HRP20211112T1 - Hemostatski zavoj za rane - Google Patents
Hemostatski zavoj za rane Download PDFInfo
- Publication number
- HRP20211112T1 HRP20211112T1 HRP20211112TT HRP20211112T HRP20211112T1 HR P20211112 T1 HRP20211112 T1 HR P20211112T1 HR P20211112T T HRP20211112T T HR P20211112TT HR P20211112 T HRP20211112 T HR P20211112T HR P20211112 T1 HRP20211112 T1 HR P20211112T1
- Authority
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- Croatia
- Prior art keywords
- fibrinogen
- amino acid
- peptide
- xaa
- colloidal porous
- Prior art date
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- 229940030225 antihemorrhagics Drugs 0.000 title claims 4
- 230000000025 haemostatic effect Effects 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 239000000463 material Substances 0.000 claims 18
- 206010052428 Wound Diseases 0.000 claims 15
- 208000027418 Wounds and injury Diseases 0.000 claims 15
- 102000008946 Fibrinogen Human genes 0.000 claims 11
- 108010049003 Fibrinogen Proteins 0.000 claims 11
- 229940012952 fibrinogen Drugs 0.000 claims 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims 11
- 239000008187 granular material Substances 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 239000000969 carrier Substances 0.000 claims 6
- VWJLJHZPMZGDDV-HOCDWTQPSA-N (4s)-4-amino-5-[[(2s)-1-[[(2s,3s)-1-[(2s)-2-[[(1s)-1-carboxyethyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxopentan-2-yl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@@H](N)CCC(O)=O)C1=CN=CN1 VWJLJHZPMZGDDV-HOCDWTQPSA-N 0.000 claims 5
- 229920001477 hydrophilic polymer Polymers 0.000 claims 4
- 125000006850 spacer group Chemical group 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 239000006260 foam Substances 0.000 claims 3
- 239000002874 hemostatic agent Substances 0.000 claims 3
- 230000002439 hemostatic effect Effects 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 230000003100 immobilizing effect Effects 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 229920000742 Cotton Polymers 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002201 Oxidized cellulose Polymers 0.000 claims 1
- 229920000297 Rayon Polymers 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000000740 bleeding effect Effects 0.000 claims 1
- 229960005188 collagen Drugs 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229940107304 oxidized cellulose Drugs 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 239000002964 rayon Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Composite Materials (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Claims (13)
1. Hemostatski zavoj za rane, naznačen time što sadrži nekoloidni porozni zavojni materijal, više peptida koji se vežu na fibrinogen imobilizirano na nekoloidni porozni zavojni materijal, gdje svaki peptid koji se veže na fibrinogen sadrži:
aminokiselinski slijed Gly-Pro-Arg-Xaa (SEQ ID NO: 1) na amino-terminalnom kraju peptida, gdje je Xaa bilo koja aminokiselina osim Val, po mogućnosti Pro, Sar ili Leu; ili
aminokiselinski slijed Gly-His-Arg-Xaa (SEQ ID NO: 2) na amino-terminalnom kraju peptida, gdje je Xaa bilo koja aminokiselina osim Pro, i
gdje nekoloidni porozni zavojni materijal sadrži sloj, kompresu, spužvu, pjenu, film, gazu, mrežicu, granule ili zrna, te gdje ako nekoloidni porozni zavojni materijal sadrži granule ili zrna, najmanje većina granula ili zrna ima maksimalnu dimenziju veću od 6 µm.
2. Zavoj za rane u skladu s patentnim zahtjevom 1, naznačen time što je više peptida koji se vežu na fibrinogen nekovalentno imobilizirano na nekoloidni porozni zavojni materijal.
3. Zavoj za rane u skladu s patentnim zahtjevom 1 ili 2, naznačen time što je više nosača imobilizirano na nekoloidni porozni zavojni materijal, a više peptida koji se vežu na fibrinogen je imobilizirano na svaki nosač, gdje se više peptida koji se vežu na fibrinogen može kovalentno imobilizirati na svaki nosač, gdje se svaki peptid koji se veže na fibrinogen može kovalentno imobilizirati na nosač nepeptidnom razmaknicom, gdje nepeptidna razmaknica može sadržavati hidrofilni polimer, te gdje hidrofilni polimer može sadržavati polietilen-glikol.
4. Zavoj za rane u skladu s patentnim zahtjevom 3, naznačen time što su nosači topljivi nosači.
5. Zavoj za rane u skladu s patentnim zahtjevom 1, naznačen time što je više peptida koji se vežu na fibrinogen kovalentno imobilizirano na nekoloidni porozni zavojni materijal, gdje se svaki peptid koji se veže na fibrinogen može kovalentno imobilizirati na nekoloidni porozni zavojni materijal nepeptidnom razmaknicom, gdje nepeptidna razmaknica može sadržavati hidrofilni polimer, te gdje hidrofilni polimer može sadržavati polietilen-glikol.
6. Zavoj za rane u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što nekoloidni porozni zavojni materijal sadrži želatinu, pamuk, rajon, poliester, kolagen, alginat ili oksidiranu celulozu.
7. Zavoj za rane u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je u suhom obliku.
8. Zavoj za rane u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je osušen smrzavanjem.
9. Zavoj za rane u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je svaki od peptida koji se vežu na fibrinogen dug 4-60 aminokiselinskih ostataka.
10. Zavoj za rane u skladu s bilo kojim od patentnih zahtjeva 1 do 9, naznačen time što se pakira s uputama o primjeni zavoja za rane na ranu.
11. Zavoj za rane u skladu s bilo kojim od patentnih zahtjeva 1 do 9, naznačen time što je namijenjen kontroliranju krvarenja.
12. Komplet namijenjen pravljenju hemostatskog zavoja za rane, naznačen time što sadrži nekoloidni porozni zavojni materijal, i, odvojeno, hemostatsko sredstvo koje sadrži više nosača i više peptida koji se vežu na fibrinogen imobilizirano na svaki nosač, gdje svaki peptid koji se veže na fibrinogen sadrži: aminokiselinski slijed Gly-Pro-Arg-Xaa (SEQ ID NO: 1) na amino-terminalnom kraju peptida, gdje je Xaa bilo koja aminokiselina osim Val, po mogućnosti Pro, Sar ili Leu; ili aminokiselinski slijed Gly-His-Arg-Xaa (SEQ ID NO: 2) na amino-terminalnom kraju peptida, gdje je Xaa bilo koja aminokiselina osim Pro, gdje nekoloidni porozni zavojni materijal sadrži sloj, kompresu, spužvu, pjenu, film, gazu, mrežicu, granule ili zrna, te gdje ako nekoloidni porozni zavojni materijal sadrži granule ili zrna, u najmanju ruku većina granula ili zrna ima maksimalnu dimenziju veću od 6 µm.
13. Postupak pravljenja hemostatskog zavoja za rane, naznačen time što se sastoji u:
a) imobiliziranju više peptida koji se vežu na fibrinogen na nekoloidni porozni zavojni materijal, gdje se više peptida koji se vežu na fibrinogen može imobilizirati na nekoloidni porozni zavojni materijal imobiliziranjem više nosača na nekoloidni porozni zavojni materijal, gdje je više peptida koji se vežu na fibrinogen imobilizirano na svaki nosač; ili
b) primjeni hemostatskog sredstva na nekoloidni porozni zavojni materijal,
gdje hemostatsko sredstvo sadrži više nosača i više peptida koji se vežu na fibrinogen imobilizirano na svaki nosač,
gdje svaki peptid koji se veže na fibrinogen sadrži:
aminokiselinski slijed Gly-Pro-Arg-Xaa (SEQ ID NO: 1) na amino-terminalnom kraju peptida, gdje je Xaa bilo koja aminokiselina osim Val, po mogućnosti Pro, Sar ili Leu; ili
aminokiselinski slijed Gly-His-Arg-Xaa (SEQ ID NO: 2) na amino-terminalnom kraju peptida, gdje je Xaa bilo koja aminokiselina osim Pro, i
gdje nekoloidni porozni zavojni materijal sadrži sloj, kompresu, spužvu, pjenu, film, gazu, mrežicu, granule, ili zrna, te gdje ako nekoloidni porozni zavojni materijal sadrži granule ili zrna, najmanje većina granula ili zrna ima maksimalnu dimenziju veću od 6 µm.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1201751.3A GB201201751D0 (en) | 2012-02-01 | 2012-02-01 | Haemostatic wound dressing |
| EP13708510.6A EP2809365B8 (en) | 2012-02-01 | 2013-02-01 | Haemostatic wound dressing |
| PCT/GB2013/050237 WO2013114132A1 (en) | 2012-02-01 | 2013-02-01 | Haemostatic wound dressing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20211112T1 true HRP20211112T1 (hr) | 2021-10-15 |
| HRP20211112T8 HRP20211112T8 (hr) | 2022-01-21 |
Family
ID=45876478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20211112TT HRP20211112T8 (hr) | 2012-02-01 | 2021-07-12 | Hemostatski zavoj za rane |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9808553B2 (hr) |
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Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0516091D0 (en) * | 2005-08-04 | 2005-09-14 | Haemostatix Ltd | Therapeutic agent |
| GB0808376D0 (en) | 2008-05-08 | 2008-06-18 | Bristol Myers Squibb Co | Wound dressing |
| GB0817796D0 (en) | 2008-09-29 | 2008-11-05 | Convatec Inc | wound dressing |
| GB201020236D0 (en) | 2010-11-30 | 2011-01-12 | Convatec Technologies Inc | A composition for detecting biofilms on viable tissues |
| CN103347561B (zh) | 2010-12-08 | 2016-09-07 | 康沃特克科技公司 | 用于评估伤口分泌液的集成系统 |
| EP2648794B1 (en) | 2010-12-08 | 2019-08-28 | ConvaTec Technologies Inc. | Wound exudate system accessory |
| GB201115182D0 (en) | 2011-09-02 | 2011-10-19 | Trio Healthcare Ltd | Skin contact material |
| GB2497406A (en) | 2011-11-29 | 2013-06-12 | Webtec Converting Llc | Dressing with a perforated binder layer |
| GB201120693D0 (en) | 2011-12-01 | 2012-01-11 | Convatec Technologies Inc | Wound dressing for use in vacuum therapy |
| JP2016507663A (ja) | 2012-12-20 | 2016-03-10 | コンバテック・テクノロジーズ・インコーポレイテッドＣｏｎｖａｔｅｃ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ | 化学修飾セルロース系繊維の加工 |
| GB201400292D0 (en) * | 2014-01-08 | 2014-02-26 | Haemostatix Ltd | Peptide dendrimers and agents |
| GB201508020D0 (en) * | 2015-05-11 | 2015-06-24 | Haemostatix Ltd | Haemostatic material |
| GB201508014D0 (en) * | 2015-05-11 | 2015-06-24 | Haemostatix Ltd | Haemostatic device |
| GB201508024D0 (en) | 2015-05-11 | 2015-06-24 | Haemostatix Ltd | Haemostatic compositions |
| WO2016200905A1 (en) * | 2015-06-08 | 2016-12-15 | The Procter & Gamble Company | Methods for identifying circadian rhythm-dependent cosmetic agents for skin care compositions |
| EP3943127A1 (en) * | 2015-09-01 | 2022-01-26 | Baxter International Inc | Hemostatic material |
| GB2543307B (en) * | 2015-10-14 | 2020-12-09 | Selentus Science Ltd | Haemostatic device |
| EP3436820A2 (en) | 2016-03-30 | 2019-02-06 | Qualizyme Diagnostics GmbH&Co KG | Detecting microbial infection in wounds |
| TW201800069A (zh) | 2016-03-30 | 2018-01-01 | 康華特科技有限公司 | 傷口中微生物感染檢測方法 |
| KR20190026858A (ko) | 2016-07-08 | 2019-03-13 | 컨바텍 테크놀러지스 인크 | 가요성 부압 시스템 |
| KR20190028467A (ko) | 2016-07-08 | 2019-03-18 | 컨바텍 테크놀러지스 인크 | 체액 수집 장치 |
| TW201805035A (zh) | 2016-07-08 | 2018-02-16 | 美商康瓦鐵克科技股份有限公司 | 流體流動感測 |
| CN106344960B (zh) * | 2016-09-20 | 2019-02-22 | 安徽思维特生物科技有限公司 | 利用微晶纤维素接枝改性胎牛皮胶原纤维制备的止血凝胶 |
| IL256405A (en) * | 2017-12-19 | 2018-01-31 | Omrix Biopharmaceuticals Ltd | Wound bandage and method for its production |
| GB2571080A (en) * | 2018-02-14 | 2019-08-21 | Medtrade Products Ltd | Haemostatic material |
| CN110448719B (zh) * | 2019-06-28 | 2020-05-22 | 浙江大学 | 一种促进凝血的丝素-多肽电纺膜及其制备方法 |
| US11331221B2 (en) | 2019-12-27 | 2022-05-17 | Convatec Limited | Negative pressure wound dressing |
| US11771819B2 (en) | 2019-12-27 | 2023-10-03 | Convatec Limited | Low profile filter devices suitable for use in negative pressure wound therapy systems |
| GB2596525A (en) * | 2020-06-26 | 2022-01-05 | Fujifilm Corp | Modified gelatins |
| CN112206307B (zh) * | 2020-09-15 | 2023-12-05 | 广州领晟医疗科技有限公司 | 一种可注射的温敏型水凝胶及其制备方法与应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0068047B1 (de) | 1981-06-25 | 1986-07-23 | Serapharm GmbH & Co. KG | Angereichertes Plasmaderivat zur Unterstützung von Wundverschluss und Wundheilung |
| GB9107628D0 (en) | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
| ATE311438T1 (de) | 1992-05-29 | 2005-12-15 | Univ North Carolina | Im immobilisierten zustand getrocknete pharmazeutisch verträgliche menschliche blutplättchen |
| AU702955B2 (en) | 1996-05-17 | 1999-03-11 | Quadrant Healthcare (Uk) Limited | Microparticles and their use in wound therapy |
| EP1028752B1 (en) | 1996-10-21 | 2004-12-15 | Quadrant Drug Delivery Limited | Platelet substitutes and conjugation methods suitable for their preparation |
| US6891077B2 (en) | 2001-07-25 | 2005-05-10 | The United States Of America As Represented By The Secretary Of The Army | Fibrinogen bandages and arterial bleeding models and methods of making and using thereof |
| CN100525829C (zh) | 2002-04-15 | 2009-08-12 | 美国国家红十字会 | 检测混合物中配体和靶标的方法 |
| US20040101546A1 (en) * | 2002-11-26 | 2004-05-27 | Gorman Anne Jessica | Hemostatic wound dressing containing aldehyde-modified polysaccharide and hemostatic agents |
| US7550282B2 (en) | 2002-11-20 | 2009-06-23 | Bar-Ilan University | Biological glue based on thrombin-conjugated nanoparticles |
| DE10323794A1 (de) | 2003-05-23 | 2004-12-09 | Dr. Suwelack Skin & Health Care Ag | Verfahren zur Herstellung von Alginat-haltigen porösen Formkörpern |
| US20050123588A1 (en) | 2003-06-16 | 2005-06-09 | Zhu Yong H. | Deployable multifunctional hemostatic agent |
| US7186684B2 (en) | 2003-08-07 | 2007-03-06 | Ethicon, Inc. | Hemostatic device containing a protein precipitate |
| US7927626B2 (en) | 2003-08-07 | 2011-04-19 | Ethicon, Inc. | Process of making flowable hemostatic compositions and devices containing such compositions |
| GB0323378D0 (en) * | 2003-10-07 | 2003-11-05 | Univ Leicester | Therapeutic agent |
| WO2006012541A2 (en) | 2004-07-22 | 2006-02-02 | Henry Eisenson | Compositions and methods for treating excessive bleeding |
| US9358318B2 (en) | 2004-10-20 | 2016-06-07 | Ethicon, Inc. | Method of making a reinforced absorbable multilayered hemostatic wound dressing |
| GB0516091D0 (en) * | 2005-08-04 | 2005-09-14 | Haemostatix Ltd | Therapeutic agent |
| GB0623607D0 (en) * | 2006-11-27 | 2007-01-03 | Haemostatix Ltd | Tissue adhesive |
| WO2008076407A2 (en) * | 2006-12-15 | 2008-06-26 | Lifebond Ltd. | Gelatin-transglutaminase hemostatic dressings and sealants |
| ATE530576T1 (de) * | 2007-08-01 | 2011-11-15 | Ethicon Inc | Collagen-assoziierte peptide und ihre verwendung |
| US8512740B2 (en) | 2008-03-26 | 2013-08-20 | Baxter International Inc. | Fibrin foam and process for making |
| US20100021527A1 (en) | 2008-07-25 | 2010-01-28 | Chunlin Yang | Collagen-related peptides and uses thereof and hemostatic foam substrates |
| WO2011006069A1 (en) | 2009-07-09 | 2011-01-13 | Georgia Tech Research Corporation | Peptides for binding fibrinogen and fibrin |
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2012
- 2012-02-01 GB GBGB1201751.3A patent/GB201201751D0/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2809365A1 (en) | 2014-12-10 |
| RU2014132763A (ru) | 2016-03-27 |
| ES2879558T3 (es) | 2021-11-22 |
| JP2015506764A (ja) | 2015-03-05 |
| WO2013114132A1 (en) | 2013-08-08 |
| RU2661036C2 (ru) | 2018-07-11 |
| EP2809365B1 (en) | 2021-05-12 |
| EP2809365B8 (en) | 2021-06-23 |
| KR20140121864A (ko) | 2014-10-16 |
| GB201301847D0 (en) | 2013-03-20 |
| CN104114198A (zh) | 2014-10-22 |
| JP6258868B2 (ja) | 2018-01-10 |
| KR102168157B1 (ko) | 2020-10-21 |
| GB2501348B (en) | 2020-06-24 |
| IN2014DN06952A (hr) | 2015-04-10 |
| US9808553B2 (en) | 2017-11-07 |
| US20150071985A1 (en) | 2015-03-12 |
| HRP20211112T8 (hr) | 2022-01-21 |
| CN104114198B (zh) | 2018-09-04 |
| GB2501348A (en) | 2013-10-23 |
| GB201201751D0 (en) | 2012-03-14 |
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