HRP20220313T1 - Procesi za pripremu spojeva sličnih oksatiazinu - Google Patents

Procesi za pripremu spojeva sličnih oksatiazinu Download PDF

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Publication number
HRP20220313T1
HRP20220313T1 HRP20220313TT HRP20220313T HRP20220313T1 HR P20220313 T1 HRP20220313 T1 HR P20220313T1 HR P20220313T T HRP20220313T T HR P20220313TT HR P20220313 T HRP20220313 T HR P20220313T HR P20220313 T1 HRP20220313 T1 HR P20220313T1
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HR
Croatia
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compound
image
compounds
processes
preparing
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HRP20220313TT
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English (en)
Croatian (hr)
Inventor
Rolf W. Pfirrmann
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Geistlich Pharma Ag
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Publication of HRP20220313T1 publication Critical patent/HRP20220313T1/hr

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/04Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups
    • C07C303/12Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by substitution of hydrogen atoms by sulfo or halosulfonyl groups by reaction with thionylhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/78Halides of sulfonic acids
    • C07C309/79Halides of sulfonic acids having halosulfonyl groups bound to acyclic carbon atoms
    • C07C309/82Halides of sulfonic acids having halosulfonyl groups bound to acyclic carbon atoms of a carbon skeleton substituted by singly-bound oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/18Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof by reaction of sulfides with compounds having functional groups with formation of sulfo or halosulfonyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/02Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
    • C07C303/22Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof from sulfonic acids, by reactions not involving the formation of sulfo or halosulfonyl groups; from sulfonic halides by reactions not involving the formation of halosulfonyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/38Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/07Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • C07C309/09Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton
    • C07C309/10Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing etherified hydroxy groups bound to the carbon skeleton with the oxygen atom of at least one of the etherified hydroxy groups further bound to an acyclic carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/07Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton
    • C07C309/12Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing oxygen atoms bound to the carbon skeleton containing esterified hydroxy groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/02Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/24Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/27Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/021,2-Thiazines; Hydrogenated 1,2-thiazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D291/00Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms
    • C07D291/02Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms not condensed with other rings
    • C07D291/06Six-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D419/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HRP20220313TT 2014-12-19 2015-12-17 Procesi za pripremu spojeva sličnih oksatiazinu HRP20220313T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462094580P 2014-12-19 2014-12-19
EP15821172.2A EP3233813B1 (en) 2014-12-19 2015-12-17 Processes for preparing oxathiazin-like compounds
PCT/IB2015/059741 WO2016098054A1 (en) 2014-12-19 2015-12-17 Processes for preparing oxathiazin-like compounds

Publications (1)

Publication Number Publication Date
HRP20220313T1 true HRP20220313T1 (hr) 2022-05-13

Family

ID=55077556

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20220313TT HRP20220313T1 (hr) 2014-12-19 2015-12-17 Procesi za pripremu spojeva sličnih oksatiazinu

Country Status (21)

Country Link
US (2) US10392355B2 (cg-RX-API-DMAC7.html)
EP (2) EP4011871A3 (cg-RX-API-DMAC7.html)
JP (4) JP6746605B2 (cg-RX-API-DMAC7.html)
KR (1) KR102594322B1 (cg-RX-API-DMAC7.html)
CN (3) CN119454714A (cg-RX-API-DMAC7.html)
AU (2) AU2015365348B2 (cg-RX-API-DMAC7.html)
CA (1) CA2971570A1 (cg-RX-API-DMAC7.html)
CY (1) CY1125047T1 (cg-RX-API-DMAC7.html)
DK (1) DK3233813T3 (cg-RX-API-DMAC7.html)
ES (1) ES2907592T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20220313T1 (cg-RX-API-DMAC7.html)
HU (1) HUE058257T2 (cg-RX-API-DMAC7.html)
IL (1) IL252912B (cg-RX-API-DMAC7.html)
LT (1) LT3233813T (cg-RX-API-DMAC7.html)
MX (2) MX369462B (cg-RX-API-DMAC7.html)
PL (1) PL3233813T3 (cg-RX-API-DMAC7.html)
PT (1) PT3233813T (cg-RX-API-DMAC7.html)
RS (1) RS62955B1 (cg-RX-API-DMAC7.html)
SI (1) SI3233813T1 (cg-RX-API-DMAC7.html)
SM (1) SMT202200091T1 (cg-RX-API-DMAC7.html)
WO (1) WO2016098054A1 (cg-RX-API-DMAC7.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11591302B2 (en) * 2014-12-19 2023-02-28 Geistlich Pharm A Ag Processes for preparing oxathiazin-like compounds
US10392355B2 (en) * 2014-12-19 2019-08-27 Geistlich Pharma Ag Processes for preparing oxathiazin-like compounds
KR20190012148A (ko) * 2016-04-07 2019-02-08 가이스틀리히 파마 아게 옥사티아진-유사 화합물의 제조 방법
JP7152030B2 (ja) * 2017-02-27 2022-10-12 株式会社シード探索研究所 抗真菌組成物
CN109602744A (zh) * 2018-12-13 2019-04-12 中国人民解放军总医院 荜茇酰胺在制备抗菌消炎药物中的应用
EP3972609B1 (en) * 2019-05-22 2025-03-26 Geistlich Pharma AG Oxathiazin_dioxide for treating, preventing, inhibiting or reducing cytokine release
US20220323452A1 (en) * 2019-05-22 2022-10-13 Geistlich Pharma Ag Methods and compositions for inhibiting gapdh
EP3972608A1 (en) * 2019-05-22 2022-03-30 Geistlich Pharma AG Oxathiazin compounds for inhibiting gapdh
CN111671758A (zh) * 2020-07-06 2020-09-18 长春迈灵生物工程有限公司 牛磺罗定在制备抗hiv病毒药物中的应用
CN111617086A (zh) * 2020-07-06 2020-09-04 长春迈灵生物工程有限公司 牛磺罗定在制备抗hpv病毒药物中的应用
BR112023000308A2 (pt) * 2020-07-06 2023-03-28 Acad Of Military Medical Sciences Uso de taurolidina contra vírus
CA3216783A1 (en) * 2021-04-29 2022-11-03 Thomas Mueller Antimicrobial and anticancer agents
CN118724762A (zh) * 2024-06-24 2024-10-01 湖南增达生物科技有限公司 一种牛磺酸的制备新工艺

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DE1160443B (de) * 1961-11-30 1964-01-02 Hoechst Ag Verfahren zur Herstellung von Tetrahydro-oxathiazin-dioxyden
GB1124285A (en) * 1964-10-06 1968-08-21 Geistlich Soehne Ag Novel perhydro-1,2,4-thiadiazine dioxides-(1,1), their preparation and compositionscontaining them
DE1234988B (de) 1964-11-28 1967-02-23 Bayer Ag Verfahren zur Herstellung von Copolymerisaten des Trioxans
DK167393B1 (da) 1985-12-30 1993-10-25 Roussel Uclaf 1-sulfonyl-2-oxo-pyrrolidinderivater, deres fremstilling og farmaceutiske praeparater med indhold deraf
GB8617482D0 (en) 1986-07-17 1986-08-28 Geistlich Soehne Ag Pharmaceutical composition
IT1296926B1 (it) 1997-12-05 1999-08-03 Zambon Spa Procedimento per la preparazione di composti ad attivita' antimicotica
WO2006033446A1 (en) 2004-09-21 2006-03-30 Astellas Pharma Inc. Aminoalcohol derivatives
US20080275032A1 (en) * 2006-12-29 2008-11-06 Yuefen Zhou Pyridazinone compounds
JP2008222659A (ja) * 2007-03-14 2008-09-25 Asahi Kasei Corp スルホンアミド化合物の製造方法
WO2008149965A1 (ja) 2007-06-07 2008-12-11 Astellas Pharma Inc. ピリドン化合物
US8088824B2 (en) * 2007-08-15 2012-01-03 Reata Pharmaceuticals Inc. Forms of CDDO methyl ester
US20120142676A1 (en) * 2010-08-18 2012-06-07 Gaik-Lean Chee Oxathiazine and dithiine oxides as inhibitors of sulfhydryl-dependent biomolecules
WO2012070066A1 (en) * 2010-11-23 2012-05-31 Biophore India Pharmaceuticals Pvt. Ltd. Process for the preparation of taurolidine and its intermediates thereof
WO2013190355A1 (en) * 2012-06-18 2013-12-27 Geistlich Pharma Ag Oxathiazine derivatives as antibacterial and anticancer agents
US10392355B2 (en) * 2014-12-19 2019-08-27 Geistlich Pharma Ag Processes for preparing oxathiazin-like compounds

Also Published As

Publication number Publication date
RS62955B1 (sr) 2022-03-31
LT3233813T (lt) 2022-04-11
SI3233813T1 (sl) 2022-05-31
US20190389819A1 (en) 2019-12-26
EP4011871A3 (en) 2022-08-24
CN119454714A (zh) 2025-02-18
JP7030093B2 (ja) 2022-03-04
SMT202200091T1 (it) 2022-03-21
IL252912B (en) 2020-01-30
JP2020040964A (ja) 2020-03-19
AU2019261702A1 (en) 2019-11-28
AU2019261702B2 (en) 2021-03-25
US20180370932A1 (en) 2018-12-27
PL3233813T3 (pl) 2022-05-30
AU2015365348B2 (en) 2019-11-28
WO2016098054A1 (en) 2016-06-23
HUE058257T2 (hu) 2022-07-28
MX2019013194A (es) 2020-01-13
JP6746605B2 (ja) 2020-08-26
WO2016098054A9 (en) 2016-12-22
AU2015365348A1 (en) 2017-07-13
BR112017013188A2 (pt) 2018-04-10
CY1125047T1 (el) 2023-03-24
ES2907592T3 (es) 2022-04-25
JP2018502909A (ja) 2018-02-01
EP3233813A1 (en) 2017-10-25
CN107257786A (zh) 2017-10-17
JP7449913B2 (ja) 2024-03-14
CN107257786B (zh) 2019-12-24
MX369462B (es) 2019-11-08
EP3233813B1 (en) 2022-02-02
KR102594322B1 (ko) 2023-10-26
DK3233813T3 (da) 2022-03-07
EP4011871A2 (en) 2022-06-15
NZ733723A (en) 2024-03-22
JP7688098B2 (ja) 2025-06-03
JP2024028794A (ja) 2024-03-05
JP2022031717A (ja) 2022-02-22
MX2017008112A (es) 2018-02-09
US10392355B2 (en) 2019-08-27
PT3233813T (pt) 2022-03-14
US10968190B2 (en) 2021-04-06
CA2971570A1 (en) 2016-06-23
CN110776479A (zh) 2020-02-11
MX392353B (es) 2025-03-24
IL252912A0 (en) 2017-08-31
KR20170113546A (ko) 2017-10-12

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