HRP20210656T1 - Supstituirani spojevi aminopurina, njihovi sastavi, te postupci liječenja istima - Google Patents
Supstituirani spojevi aminopurina, njihovi sastavi, te postupci liječenja istima Download PDFInfo
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- HRP20210656T1 HRP20210656T1 HRP20210656TT HRP20210656T HRP20210656T1 HR P20210656 T1 HRP20210656 T1 HR P20210656T1 HR P20210656T T HRP20210656T T HR P20210656TT HR P20210656 T HRP20210656 T HR P20210656T HR P20210656 T1 HRP20210656 T1 HR P20210656T1
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- Croatia
- Prior art keywords
- purin
- cyclohexanecarboxamide
- ylamino
- chloro
- dichloro
- Prior art date
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- 238000000034 method Methods 0.000 title claims 6
- -1 aminopurine compounds Chemical class 0.000 title claims 3
- 239000000203 mixture Chemical class 0.000 title 1
- PNZXMIKHJXIPEK-UHFFFAOYSA-N cyclohexanecarboxamide Chemical compound NC(=O)C1CCCCC1 PNZXMIKHJXIPEK-UHFFFAOYSA-N 0.000 claims 599
- 150000001875 compounds Chemical class 0.000 claims 33
- DNUTZBZXLPWRJG-UHFFFAOYSA-M piperidine-1-carboxylate Chemical compound [O-]C(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-M 0.000 claims 26
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 12
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 2
- 125000003551 oxepanyl group Chemical group 0.000 claims 2
- 125000003566 oxetanyl group Chemical group 0.000 claims 2
- 125000005936 piperidyl group Chemical group 0.000 claims 2
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 2
- BUGOPWGPQGYYGR-UHFFFAOYSA-N thiane 1,1-dioxide Chemical compound O=S1(=O)CCCCC1 BUGOPWGPQGYYGR-UHFFFAOYSA-N 0.000 claims 2
- AQQAHBQCIBGFLA-UHFFFAOYSA-N 2-chloroheptanamide Chemical compound CCCCCC(Cl)C(N)=O AQQAHBQCIBGFLA-UHFFFAOYSA-N 0.000 claims 1
- 241001024304 Mino Species 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 108060006633 protein kinase Proteins 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (19)
1. Spoj formule (I):
[image]
ili njegova farmaceutski prihvatljiva sol, tautomer, stereoizomer, ili enantiomer, pri čemu:
R1 je supstituirani ili nesupstituirani ne-aromatski heterociklil, poželjno pri čemu R1 je:
(i) supstituirani ili nesupstituirani oksetanil, tetrahidrofuranil, tetrahidropiranil, tetrahidro-tiopirandioksid, piperidil, oksepanil, ili oksaspiroheptil; ili
(ii) supstituiran s jednim ili više supstituenata neovisno odabranih od halogena, OR, SO2R4, C(=O)R5, C(=O)OR6, C(=O)NRR7, supstituiranog ili nesupstituiranog C1-3 alkila, supstituiranog ili nesupstituiranog arila, supstituiranog ili nesupstituiranog heteroarila, supstituiranog ili nesupstituiranog alkilarila, pri čemu je svaki R neovisno H ili supstituirani ili nesupstituirani C1-3 alkil; R4 je supstituirani ili nesupstituirani C1-3 alkil, ili supstituirani ili nesupstituirani aril; R5 je supstituirani ili nesupstituirani C1-3 alkil; R6 je supstituirani ili nesupstituirani C1-6 alkil; i R7 je supstituirani ili nesupstituirani C1-3 alkil, ili supstituirani ili nesupstituirani aril; ili
(iii) oksetanil, tetrahidrofuranil, tetrahidropiranil, tetrahidro-tiopirandioksid, piperidil, oksepanil, ili oksaspiroheptil, izborno supstituiran s jednim ili više supstituenata neovisno odabranih od F, OH, SO2CH3, SO2-tosila, C(=O)CH3, C(=O)OCH3, C(=O)O-terc-butila, C(=O)O-izopropila, C(=O)NHCH3, C(=O)NH-fenila, metila, etila, izopropila, CH2OH, fenila, piridila, ili benzila;
R2 je H ili supstituirani ili nesupstituirani C1-3 alkil;
R3 je fenil, supstituiran s jednim ili više halogenom, izborno nadalje supstituiran s jednim ili više supstituenata neovisno odabranih od supstituiranog ili nesupstituiranog C1-3 alkila, CN, i –OR', pri čemu je svaki R' neovisno supstituirani ili nesupstituirani C1-3 alkil.
2. Spoj prema zahtjevu 1, pri čemu R2 je H ili CH3.
3. Spoj prema zahtjevu 1 ili 2,
pri čemu R3 je orto-halogen supstituirani fenil; ili
pri čemu R3 je para-halogen supstituirani fenil; ili
pri čemu R3 je orto, orto-dihalogen supstituirani fenil; ili
pri čemu R3 je orto, para-dihalogen supstituirani fenil; ili
pri čemu R3 je 2,4,6-trihalogen supstituirani fenil; ili
pri čemu R3 je orto-halogen, para-CN supstituirani fenil; ili
pri čemu R3 je
[image]
pri čemu
svaki Hal je neovisno halogen;
svaki R8 je neovisno supstituirani ili nesupstituirani C1-3 alkil, CN, ili OR';
svaki R' je neovisno supstituirani ili nesupstituirani C1-3 alkil;
m je 1-3;
i p je 0-2; poželjno
(i) pri čemu svaki Hal je neovisno Cl ili F; ili
(ii) pri čemu svaki R8 je neovisno CH3, CF3, CN, ili OCH3; ili
(iii) pri čemu m je 2 ili 3; ili
(iv) pri čemu p je 0 ili 1; ili
(v) pri čemu R3 je
[image]
te svaki Hal je neovisno halogen, poželjnije pri čemu svaki Hal je neovisno F ili Cl.
4. Spoj prema zahtjevu 1, pri čemu spoj je:
(1s,4s)-4-(8-(3-klorofenilamino)-2-(4-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-difluorofenilamino)-2-(3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-difluorofenilamino)-2-((3R,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(4-metiltetrahidro-2H-piran-4-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-kloro-2-fluorofenilamino)-2-(4-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(tetrahidro-2H-piran-4-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((3R,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-difluorofenilamino)-2-((3R,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-6-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-diklorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-klorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3,4-diklorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(5-kloro-2-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-kloro-2-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,5-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-kloro-2-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(tetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,3-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-diklorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-5-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-fluoro-2-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-bromo-2-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-fluoro-4-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-(trifluorometil)fenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-fluoro-2-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(tetrahidro-2H-piran-4-ilamino)-8-(2,3,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-1-metil-4-(2-(tetrahidro-2H-piran-4-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(oksetan-3-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-diklorofenilamino)-2-(oksetan-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-(oksetan-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(tetrahidro-2H-piran-4-ilamino)-8-(2,4,5-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-3-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,3-diklorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-fluoro-6-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(5-kloro-2,4-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(tetrahidro-2H-piran-4-ilamino)-8-(2,4,5-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(tetrahidro-2H-piran-4-ilamino)-8-(2,3,4-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-kloro-2,6-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-3-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,5-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2-fluoro-5-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,3-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(tetrahidro-2H-piran-4-ilamino)-8-(2,3,4-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-fluoro-6-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2-fluoro-6-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-tetrahidrofuran-3-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-kloro-6-fluoro-2-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,5-dikloro-4-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,3-dikloro-4-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-3-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,3-difluoro-4-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-3-fluoro-4-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,3-dikloro-4-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-difluoro-6-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((S)-tetrahidrofuran-3-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-3-fluoro-2-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-3,6-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-6-fluoro-3-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-((1,1-dioksidotetrahidro-2H-tiopiran-4-il)amino)-8-((2,4,6-triklorofenil)amino)-9H-purin-9-il)cikloheksan-1-karboksamid,
(1s,4s)-4-(8-(2-kloro-4,5-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,5-dimetilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2-fluoro-3-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,3-dikloro-6-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-5-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,5-difluoro-4-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-(1-(piridin-3-il)piperidin-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-(1-fenilpiperidin-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-tetrahidro-2H-piran-3-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3,4-dikloro-2-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(6-kloro-2,3-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-(1-(metilsulfonil)piperidin-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-difluoro-4-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-metilfenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(3R,4S)-tert-butil4-(9-((1s,4R)-4-karbamoilcikloheksil)-8-(2,4,6-trifluorofenilamino)-9H-purin-2-ilamino)-3-fluoropiperidin-1-karboksilat,
(3R,4S)-tert-butil 4-(9-((1s,4R)-4-karbamoilcikloheksil)-8-(2,6-difluorofenilamino)-9H-purin-2-ilamino)-3-fluoropiperidin-1-karboksilat,
(1R,4s)-4-(2-((3R,4S)-3-fluoropiperidin-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(3R,4S)-tert-butil 4-(9-((1s,4R)-4-karbamoilcikloheksil)-8-(4-kloro-2,6-difluorofenilamino)-9H-purin-2-ilamino)-3-fluoropiperidin-1-karboksilat,
(1s,4s)-4-(8-((4-kloro-2,6-difluorofenil)amino)-2-((1,1-dioksidotetrahidro-2H-tiopiran-4-il)amino)-9H-purin-9-il)cikloheksan-1-karboksamid,
(1s,4s)-4-(8-((2,4-dikloro-6-fluorofenil)amino)-2-((1,1-dioksidotetrahidro-2H-tiopiran-4-il)amino)-9H-purin-9-il)cikloheksan-1-karboksamid,
(R)-tert-butil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,4,6-trifluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-tert-butil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,6-difluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-tert-butil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,6-diklorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-tert-butil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2-kloro-4,6-difluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-tert-butil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(4-kloro-2,6-difluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-tert-butil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,4,6-triklorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(1s,4s)-4-(2-(2-oksaspiro[3.3]heptan-6-ilamino)-8-(2,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(2-oksaspiro[3.3]heptan-6-ilamino)-8-(2,6-diklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(2-oksaspiro[3.3]heptan-6-ilamino)-8-(2-kloro-4,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(2-oksaspiro[3.3]heptan-6-ilamino)-8-(4-kloro-2,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(2-oksaspiro[3.3]heptan-6-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(4-hidroksitetrahidrofuran-3-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-diklorofenilamino)-2-(4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(4-hidroksitetrahidrofuran-3-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-(4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((R)-tetrahidro-2H-piran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((R)-tetrahidro-2H-piran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((R)-tetrahidro-2H-piran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((R)-tetrahidro-2H-piran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-diklorofenilamino)-2-(4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-kloro-2-fluorofenilamino)-2-(4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(2-oksaspiro[3.3]heptan-6-ilamino)-8-(2,6-dikloro-4-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(2-oksaspiro[3.3]heptan-6-ilamino)-8-(4-kloro-2,3-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(2-oksaspiro[3.3]heptan-6-ilamino)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(2-oksaspiro[3.3]heptan-6-ilamino)-8-(3-kloro-2,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(1-acetilpiperidin-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(1-acetilpiperidin-4-ilamino)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((R)-tetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((S)-tetrahidro-2H-piran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((S)-tetrahidro-2H-piran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((S)-tetrahidro-2H-piran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((R)-tetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((R)-tetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((R)-tetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((S)-tetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((S)-tetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((S)-tetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((S)-tetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((S)-tetrahidro-2H-piran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((3R,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-difluorofenilamino)-2-((3R,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-cijanofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((3S,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-difluorofenilamino)-2-((3S,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((3S,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((3R,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(1-(metilsulfonil)piperidin-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-diklorofenilamino)-2-(1-(metilsulfonil)piperidin-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(1-(metilsulfonil)piperidin-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(1-(metilsulfonil)piperidin-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(1-(metilsulfonil)piperidin-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-(1-(metilsulfonil)piperidin-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,3-difluorofenilamino)-2-(1-(metilsulfonil)piperidin-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-diklorofenilamino)-2-(1-(metilsulfonil)piperidin-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1 S,4s)-4-(2-((3R,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((3S,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-difluorofenilamino)-2-((3R,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-difluorofenilamino)-2-((3S,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((3S,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1 S,4s)-4-(2-((3R,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((3S,4R)-4-hidroksitetrahidrofuran-3-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((3S,4R)-4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((3S,4R)-4-hidroksitetrahidrofuran-3-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((3R,4S)-4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((3R,4S)-4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((3R,4S)-4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,3-difluorofenilamino)-2-((3S,4R)-4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(3-kloro-2,6-difluorofenilamino)-2-((3S,4R)-4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-diklorofenilamino)-2-((3S,4R)-4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(5-kloro-2-fluorofenilamino)-2-((3S,4R)-4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,5-difluorofenilamino)-2-((3R,4S)-4-hidroksitetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-(trifluorometoksi)fenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,3-difluoro-4-metoksifenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-6-fluoro-4-(trifluorometil)fenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(R)-metil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,4,6-trifluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-metil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,6-difluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-metil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,6-diklorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-metil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2-kloro-6-fluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-metil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2-kloro-4,6-difluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-metil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(4-kloro-2,6-difluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-metil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,4,6-triklorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-metil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,6-dikloro-4-fluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-metil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(4-kloro-2,3-difluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-metil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-metil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(3-kloro-2,6-difluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-metil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,3,4-trifluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(1s,4s)-4-(8-(2,6-dikloro-4-(trifluorometil)fenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-3-cijanofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((2S,4R)-2-(hidroksimetil)tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((2S,4R)-2-(hidroksimetil)tetrahidro-2H-piran-4-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-cijano-2,6-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1r,4r)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1r,4r)-1-metil-4-(2-(tetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1r,4r)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((3S,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((3R,4S)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((3R,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((3S,4S)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((3S,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((3R,4S)-3-metiltetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1 S,4s)-4-(2-((3R,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((3S,4S)-3-metiltetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((3S,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((3R,4S)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((3R,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((3S,4S)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((3R,4S)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((3R,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((3S,4S)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((3R,4S)-3-metiltetrahidro-2H-piran-4-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((3S,4S)-3-metiltetrahidro-2H-piran-4-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((R)-tetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1 S,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((R)-tetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1s,4s)-1-metil-4-(2-(tetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-(trifluorometil)fenilamino)-2-((R)-tetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-((R)-tetrahidrofuran-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-tetrahidrofuran-3-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((3S,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((3S,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1s,4s)-4-(2-(oksepan-4-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(oksepan-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(oksepan-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(oksepan-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(oksepan-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-(oksepan-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-(oksepan-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-(oksepan-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-(trifluorometil)fenilamino)-2-(oksepan-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(oksepan-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(2-oksaspiro[3.3]heptan-6-ilamino)-8-(2,6-dikloro-4-(trifluorometil)fenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(2-oksaspiro[3.3]heptan-6-ilamino)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(2-oksaspiro[3.3]heptan-6-ilamino)-8-(2-kloro-4-cijano-6-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(2-oksaspiro[3.3]heptan-6-ilamino)-8-(4-cijano-2,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((3S,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((3S,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-((3S,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((3S,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((3 S,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((3S,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1s,4s)-4-(8-(4-bromo-2,6-diklorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((3S,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,3-dikloro-4-cijanofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-(metilsulfonil)piperidin-3-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((R)-1-(metilsulfonil)piperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((R)-l-(metilsulfonil)piperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((R)-1-(metilsulfonil)piperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((R)-1-(metilsulfonil)piperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(R)-3-(9-((ls,4S)-4-karbamoilcikloheksil)-8-(2,4,6-triklorofenilamino)-9H-purin-2-ilamino)-N-metilpiperidin-l-karboksamid,
(R)-3-(9-((ls,4S)-4-karbamoilcikloheksil)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-2-ilamino)-N-metilpiperidin-1-karboksamid,
(R)-3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-2-ilamino)-N-metilpiperidin-1-karboksamid,
(R)-metil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-metil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2-kloro-4-cijano-6-fluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(1S,4s)-4-(2-((R)-1-acetilpiperidin-3-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-acetilpiperidin-3-ilamino)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-acetilpiperidin-3-ilamino)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-acetilpiperidin-3-ilamino)-8-(4-kloro-2,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((3S,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((3S,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((3S,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((3S,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(2-((3S,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(2-((3S,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((3S,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((3S,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((3S,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((3S,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((3S,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((3S,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((3S,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-1-metil-4-(2-((3S,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((3S,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-etilpiperidin-3-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((R)-1-etilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((R)-1-etilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-(trifluorometil)fenilamino)-2-((R)-1-etilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-izopropilpiperidin-3-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((R)-1-izopropilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((R)-1-izopropilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((R)-1-izopropilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((R)-1-fenilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-fenilpiperidin-3-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((R)-1-fenilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-((R)-1-fenilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-fenilpiperidin-3-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((R)-1-fenilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((R)-1-fenilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((R)-1-fenilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((R)-1-fenilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-benzilpiperidin-3-ilamino)-8-(2-kloro-4,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-benzilpiperidin-3-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-benzilpiperidin-3-ilamino)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-benzilpiperidin-3-ilamino)-8-(2,6-dikloro-4-(trifluorometil)fenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-benzilpiperidin-3-ilamino)-8-(4-cijano-2,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-benzilpiperidin-3-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-benzilpiperidin-3-ilamino)-8-(4-kloro-2,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-benzilpiperidin-3-ilamino)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-benzilpiperidin-3-ilamino)-8-(2,6-dikloro-4-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((3S,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((3S,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((3S,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((3S,4R)-3-metiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((R)-3,3-dimetiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((3S,4S)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-3,3-dimetiltetrahidro-2H-piran-4-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(R)-izopropil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2-kloro-4,6-difluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-izopropil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,4,6-triklorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-izopropil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-izopropil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,6-dikloro-4-(trifluorometil)fenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-izopropil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(4-cijano-2,6-difluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-izopropil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,4,6-trifluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-izopropil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(4-kloro-2,6-difluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-izopropil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-izopropil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,6-dikloro-4-fluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(R)-izopropil 3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2-kloro-4-cijano-6-fluorofenilamino)-9H-purin-2-ilamino)piperidin-1-karboksilat,
(1S,4s)-4-(2-((R)-1-benzilpiperidin-3-ilamino)-8-(2-kloro-4-cijano-6-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(R)-3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2-kloro-4,6-difluorofenilamino)-9H-purin-2-ilamino)-N-fenilpiperidin-1-karboksamid,
(R)-3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,4,6-triklorofenilamino)-9H-purin-2-ilamino)-N-fenilpiperidin-1-karboksamid,
(R)-3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-2-ilamino)-N-fenilpiperidin-1-karboksamid,
(R)-3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,4,6-trifluorofenilamino)-9H-purin-2-ilamino)-N-fenilpiperidin-1-karboksamid,
(R)-3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(4-kloro-2,6-difluorofenilamino)-9H-purin-2-ilamino)-N-fenilpiperidin-1-karboksamid,
(R)-3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-2-ilamino)-N-fenilpiperidin-1-karboksamid,
(R)-3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,6-dikloro-4-fluorofenilamino)-9H-purin-2-ilamino)-N-fenilpiperidin-1-karboksamid,
(R)-3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2-kloro-4-cijano-6-fluorofenilamino)-9H-purin-2-ilamino)-N-fenilpiperidin-1-karboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((R)-3,3-dimetiltetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((R)-1-tosilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-tosilpiperidin-3-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((R)-1-tosilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-((R)-1-tosilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-tosilpiperidin-3-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((R)-1-tosilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((R)-1-tosilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((R)-1-tosilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((R)-1-tosilpiperidin-3-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(R)-3-(9-((1s,4S)-4-karbamoilcikloheksil)-8-(2,6-dikloro-4-(trifluorometil)fenilamino)-9H-purin-2-ilamino)-N-metilpiperidin-1-karboksamid,
(1S,4s)-4-(2-((R)-1-acetilpiperidin-3-ilamino)-8-(2-kloro-4,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-acetilpiperidin-3-ilamino)-8-(2,6-dikloro-4-(trifluorometil)fenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-acetilpiperidin-3-ilamino)-8-(2,6-dikloro-4-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-acetilpiperidin-3-ilamino)-8-(2,6-diklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-((3S,4R)-3-fluorotetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-(((3R,4S)-3-fluorotetrahidro-2H-piran-4-il)amino)-8-((2,4,6-triklorofenil)amino)-9H-purin-9-il)-1-metilcikloheksan-1-karboksamid,
(1S,4s)-4-(2-(((3S,4R)-3-fluorotetrahidro-2H-piran-4-il)amino)-8-((2,4,6-triklorofenil)amino)-9H-purin-9-il)-1-metilcikloheksan-1-karboksamid,
(1S,4s)-4-(8-((4-kloro-2,6-difluorofenil)amino)-2-(((3S,4R)-3-metiltetrahidro-2H-piran-4-il)amino)-9H-purin-9-il)cikloheksan-1-karboksamid, ili
(1s,4s)-4-(8-((4-kloro-2,6-difluorofenil)amino)-2-((tetrahidro-2H-piran-4-il)amino)-9H-purin-9-il)cikloheksan-1-karboksamid; ili
njihova farmaceutski prihvatljiva sol, tautomer, stereoizomer, enantiomer, ili izotopolog.
5. Spoj, pri čemu spoj je:
(1s,4s)-4-(8-(3-klorofenilamino)-2-(izopropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-klorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,4-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-difluorofenilamino)-2-(1-metilciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(tert-butilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklobutilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklobutilamino)-8-(2,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-(ciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-difluorofenilamino)-2-(izopropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-(izopropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklobutilamino)-8-(2,6-diklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-diklorofenilamino)-2-(izopropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,6-diklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(izopropilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-((1r,4r)-4-metoksicikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-((1r,4r)-4-hidroksicikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(4,4-difluorocikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-klorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,4-diklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2-fluorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1 s,4s)-4-(8-(2,4-diklorofenilamino)-2-(izopropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-fluorofenilamino)-2-(izopropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(izopropilamino)-8-(2,3,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(izopropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4,6-triklorofenilamino)-2-(2,2,2-trifluoroetilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1ls,4s)-4-(2-(ciklobutilmetilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(ciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklobutilamino)-8-(2,6-dikloro-4-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,6-dikloro-4-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-(izopropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(izopropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(izopropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((R)-1-hidroksibutan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(ciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklobutilamino)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((R)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((R)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((R)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((R)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-1-hidroksibutan-2-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,3-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-kloro-2-fluorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,3,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((S)-1-metoksipropan-2-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((S)-1-hidroksibutan-2-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-((S)-1-hidroksibutan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((S)-1-hidroksibutan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((S)-1-hidroksibutan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((S)-1-hidroksibutan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((S)-1-hidroksibutan-2-ilamino)-8-(2,3,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-diklorofenilamino)-2-((S)-1-hidroksibutan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(3-kloro-2-fluorofenilamino)-2-((S)-1-hidroksibutan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((S)-1-hidroksibutan-2-ilamino)-8-(2,3,4-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((R)-2-hidroksipropilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-diklorofenilamino)-2-((S)-1-hidroksibutan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((S)-1-hidroksibutan-2-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((S)-1-hidroksipropan-2-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((S)-1-hidroksipropan-2-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-difluorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-diklorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-diklorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(5-kloro-2-fluorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(3-kloro-2-fluorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-((1-(hidroksimetil)ciklopropil)metilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1-(hidroksimetil)ciklopropil)metilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3R)-3-hidroksiciklopentilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-difluorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-diklorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3R)-3-hidroksiciklopentilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,3-difluorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(3-kloro-2,6-difluorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3R)-3-hidroksiciklopentilamino)-8-(2,3,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-diklorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3R)-3-hidroksiciklopentilamino)-8-(2,3,4-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(3,3-difluorociklobutilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(3,3-difluorociklobutilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(3,3-difluorociklobutilamino)-8-(2,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,3-difluorofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(3,3-difluorociklobutilamino)-8-(2,3,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-kloro-2,6-difluorofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-diklorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-kloro-2-fluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,5-difluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(4,4-difluorocikloheksilamino)-8-(2,3,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-diklorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,2R)-2-hidroksiciklopentilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-((1R,2R)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-difluorofenilamino)-2-((1R,2R)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1R,2R)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-diklorofenilamino)-2-((1R,2R)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,2R)-2-hidroksiciklopentilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1R,2R)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1R,2R)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1R,2R)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,3-difluorofenilamino)-2-((1R,2R)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(3-kloro-2,6-difluorofenilamino)-2-((1R,2R)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,2R)-2-hidroksiciklopentilamino)-8-(2,3,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-diklorofenilamino)-2-((1R,2R)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(5-kloro-2-fluorofenilamino)-2-((1R,2R)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(3-kloro-2-fluorofenilamino)-2-((1R,2R)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,2R)-2-hidroksiciklopentilamino)-8-(2,3,4-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,5-difluorofenilamino)-2-((1R,2R)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((1S,2S)-2-hidroksiciklopentilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-difluorofenilamino)-2-((1S,2S)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-diklorofenilamino)-2-((1S,2S)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1S,2S)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((1S,2S)-2-hidroksiciklopentilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1S,2S)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1S,2S)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(3-kloro-2,6-difluorofenilamino)-2-((1S,2S)-2-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-((1r,3r)-3-hidroksiciklobutilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-diklorofenilamino)-2-((1r,3r)-3-hidroksiciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-((1r,3r)-3-hidroksiciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1r,3r)-3-hidroksiciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1r,3r)-3-hidroksiciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1r,3r)-3-hidroksiciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,3-difluorofenilamino)-2-((1r,3r)-3-hidroksiciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-kloro-2,6-difluorofenilamino)-2-((1r,3r)-3-hidroksiciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-kloro-2,5-difluorofenilamino)-2-((1r,3r)-3-hidroksiciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(4,4-difluorocikloheksilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(4,4-difluorocikloheksilamino)-8-(2,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,3-difluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(3-kloro-2,6-difluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-((1r,3r)-3-hidroksiciklobutilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1r,3r)-3-hidroksiciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,3-difluorofenilamino)-2-((1s,3s)-3-hidroksiciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1s,3s)-3-hidroksiciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-((1s,3s)-3-hidroksiciklobutilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1s,3s)-3-hidroksiciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-((1S,3 S)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-difluorofenilamino)-2-((1S,3S)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-diklorofenilamino)-2-((1S,3S)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1R,3S)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1S,3S)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((1S,3S)-3-hidroksiciklopentilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((1S,3S)-3-hidroksiciklopentilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3S)-3-hidroksiciklopentilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3S)-3-hidroksiciklopentilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-(sec-butilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-(sec-butilamino)-8-(2,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-(sec-butilamino)-8-(2,6-diklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-(sec-butilamino)-8-(2-kloro-6-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-(sec-butilamino)-8-(2-kloro-4,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-(sec-butilamino)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-(sec-butilamino)-8-(3-kloro-2,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3R,4R)-3-hidroksi-4-metilcikloheksilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-((1R,3R,4R)-3-hidroksi-4-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-difluorofenilamino)-2-((1R,3R,4R)-3-hidroksi-4-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1R,3R,4R)-3-hidroksi-4-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-diklorofenilamino)-2-((1R,3R,4R)-3-hidroksi-4-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1R,3R,4R)-3-hidroksi-4-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3S)-3-hidroksicikloheksilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-difluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-diklorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3S)-3-hidroksicikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1R,3R,4R)-3-hidroksi-4-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1R,3R,4R)-3-hidroksi-4-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,3-difluorofenilamino)-2-((1R,3R,4R)-3-hidroksi-4-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(3-kloro-2,6-difluorofenilamino)-2-((1R,3R,4R)-3-hidroksi-4-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3R,4R)-3-hidroksi-4-metilcikloheksilamino)-8-(2,3,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,3-difluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(3-kloro-2,6-difluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,5-difluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3S)-3-hidroksicikloheksilamino)-8-(2,3,4-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-(ciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-diklorofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((1S,3R)-3-hidroksicikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,3-difluorofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(3-kloro-2,6-difluorofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-cijano-2,3-difluorofenilamino)-2-(tetrahidro-2H-piran-4-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1 S,4s)-4-(2-((1R,3R)-3-hidroksi-4,4-dimetilcikloheksilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-difluorofenilamino)-2-((1R,3R)-3-hidroksi-4,4-dimetilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-diklorofenilamino)-2-((1R,3R)-3-hidroksi-4,4-dimetilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-((1R,3R)-3-hidroksi-4,4-dimetilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1R,3R)-3-hidroksi-4,4-dimetilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1R,3R)-3-hidroksi-4,4-dimetilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3R)-3-hidroksi-4,4-dimetilcikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1R,3R)-3-hidroksi-4,4-dimetilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1R,3R)-3-hidroksi-4,4-dimetilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(3-kloro-2,6-difluorofenilamino)-2-((1R,3R)-3-hidroksi-4,4-dimetilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-diklorofenilamino)-2-((1R,3R,4R)-3-hidroksi-4-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklobutilamino)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-(ciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-((S)-1-hidroksibutan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3R)-3-hidroksicikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-diklorofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3R)-3-hidroksicikloheksilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-difluorofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-diklorofenilamino)-2-((1R,3S)-3-hidroksi-3-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1R,3S)-3-hidroksi-3-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1R,3S)-3-hidroksi-3-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1R,3S)-3-hidroksi-3-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1R,3S)-3-hidroksi-3-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4-fluorofenilamino)-2-((1R,3S)-3-hidroksi-3-metilcikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-(izopropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(izopropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((S)-1-hidroksibutan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((S)-1-hidroksibutan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3S)-3-hidroksicikloheptilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-diklorofenilamino)-2-((1R,3S)-3-hidroksicikloheptilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-6-fluorofenilamino)-2-((1R,3S)-3-hidroksicikloheptilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1R,3S)-3-hidroksicikloheptilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1R,3S)-3-hidroksicikloheptilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3S)-3-hidroksicikloheptilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,3-difluorofenilamino)-2-((1R,3S)-3-hidroksicikloheptilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-(izopropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((1S,3R)-3-hidroksicikloheptilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((1S,3 S)-3-hidroksicikloheptilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((1S,3 S)-3-hidroksicikloheptilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(2,2-difluoro-3-hidroksipropilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(2,2-difluoro-3-hidroksipropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-(2,2-difluoro-3-hidroksipropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(2,2-difluoro-3-hidroksipropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-(trifluorometil)fenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((1 S,3 S)-3-hidroksicikloheksilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1S,3 S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1S,3 S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((1S,3S)-3-hidroksicikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1S,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,3-difluorofenilamino)-2-((1S,3 S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1S,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,5-difluorofenilamino)-2-((1S,3 S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1R,2R)-2-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1R,2R)-2-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,2R)-2-hidroksicikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1R,2R)-2-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1R,2R)-2-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((R)-1,1,1-trifluoro-3-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((R)-1,1,1-trifluoro-3-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1r,4r)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1r,4r)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1r,4r)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1r,4r)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4r)-4-(8-(2,6-dikloro-4-(trifluorometil)fenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4r)-4-(2-((S)-1-hidroksipropan-2-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(3-hidroksi-2,2-dimetilpropilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(2-((1R,2S)-2-hidroksicikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4r)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1r,4r)-4-(2-(ciklopentilamino)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1r,4r)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1r,4r)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1r,4r)-4-(2-(ciklopentilamino)-8-(2,6-dikloro-4-(trifluorometil)fenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1r,4r)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1r,4r)-4-(2-(ciklopentilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1r,4r)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1r,4r)-4-(2-(ciklopentilamino)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1r,4r)-4-(2-(ciklopentilamino)-8-(2,6-dikloro-4-fluorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1r,4r)-4-(2-(ciklopentilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1R,4s)-4-(2-((1 S,2R)-2-hidroksicikloheksilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1S,2R)-2-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((1S,2R)-2-hidroksicikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1S,2R)-2-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1S,2R)-2-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((1S,2R)-2-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((1S,2R)-2-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1s,4s)-4-(2-(1-morfolinopropan-2-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4s)-4-(2-((R)-3,3-difluorociklopentilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((S)-1-hidroksipropan-2-ilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(2-((S)-1-hidroksipropan-2-ilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-(trifluorometil)fenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,6-dikloro-4-fluorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,6-dikloro-4-(trifluorometil)fenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3S)-3-hidroksicikloheksilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3S)-3-hidroksicikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-punn-9-il)-1-metilcikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-(ciklopentilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-(trifluorometil)fenilamino)-2-((1R,3 S)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1s,4s)-4-(2-(3,3-difluorociklobutilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1s,4s)-4-(2-(3,3-difluorociklobutilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-(trifluorometil)fenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((S)-3,3-difluorociklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((R)-3,3-difluorociklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((S)-3,3-difluorociklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((R)-3,3-difluorociklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((S)-3,3-difluorociklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((R)-3,3-difluorociklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((S)-3,3-difluorociklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((R)-3,3-difluorociklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((S)-3,3-difluorociklopentilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-((S)-3,3-difluorociklopentilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-(trifluorometoksi)fenilamino)-2-((1R,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-(trifluorometoksi)fenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,6-dikloro-4-(trifluorometoksi)fenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklobutilamino)-8-(2,6-dikloro-4-(trifluorometoksi)fenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1s,4s)-4-(2-(ciklobutilamino)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-(ciklobutilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-(ciklobutilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklobutilamino)-8-(2,6-dikloro-4-(trifluorometil)fenilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1s,4s)-4-(2-(ciklobutilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(ciklobutilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklobutilamino)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklobutilamino)-8-(2,6-dikloro-4-fluorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklobutilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(ciklobutilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid,
(1R,4s)-4-(2-((1S,3S)-3-hidroksicikloheksilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1S,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(2-((1S,3S)-3-hidroksicikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1S,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1S,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1S,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((1S,3S)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((1S,3 S)-3-hidroksicikloheksilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3R)-3-hidroksicikloheksilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3R)-3-hidroksicikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(2-((1 S,3R)-3-hidroksicikloheksilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(2-((1S,3R)-3-hidroksicikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3R)-3-hidroksiciklopentilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(2-((1R,3R)-3-hidroksiciklopentilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1S,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(2-((1S,3 S)-3-hidroksiciklopentilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-((1S,3S)-3-hidroksiciklopentilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(2-((1S,3S)-3-hidroksiciklopentilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1S,3S)-3-hidroksiciklopentilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((1S,3S)-3-hidroksiciklopentilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-((1S,3S)-3-hidroksiciklopentilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((1S,3S)-3-hidroksiciklopentilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((1S,3S)-3-hidroksiciklopentilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)- 1-metilcikloheksankarboksamid,
(1R,4s)-4-(2-(((1S,2S)-2-hidroksicikloheksil)metilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(((1S,2S)-2-hidroksicikloheksil)metilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-(((1S,2S)-2-hidroksicikloheksil)metilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(((1 S,2S)-2-hidroksicikloheksil)metilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-(((1 S,2S)-2-hidroksicikloheksil)metilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(((1 S,2S)-2-hidroksicikloheksil)metilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-(((1S,2S)-2-hidroksicikloheksil)metilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(((1S,2S)-2-hidroksicikloheksil)metilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4,6-difluorofenilamino)-2-(((1S,2R)-2-hidroksicikloheksil)metilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(2-(((1S,2R)-2-hidroksicikloheksil)metilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(((1 S,2R)-2-hidroksicikloheksil)metilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(((1 S,2R)-2-hidroksicikloheksil)metilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-(((1S,2R)-2-hidroksicikloheksil)metilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(((1S,2R)-2-hidroksicikloheksil)metilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(3,3-difluorociklobutilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(4-(2,5-dioksopirolidin-1-il)cikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(4-(2,5-dioksopirolidin-1-il)cikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(4-(1,2,4-oksadiazol-5-il)cikloheksilamino)-8-(2,4-dikloro-6-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(4-(1,2,4-oksadiazol-5-il)cikloheksilamino)-8-(2-kloro-4,6-difluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(4-(1,2,4-oksadiazol-5-il)cikloheksilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(4-(1,2,4-oksadiazol-5-il)cikloheksilamino)-8-(2,6-dikloro-4-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(4-(1,2,4-oksadiazol-5-il)cikloheksilamino)-8-(2-kloro-4-cijano-6-fluorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(4-(1,2,4-oksadiazol-5-il)cikloheksilamino)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((1R,3R)-3-hidroksiciklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((1R,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((1S,3 S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((1S,3 S)-3-hidroksicikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(4-bromo-2,6-diklorofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(ciklopentilamino)-8-(2,3-dikloro-4-cijanofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1R,4s)-4-(8-(2,3-dikloro-4-cijanofenilamino)-2-((S)-1-hidroksipropan-2-ilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,3-dikloro-4-cijanofenilamino)-2-(4,4-difluorocikloheksilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(4-cijano-2,6-difluorofenilamino)-2-((R)-3,3-difluorociklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2-kloro-4-cijano-6-fluorofenilamino)-2-((R)-3,3-difluorociklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1S,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-((R)-3,3-difluorociklopentilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(2-(3-(metilsulfonil)ciklobutilamino)-8-(2,4,6-triklorofenilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-cijanofenilamino)-2-(3-(metilsulfonil)ciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-(3-(metilsulfonil)ciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid,
(1s,4s)-4-(8-(2,6-dikloro-4-(trifluorometil)fenilamino)-2-(3-(metilsulfonil)ciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid, ili
(1s,4s)-4-(8-(4-kloro-2,6-difluorofenilamino)-2-(3-(metilsulfonil)ciklobutilamino)-9H-purin-9-il)cikloheksankarboksamid; ili
njihova farmaceutski prihvatljiva sol, tautomer, stereoizomer, enantiomer, ili izotopolog.
6. Spoj prema zahtjevu 5, pri čemu spoj je (1s,4s)-4-(2-(ciklobutilamino)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-9-il)cikloheksankarboksamid.
7. Spoj prema zahtjevu 5, pri čemu spoj je (1s,4s)-4-(2-(ciklobutilamino)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid.
8. Spoj prema zahtjevu 5, pri čemu spoj je (1s,4s)-4-(2-(3,3-difluorociklobutilamino)-8-(2,4,6-trifluorofenilamino)-9H-purin-9-il)-1-metil cikloheksankarboksamid.
9. Spoj prema zahtjevu 5, pri čemu spoj je (1s,4s)-4-(2-(ciklopentilamino)-8-(2,6-dikloro-4-cijanofenilamino)-9H-purin-9-il)cikloheksankarboksamid.
10. Spoj prema zahtjevu 5, pri čemu spoj je (1S,4s)-4-(8-(2,6-dikloro-4-fluorofenilamino)-2-((R)-3,3-difluorociklopentilamino)-9H-purin-9-il)cikloheksankarboksamid.
11. Spoj prema zahtjevu 4, pri čemu spoj je (1R,4s)-4-(2-(((3R,4S)-3-fluorotetrahidro-2H-piran-4-il)amino)-8-((2,4,6-triklorofenil)amino)-9H-purin-9-il)-1-metilcikloheksan-1-karboksamid.
12. Spoj prema zahtjevu 5, pri čemu spoj je (1R,4s)-4-(8-(2,4-dikloro-6-fluorofenilamino)-2-((1S,3R)-3-hidroksicikloheksilamino)-9H-purin-9-il)-1-metilcikloheksankarboksamid.
13. Spoj prema zahtjevu 4, pri čemu spoj je (1S,4s)-4-(2-(((3S,4R)-3-fluorotetrahidro-2H-piran-4-il)amino)-8-((2,4,6-triklorofenil)amino)-9H-purin-9-il)-1-metilcikloheksan-1-karboksamid.
14. Spoj prema zahtjevu 4, pri čemu spoj je (1S,4s)-4-(8-((4-kloro-2,6-difluorofenil)amino)-2-(((3S,4R)-3-metiltetrahidro-2H-piran-4-il)amino)-9H-purin-9-il)cikloheksan-1-karboksamid.
15. Spoj prema zahtjevu 4, pri čemu spoj je (1s,4s)-4-(8-((4-kloro-2,6-difluorofenil)amino)-2-((tetrahidro-2H-piran-4-il)amino)-9H-purin-9-il)cikloheksan-1-karboksamid.
16. Spoj prema bilo kojem od zahtjeva 1-15, pri čemu spoj pri koncentraciji od 10 µM usporava proliferaciju stanica melanoma od barem oko 50 %.
17. Farmaceutski sastav koji sadrži efikasnu količinu spoja prema bilo kojem od zahtjeva 1-16, te farmaceutski prihvatljivi nosač, ekscipijent ili transportno sredstvo.
18. Postupak usporavanja kinaze u stanici koja ekspresira spomenutu kinazu, koji sadrži dovođenje u kontakt spomenute stanice s efikasnom količinom spoja prema bilo kojem od zahtjeva 1-16, pri čemu je postupak in vitro postupak ili ex vivo postupak.
19. Spoj prema bilo kojem od zahtjeva 1-16 za uporabu u postupku liječenja ili prevencije melanoma, pri čemu postupak sadrži primjenu efikasne količine spoja kod subjekta kome je to potrebno.
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| SI3204386T1 (sl) * | 2014-10-06 | 2021-08-31 | Signal Pharmaceuticals, Llc | Substituirane spojine aminopurina, njihove sestave in načini zdravljenja v povezavi z njimi |
| WO2016100308A1 (en) | 2014-12-16 | 2016-06-23 | Signal Pharmaceuticals, Llc | Methods for measurement of inhibition of c-jun n-terminal kinase in skin |
| WO2016123291A1 (en) | 2015-01-29 | 2016-08-04 | Signal Pharmaceuticals, Llc | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| CA2980159A1 (en) | 2015-03-18 | 2016-09-22 | Bristol-Myers Squibb Company | Substituted tricyclic heterocyclic compounds |
| JP6779899B2 (ja) | 2015-03-18 | 2020-11-04 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｔｎｆ阻害剤として有用なヘテロ環式化合物 |
| US10308652B2 (en) | 2015-03-18 | 2019-06-04 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds useful as inhibitors of TNF |
| JP6805232B2 (ja) | 2015-07-24 | 2020-12-23 | セルジーン コーポレイション | （１ｒ，２ｒ，５ｒ）−５−アミノ−２−メチルシクロヘキサノール塩酸塩の合成方法及びそれに有用な中間体 |
| CA2994703A1 (en) | 2015-08-03 | 2017-02-09 | Bristol-Myers Squibb Company | Cyclic compounds useful as modulators of tnf alpha |
| AU2017240050B2 (en) * | 2016-04-01 | 2021-12-16 | Signal Pharmaceuticals, Llc | Solid forms of (1s,4s)-4-(2-(((3S4R)-3-fluorotetrahydro-2H-pyran-4-yl) amino)-8-((2,4,6-trichlorophenyl) amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide and methods of their use |
| CN109069512B (zh) * | 2016-04-01 | 2022-06-14 | 西格诺药品有限公司 | 取代的氨基嘌呤化合物、其组合物以及相关治疗方法 |
| CN109563095B (zh) * | 2016-06-02 | 2021-10-29 | 细胞基因公司 | 动物和人抗疟剂 |
| CN109476696B (zh) | 2016-06-02 | 2022-06-10 | 细胞基因公司 | 动物及人抗锥虫和抗利什曼原虫剂 |
| JP7287955B2 (ja) | 2017-10-04 | 2023-06-06 | セルジーン コーポレイション | シス－４－［２－｛［（３ｓ，４ｒ）－３－フルオロオキサン－４－イル］アミノ｝－８－（２，４，６－トリクロロアニリノ）－９ｈ－プリン－９－イル］－１－メチルシクロヘキサン－１－カルボキサミドの組成物及び使用方法 |
| US10590136B2 (en) | 2017-10-04 | 2020-03-17 | Celgene Corporation | Processes for the preparation of cis-4-[2-{[(3S,4R)-3-fluorooxan-4-yl]amino}-8-(2,4,6-trichloroanilino)-9H-purin-9-yl]-1-methylcyclohexane-1-carboxamide |
| TW202202498A (zh) * | 2020-07-01 | 2022-01-16 | 大陸商四川海思科製藥有限公司 | 一種並環雜環衍生物及其在醫藥上的應用 |
| CN114478326B (zh) * | 2022-01-21 | 2023-10-03 | 安徽宁亿泰科技有限公司 | 一种苯嘧磺草胺关键中间体的合成方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL99699A (en) | 1990-10-10 | 2002-04-21 | Autoimmune Inc | Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes |
| FI109088B (fi) | 1997-09-19 | 2002-05-31 | Leiras Oy | Tabletti ja menetelmä sen valmistamiseksi |
| CZ27399A3 (cs) * | 1999-01-26 | 2000-08-16 | Ústav Experimentální Botaniky Av Čr | Substituované dusíkaté heterocyklické deriváty, způsob jejich přípravy, tyto deriváty pro použití jako léčiva, farmaceutická kompozice a kombinovaný farmaceutický přípravek tyto deriváty obsahující a použití těchto derivátů pro výrobu léčiv |
| US7672705B2 (en) * | 2004-07-19 | 2010-03-02 | Resonant Medical, Inc. | Weighted surface-to-surface mapping |
| US7759342B2 (en) | 2005-01-13 | 2010-07-20 | Signal Pharmaceuticals, Llc | Methods of treatment and prevention using haloaryl substituted aminopurines |
| US7521446B2 (en) | 2005-01-13 | 2009-04-21 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
| US7723340B2 (en) | 2005-01-13 | 2010-05-25 | Signal Pharmaceuticals, Llc | Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith |
| WO2007062338A2 (en) | 2005-11-18 | 2007-05-31 | Astrazeneca Ab | Solid formulations |
| JO3235B1 (ar) | 2006-05-26 | 2018-03-08 | Astex Therapeutics Ltd | مركبات بيررولوبيريميدين و استعمالاتها |
| JP5523833B2 (ja) | 2006-10-27 | 2014-06-18 | シグナル ファーマシューティカルズ，エルエルシー | ４−［９−（テトラヒドロ−フラン−３−イル）−８−（２，４，６−トリフルオロ−フェニルアミノ）−９ｈ−プリン−２−イルアミノ］−シクロヘキサン−１−オールを含む固体形態、それらの組成物、及びそれらの使用 |
| US8491930B2 (en) | 2008-04-23 | 2013-07-23 | Farmasierra Manufacturing, S.L. | Pharmaceutical formulation containing ibuprofen and codeine |
| WO2011071491A1 (en) | 2009-12-09 | 2011-06-16 | Signal Pharmaceuticals, Llc | Isotopologues of 4-[9-(tetrahydro-furan-3-yl)-8-(2, 4, 6- trifluoro-phenylamino)-9h-purin-2-ylamino]-cyclohexan-1-ol |
| US8680076B2 (en) * | 2010-10-25 | 2014-03-25 | Signal Pharmaceuticals, Llc | Methods of treatment, improvement and prevention using haloaryl substituted aminopurines |
| US8603527B2 (en) | 2010-10-25 | 2013-12-10 | Signal Pharmaceuticals, Llc | Pharmaceutical formulations of a substituted diaminopurine |
| US20160082015A1 (en) | 2013-04-18 | 2016-03-24 | President And Fellows Of Harvard College | Methods, compositions and kits for promoting motor neuron survival and treating and diagnosing neurodegenerative disorders |
| GB201321737D0 (en) | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| SI3204386T1 (sl) | 2014-10-06 | 2021-08-31 | Signal Pharmaceuticals, Llc | Substituirane spojine aminopurina, njihove sestave in načini zdravljenja v povezavi z njimi |
| AU2017240050B2 (en) | 2016-04-01 | 2021-12-16 | Signal Pharmaceuticals, Llc | Solid forms of (1s,4s)-4-(2-(((3S4R)-3-fluorotetrahydro-2H-pyran-4-yl) amino)-8-((2,4,6-trichlorophenyl) amino)-9H-purin-9-yl)-1-methylcyclohexane-1-carboxamide and methods of their use |
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