HRP20230928T1 - Platforme za skrining kemijski kodiranih prostorno adresiranih biblioteka - Google Patents
Platforme za skrining kemijski kodiranih prostorno adresiranih biblioteka Download PDFInfo
- Publication number
- HRP20230928T1 HRP20230928T1 HRP20230928TT HRP20230928T HRP20230928T1 HR P20230928 T1 HRP20230928 T1 HR P20230928T1 HR P20230928T T HRP20230928T T HR P20230928TT HR P20230928 T HRP20230928 T HR P20230928T HR P20230928 T1 HRP20230928 T1 HR P20230928T1
- Authority
- HR
- Croatia
- Prior art keywords
- ligand
- linker
- microparticle
- binder
- domain
- Prior art date
Links
- 238000012216 screening Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims 18
- 239000003446 ligand Substances 0.000 claims 17
- 239000011230 binding agent Substances 0.000 claims 9
- 239000011859 microparticle Substances 0.000 claims 7
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 150000007523 nucleic acids Chemical group 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 230000001681 protective effect Effects 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 239000000908 ammonium hydroxide Substances 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 229910021529 ammonia Inorganic materials 0.000 claims 1
- 150000001735 carboxylic acids Chemical class 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
- C40B50/16—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support involving encoding steps
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Plant Pathology (AREA)
- Structural Engineering (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biophysics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Signal Processing For Digital Recording And Reproducing (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562120262P | 2015-02-24 | 2015-02-24 | |
| EP19196007.9A EP3650458B1 (en) | 2015-02-24 | 2016-02-24 | Chemically encoded spatially addressed library screening platforms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20230928T1 true HRP20230928T1 (hr) | 2023-11-24 |
Family
ID=56789474
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20230928TT HRP20230928T1 (hr) | 2015-02-24 | 2016-02-24 | Platforme za skrining kemijski kodiranih prostorno adresiranih biblioteka |
| HRP20231536TT HRP20231536T1 (hr) | 2015-02-24 | 2016-02-24 | Platforme za pregled kemijski kodiranih prostorno adresiranih biblioteka |
| HRP20220093TT HRP20220093T1 (hr) | 2015-02-24 | 2016-02-24 | Platforme za provjeravanje kemijski kodiranih prostorno adresiranih biblioteka |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20231536TT HRP20231536T1 (hr) | 2015-02-24 | 2016-02-24 | Platforme za pregled kemijski kodiranih prostorno adresiranih biblioteka |
| HRP20220093TT HRP20220093T1 (hr) | 2015-02-24 | 2016-02-24 | Platforme za provjeravanje kemijski kodiranih prostorno adresiranih biblioteka |
Country Status (19)
| Country | Link |
|---|---|
| US (6) | US10760181B2 (https=) |
| EP (4) | EP3650458B1 (https=) |
| JP (2) | JP6872501B2 (https=) |
| AU (2) | AU2016222755B2 (https=) |
| CA (1) | CA2976946C (https=) |
| CY (1) | CY1124954T1 (https=) |
| DK (3) | DK3650458T5 (https=) |
| ES (3) | ES2965764T3 (https=) |
| FI (2) | FI3650458T3 (https=) |
| HR (3) | HRP20230928T1 (https=) |
| HU (3) | HUE063406T2 (https=) |
| LT (3) | LT3650459T (https=) |
| NZ (1) | NZ734644A (https=) |
| PL (3) | PL3650458T3 (https=) |
| PT (3) | PT3650458T (https=) |
| RS (3) | RS64899B1 (https=) |
| SI (3) | SI3262059T1 (https=) |
| SM (3) | SMT202200039T1 (https=) |
| WO (1) | WO2016138184A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2622112B2 (ja) | 1986-09-26 | 1997-06-18 | キヤノン株式会社 | 画像処理システム |
| WO2009069203A1 (ja) * | 2007-11-28 | 2009-06-04 | Glory Ltd. | チケット処理装置、チケット処理システム及びチケット処理方法 |
| NZ734644A (en) * | 2015-02-24 | 2023-02-24 | Hope City | Chemically encoded spatially addressed library screening platforms |
| CN106048736B (zh) * | 2015-04-14 | 2019-09-03 | 成都先导药物开发股份有限公司 | 一种固相合成dna编码化合物库的方法 |
| AU2017357638B2 (en) * | 2016-11-08 | 2023-11-16 | Nanna Therapeutics Limited | Tagless encoded chemical library |
| WO2019060830A1 (en) | 2017-09-25 | 2019-03-28 | Plexium, Inc. | CHEMICAL LIBRARIES CODED BY OLIGONUCLEOTIDES |
| EP3704246A4 (en) | 2017-10-31 | 2021-08-11 | Encodia, Inc. | PROCEDURES AND KITS USING NUCLEIC ACID ENCODING AND / OR MARKING |
| AU2020361681A1 (en) | 2019-10-10 | 2022-05-05 | 1859, Inc. | Methods and systems for microfluidic screening |
| US12577702B2 (en) | 2020-01-28 | 2026-03-17 | Plexium, Inc. | Oligonucleotide encoded chemical libraries, related systems, devices, and methods for detecting, analyzing, quantifying, and testing biologics/genetics |
| WO2022170034A1 (en) * | 2021-02-05 | 2022-08-11 | Affinergy, Llc | Rapid assay for apol1 g0 protein |
| JP7502835B2 (ja) * | 2021-08-27 | 2024-06-19 | 国立大学法人神戸大学 | 基材上に収率よく空孔を形成する技術のためのコアシェル鋳型分子・粒子 |
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| US4672040A (en) * | 1983-05-12 | 1987-06-09 | Advanced Magnetics, Inc. | Magnetic particles for use in separations |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| JP2001524926A (ja) | 1991-09-18 | 2001-12-04 | アフィマックス テクノロジーズ ナームロゼ フェンノートシャップ | オリゴマーの雑多ライブラリーの集合体を合成する方法 |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5565324A (en) | 1992-10-01 | 1996-10-15 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| CA2151473A1 (en) | 1992-12-11 | 1994-06-23 | Ronald N . Zuckermann | Synthesis of encoded polymers |
| JP3394777B2 (ja) * | 1993-05-27 | 2003-04-07 | セレクタイド コーポレーション | 位相学的に分離された、コードされた固相ライブラリー |
| EP0751779B1 (en) * | 1993-06-21 | 2001-12-19 | Selectide Corporation | Selectively cleavable linkers based on iminodiacetic acid ester bonds |
| US6087186A (en) * | 1993-07-16 | 2000-07-11 | Irori | Methods and apparatus for synthesizing labeled combinatorial chemistry libraries |
| CN1134156A (zh) * | 1993-11-02 | 1996-10-23 | 阿菲马克斯技术公司 | 合成和筛选多种分子 |
| US6936477B2 (en) | 1994-04-13 | 2005-08-30 | The Trustees Of Columbia University In The City Of New York | Complex combinatorial chemical libraries encoded with tags |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US7615368B1 (en) | 1994-06-17 | 2009-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Microarrays of polypeptides |
| US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
| US5846839A (en) | 1995-12-22 | 1998-12-08 | Glaxo Group Limited | Methods for hard-tagging an encoded synthetic library |
| JP4034351B2 (ja) * | 1996-04-25 | 2008-01-16 | バイオアレイ ソリューションズ エルエルシー | 粒子近接表面の光制御した動電学的アッセンブリ |
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| NZ734644A (en) | 2015-02-24 | 2023-02-24 | Hope City | Chemically encoded spatially addressed library screening platforms |
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2016
- 2016-02-24 NZ NZ734644A patent/NZ734644A/en unknown
- 2016-02-24 LT LTEP19196019.4T patent/LT3650459T/lt unknown
- 2016-02-24 SM SM20220039T patent/SMT202200039T1/it unknown
- 2016-02-24 JP JP2017562972A patent/JP6872501B2/ja active Active
- 2016-02-24 EP EP19196007.9A patent/EP3650458B1/en active Active
- 2016-02-24 HR HRP20230928TT patent/HRP20230928T1/hr unknown
- 2016-02-24 HR HRP20231536TT patent/HRP20231536T1/hr unknown
- 2016-02-24 SI SI201631454T patent/SI3262059T1/sl unknown
- 2016-02-24 SI SI201631770T patent/SI3650459T1/sl unknown
- 2016-02-24 CA CA2976946A patent/CA2976946C/en active Active
- 2016-02-24 PL PL19196007.9T patent/PL3650458T3/pl unknown
- 2016-02-24 PT PT191960079T patent/PT3650458T/pt unknown
- 2016-02-24 RS RS20231135A patent/RS64899B1/sr unknown
- 2016-02-24 SM SM20230430T patent/SMT202300430T1/it unknown
- 2016-02-24 LT LTEP19196007.9T patent/LT3650458T/lt unknown
- 2016-02-24 PL PL19196019.4T patent/PL3650459T3/pl unknown
- 2016-02-24 PL PL16756316T patent/PL3262059T3/pl unknown
- 2016-02-24 US US15/553,140 patent/US10760181B2/en active Active
- 2016-02-24 RS RS20220051A patent/RS62847B1/sr unknown
- 2016-02-24 EP EP23195322.5A patent/EP4276059A3/en not_active Withdrawn
- 2016-02-24 EP EP19196019.4A patent/EP3650459B1/en active Active
- 2016-02-24 PT PT167563162T patent/PT3262059T/pt unknown
- 2016-02-24 PT PT191960194T patent/PT3650459T/pt unknown
- 2016-02-24 HR HRP20220093TT patent/HRP20220093T1/hr unknown
- 2016-02-24 AU AU2016222755A patent/AU2016222755B2/en active Active
- 2016-02-24 EP EP16756316.2A patent/EP3262059B1/en active Active
- 2016-02-24 DK DK19196007.9T patent/DK3650458T5/da active
- 2016-02-24 ES ES19196019T patent/ES2965764T3/es active Active
- 2016-02-24 ES ES19196007T patent/ES2954467T3/es active Active
- 2016-02-24 DK DK19196019.4T patent/DK3650459T5/da active
- 2016-02-24 HU HUE19196007A patent/HUE063406T2/hu unknown
- 2016-02-24 LT LTEPPCT/US2016/019426T patent/LT3262059T/lt unknown
- 2016-02-24 RS RS20230660A patent/RS64567B1/sr unknown
- 2016-02-24 DK DK16756316.2T patent/DK3262059T3/da active
- 2016-02-24 SM SM20230275T patent/SMT202300275T1/it unknown
- 2016-02-24 FI FIEP19196007.9T patent/FI3650458T3/fi active
- 2016-02-24 SI SI201631737T patent/SI3650458T1/sl unknown
- 2016-02-24 HU HUE19196019A patent/HUE064689T2/hu unknown
- 2016-02-24 HU HUE16756316A patent/HUE058813T2/hu unknown
- 2016-02-24 FI FIEP19196019.4T patent/FI3650459T3/fi active
- 2016-02-24 WO PCT/US2016/019426 patent/WO2016138184A1/en not_active Ceased
- 2016-02-24 ES ES16756316T patent/ES2904997T3/es active Active
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2019
- 2019-08-29 US US16/555,531 patent/US10767278B2/en active Active
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2020
- 2020-07-28 US US16/940,499 patent/US11015265B2/en active Active
- 2020-07-30 US US16/943,630 patent/US11015266B2/en active Active
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2021
- 2021-01-21 AU AU2021200399A patent/AU2021200399B2/en active Active
- 2021-04-15 JP JP2021068860A patent/JP7109618B6/ja active Active
- 2021-04-22 US US17/238,150 patent/US20210324538A1/en active Pending
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2022
- 2022-01-21 CY CY20221100054T patent/CY1124954T1/el unknown
- 2022-06-21 US US17/845,949 patent/US20220341059A1/en active Pending
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