JP2017536385A5 - - Google Patents
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- Publication number
- JP2017536385A5 JP2017536385A5 JP2017528789A JP2017528789A JP2017536385A5 JP 2017536385 A5 JP2017536385 A5 JP 2017536385A5 JP 2017528789 A JP2017528789 A JP 2017528789A JP 2017528789 A JP2017528789 A JP 2017528789A JP 2017536385 A5 JP2017536385 A5 JP 2017536385A5
- Authority
- JP
- Japan
- Prior art keywords
- difluorophenyl
- piperazin
- triazol
- tetrahydrofuran
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14196662 | 2014-12-05 | ||
| EP14196662.2 | 2014-12-05 | ||
| PCT/GB2015/053733 WO2016087880A1 (en) | 2014-12-05 | 2015-12-04 | Antimycotic compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017536385A JP2017536385A (ja) | 2017-12-07 |
| JP2017536385A5 true JP2017536385A5 (enExample) | 2019-01-31 |
| JP6666345B2 JP6666345B2 (ja) | 2020-03-13 |
Family
ID=52006914
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528775A Active JP6669751B2 (ja) | 2014-12-05 | 2015-12-04 | 抗真菌化合物 |
| JP2017528789A Active JP6666345B2 (ja) | 2014-12-05 | 2015-12-04 | 抗真菌化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017528775A Active JP6669751B2 (ja) | 2014-12-05 | 2015-12-04 | 抗真菌化合物 |
Country Status (18)
| Country | Link |
|---|---|
| US (12) | US10106531B2 (enExample) |
| EP (2) | EP3227278B1 (enExample) |
| JP (2) | JP6669751B2 (enExample) |
| KR (1) | KR102579848B1 (enExample) |
| CN (2) | CN112375073B (enExample) |
| AU (1) | AU2015356795B2 (enExample) |
| BR (1) | BR112017008481B1 (enExample) |
| CA (1) | CA2963625C (enExample) |
| DK (2) | DK3227277T3 (enExample) |
| EA (1) | EA033736B1 (enExample) |
| ES (2) | ES2786374T3 (enExample) |
| HU (2) | HUE048905T2 (enExample) |
| IL (1) | IL251631B (enExample) |
| MX (1) | MX370412B (enExample) |
| PL (1) | PL3227277T3 (enExample) |
| PT (1) | PT3227277T (enExample) |
| SG (1) | SG11201702835RA (enExample) |
| WO (2) | WO2016087880A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017008481B1 (pt) * | 2014-12-05 | 2022-09-06 | Pulmocide Limited | Composto antimicótico, uso do referido composto, composição farmacêutica e processo para preparar o mesmo |
| WO2016097761A1 (en) | 2014-12-18 | 2016-06-23 | Pulmocide Limited | 4,5-dihydro-6h-thieno[3,2-d]benzazepine derivatives and their use to treat respiratory syncytial virus (rsv) infections |
| EP3298006B1 (en) | 2015-05-21 | 2020-01-01 | Pulmocide Limited | Antifungal 4-(4-(4-(((3r,5r)-5-((1 h -1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)-3-methylphenyl)piperazin-1-yl )-n -(2-hydroxycyclohexyl)benzamide, or a pharmaceutically acceptable salt thereof. |
| WO2017093491A1 (en) * | 2015-12-04 | 2017-06-08 | Pulmocide Limited | Antimycotic triazole compound |
| BR112019010809A2 (pt) * | 2016-11-28 | 2019-10-01 | Cellix Bio Private Ltd | composto de fórmula i, composto de fórmula ii, composto de fórmula iii, composto de fórmula iv, composto de fórmula v, composto de fórmula vi, composto de fórmula vii, composto de fórmula viii, composto de fórmula ix, composto de fórmula x, composto de fórmula xi, composto de fórmula xii, e composição farmacêutica |
| WO2018115319A2 (en) | 2016-12-23 | 2018-06-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Inhibitors of cytochrome p450 family 7 subfamily b member 1 (cyp7b1) for use in treating diseases |
| GB201917867D0 (en) | 2019-12-06 | 2020-01-22 | Pulmocide Ltd | Polymorphs |
| EP3858357A1 (en) * | 2020-01-28 | 2021-08-04 | Diaccurate | Use of azole compounds to stimulate the immune system and as inhibitors for s-pla2gib |
| RU2770598C1 (ru) * | 2021-06-29 | 2022-04-18 | Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) | ПРИМЕНЕНИЕ ПРОТИВОГРИБКОВОГО СРЕДСТВА НА ОСНОВЕ 2-((4-R1-5-R2-3-(ЭТОКСИКАРБОНИЛ)ТИОФЕН-2-ИЛ)АМИНО)-4-ОКСО-4-R3-БУТ-2-ЕНОВЫХ КИСЛОТ ПО ОТНОШЕНИЮ К Candida aldicans |
| AR134544A1 (es) | 2023-11-30 | 2026-01-28 | Basilea Pharmaceutica Int Ag Allschwil | Combinaciones farmacéuticas para su uso en el tratamiento de infecciones fúngicas |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5533466A (en) * | 1978-07-14 | 1980-03-08 | Janssen Pharmaceutica Nv | Novel azole derivatives and their manufacture |
| CH655103A5 (de) * | 1983-03-11 | 1986-03-27 | Sandoz Ag | Azolderivate, verfahren zu ihrer herstellung und ihre verwendung. |
| CA1292472C (en) | 1985-12-03 | 1991-11-26 | Alfonsus Guilielmus Knaeps | Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles |
| DE3609598A1 (de) * | 1986-03-21 | 1987-10-01 | Hoechst Ag | 2-azolylmethyl-2-aryl-1,3-dioxolane und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
| AU2811689A (en) | 1987-11-20 | 1989-06-14 | Schering Corporation | Tri-and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| US5039678A (en) | 1989-03-23 | 1991-08-13 | Wake Forest University | Method of increasing cranial vessel proliferation by administering nimodipine |
| US5039676A (en) | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| US5403937A (en) * | 1993-04-30 | 1995-04-04 | Schering Corporation | Process for preparing intermediates for the synthesis of antifungal agents |
| PL181193B1 (pl) | 1993-12-21 | 2001-06-29 | Schering Corp | Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków |
| US5714490A (en) | 1993-12-21 | 1998-02-03 | Schering Corporation | Tetrahydrofuran antifungals |
| US5486625A (en) | 1994-07-08 | 1996-01-23 | Schering Corporation | Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents |
| SK27097A3 (en) | 1995-06-02 | 1997-09-10 | Schering Corp | Tetrahydrofuran antifungals |
| EP0957101A1 (en) | 1998-05-14 | 1999-11-17 | Janssen Pharmaceutica N.V. | Water soluble azoles as broad-spectrum antifungals |
| CA2443089C (en) | 2001-04-03 | 2011-11-01 | Schering Corporation | Antifungal suspension of micronized posaconazole |
| US8642660B2 (en) * | 2007-12-21 | 2014-02-04 | The University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US8324385B2 (en) * | 2008-10-30 | 2012-12-04 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| JP6162694B2 (ja) * | 2011-07-18 | 2017-07-12 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | ベンズアミド類 |
| WO2013036866A1 (en) | 2011-09-07 | 2013-03-14 | The Johns Hopkins University | Itraconazole analogs and use thereof |
| BR112017008481B1 (pt) * | 2014-12-05 | 2022-09-06 | Pulmocide Limited | Composto antimicótico, uso do referido composto, composição farmacêutica e processo para preparar o mesmo |
| GB201917867D0 (en) | 2019-12-06 | 2020-01-22 | Pulmocide Ltd | Polymorphs |
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2015
- 2015-12-04 BR BR112017008481-3A patent/BR112017008481B1/pt active IP Right Grant
- 2015-12-04 WO PCT/GB2015/053733 patent/WO2016087880A1/en not_active Ceased
- 2015-12-04 JP JP2017528775A patent/JP6669751B2/ja active Active
- 2015-12-04 CN CN202011308132.2A patent/CN112375073B/zh active Active
- 2015-12-04 PT PT158087700T patent/PT3227277T/pt unknown
- 2015-12-04 SG SG11201702835RA patent/SG11201702835RA/en unknown
- 2015-12-04 WO PCT/GB2015/053731 patent/WO2016087878A1/en not_active Ceased
- 2015-12-04 EA EA201791174A patent/EA033736B1/ru not_active IP Right Cessation
- 2015-12-04 MX MX2017007188A patent/MX370412B/es active IP Right Grant
- 2015-12-04 EP EP15817507.5A patent/EP3227278B1/en active Active
- 2015-12-04 EP EP15808770.0A patent/EP3227277B1/en active Active
- 2015-12-04 AU AU2015356795A patent/AU2015356795B2/en active Active
- 2015-12-04 KR KR1020177013730A patent/KR102579848B1/ko active Active
- 2015-12-04 CN CN201580066092.6A patent/CN107001343B/zh active Active
- 2015-12-04 CA CA2963625A patent/CA2963625C/en active Active
- 2015-12-04 HU HUE15808770A patent/HUE048905T2/hu unknown
- 2015-12-04 US US15/524,505 patent/US10106531B2/en active Active
- 2015-12-04 DK DK15808770.0T patent/DK3227277T3/da active
- 2015-12-04 ES ES15817507T patent/ES2786374T3/es active Active
- 2015-12-04 PL PL15808770T patent/PL3227277T3/pl unknown
- 2015-12-04 ES ES15808770T patent/ES2790875T3/es active Active
- 2015-12-04 DK DK15817507.5T patent/DK3227278T3/da active
- 2015-12-04 JP JP2017528789A patent/JP6666345B2/ja active Active
- 2015-12-04 HU HUE15817507A patent/HUE048685T2/hu unknown
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2016
- 2016-10-20 US US15/298,431 patent/US10093659B2/en active Active
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2017
- 2017-04-06 IL IL251631A patent/IL251631B/en active IP Right Grant
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2018
- 2018-09-12 US US16/129,322 patent/US10487073B2/en active Active
- 2018-09-24 US US16/139,591 patent/US10344022B2/en active Active
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2019
- 2019-05-24 US US16/422,062 patent/US10450304B2/en active Active
- 2019-09-12 US US16/569,128 patent/US10662179B2/en active Active
- 2019-10-04 US US16/593,444 patent/US10800762B2/en active Active
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2020
- 2020-04-15 US US16/849,476 patent/US10858345B2/en active Active
- 2020-09-04 US US17/012,685 patent/US11008307B2/en active Active
- 2020-11-04 US US17/089,441 patent/US11661415B2/en active Active
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2021
- 2021-04-14 US US17/230,009 patent/US20210238169A1/en not_active Abandoned
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2023
- 2023-04-18 US US18/302,557 patent/US12269814B2/en active Active