MA34586B1 - MICRONIZED TACROLIMUS CRYSTALLINE PARTICLES WITH MODIFIED SURFACE AND PHARMACEUTICAL COMPOSITIONS THEREOF - Google Patents

MICRONIZED TACROLIMUS CRYSTALLINE PARTICLES WITH MODIFIED SURFACE AND PHARMACEUTICAL COMPOSITIONS THEREOF

Info

Publication number
MA34586B1
MA34586B1 MA35763A MA35763A MA34586B1 MA 34586 B1 MA34586 B1 MA 34586B1 MA 35763 A MA35763 A MA 35763A MA 35763 A MA35763 A MA 35763A MA 34586 B1 MA34586 B1 MA 34586B1
Authority
MA
Morocco
Prior art keywords
pharmaceutical compositions
crystalline particles
modified surface
micronized tacrolimus
tacrolimus crystalline
Prior art date
Application number
MA35763A
Other languages
French (fr)
Inventor
Mohamed Amine Boujbel
Stephen Lukas
Karel Ren
Lassaad Boujbel
Original Assignee
Medis Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medis Lab filed Critical Medis Lab
Publication of MA34586B1 publication Critical patent/MA34586B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Abstract

Cette invention concerne une composition pharmaceutique comprenant des particules cristallines de tacrolimus micronisé à surface modifiée ayant une valeur d90 comprise entre 2 ¼m et 10 ¼m.This invention relates to a pharmaceutical composition comprising surface-modified micronized tacrolimus crystalline particles having a d90 value of between 2 ¼m and 10 ¼m.

MA35763A 2010-08-25 2011-08-24 MICRONIZED TACROLIMUS CRYSTALLINE PARTICLES WITH MODIFIED SURFACE AND PHARMACEUTICAL COMPOSITIONS THEREOF MA34586B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TN10391 2010-08-25
PCT/TN2011/000003 WO2012026896A1 (en) 2010-08-25 2011-08-24 Surface modified micronized tacrolimus crystalline particles and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
MA34586B1 true MA34586B1 (en) 2013-10-02

Family

ID=44910279

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35763A MA34586B1 (en) 2010-08-25 2011-08-24 MICRONIZED TACROLIMUS CRYSTALLINE PARTICLES WITH MODIFIED SURFACE AND PHARMACEUTICAL COMPOSITIONS THEREOF

Country Status (2)

Country Link
MA (1) MA34586B1 (en)
WO (1) WO2012026896A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9439892B2 (en) 2013-05-16 2016-09-13 Surmodics, Inc. Macrolide particulates, methods for preparation, and medical devices associated therewith
MX362180B (en) * 2013-06-12 2019-01-08 Surmodics Inc Solvent methods for preparing crystalline macrolide particulates, compositions, and articles containing particulates.
WO2017173121A1 (en) 2016-03-31 2017-10-05 Surmodics, Inc. Drug-containing particulate composition with cationic agent, associated medical devices, and methods for treatment
US11123459B2 (en) 2016-12-16 2021-09-21 Surmodics, Inc. Hydrophobic active agent particle coatings and methods for treatment
CN107595772B (en) * 2017-09-26 2020-09-18 山东省药学科学院 Preparation method of tacrolimus nano suspension eye drops
CA3063417C (en) * 2018-12-04 2023-01-03 Leon-Nanodrugs Gmbh Nanoparticles comprising tacrolimus

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
GB8608080D0 (en) 1986-04-02 1986-05-08 Fujisawa Pharmaceutical Co Solid dispersion composition
SI1064942T1 (en) * 1998-03-26 2004-12-31 Fujisawa Pharmaceutical Co., Ltd. Sustained release preparation of a macrolide
CA2590675A1 (en) 2004-12-15 2006-06-22 Elan Pharma International Ltd. Nanoparticulate tacrolimus formulations
WO2008013416A1 (en) * 2006-07-27 2008-01-31 Amorepacific Corporation Process for preparing powder comprising nanoparticles of sparingly soluble drug

Also Published As

Publication number Publication date
WO2012026896A1 (en) 2012-03-01

Similar Documents

Publication Publication Date Title
MA34586B1 (en) MICRONIZED TACROLIMUS CRYSTALLINE PARTICLES WITH MODIFIED SURFACE AND PHARMACEUTICAL COMPOSITIONS THEREOF
IN2013CN01340A (en)
BR112013017988A2 (en) bace-2 inhibitors for the treatment of metabolic disorders
NZ602557A (en) Solid form of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
AU2012259422A8 (en) Solid forms of a pharmaceutically active substance
MA37610B1 (en) Proliposomal testosterone formulations
BR112015022861A8 (en) bromodomain inhibitors
MY165124A (en) Semifluorinated alkane compositions
TR201902788T4 (en) 1-arylcarbonyl-4-oxy-piperidine compounds useful in the treatment of neurodegenerative diseases.
MX2011002065A (en) Micronised progesterone pharmaceutical composition and uses thereof.
MX2019003618A (en) Pyrimidinyl tyrosine kinase inhibitors.
EA201400537A1 (en) 18-METHYL-6,7-METHYLENE-3-OXO-17-PREGN-4-EN-21,17β-CARBOLACONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE INDICATED COMPOUNDS AND THEIR APPLICATION IN THE TREATMENT OF ENDOMETRIOZA
MY161390A (en) Compositions and methods containing alkylglycosides for stabilizing protein-containing formulations
BR112014009376A2 (en) compositions
BR112014005025A2 (en) pharmaceutical composition for use in the treatment of a neurodegenerative disease
MX2019004859A (en) Combination treatments comprising administration of imidazopyrazinones.
IN2014CN00795A (en)
UY33530A (en) PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF RESPIRATORY AND INFLAMMATORY DISEASES
NZ701463A (en) Anti-phytopathogenic composition
CY1119064T1 (en) Fibrolytic compositions containing bromelain and natokinase for the prevention and treatment of pulmonary conditions
WO2011045760A3 (en) Micronized olmesartan medoxomil compositions
MX2019012375A (en) Lfa-1 inhibitor formulations.
WO2012061015A3 (en) L-citrulline supplementation during arginine depletion therapy with arginase
PH12015502727A1 (en) Methods and compositions for enhancing cognitive performance
AU2012345659A8 (en) Acamprosate formulations, methods of using the same, and combinations comprising the same