HRP20250042T1 - Polimorfi triazolnog antifungalnog spoja pc945 - Google Patents
Polimorfi triazolnog antifungalnog spoja pc945 Download PDFInfo
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- HRP20250042T1 HRP20250042T1 HRP20250042TT HRP20250042T HRP20250042T1 HR P20250042 T1 HRP20250042 T1 HR P20250042T1 HR P20250042T T HRP20250042T T HR P20250042TT HR P20250042 T HRP20250042 T HR P20250042T HR P20250042 T1 HRP20250042 T1 HR P20250042T1
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- 150000001875 compounds Chemical class 0.000 title claims 13
- 229940121375 antifungal agent Drugs 0.000 title claims 2
- 230000000843 anti-fungal effect Effects 0.000 title 1
- 150000003852 triazoles Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 4
- 239000012736 aqueous medium Substances 0.000 claims 4
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 241001225321 Aspergillus fumigatus Species 0.000 claims 3
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- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 229940091771 aspergillus fumigatus Drugs 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 2
- OSAMZQJKSCAOHA-CWRQMEKBSA-N 4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]-3-methylphenyl]piperazin-1-yl]-N-(4-fluorophenyl)benzamide Chemical compound N1(N=CN=C1)C[C@@]1(C[C@@H](CO1)COC1=C(C=C(C=C1)N1CCN(CC1)C1=CC=C(C(=O)NC2=CC=C(C=C2)F)C=C1)C)C1=C(C=C(C=C1)F)F OSAMZQJKSCAOHA-CWRQMEKBSA-N 0.000 claims 2
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- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical compound COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 claims 2
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
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- 239000003814 drug Substances 0.000 claims 2
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- 238000000634 powder X-ray diffraction Methods 0.000 claims 2
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- YKSVGLFNJPQDJE-YDMQLZBCSA-N (19E,21E,23E,25E,27E,29E,31E)-33-[(2R,3S,4R,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-17-[7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl]-1,3,5,7,37-pentahydroxy-18-methyl-9,13,15-trioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid Chemical compound CC(CC(C)C1OC(=O)CC(=O)CCCC(=O)CC(O)CC(O)CC(O)CC2(O)CC(O)C(C(CC(O[C@@H]3O[C@H](C)[C@@H](O)[C@@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\C1C)O2)C(O)=O)C(O)CC(=O)C1=CC=C(N)C=C1 YKSVGLFNJPQDJE-YDMQLZBCSA-N 0.000 claims 1
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- MQHLMHIZUIDKOO-OKZBNKHCSA-N (2R,6S)-2,6-dimethyl-4-[(2S)-2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine Chemical compound C1=CC(C(C)(C)CC)=CC=C1C[C@H](C)CN1C[C@@H](C)O[C@@H](C)C1 MQHLMHIZUIDKOO-OKZBNKHCSA-N 0.000 claims 1
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- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 claims 1
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 claims 1
- QXHHHPZILQDDPS-UHFFFAOYSA-N 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound S1C=CC(COC(CN2C=NC=C2)C=2C(=CC(Cl)=CC=2)Cl)=C1Cl QXHHHPZILQDDPS-UHFFFAOYSA-N 0.000 claims 1
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- VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims 1
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- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 claims 1
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- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 claims 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims 1
- 229960000570 luliconazole Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229960002159 micafungin Drugs 0.000 claims 1
- PIEUQSKUWLMALL-YABMTYFHSA-N micafungin Chemical compound C1=CC(OCCCCC)=CC=C1C1=CC(C=2C=CC(=CC=2)C(=O)N[C@@H]2C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C2)[C@H](O)CC(N)=O)[C@H](O)[C@@H](O)C=2C=C(OS(O)(=O)=O)C(O)=CC=2)[C@@H](C)O)=O)=NO1 PIEUQSKUWLMALL-YABMTYFHSA-N 0.000 claims 1
- 229960002509 miconazole Drugs 0.000 claims 1
- 229960004313 naftifine Drugs 0.000 claims 1
- OZGNYLLQHRPOBR-DHZHZOJOSA-N naftifine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)C\C=C\C1=CC=CC=C1 OZGNYLLQHRPOBR-DHZHZOJOSA-N 0.000 claims 1
- 229960003255 natamycin Drugs 0.000 claims 1
- 235000010298 natamycin Nutrition 0.000 claims 1
- 239000004311 natamycin Substances 0.000 claims 1
- NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 claims 1
- 229960000988 nystatin Drugs 0.000 claims 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 claims 1
- 229960004031 omoconazole Drugs 0.000 claims 1
- JMFOSJNGKJCTMJ-ZHZULCJRSA-N omoconazole Chemical compound C1=CN=CN1C(/C)=C(C=1C(=CC(Cl)=CC=1)Cl)\OCCOC1=CC=C(Cl)C=C1 JMFOSJNGKJCTMJ-ZHZULCJRSA-N 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 229960003483 oxiconazole Drugs 0.000 claims 1
- QRJJEGAJXVEBNE-MOHJPFBDSA-N oxiconazole Chemical compound ClC1=CC(Cl)=CC=C1CO\N=C(C=1C(=CC(Cl)=CC=1)Cl)\CN1C=NC=C1 QRJJEGAJXVEBNE-MOHJPFBDSA-N 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229960001589 posaconazole Drugs 0.000 claims 1
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 claims 1
- 229960002965 pravastatin Drugs 0.000 claims 1
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- STJLVHWMYQXCPB-UHFFFAOYSA-N propiconazole Chemical compound O1C(CCC)COC1(C=1C(=CC(Cl)=CC=1)Cl)CN1N=CN=C1 STJLVHWMYQXCPB-UHFFFAOYSA-N 0.000 claims 1
- 235000019423 pullulan Nutrition 0.000 claims 1
- OPAHEYNNJWPQPX-RCDICMHDSA-N ravuconazole Chemical compound C=1SC([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=1C1=CC=C(C#N)C=C1 OPAHEYNNJWPQPX-RCDICMHDSA-N 0.000 claims 1
- 229950004154 ravuconazole Drugs 0.000 claims 1
- 229960005429 sertaconazole Drugs 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229960002607 sulconazole Drugs 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 229960002722 terbinafine Drugs 0.000 claims 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims 1
- 229960000580 terconazole Drugs 0.000 claims 1
- 229960004214 tioconazole Drugs 0.000 claims 1
- 229960004880 tolnaftate Drugs 0.000 claims 1
- FUSNMLFNXJSCDI-UHFFFAOYSA-N tolnaftate Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 FUSNMLFNXJSCDI-UHFFFAOYSA-N 0.000 claims 1
- 229960002703 undecylenic acid Drugs 0.000 claims 1
- 229960004740 voriconazole Drugs 0.000 claims 1
- BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1917867.2A GB201917867D0 (en) | 2019-12-06 | 2019-12-06 | Polymorphs |
| EP20824979.7A EP4069690B1 (en) | 2019-12-06 | 2020-12-04 | Polymorphs of triazole antifungal compound pc945 |
| PCT/GB2020/053107 WO2021111142A1 (en) | 2019-12-06 | 2020-12-04 | Polymorphs of triazole antifungal compound pc945 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20250042T1 true HRP20250042T1 (hr) | 2025-03-14 |
Family
ID=69171938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20250042TT HRP20250042T1 (hr) | 2019-12-06 | 2020-12-04 | Polimorfi triazolnog antifungalnog spoja pc945 |
Country Status (26)
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|---|---|
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| EP (2) | EP4069690B1 (enExample) |
| JP (1) | JP2023505227A (enExample) |
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| AU (1) | AU2020397613A1 (enExample) |
| BR (1) | BR112022006259A2 (enExample) |
| CA (1) | CA3155829A1 (enExample) |
| CL (1) | CL2022001464A1 (enExample) |
| CO (1) | CO2022007808A2 (enExample) |
| DK (1) | DK4069690T3 (enExample) |
| ES (1) | ES3000984T3 (enExample) |
| FI (1) | FI4069690T3 (enExample) |
| GB (1) | GB201917867D0 (enExample) |
| HR (1) | HRP20250042T1 (enExample) |
| HU (1) | HUE069799T2 (enExample) |
| IL (1) | IL293401A (enExample) |
| LT (1) | LT4069690T (enExample) |
| MX (1) | MX2022006654A (enExample) |
| PL (1) | PL4069690T3 (enExample) |
| PT (1) | PT4069690T (enExample) |
| RS (1) | RS66401B1 (enExample) |
| SA (1) | SA522432879B1 (enExample) |
| SI (1) | SI4069690T1 (enExample) |
| SM (1) | SMT202400514T1 (enExample) |
| WO (1) | WO2021111142A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2790875T3 (es) | 2014-12-05 | 2020-10-29 | Pulmocide Ltd | Compuesto antimicótico |
| CN117510488B (zh) * | 2022-07-28 | 2025-12-05 | 博瑞制药(苏州)有限公司 | 一种硫酸艾沙康唑的制备方法 |
| CN117330660A (zh) * | 2023-09-14 | 2024-01-02 | 广州医科大学附属第一医院（广州呼吸中心） | Uplc-ms/ms联用检测艾沙康唑的方法及应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1292472C (en) | 1985-12-03 | 1991-11-26 | Alfonsus Guilielmus Knaeps | Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles |
| AU2811689A (en) | 1987-11-20 | 1989-06-14 | Schering Corporation | Tri-and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| US5039676A (en) | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| IL112081A (en) | 1993-12-21 | 2001-08-26 | Schering Plough Corp | Tetrahydrofuran derivatives, their preparation and antifungal pharmaceutical compositions containing them |
| US5714490A (en) | 1993-12-21 | 1998-02-03 | Schering Corporation | Tetrahydrofuran antifungals |
| US5486625A (en) | 1994-07-08 | 1996-01-23 | Schering Corporation | Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents |
| IL118464A (en) | 1995-06-02 | 2000-08-13 | Schering Corp | (2R-cis)-4-¬4-¬4-¬4¬¬-5-(2',4 dihalophenyl)-tetrahydro-5-(1-H-1,2,4,triazol-1-yl-methyl)furan-3-yl(methoxy¾phenyl¾-1-piperazinyl¬phenyl2,4,dihydro2¬(5)-1-ethyl-2-(5)hydroxy propyl¾-3H-1,2,4-triazol-3-one and pharmaceutical compositions comprising them |
| EP0957101A1 (en) | 1998-05-14 | 1999-11-17 | Janssen Pharmaceutica N.V. | Water soluble azoles as broad-spectrum antifungals |
| WO2002080678A1 (en) | 2001-04-03 | 2002-10-17 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| EP2141159A1 (en) * | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| WO2013036866A1 (en) | 2011-09-07 | 2013-03-14 | The Johns Hopkins University | Itraconazole analogs and use thereof |
| ES2790875T3 (es) * | 2014-12-05 | 2020-10-29 | Pulmocide Ltd | Compuesto antimicótico |
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2019
- 2019-12-06 GB GBGB1917867.2A patent/GB201917867D0/en not_active Ceased
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2020
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- 2020-12-04 CA CA3155829A patent/CA3155829A1/en active Pending
- 2020-12-04 HR HRP20250042TT patent/HRP20250042T1/hr unknown
- 2020-12-04 SM SM20240514T patent/SMT202400514T1/it unknown
- 2020-12-04 EP EP20824979.7A patent/EP4069690B1/en active Active
- 2020-12-04 JP JP2022533459A patent/JP2023505227A/ja active Pending
- 2020-12-04 EP EP24212504.5A patent/EP4509179A3/en active Pending
- 2020-12-04 PL PL20824979.7T patent/PL4069690T3/pl unknown
- 2020-12-04 KR KR1020227012753A patent/KR20220110726A/ko active Pending
- 2020-12-04 MX MX2022006654A patent/MX2022006654A/es unknown
- 2020-12-04 RS RS20250045A patent/RS66401B1/sr unknown
- 2020-12-04 DK DK20824979.7T patent/DK4069690T3/da active
- 2020-12-04 FI FIEP20824979.7T patent/FI4069690T3/fi active
- 2020-12-04 BR BR112022006259A patent/BR112022006259A2/pt unknown
- 2020-12-04 LT LTEPPCT/GB2020/053107T patent/LT4069690T/lt unknown
- 2020-12-04 SI SI202030565T patent/SI4069690T1/sl unknown
- 2020-12-04 US US17/782,232 patent/US12491182B2/en active Active
- 2020-12-04 CN CN202080082529.6A patent/CN114746415B/zh active Active
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- 2020-12-04 IL IL293401A patent/IL293401A/en unknown
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- 2022-06-05 SA SA522432879A patent/SA522432879B1/ar unknown
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2025
- 2025-10-15 US US19/359,464 patent/US20260060980A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES3000984T3 (es) | 2025-03-04 |
| BR112022006259A2 (pt) | 2022-06-21 |
| AU2020397613A1 (en) | 2022-06-02 |
| PT4069690T (pt) | 2024-12-13 |
| CN114746415B (zh) | 2025-04-11 |
| US20230028714A1 (en) | 2023-01-26 |
| MX2022006654A (es) | 2022-09-07 |
| PL4069690T3 (pl) | 2025-03-10 |
| RS66401B1 (sr) | 2025-02-28 |
| KR20220110726A (ko) | 2022-08-09 |
| SI4069690T1 (sl) | 2025-03-31 |
| EP4509179A2 (en) | 2025-02-19 |
| CA3155829A1 (en) | 2021-06-10 |
| SMT202400514T1 (it) | 2025-01-14 |
| IL293401A (en) | 2022-07-01 |
| GB201917867D0 (en) | 2020-01-22 |
| EP4069690A1 (en) | 2022-10-12 |
| SA522432879B1 (ar) | 2025-01-26 |
| US20260060980A1 (en) | 2026-03-05 |
| EP4069690B1 (en) | 2024-11-13 |
| JP2023505227A (ja) | 2023-02-08 |
| DK4069690T3 (da) | 2025-01-20 |
| CO2022007808A2 (es) | 2022-06-30 |
| WO2021111142A1 (en) | 2021-06-10 |
| FI4069690T3 (fi) | 2025-01-21 |
| HUE069799T2 (hu) | 2025-04-28 |
| CN114746415A (zh) | 2022-07-12 |
| CL2022001464A1 (es) | 2023-03-24 |
| EP4509179A3 (en) | 2025-02-26 |
| US12491182B2 (en) | 2025-12-09 |
| LT4069690T (lt) | 2025-01-10 |
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