ES3000984T3 - Polimorfos del compuesto antifúngico de triazol PC945 - Google Patents
Polimorfos del compuesto antifúngico de triazol PC945 Download PDFInfo
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- ES3000984T3 ES3000984T3 ES20824979T ES20824979T ES3000984T3 ES 3000984 T3 ES3000984 T3 ES 3000984T3 ES 20824979 T ES20824979 T ES 20824979T ES 20824979 T ES20824979 T ES 20824979T ES 3000984 T3 ES3000984 T3 ES 3000984T3
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- 238000011282 treatment Methods 0.000 claims description 24
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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Landscapes
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| PCT/GB2020/053107 WO2021111142A1 (en) | 2019-12-06 | 2020-12-04 | Polymorphs of triazole antifungal compound pc945 |
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| ES3000984T3 true ES3000984T3 (es) | 2025-03-04 |
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| ES20824979T Active ES3000984T3 (es) | 2019-12-06 | 2020-12-04 | Polimorfos del compuesto antifúngico de triazol PC945 |
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| CA2963625C (en) | 2014-12-05 | 2023-08-22 | Pulmocide Limited | 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl)-n-(4-fluorophenyl)benzamide or salts thereof, and use to treat mycoses |
| CN117510488B (zh) * | 2022-07-28 | 2025-12-05 | 博瑞制药(苏州)有限公司 | 一种硫酸艾沙康唑的制备方法 |
| CN117330660A (zh) * | 2023-09-14 | 2024-01-02 | 广州医科大学附属第一医院（广州呼吸中心） | Uplc-ms/ms联用检测艾沙康唑的方法及应用 |
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| CA1292472C (en) | 1985-12-03 | 1991-11-26 | Alfonsus Guilielmus Knaeps | Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles |
| WO1989004829A1 (en) | 1987-11-20 | 1989-06-01 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| US5039676A (en) | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| AU681753B2 (en) | 1993-12-21 | 1997-09-04 | Merck Sharp & Dohme Corp. | Tetrahydrofuran antifungals |
| US5714490A (en) | 1993-12-21 | 1998-02-03 | Schering Corporation | Tetrahydrofuran antifungals |
| US5486625A (en) | 1994-07-08 | 1996-01-23 | Schering Corporation | Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents |
| AU5928096A (en) | 1995-06-02 | 1996-12-18 | Schering Corporation | Tetrahydrofuran antifungals |
| EP0957101A1 (en) | 1998-05-14 | 1999-11-17 | Janssen Pharmaceutica N.V. | Water soluble azoles as broad-spectrum antifungals |
| EP1372394A1 (en) | 2001-04-03 | 2004-01-02 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| EP2141159A1 (en) * | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| WO2013036866A1 (en) | 2011-09-07 | 2013-03-14 | The Johns Hopkins University | Itraconazole analogs and use thereof |
| CA2963625C (en) * | 2014-12-05 | 2023-08-22 | Pulmocide Limited | 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl)-n-(4-fluorophenyl)benzamide or salts thereof, and use to treat mycoses |
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| HUE069799T2 (hu) | 2025-04-28 |
| AU2020397613A1 (en) | 2022-06-02 |
| JP2023505227A (ja) | 2023-02-08 |
| CN114746415A (zh) | 2022-07-12 |
| CL2022001464A1 (es) | 2023-03-24 |
| IL293401A (en) | 2022-07-01 |
| LT4069690T (lt) | 2025-01-10 |
| US20230028714A1 (en) | 2023-01-26 |
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| SI4069690T1 (sl) | 2025-03-31 |
| PT4069690T (pt) | 2024-12-13 |
| RS66401B1 (sr) | 2025-02-28 |
| KR20220110726A (ko) | 2022-08-09 |
| GB201917867D0 (en) | 2020-01-22 |
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| EP4069690A1 (en) | 2022-10-12 |
| PL4069690T3 (pl) | 2025-03-10 |
| FI4069690T3 (fi) | 2025-01-21 |
| CN114746415B (zh) | 2025-04-11 |
| EP4509179A2 (en) | 2025-02-19 |
| CA3155829A1 (en) | 2021-06-10 |
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