CN114746415B - 三唑抗真菌化合物pc945的多晶型物 - Google Patents

三唑抗真菌化合物pc945的多晶型物 Download PDF

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Publication number
CN114746415B
CN114746415B CN202080082529.6A CN202080082529A CN114746415B CN 114746415 B CN114746415 B CN 114746415B CN 202080082529 A CN202080082529 A CN 202080082529A CN 114746415 B CN114746415 B CN 114746415B
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compound
pharmaceutical composition
polymorphic
aspergillus
species
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English (en)
Chinese (zh)
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CN114746415A (zh
Inventor
C·J·沃利斯
G·斯蒂尔
S·巴特尔
O·苏莱曼
J·诺森
J·米基提尤克
J·马歇尔
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Pulmocide Ltd
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Pulmocide Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202080082529.6A 2019-12-06 2020-12-04 三唑抗真菌化合物pc945的多晶型物 Active CN114746415B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1917867.2 2019-12-06
GBGB1917867.2A GB201917867D0 (en) 2019-12-06 2019-12-06 Polymorphs
PCT/GB2020/053107 WO2021111142A1 (en) 2019-12-06 2020-12-04 Polymorphs of triazole antifungal compound pc945

Publications (2)

Publication Number Publication Date
CN114746415A CN114746415A (zh) 2022-07-12
CN114746415B true CN114746415B (zh) 2025-04-11

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US (1) US12491182B2 (enExample)
EP (2) EP4069690B1 (enExample)
JP (1) JP2023505227A (enExample)
KR (1) KR20220110726A (enExample)
CN (1) CN114746415B (enExample)
AU (1) AU2020397613A1 (enExample)
BR (1) BR112022006259A2 (enExample)
CA (1) CA3155829A1 (enExample)
CL (1) CL2022001464A1 (enExample)
CO (1) CO2022007808A2 (enExample)
DK (1) DK4069690T3 (enExample)
ES (1) ES3000984T3 (enExample)
FI (1) FI4069690T3 (enExample)
GB (1) GB201917867D0 (enExample)
HR (1) HRP20250042T1 (enExample)
HU (1) HUE069799T2 (enExample)
IL (1) IL293401A (enExample)
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RS (1) RS66401B1 (enExample)
SA (1) SA522432879B1 (enExample)
SI (1) SI4069690T1 (enExample)
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WO (1) WO2021111142A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2963625C (en) 2014-12-05 2023-08-22 Pulmocide Limited 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl)-n-(4-fluorophenyl)benzamide or salts thereof, and use to treat mycoses
CN117510488B (zh) * 2022-07-28 2025-12-05 博瑞制药(苏州)有限公司 一种硫酸艾沙康唑的制备方法
CN117330660A (zh) * 2023-09-14 2024-01-02 广州医科大学附属第一医院（广州呼吸中心） Uplc-ms/ms联用检测艾沙康唑的方法及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107001343A (zh) * 2014-12-05 2017-08-01 普尔莫赛德有限公司 抗真菌的化合物

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Publication number Priority date Publication date Assignee Title
CA1292472C (en) 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
WO1989004829A1 (en) 1987-11-20 1989-06-01 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
US5039676A (en) 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
AU681753B2 (en) 1993-12-21 1997-09-04 Merck Sharp & Dohme Corp. Tetrahydrofuran antifungals
US5714490A (en) 1993-12-21 1998-02-03 Schering Corporation Tetrahydrofuran antifungals
US5486625A (en) 1994-07-08 1996-01-23 Schering Corporation Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents
AU5928096A (en) 1995-06-02 1996-12-18 Schering Corporation Tetrahydrofuran antifungals
EP0957101A1 (en) 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
EP1372394A1 (en) 2001-04-03 2004-01-02 Schering Corporation Antifungal composition with enhanced bioavailability
EP2141159A1 (en) * 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
WO2013036866A1 (en) 2011-09-07 2013-03-14 The Johns Hopkins University Itraconazole analogs and use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107001343A (zh) * 2014-12-05 2017-08-01 普尔莫赛德有限公司 抗真菌的化合物

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SA522432879B1 (ar) 2025-01-26
WO2021111142A1 (en) 2021-06-10
US12491182B2 (en) 2025-12-09
EP4509179A3 (en) 2025-02-26
HUE069799T2 (hu) 2025-04-28
AU2020397613A1 (en) 2022-06-02
JP2023505227A (ja) 2023-02-08
CN114746415A (zh) 2022-07-12
CL2022001464A1 (es) 2023-03-24
IL293401A (en) 2022-07-01
LT4069690T (lt) 2025-01-10
US20230028714A1 (en) 2023-01-26
BR112022006259A2 (pt) 2022-06-21
SI4069690T1 (sl) 2025-03-31
PT4069690T (pt) 2024-12-13
RS66401B1 (sr) 2025-02-28
KR20220110726A (ko) 2022-08-09
GB201917867D0 (en) 2020-01-22
DK4069690T3 (da) 2025-01-20
CO2022007808A2 (es) 2022-06-30
ES3000984T3 (es) 2025-03-04
MX2022006654A (es) 2022-09-07
EP4069690B1 (en) 2024-11-13
SMT202400514T1 (it) 2025-01-14
HRP20250042T1 (hr) 2025-03-14
EP4069690A1 (en) 2022-10-12
PL4069690T3 (pl) 2025-03-10
FI4069690T3 (fi) 2025-01-21
EP4509179A2 (en) 2025-02-19
CA3155829A1 (en) 2021-06-10

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