PL3662894T3 - Nanocząstki zawierające takrolimus - Google Patents

Nanocząstki zawierające takrolimus

Info

Publication number
PL3662894T3
PL3662894T3 PL19213120T PL19213120T PL3662894T3 PL 3662894 T3 PL3662894 T3 PL 3662894T3 PL 19213120 T PL19213120 T PL 19213120T PL 19213120 T PL19213120 T PL 19213120T PL 3662894 T3 PL3662894 T3 PL 3662894T3
Authority
PL
Poland
Prior art keywords
takrolimus
nanoparticles containing
nanoparticles
containing takrolimus
Prior art date
Application number
PL19213120T
Other languages
English (en)
Inventor
Wolfgang Beier
Elke Horstkotte
Original Assignee
Leon-Nanodrugs Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leon-Nanodrugs Gmbh filed Critical Leon-Nanodrugs Gmbh
Publication of PL3662894T3 publication Critical patent/PL3662894T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5161Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5138Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
PL19213120T 2018-12-04 2019-12-03 Nanocząstki zawierające takrolimus PL3662894T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102018130848 2018-12-04
EP19213120.9A EP3662894B1 (en) 2018-12-04 2019-12-03 Nanoparticles comprising tacrolimus

Publications (1)

Publication Number Publication Date
PL3662894T3 true PL3662894T3 (pl) 2022-01-10

Family

ID=68766584

Family Applications (2)

Application Number Title Priority Date Filing Date
PL19213120T PL3662894T3 (pl) 2018-12-04 2019-12-03 Nanocząstki zawierające takrolimus
PL19816295.0T PL3846783T3 (pl) 2018-12-04 2019-12-04 Nanocząstki zawierające takrolimus

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL19816295.0T PL3846783T3 (pl) 2018-12-04 2019-12-04 Nanocząstki zawierające takrolimus

Country Status (18)

Country Link
US (2) US11311479B2 (pl)
EP (2) EP3662894B1 (pl)
JP (1) JP7641220B2 (pl)
KR (1) KR20210100142A (pl)
CN (2) CN113242732A (pl)
AU (1) AU2019392718B2 (pl)
CA (1) CA3063417C (pl)
DK (2) DK3662894T3 (pl)
ES (2) ES2894112T3 (pl)
FI (1) FI3846783T3 (pl)
HR (1) HRP20240072T1 (pl)
HU (2) HUE056067T2 (pl)
IL (1) IL283458A (pl)
PL (2) PL3662894T3 (pl)
PT (1) PT3846783T (pl)
SG (1) SG11202105778PA (pl)
SI (2) SI3662894T1 (pl)
WO (1) WO2020115140A1 (pl)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113425716A (zh) * 2021-05-27 2021-09-24 南京诺亚药业有限公司 一种他克莫司药物组合物及其制备方法
EP4104816A1 (en) * 2021-06-14 2022-12-21 Nucleus Medical GmbH Non-nanoparticulate applications forms of macrolides
WO2023170184A1 (en) * 2022-03-11 2023-09-14 Lts Lohmann Therapie-Systeme Ag Transmucosal therapeutic system containing a macrolide immunosuppressant
US20250319019A1 (en) * 2022-09-10 2025-10-16 Smita PATTANAIK Buccomucoadhesive patch-based drug delivery system for tacrolimus
CN120957719A (zh) * 2023-02-06 2025-11-14 核心医疗有限公司 一种用于预防或治疗免疫疾病或病症的方法中的大环内酯
EP4410287A1 (en) * 2023-02-06 2024-08-07 Nucleus Medical GmbH A macrolide for use in a method of preventing or treating an immunological disease or disorder
EP4501320A1 (en) * 2023-08-02 2025-02-05 IQ medical GmbH A method of preparing an aqueous dispersion of nanoparticles

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2535846A1 (en) * 2003-08-15 2005-02-24 Qlt Usa, Inc. Adhesive bioerodible transmucosal drug delivery system
CA2590675A1 (en) * 2004-12-15 2006-06-22 Elan Pharma International Ltd. Nanoparticulate tacrolimus formulations
CA2680680A1 (en) * 2007-03-29 2009-02-19 Panacea Biotec Limited Modified dosage forms of tacrolimus
WO2012026896A1 (en) * 2010-08-25 2012-03-01 Les Laboratoires Medis Sa Surface modified micronized tacrolimus crystalline particles and pharmaceutical compositions thereof
EP2958555A2 (en) * 2013-02-21 2015-12-30 Massachusetts Institute of Technology Targeted buccal delivery of agents
EP3270891A1 (en) * 2015-03-17 2018-01-24 Leon-Nanodrugs GmbH Nanoparticles comprising a stabilized boronic acid compound
DE102016101232A1 (de) 2016-01-25 2017-07-27 Instillo Gmbh Verfahren zum Herstellen von Emulsionen

Also Published As

Publication number Publication date
JP7641220B2 (ja) 2025-03-06
HUE056067T2 (hu) 2022-01-28
HUE065588T2 (hu) 2024-06-28
HRP20240072T1 (hr) 2024-05-10
CA3063417C (en) 2023-01-03
CN113242732A (zh) 2021-08-10
FI3846783T3 (fi) 2024-01-15
PT3846783T (pt) 2024-01-19
ES2894112T3 (es) 2022-02-11
US11904048B2 (en) 2024-02-20
ES2969096T3 (es) 2024-05-16
JP2022513697A (ja) 2022-02-09
EP3846783B8 (en) 2023-11-22
AU2019392718B2 (en) 2025-07-24
CN120324378A (zh) 2025-07-18
US11311479B2 (en) 2022-04-26
SG11202105778PA (en) 2021-06-29
DK3662894T3 (da) 2021-09-20
CA3063417A1 (en) 2020-06-04
IL283458A (en) 2021-07-29
PL3846783T3 (pl) 2024-04-02
US20220079872A1 (en) 2022-03-17
EP3662894A1 (en) 2020-06-10
EP3662894B1 (en) 2021-07-28
SI3846783T1 (sl) 2024-03-29
WO2020115140A1 (en) 2020-06-11
DK3846783T3 (da) 2024-01-15
SI3662894T1 (sl) 2021-11-30
US20200170934A1 (en) 2020-06-04
KR20210100142A (ko) 2021-08-13
EP3846783B1 (en) 2023-10-18
EP3846783A1 (en) 2021-07-14
AU2019392718A1 (en) 2021-06-10

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