HRP20240072T1 - Nanočestice koje sadrže takrolimus - Google Patents
Nanočestice koje sadrže takrolimus Download PDFInfo
- Publication number
- HRP20240072T1 HRP20240072T1 HRP20240072TT HRP20240072T HRP20240072T1 HR P20240072 T1 HRP20240072 T1 HR P20240072T1 HR P20240072T T HRP20240072T T HR P20240072TT HR P20240072 T HRP20240072 T HR P20240072T HR P20240072 T1 HRP20240072 T1 HR P20240072T1
- Authority
- HR
- Croatia
- Prior art keywords
- film according
- buccal film
- mucoadhesive buccal
- nanoparticles
- cellulose
- Prior art date
Links
- 239000002105 nanoparticle Substances 0.000 title claims 6
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 title claims 3
- 229960001967 tacrolimus Drugs 0.000 title claims 3
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 title claims 3
- 229940002226 buccal film Drugs 0.000 claims 10
- 230000003232 mucoadhesive effect Effects 0.000 claims 10
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 3
- 239000010410 layer Substances 0.000 claims 3
- 239000011159 matrix material Substances 0.000 claims 3
- 239000003381 stabilizer Substances 0.000 claims 3
- 238000011282 treatment Methods 0.000 claims 3
- 229920002554 vinyl polymer Polymers 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- -1 acetate-polyethylene Chemical group 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 2
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 2
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 238000011321 prophylaxis Methods 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 229920001353 Dextrin Polymers 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- 229920000084 Gum arabic Polymers 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 235000010582 Pisum sativum Nutrition 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 229920001218 Pullulan Polymers 0.000 claims 1
- 239000004373 Pullulan Substances 0.000 claims 1
- 241000978776 Senegalia senegal Species 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- 239000000205 acacia gum Substances 0.000 claims 1
- 235000010489 acacia gum Nutrition 0.000 claims 1
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 239000012752 auxiliary agent Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003995 emulsifying agent Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 235000003599 food sweetener Nutrition 0.000 claims 1
- 229920000578 graft copolymer Polymers 0.000 claims 1
- 239000003906 humectant Substances 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920000193 polymethacrylate Polymers 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 239000011241 protective layer Substances 0.000 claims 1
- 235000019423 pullulan Nutrition 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 239000006068 taste-masking agent Substances 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Claims (9)
1. Mukoadhezivni bukalni film koji sadrži najmanje jedan sloj matrice koji sadrži najmanje jedan polimer i nanočestice koje sadrže takrolimus ili njegovu sol, pri čemu nanočestice imaju veličinu čestica od oko 10 do oko 400 nm.
2. Mukoadhezivni bukalni film prema patentnom zahtjevu 1, pri čemu nanočestice imaju indeks polidisperznosti od ~ oko 0,4.
3. Mukoadhezivni bukalni film prema bilo kojem od patentnih zahtjeva 1-2, pri čemu nanočestice dalje sadrže najmanje jedan agens za stabilizaciju i/ili surfaktant.
4. Mukoadhezivni bukalni film prema patentnom zahtjevu 3, pri čemu nanočestice dalje sadrže najmanje jedan agens za stabilizaciju, pri čemu najmanje jedan agens za stabilizaciju sadrži polivinil pirolidon, vinil pirolidon-/vinilacetat-kopolimer, polietilenglikol i/ili derivat celuloze kao što je hidroksipropilmetil celuloza (HPMC), hidroksipropilmetil celuloza ftalat (HPMCP), hidroksipropilmetil celuloza acetat sukcinat (HPMCAS), hidroksipropil celuloza (HPC) i/ili karboksimetil celuloza (CMC).
5. Mukoadhezivni bukalni film prema bilo kojem od prethodnih patentnih zahtjeva, pri čemu najmanje jedan polimer sadrži hidroksipropilmetil celulozu, hidroksipropil celulozu, hidroksietil celulozu, škrob od graška, pululan, poli(met)akrilat, polivinil kaprolaktam-polivinil acetat-polietilen glikol graft kopolimer, kitozan, arapsku gumu, dekstran, dekstrin, alginat, polivinilalkohol, polivinilpirolidon i/ili vinil pirolidon-vinilacetat-kopolimer.
6. Mukoadhezivni bukalni film prema bilo kojem od prethodnih patentnih zahtjeva, pri čemu najmanje jedan sloj matrice dalje sadrži najmanje jedno pomoćno sredstvo izabrano iz grupe koja sadrži boje, arome, zaslađivače, agense za maskiranje okusa, emulgatore, pojačivače, regulatore pH, humektante, konzervanse i/ili antioksidanse.
7. Mukoadhezivni bukalni film prema bilo kojem od prethodnih patentnih zahtjeva, pri čemu mukoadhezivni bukalni film sadrži jedan zaštitni sloj, koji je poželjno nepropustan za takrolimus na jednoj strani najmanje jednog sloja matrice.
8. Mukoadhezivni bukalni film prema bilo kojem od prethodnih patentnih zahtjeva, za primjenu kao medikament, posebno za primjenu u profilaksi i/ili liječenju odbacivanja presađenog čvrstog organa.
9. Mukoadhezivni bukalni film prema bilo kojem od patentnih zahtjeva 1-7, za primjenu kao medikament za liječenje pedijatrijskih pacijenata, posebno za primjenu u profilaksi i/ili liječenju odbacivanja presađenog čvrstog organa.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102018130848 | 2018-12-04 | ||
| EP19816295.0A EP3846783B8 (en) | 2018-12-04 | 2019-12-04 | Nanoparticles comprising tacrolimus |
| PCT/EP2019/083691 WO2020115140A1 (en) | 2018-12-04 | 2019-12-04 | Nanoparticles comprising tacrolimus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20240072T1 true HRP20240072T1 (hr) | 2024-05-10 |
Family
ID=68766584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240072TT HRP20240072T1 (hr) | 2018-12-04 | 2019-12-04 | Nanočestice koje sadrže takrolimus |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11311479B2 (hr) |
| EP (2) | EP3662894B1 (hr) |
| JP (1) | JP2022513697A (hr) |
| KR (1) | KR20210100142A (hr) |
| CN (1) | CN113242732A (hr) |
| AU (1) | AU2019392718A1 (hr) |
| CA (1) | CA3063417C (hr) |
| DK (2) | DK3662894T3 (hr) |
| ES (2) | ES2894112T3 (hr) |
| FI (1) | FI3846783T3 (hr) |
| HR (1) | HRP20240072T1 (hr) |
| HU (2) | HUE056067T2 (hr) |
| IL (1) | IL283458A (hr) |
| PL (2) | PL3662894T3 (hr) |
| PT (1) | PT3846783T (hr) |
| SG (1) | SG11202105778PA (hr) |
| SI (2) | SI3662894T1 (hr) |
| WO (1) | WO2020115140A1 (hr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113425716A (zh) * | 2021-05-27 | 2021-09-24 | 南京诺亚药业有限公司 | 一种他克莫司药物组合物及其制备方法 |
| EP4104816A1 (en) * | 2021-06-14 | 2022-12-21 | Nucleus Medical GmbH | Non-nanoparticulate applications forms of macrolides |
| AU2023232910A1 (en) * | 2022-03-11 | 2024-09-12 | Lts Lohmann Therapie-Systeme Ag | Transmucosal therapeutic system containing a macrolide immunosuppressant |
| WO2024052883A1 (en) * | 2022-09-10 | 2024-03-14 | Pattanaik Smita | Buccomucoadhesive patch-based drug delivery system for tacrolimus |
| EP4410287A1 (en) * | 2023-02-06 | 2024-08-07 | Nucleus Medical GmbH | A macrolide for use in a method of preventing or treating an immunological disease or disorder |
| WO2024165562A1 (en) * | 2023-02-06 | 2024-08-15 | Nucleus Medical Gmbh | A macrolide for use in a method of preventing or treating an immunological disease or disorder |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007502823A (ja) * | 2003-08-15 | 2007-02-15 | キューエルティー・ユーエスエイ・インコーポレーテッド | 接着性および生体侵食性の経粘膜薬物送達システム |
| EP1835889A1 (en) * | 2004-12-15 | 2007-09-26 | Elan Pharma International Limited | Nanoparticulate tacrolimus formulations |
| CN101652141A (zh) * | 2007-03-29 | 2010-02-17 | 万能药生物有限公司 | 他克莫司的调节释放剂型 |
| MA34586B1 (fr) * | 2010-08-25 | 2013-10-02 | Medis Lab | Particules cristallines de tacrolimus micronise a surface modifiee et compositions pharmaceutiques associees |
| EP2958555A2 (en) * | 2013-02-21 | 2015-12-30 | Massachusetts Institute of Technology | Targeted buccal delivery of agents |
| JP2018510859A (ja) * | 2015-03-17 | 2018-04-19 | レオン−ナノドラッグズ ゲーエムベーハー | 安定化されたボロン酸化合物を含むナノ粒子 |
| DE102016101232A1 (de) | 2016-01-25 | 2017-07-27 | Instillo Gmbh | Verfahren zum Herstellen von Emulsionen |
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2019
- 2019-11-29 CA CA3063417A patent/CA3063417C/en active Active
- 2019-12-03 ES ES19213120T patent/ES2894112T3/es active Active
- 2019-12-03 PL PL19213120T patent/PL3662894T3/pl unknown
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| Publication number | Publication date |
|---|---|
| CN113242732A (zh) | 2021-08-10 |
| DK3662894T3 (da) | 2021-09-20 |
| KR20210100142A (ko) | 2021-08-13 |
| CA3063417A1 (en) | 2020-06-04 |
| US20220079872A1 (en) | 2022-03-17 |
| PT3846783T (pt) | 2024-01-19 |
| HUE056067T2 (hu) | 2022-01-28 |
| PL3662894T3 (pl) | 2022-01-10 |
| WO2020115140A1 (en) | 2020-06-11 |
| US20200170934A1 (en) | 2020-06-04 |
| EP3846783B8 (en) | 2023-11-22 |
| ES2894112T3 (es) | 2022-02-11 |
| ES2969096T3 (es) | 2024-05-16 |
| DK3846783T3 (da) | 2024-01-15 |
| EP3846783A1 (en) | 2021-07-14 |
| HUE065588T2 (hu) | 2024-06-28 |
| SI3662894T1 (sl) | 2021-11-30 |
| EP3662894A1 (en) | 2020-06-10 |
| AU2019392718A1 (en) | 2021-06-10 |
| US11311479B2 (en) | 2022-04-26 |
| PL3846783T3 (pl) | 2024-04-02 |
| FI3846783T3 (fi) | 2024-01-15 |
| SI3846783T1 (sl) | 2024-03-29 |
| EP3662894B1 (en) | 2021-07-28 |
| JP2022513697A (ja) | 2022-02-09 |
| CA3063417C (en) | 2023-01-03 |
| EP3846783B1 (en) | 2023-10-18 |
| SG11202105778PA (en) | 2021-06-29 |
| IL283458A (en) | 2021-07-29 |
| US11904048B2 (en) | 2024-02-20 |
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