HRP920835A2 - Floatable oral therapeutic system - Google Patents
Floatable oral therapeutic system Download PDFInfo
- Publication number
- HRP920835A2 HRP920835A2 HR920835A HRP920835A HRP920835A2 HR P920835 A2 HRP920835 A2 HR P920835A2 HR 920835 A HR920835 A HR 920835A HR P920835 A HRP920835 A HR P920835A HR P920835 A2 HRP920835 A2 HR P920835A2
- Authority
- HR
- Croatia
- Prior art keywords
- structural element
- active substance
- elements
- subsystems
- floating
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title claims description 15
- 239000013543 active substance Substances 0.000 claims description 39
- 210000002784 stomach Anatomy 0.000 claims description 15
- 239000006260 foam Substances 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 8
- 239000004793 Polystyrene Substances 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 6
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 230000002496 gastric effect Effects 0.000 claims description 6
- -1 polypropylene Polymers 0.000 claims description 6
- 239000004743 Polypropylene Substances 0.000 claims description 5
- 239000011888 foil Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 229920001155 polypropylene Polymers 0.000 claims description 5
- 230000001105 regulatory effect Effects 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 4
- 230000004962 physiological condition Effects 0.000 claims description 4
- 239000011230 binding agent Substances 0.000 claims description 3
- 210000000936 intestine Anatomy 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 2
- 239000012943 hotmelt Substances 0.000 claims description 2
- 229910010272 inorganic material Inorganic materials 0.000 claims description 2
- 239000000017 hydrogel Substances 0.000 claims 2
- 239000004952 Polyamide Substances 0.000 claims 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- 239000011147 inorganic material Substances 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 229920000058 polyacrylate Polymers 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 239000005033 polyvinylidene chloride Substances 0.000 claims 1
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 54
- 229960000278 theophylline Drugs 0.000 description 27
- 239000003826 tablet Substances 0.000 description 20
- 239000000463 material Substances 0.000 description 14
- 238000003825 pressing Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 9
- 239000000843 powder Substances 0.000 description 8
- 210000004379 membrane Anatomy 0.000 description 7
- 230000006870 function Effects 0.000 description 6
- 210000004051 gastric juice Anatomy 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
- 229920000178 Acrylic resin Polymers 0.000 description 5
- 239000004925 Acrylic resin Substances 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 4
- 238000005520 cutting process Methods 0.000 description 3
- 230000005484 gravity Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 229920003155 Eudragit® RL 100 Polymers 0.000 description 2
- 238000004026 adhesive bonding Methods 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- 238000005266 casting Methods 0.000 description 2
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- HNUQMTZUNUBOLQ-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO HNUQMTZUNUBOLQ-UHFFFAOYSA-N 0.000 description 1
- JKXYOQDLERSFPT-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO JKXYOQDLERSFPT-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 229920003159 Eudragit® RS 100 Polymers 0.000 description 1
- 229920000299 Nylon 12 Polymers 0.000 description 1
- 229920002398 Oppanol® B Polymers 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 239000007942 layered tablet Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 239000012229 microporous material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 230000036186 satiety Effects 0.000 description 1
- 235000019627 satiety Nutrition 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3803482A DE3803482A1 (de) | 1988-02-05 | 1988-02-05 | Schwimmfaehiges orales therapeutisches system |
| YU00254/89A YU25489A (en) | 1988-02-05 | 1989-02-03 | Floating oral therapeutic system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP920835A2 true HRP920835A2 (en) | 1994-10-31 |
Family
ID=6346718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR920835A HRP920835A2 (en) | 1988-02-05 | 1992-10-02 | Floatable oral therapeutic system |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5626876A (hu) |
| EP (1) | EP0326816A1 (hu) |
| JP (1) | JP2929548B2 (hu) |
| KR (1) | KR900700081A (hu) |
| AU (1) | AU637043B2 (hu) |
| CA (1) | CA1325366C (hu) |
| CZ (1) | CZ288441B6 (hu) |
| DD (1) | DD278720A5 (hu) |
| DE (1) | DE3803482A1 (hu) |
| DK (1) | DK489189D0 (hu) |
| FI (1) | FI894688A (hu) |
| HR (1) | HRP920835A2 (hu) |
| HU (1) | HU215971B (hu) |
| IE (1) | IE890135L (hu) |
| IL (1) | IL89105A (hu) |
| MY (1) | MY104821A (hu) |
| NO (1) | NO301688B1 (hu) |
| NZ (1) | NZ227859A (hu) |
| PL (1) | PL165146B1 (hu) |
| PT (1) | PT89618A (hu) |
| SI (1) | SI8910254A (hu) |
| SK (1) | SK281011B6 (hu) |
| WO (1) | WO1989006956A1 (hu) |
| YU (1) | YU25489A (hu) |
| ZA (1) | ZA89506B (hu) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995005809A1 (fr) | 1993-08-20 | 1995-03-02 | Nippon Shinyaku Co., Ltd. | Preparation restant dans l'estomac, forme moulee gonflee, et procede de preparation |
| DE4406424A1 (de) * | 1994-02-28 | 1995-08-31 | Bayer Ag | Expandierbare Arzneiformen |
| GB9718664D0 (en) * | 1997-09-04 | 1997-11-05 | Scherer Corp R P | Improvements in or relating to capsules |
| IN186245B (hu) | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
| DE19822278A1 (de) * | 1998-05-18 | 1999-12-02 | Lohmann Therapie Syst Lts | Vorrichtung zur kontrollierten Freisetzung von Wirkstoff im Gastrointestinaltrakt mit verzögerter Pyloruspassage |
| US6351665B1 (en) | 1999-05-07 | 2002-02-26 | Kenneth L Koch | Method and apparatus for evaluating myoelectric signals and identifying artifact |
| EP1066836A1 (en) * | 1999-06-11 | 2001-01-10 | Sensus, part of Coöperatie COSUN U.A. | Filler/binder hollow particles for tablets |
| FR2797185B1 (fr) * | 1999-08-06 | 2001-10-26 | Galenix Dev | Composition pharmaceutique flottante comprenant une phase active et une phase non active |
| DE10014588A1 (de) | 2000-03-27 | 2001-10-04 | Basf Ag | Wirkstoffhaltige Schwimmformen enthaltend Polyvinylacetat und Polyvinylpyrrolidon, deren Verwendung und Herstellung |
| DE10032456A1 (de) * | 2000-07-04 | 2002-01-31 | Lohmann Therapie Syst Lts | Schnell zerfallende Darreichungsform zur Freisetzung von Wirkstoffen im Mundraum oder in Körperhöhlen |
| AU2005202270B2 (en) * | 2000-07-04 | 2006-10-26 | Lts Lohmann Therapie-Systeme Ag | Rapidly Disintegrating Dosage form For Releasing Nicotine in the Oral Cavity or in Body Cavities |
| EP1245227A1 (en) * | 2001-03-31 | 2002-10-02 | Jagotec Ag | A pharmaceutical tablet system that floats in the stomach for programmed release of active substance and process of producing buoyant material contained in same |
| GB0214013D0 (en) * | 2002-06-18 | 2002-07-31 | Euro Celtique Sa | Pharmaceutical product |
| DE102004023069A1 (de) | 2004-05-11 | 2005-12-08 | Bayer Healthcare Ag | Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil |
| CN1853728A (zh) * | 2005-04-19 | 2006-11-01 | 上海天博生物科技有限公司 | 一种改善药物或营养物口服吸收的方法、配方及其应用 |
| AT505225A1 (de) | 2007-04-26 | 2008-11-15 | Sanochemia Pharmazeutika Ag | 0erfahren zur herstellung von hoch reinem 2,4'-dimethyl-3-piperidino-propiophenon (tolperison), dieses enthaltende pharmazeutische zusammensetzungen, sowie tolperison enthaltende wirkstoffformulierungen |
| DE102007026037A1 (de) * | 2007-06-04 | 2008-12-11 | Lts Lohmann Therapie-Systeme Ag | Gastroretentives System mit Alginat-Körper |
| EP2133071A1 (en) * | 2008-06-09 | 2009-12-16 | Université de la Méditerranée | Process for making gastroretentive dosage forms |
| US20100249423A1 (en) * | 2009-03-09 | 2010-09-30 | Sanochemia Pharmazeutika Ag | Tolperisone controlled release tablet |
| FR2945945B1 (fr) * | 2009-05-29 | 2011-07-29 | Flamel Tech Sa | Procede de preparation de particules creuses et leurs applications |
| FR2945947B1 (fr) | 2009-05-29 | 2011-07-29 | Flamel Tech Sa | Compositions pharmaceutiques flottantes a liberation controlee |
| US20120100212A1 (en) * | 2009-07-06 | 2012-04-26 | Kyorin Pharmaceutical, Co., Ltd. | Tablet having hollow structure |
| EP2444064A1 (en) * | 2010-10-22 | 2012-04-25 | Meliatys | Process for making multiparticulate gastroretentive dosage forms |
| EP2765998A1 (en) | 2011-10-11 | 2014-08-20 | Ranbaxy Laboratories Limited | A gastroretentive dosage system and process of preparation thereof |
| JP2016533864A (ja) * | 2013-10-22 | 2016-11-04 | キャプソ・ヴィジョン・インコーポレーテッド | マルチ密度相を有するカプセル装置に用いられるシステム及び方法 |
| CA3018011A1 (en) * | 2016-03-18 | 2017-09-21 | Grunenthal Gmbh | Floating pharmaceutical dosage form |
| CN110214008A (zh) * | 2017-06-14 | 2019-09-06 | 江苏恒瑞医药股份有限公司 | 一种非布司他控释组合物及其制备方法 |
| WO2019069108A1 (en) * | 2017-10-04 | 2019-04-11 | Debreceni Egyetem | SOLID GALENIC FORM, MOLDED, GASTRIC RETENTION AND EXTENDED RELEASE AND METHOD OF PREPARING THE SAME |
| WO2021176360A1 (en) * | 2020-03-02 | 2021-09-10 | Craft Health Pte Ltd | Oral dosage forms for extended drug release |
| AU2021396978A1 (en) | 2020-12-08 | 2023-02-23 | Ruminant Biotech Corp Limited | Improvements to devices and methods for delivery of substances to animals |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5512411B2 (hu) * | 1974-03-12 | 1980-04-02 | ||
| GB2077585A (en) * | 1980-06-12 | 1981-12-23 | Standard Telephones Cables Ltd | Sustained-release bodies of soluble glass tubules |
| US4764380A (en) * | 1982-03-22 | 1988-08-16 | Alza Corporation | Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills |
| US4451260A (en) * | 1982-03-26 | 1984-05-29 | Minnesota Mining And Manufacturing Company | Sustained release oral medicinal delivery device |
| DE3214667C2 (de) * | 1982-04-21 | 1985-07-18 | Akzo Gmbh, 5600 Wuppertal | Zusammengesetzter Körper für die Langzeitabgabe von Wirkstoffen |
| US4539256A (en) * | 1982-09-09 | 1985-09-03 | Minnesota Mining And Manufacturing Co. | Microporous sheet material, method of making and articles made therewith |
| US4818542A (en) * | 1983-11-14 | 1989-04-04 | The University Of Kentucky Research Foundation | Porous microspheres for drug delivery and methods for making same |
| US4865789A (en) * | 1983-11-14 | 1989-09-12 | Akzo Nv | Method for making porous structures |
| DE3571924D1 (en) * | 1984-04-11 | 1989-09-07 | Thiemann Arzneimittel Gmbh | Dosage units for controlled release of active material |
| PL149493B1 (en) * | 1985-04-12 | 1990-02-28 | Method of obtaining a tablet capable to buoy over surface of gastric juice | |
| GB8518301D0 (en) * | 1985-07-19 | 1985-08-29 | Fujisawa Pharmaceutical Co | Hydrodynamically explosive systems |
| EP0250572A1 (en) * | 1986-01-03 | 1988-01-07 | The University Of Melbourne | Gastro-oesophageal reflux composition |
| DE3612212A1 (de) * | 1986-04-11 | 1987-10-15 | Basf Ag | Verfahren zur herstellung von festen pharmazeutischen formen |
| DE3630603A1 (de) * | 1986-09-09 | 1988-03-10 | Desitin Arzneimittel Gmbh | Darreichungs- und dosierungsform fuer arzneimittelwirkstoffe, reagentien oder dergleichen sowie verfahren zu deren herstellung |
| US4830860A (en) * | 1986-10-30 | 1989-05-16 | Pfizer Inc. | Stressed polymeric device for controlled release of a substance to an ambient environment |
-
1988
- 1988-02-05 DE DE3803482A patent/DE3803482A1/de not_active Withdrawn
-
1989
- 1989-01-10 KR KR1019890701835A patent/KR900700081A/ko not_active Application Discontinuation
- 1989-01-10 WO PCT/DE1989/000008 patent/WO1989006956A1/de active Application Filing
- 1989-01-10 AU AU29143/89A patent/AU637043B2/en not_active Ceased
- 1989-01-10 EP EP89100341A patent/EP0326816A1/de not_active Ceased
- 1989-01-10 JP JP1501012A patent/JP2929548B2/ja not_active Expired - Lifetime
- 1989-01-10 HU HU89731A patent/HU215971B/hu not_active IP Right Cessation
- 1989-01-18 IE IE890135A patent/IE890135L/xx unknown
- 1989-01-23 ZA ZA89506A patent/ZA89506B/xx unknown
- 1989-01-24 CA CA000589062A patent/CA1325366C/en not_active Expired - Lifetime
- 1989-01-25 CZ CS1989493A patent/CZ288441B6/cs not_active IP Right Cessation
- 1989-01-25 MY MYPI89000087A patent/MY104821A/en unknown
- 1989-01-25 SK SK493-89A patent/SK281011B6/sk unknown
- 1989-01-27 IL IL89105A patent/IL89105A/xx not_active IP Right Cessation
- 1989-02-01 DD DD89325415A patent/DD278720A5/de not_active IP Right Cessation
- 1989-02-02 PL PL89277506A patent/PL165146B1/pl unknown
- 1989-02-03 SI SI8910254A patent/SI8910254A/sl unknown
- 1989-02-03 PT PT89618A patent/PT89618A/pt not_active Application Discontinuation
- 1989-02-03 YU YU00254/89A patent/YU25489A/xx unknown
- 1989-02-03 NZ NZ227859A patent/NZ227859A/en unknown
- 1989-09-27 NO NO893838A patent/NO301688B1/no not_active IP Right Cessation
- 1989-10-03 FI FI894688A patent/FI894688A/fi not_active Application Discontinuation
- 1989-10-04 DK DK489189A patent/DK489189D0/da not_active Application Discontinuation
-
1992
- 1992-10-02 HR HR920835A patent/HRP920835A2/hr not_active Application Discontinuation
-
1993
- 1993-10-25 US US08/142,843 patent/US5626876A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU637043B2 (en) | 1993-05-20 |
| HU215971B (hu) | 1999-03-29 |
| NO893838D0 (no) | 1989-09-27 |
| FI894688A0 (fi) | 1989-10-03 |
| NO301688B1 (no) | 1997-12-01 |
| PL165146B1 (pl) | 1994-11-30 |
| AU2914389A (en) | 1989-08-25 |
| ZA89506B (en) | 1990-02-28 |
| HU890731D0 (hu) | 1990-03-28 |
| IL89105A (en) | 1993-02-21 |
| IL89105A0 (en) | 1989-08-15 |
| JP2929548B2 (ja) | 1999-08-03 |
| CA1325366C (en) | 1993-12-21 |
| DK489189A (da) | 1989-10-04 |
| CZ49389A3 (cs) | 1999-08-11 |
| NO893838L (no) | 1989-09-27 |
| HUT54490A (en) | 1991-03-28 |
| SK49389A3 (en) | 2000-10-09 |
| YU25489A (en) | 1991-04-30 |
| DD278720A5 (de) | 1990-05-16 |
| JPH02503087A (ja) | 1990-09-27 |
| SI8910254A (en) | 1997-02-28 |
| IE890135L (en) | 1989-08-05 |
| NZ227859A (en) | 1992-01-29 |
| WO1989006956A1 (en) | 1989-08-10 |
| PT89618A (pt) | 1989-10-04 |
| DK489189D0 (da) | 1989-10-04 |
| EP0326816A1 (de) | 1989-08-09 |
| US5626876A (en) | 1997-05-06 |
| MY104821A (en) | 1994-06-30 |
| SK281011B6 (sk) | 2000-10-09 |
| FI894688A (fi) | 1989-10-03 |
| CZ288441B6 (en) | 2001-06-13 |
| DE3803482A1 (de) | 1989-08-17 |
| KR900700081A (ko) | 1990-08-11 |
| PL277506A1 (en) | 1989-10-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP920835A2 (en) | Floatable oral therapeutic system | |
| EP0090560B1 (en) | Sustained release oral medicinal delivery device | |
| US4844905A (en) | Granule remaining in stomach | |
| US4217898A (en) | System with microporous reservoir having surface for diffusional delivery of agent | |
| JP3307929B2 (ja) | 薬剤の遅延投与のための浸透圧デバイス | |
| JP5680627B2 (ja) | 浮遊性放出制御医薬組成物 | |
| DK175178B1 (da) | Indretning til styret afgivelse af et eller flere aktive stoffer til et brugsmiljö og fremgangsmåde til fremstilling deraf | |
| JP2002528482A (ja) | 長期胃内滞留時間を有する膨張性胃内保持治療システム | |
| NO312123B1 (no) | Osmotiske anordninger for fordeling av et formålstjenlig middel til et vandig miljö | |
| EP1503741A2 (en) | Diffusion-controlled dosage form and method of fabrication including three dimensional printing | |
| Park et al. | Oral controlled release systems | |
| Ayalasomayajula et al. | Review on non effervescent gastro retentive drug delivery systems-microballons | |
| JP2005533084A (ja) | 液体の有効成分の製剤を含んでなりかつ膨張可能な浸透圧組成物によりその放出を制御する経口の投薬形態 | |
| Ghonge et al. | Design and in vitro evaluation of multiparticulate floating drug delivery system of Gastroprokinetic drug | |
| CN108721246B (zh) | 高分子材料构建的多单元超长效口服制剂及其制备方法 | |
| AU734740B2 (en) | Improvements in or relating to capsules | |
| JPS6322014A (ja) | 胃内浮遊性持続型カプセル剤 | |
| Swati et al. | Available online through | |
| Stithit | Development and characterization of buoyant theophylline microspheres with near zero order dissolution kinetics | |
| Srikanth et al. | Advanced Pharmaceutics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| ODBI | Application refused |