SG11202105778PA - Nanoparticles comprising tacrolimus - Google Patents

Nanoparticles comprising tacrolimus

Info

Publication number
SG11202105778PA
SG11202105778PA SG11202105778PA SG11202105778PA SG11202105778PA SG 11202105778P A SG11202105778P A SG 11202105778PA SG 11202105778P A SG11202105778P A SG 11202105778PA SG 11202105778P A SG11202105778P A SG 11202105778PA SG 11202105778P A SG11202105778P A SG 11202105778PA
Authority
SG
Singapore
Prior art keywords
tacrolimus
nanoparticles
Prior art date
Application number
SG11202105778PA
Inventor
Wolfgang Beier
Elke Horstkotte
Original Assignee
Leon Nanodrugs Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leon Nanodrugs Gmbh filed Critical Leon Nanodrugs Gmbh
Publication of SG11202105778PA publication Critical patent/SG11202105778PA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5138Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5161Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
SG11202105778PA 2018-12-04 2019-12-04 Nanoparticles comprising tacrolimus SG11202105778PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102018130848 2018-12-04
PCT/EP2019/083691 WO2020115140A1 (en) 2018-12-04 2019-12-04 Nanoparticles comprising tacrolimus

Publications (1)

Publication Number Publication Date
SG11202105778PA true SG11202105778PA (en) 2021-06-29

Family

ID=68766584

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202105778PA SG11202105778PA (en) 2018-12-04 2019-12-04 Nanoparticles comprising tacrolimus

Country Status (18)

Country Link
US (2) US11311479B2 (en)
EP (2) EP3662894B1 (en)
JP (1) JP2022513697A (en)
KR (1) KR20210100142A (en)
CN (1) CN113242732A (en)
AU (1) AU2019392718A1 (en)
CA (1) CA3063417C (en)
DK (2) DK3662894T3 (en)
ES (1) ES2894112T3 (en)
FI (1) FI3846783T3 (en)
HR (1) HRP20240072T1 (en)
HU (1) HUE056067T2 (en)
IL (1) IL283458A (en)
PL (2) PL3662894T3 (en)
PT (1) PT3846783T (en)
SG (1) SG11202105778PA (en)
SI (2) SI3662894T1 (en)
WO (1) WO2020115140A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113425716A (en) * 2021-05-27 2021-09-24 南京诺亚药业有限公司 Tacrolimus pharmaceutical composition and preparation method thereof
EP4104816A1 (en) * 2021-06-14 2022-12-21 Nucleus Medical GmbH Non-nanoparticulate applications forms of macrolides
WO2023170184A1 (en) * 2022-03-11 2023-09-14 Lts Lohmann Therapie-Systeme Ag Transmucosal therapeutic system containing a macrolide immunosuppressant
WO2024052883A1 (en) * 2022-09-10 2024-03-14 Pattanaik Smita Buccomucoadhesive patch-based drug delivery system for tacrolimus

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06001776A (en) 2003-08-15 2007-09-07 Qlt Usa Inc Adhesive bioerodible transmucosal drug delivery system.
MX2007007342A (en) * 2004-12-15 2007-12-11 Elan Pharma Int Ltd Nanoparticulate tacrolimus formulations.
JP2010522742A (en) * 2007-03-29 2010-07-08 パナセア バイオテック リミテッド Modified form of tacrolimus
MA34586B1 (en) * 2010-08-25 2013-10-02 Medis Lab MICRONIZED TACROLIMUS CRYSTALLINE PARTICLES WITH MODIFIED SURFACE AND PHARMACEUTICAL COMPOSITIONS THEREOF
BR112015020851A2 (en) * 2013-02-21 2017-07-18 Massachusetts Inst Technology formulation for delivering an agent to a site in a mucosal cavity and method for delivering an agent to a site in a mucosal cavity.
JP2018510859A (en) 2015-03-17 2018-04-19 レオン−ナノドラッグズ ゲーエムベーハー Nanoparticles containing stabilized boronic acid compounds
DE102016101232A1 (en) 2016-01-25 2017-07-27 Instillo Gmbh Process for producing emulsions

Also Published As

Publication number Publication date
CA3063417C (en) 2023-01-03
AU2019392718A1 (en) 2021-06-10
EP3846783A1 (en) 2021-07-14
DK3662894T3 (en) 2021-09-20
HUE056067T2 (en) 2022-01-28
US20200170934A1 (en) 2020-06-04
IL283458A (en) 2021-07-29
EP3662894B1 (en) 2021-07-28
PT3846783T (en) 2024-01-19
KR20210100142A (en) 2021-08-13
US11311479B2 (en) 2022-04-26
JP2022513697A (en) 2022-02-09
ES2894112T3 (en) 2022-02-11
SI3846783T1 (en) 2024-03-29
WO2020115140A1 (en) 2020-06-11
US11904048B2 (en) 2024-02-20
EP3662894A1 (en) 2020-06-10
CN113242732A (en) 2021-08-10
EP3846783B1 (en) 2023-10-18
PL3846783T3 (en) 2024-04-02
EP3846783B8 (en) 2023-11-22
PL3662894T3 (en) 2022-01-10
DK3846783T3 (en) 2024-01-15
CA3063417A1 (en) 2020-06-04
HRP20240072T1 (en) 2024-05-10
US20220079872A1 (en) 2022-03-17
FI3846783T3 (en) 2024-01-15
SI3662894T1 (en) 2021-11-30

Similar Documents

Publication Publication Date Title
IL270695B1 (en) Catheter
AU201712948S (en) Catheter
EP3276442A4 (en) Moving body
HUE058967T2 (en) Earphone
EP3399378A4 (en) Moving body
IL283458A (en) Nanoparticles comprising tacrolimus
GB201705755D0 (en) Nanostructure
SG11202001205PA (en) Anti-occlusion catheter
EP3485946A4 (en) Ball
EP3378695A4 (en) Moving body
GB2555955B (en) Antimicrobial rubber and processes for making the same
SG11202000566RA (en) Takraw balls
PL3625112T3 (en) Multimodal vehicle
EP3547064A4 (en) Moving body
EP3483045A4 (en) Golf car
GB201610642D0 (en) Nanoparticles
GB201614126D0 (en) Delivery vehicle
GB201811066D0 (en) Nanoparticles
GB2551906B (en) Body component
EP3560984A4 (en) Structure body
AP01040S1 (en) Lunix balloon
AU2017903363A0 (en) Nanoparticles
GB201704303D0 (en) Catheter
GB201702089D0 (en) Phantom
GB201701853D0 (en) Phantom