL174178B1 (pl) 1998-06-30
DE69306119D1 (de) 1997-01-02
CY2105B1 (en) 2002-04-26
NO950829L (no) 1995-05-02
FI950975A0 (fi) 1995-03-02
HRP931158A2 (en) 1995-06-30
CZ54295A3 (en) 1995-09-13
ZA936493B (en) 1995-03-02
EP0658103A1 (fr) 1995-06-21

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