EA033736B1 - Антимикотическое соединение - Google Patents

Антимикотическое соединение Download PDF

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Publication number
EA033736B1
EA033736B1 EA201791174A EA201791174A EA033736B1 EA 033736 B1 EA033736 B1 EA 033736B1 EA 201791174 A EA201791174 A EA 201791174A EA 201791174 A EA201791174 A EA 201791174A EA 033736 B1 EA033736 B1 EA 033736B1
Authority
EA
Eurasian Patent Office
Prior art keywords
compound
spp
salt
formula
aspergillus
Prior art date
Application number
EA201791174A
Other languages
English (en)
Russian (ru)
Other versions
EA201791174A1 (ru
Inventor
Mihiro Sunose
Thomas Christopher Colley
Kazuhiro Ito
Garth Rapeport
Peter Strong
Original Assignee
Pulmocide Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pulmocide Ltd filed Critical Pulmocide Ltd
Publication of EA201791174A1 publication Critical patent/EA201791174A1/ru
Publication of EA033736B1 publication Critical patent/EA033736B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06F—ELECTRIC DIGITAL DATA PROCESSING
    • G06F1/00—Details not covered by groups G06F3/00 - G06F13/00 and G06F21/00
    • G06F1/26—Power supply means, e.g. regulation thereof
    • G06F1/32—Means for saving power
    • G06F1/3203—Power management, i.e. event-based initiation of a power-saving mode
    • G06F1/3234—Power saving characterised by the action undertaken
    • G06F1/325—Power saving in peripheral device
    • G06F1/3268—Power saving in hard disk drive
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11C—STATIC STORES
    • G11C11/00—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor
    • G11C11/21—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements
    • G11C11/34—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices
    • G11C11/40—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices using transistors
    • G11C11/401—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices using transistors forming cells needing refreshing or charge regeneration, i.e. dynamic cells
    • G11C11/4063—Auxiliary circuits, e.g. for addressing, decoding, driving, writing, sensing or timing
    • G11C11/407—Auxiliary circuits, e.g. for addressing, decoding, driving, writing, sensing or timing for memory cells of the field-effect type
    • G11C11/4074—Power supply or voltage generation circuits, e.g. bias voltage generators, substrate voltage generators, back-up power, power control circuits

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Computer Hardware Design (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EA201791174A 2014-12-05 2015-12-04 Антимикотическое соединение EA033736B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14196662 2014-12-05
PCT/GB2015/053731 WO2016087878A1 (en) 2014-12-05 2015-12-04 Antimycotic compound

Publications (2)

Publication Number Publication Date
EA201791174A1 EA201791174A1 (ru) 2017-10-31
EA033736B1 true EA033736B1 (ru) 2019-11-20

Family

ID=52006914

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791174A EA033736B1 (ru) 2014-12-05 2015-12-04 Антимикотическое соединение

Country Status (18)

Country Link
US (12) US10106531B2 (enExample)
EP (2) EP3227278B1 (enExample)
JP (2) JP6669751B2 (enExample)
KR (1) KR102579848B1 (enExample)
CN (2) CN112375073B (enExample)
AU (1) AU2015356795B2 (enExample)
BR (1) BR112017008481B1 (enExample)
CA (1) CA2963625C (enExample)
DK (2) DK3227277T3 (enExample)
EA (1) EA033736B1 (enExample)
ES (2) ES2786374T3 (enExample)
HU (2) HUE048905T2 (enExample)
IL (1) IL251631B (enExample)
MX (1) MX370412B (enExample)
PL (1) PL3227277T3 (enExample)
PT (1) PT3227277T (enExample)
SG (1) SG11201702835RA (enExample)
WO (2) WO2016087880A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2770598C1 (ru) * 2021-06-29 2022-04-18 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) ПРИМЕНЕНИЕ ПРОТИВОГРИБКОВОГО СРЕДСТВА НА ОСНОВЕ 2-((4-R1-5-R2-3-(ЭТОКСИКАРБОНИЛ)ТИОФЕН-2-ИЛ)АМИНО)-4-ОКСО-4-R3-БУТ-2-ЕНОВЫХ КИСЛОТ ПО ОТНОШЕНИЮ К Candida aldicans

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016087880A1 (en) * 2014-12-05 2016-06-09 Pulmocide Limited Antimycotic compound
US10160772B2 (en) 2014-12-18 2018-12-25 Pulmocide Limited 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivatives
ES2790723T3 (es) 2015-05-21 2020-10-29 Pulmocide Ltd Antifúngico 4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-il)metil)-5-(2,4-difluorofenil)tetrahidrofurano-3-il)metoxi)-3-metilfenil)piperazina-1-il)-N -(2-hidroxiciclohexil)benzamida, o una sal farmacéuticamente aceptable del mismo
WO2017093491A1 (en) * 2015-12-04 2017-06-08 Pulmocide Limited Antimycotic triazole compound
CN110198707A (zh) * 2016-11-28 2019-09-03 赛力克斯生物私人有限公司 用于治疗口腔感染性疾病的组合物和方法
US11185548B2 (en) 2016-12-23 2021-11-30 Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases
GB201917867D0 (en) * 2019-12-06 2020-01-22 Pulmocide Ltd Polymorphs
EP3858357A1 (en) * 2020-01-28 2021-08-04 Diaccurate Use of azole compounds to stimulate the immune system and as inhibitors for s-pla2gib
TW202541814A (zh) 2023-11-30 2025-11-01 瑞士商巴塞利亞阿爾斯維爾藥業國際股份有限公司 用於治療真菌感染的藥物組合

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2770598C1 (ru) * 2021-06-29 2022-04-18 Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) ПРИМЕНЕНИЕ ПРОТИВОГРИБКОВОГО СРЕДСТВА НА ОСНОВЕ 2-((4-R1-5-R2-3-(ЭТОКСИКАРБОНИЛ)ТИОФЕН-2-ИЛ)АМИНО)-4-ОКСО-4-R3-БУТ-2-ЕНОВЫХ КИСЛОТ ПО ОТНОШЕНИЮ К Candida aldicans

Also Published As

Publication number Publication date
US10800762B2 (en) 2020-10-13
MX2017007188A (es) 2017-08-28
JP6666345B2 (ja) 2020-03-13
CA2963625A1 (en) 2016-06-09
AU2015356795A1 (en) 2017-04-27
PT3227277T (pt) 2020-04-14
US20210238169A1 (en) 2021-08-05
US20170320858A1 (en) 2017-11-09
ES2790875T3 (es) 2020-10-29
NZ730861A (en) 2021-04-30
CA2963625C (en) 2023-08-22
EA201791174A1 (ru) 2017-10-31
DK3227278T3 (da) 2020-04-27
HUE048905T2 (hu) 2020-08-28
US10858345B2 (en) 2020-12-08
IL251631B (en) 2020-05-31
HUE048685T2 (hu) 2020-07-28
CN107001343A (zh) 2017-08-01
US20210048874A1 (en) 2021-02-18
KR102579848B1 (ko) 2023-09-18
US10344022B2 (en) 2019-07-09
US20200239453A1 (en) 2020-07-30
US10450304B2 (en) 2019-10-22
US20190023697A1 (en) 2019-01-24
SG11201702835RA (en) 2017-05-30
US20230295133A1 (en) 2023-09-21
US20200002320A1 (en) 2020-01-02
WO2016087878A1 (en) 2016-06-09
BR112017008481B1 (pt) 2022-09-06
US12269814B2 (en) 2025-04-08
JP6669751B2 (ja) 2020-03-18
BR112017008481A2 (pt) 2018-01-09
PL3227277T3 (pl) 2020-08-10
JP2017536385A (ja) 2017-12-07
US20190023696A1 (en) 2019-01-24
US20200031809A1 (en) 2020-01-30
US11661415B2 (en) 2023-05-30
IL251631A0 (en) 2017-06-29
DK3227277T3 (da) 2020-04-27
US20200399253A1 (en) 2020-12-24
CN107001343B (zh) 2020-12-11
US10093659B2 (en) 2018-10-09
US10106531B2 (en) 2018-10-23
KR20170088850A (ko) 2017-08-02
MX370412B (es) 2019-12-11
US11008307B2 (en) 2021-05-18
US20170037035A1 (en) 2017-02-09
CN112375073A (zh) 2021-02-19
AU2015356795B2 (en) 2020-01-16
US10662179B2 (en) 2020-05-26
ES2786374T3 (es) 2020-10-09
US10487073B2 (en) 2019-11-26
WO2016087880A1 (en) 2016-06-09
EP3227277B1 (en) 2020-02-05
US20190276441A1 (en) 2019-09-12
HK1244795A1 (en) 2018-08-17
EP3227277A1 (en) 2017-10-11
EP3227278A1 (en) 2017-10-11
CN112375073B (zh) 2024-04-16
JP2017536382A (ja) 2017-12-07
EP3227278B1 (en) 2020-02-05

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM KG TJ TM