HRP20210025T1 - Farmaceutske kompozicije koje sadrže levodop, inhibitor dopaminske dekarboksilaze i komt inhibitor i metoda administracije istih - Google Patents

Farmaceutske kompozicije koje sadrže levodop, inhibitor dopaminske dekarboksilaze i komt inhibitor i metoda administracije istih Download PDF

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Publication number
HRP20210025T1
HRP20210025T1 HRP20210025TT HRP20210025T HRP20210025T1 HR P20210025 T1 HRP20210025 T1 HR P20210025T1 HR P20210025T T HRP20210025T T HR P20210025TT HR P20210025 T HRP20210025 T HR P20210025T HR P20210025 T1 HRP20210025 T1 HR P20210025T1
Authority
HR
Croatia
Prior art keywords
inhibitor
gel composition
composition according
komt
pharmaceutical gel
Prior art date
Application number
HRP20210025TT
Other languages
English (en)
Croatian (hr)
Inventor
Roger BOLSÖY
Original Assignee
Lobsor Pharmaceuticals Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE1451034A external-priority patent/SE538425C2/en
Application filed by Lobsor Pharmaceuticals Aktiebolag filed Critical Lobsor Pharmaceuticals Aktiebolag
Publication of HRP20210025T1 publication Critical patent/HRP20210025T1/hr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/275Nitriles; Isonitriles
    • A61K31/277Nitriles; Isonitriles having a ring, e.g. verapamil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38Cellulose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HRP20210025TT 2014-09-04 2015-09-04 Farmaceutske kompozicije koje sadrže levodop, inhibitor dopaminske dekarboksilaze i komt inhibitor i metoda administracije istih HRP20210025T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE1451034A SE538425C2 (en) 2014-09-04 2014-09-04 Pharmaceutical compositions comprising levodopa, carbidopa and a comt inhibitor and method of administration thereof
SE1550344 2015-03-24
EP15838800.9A EP3188725B1 (en) 2014-09-04 2015-09-04 Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a comt inhibitor and method of administration thereof
PCT/SE2015/050939 WO2016036308A1 (en) 2014-09-04 2015-09-04 Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a comt inhibitor and method of administration thereof

Publications (1)

Publication Number Publication Date
HRP20210025T1 true HRP20210025T1 (hr) 2021-03-05

Family

ID=55440194

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20210025TT HRP20210025T1 (hr) 2014-09-04 2015-09-04 Farmaceutske kompozicije koje sadrže levodop, inhibitor dopaminske dekarboksilaze i komt inhibitor i metoda administracije istih
HRP20240314TT HRP20240314T1 (hr) 2014-09-04 2015-09-04 Farmaceutske gel kompozicije koje sadrže levodopu, karbidopu i entakapon

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20240314TT HRP20240314T1 (hr) 2014-09-04 2015-09-04 Farmaceutske gel kompozicije koje sadrže levodopu, karbidopu i entakapon

Country Status (16)

Country Link
US (5) US10071069B2 (enExample)
EP (3) EP3782617B1 (enExample)
JP (2) JP6622310B2 (enExample)
CN (1) CN107072973A (enExample)
AU (3) AU2015312430B2 (enExample)
CA (2) CA3175785A1 (enExample)
DK (2) DK3782617T3 (enExample)
ES (2) ES2844500T3 (enExample)
FI (1) FI3782617T3 (enExample)
HR (2) HRP20210025T1 (enExample)
HU (2) HUE066097T2 (enExample)
PL (2) PL3188725T3 (enExample)
PT (2) PT3188725T (enExample)
RS (1) RS65337B1 (enExample)
SI (2) SI3188725T1 (enExample)
WO (1) WO2016036308A1 (enExample)

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WO2016036308A1 (en) 2014-09-04 2016-03-10 Lobsor Pharmaceuticals Aktiebolag Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a comt inhibitor and method of administration thereof
RU2017120184A (ru) * 2014-11-28 2018-12-28 БИАЛ - ПОРТЕЛА ЭНД Ка, С.А. Лекарства для замедления течения болезни паркинсона
KR20180004756A (ko) 2015-05-06 2018-01-12 신애질 코포레이션 약물 입자를 함유하는 제약 현탁액, 그의 투여를 위한 장치, 및 그의 사용 방법
WO2017039525A1 (en) 2015-09-04 2017-03-09 Lobsor Pharmaceuticals Aktiebolag Method of treating a dopamine related disorder in a subject by administering levodopa, in combination with a dopamine decarboxylase inhibitor and a catechol-o-methyltransferase inhibitor
WO2017177262A1 (en) 2016-04-11 2017-10-19 University Of Canberra Ophthalmic compositions comprising levodopa, an antioxidant and an aqueous carrier
WO2018017850A1 (en) * 2016-07-20 2018-01-25 Abbvie Inc. Levodopa and carbidopa intestinal gel and methods of use
EP3275433A1 (en) * 2016-07-29 2018-01-31 Som Innovation Biotech S.L. Sustained release composition comprising micronized tolcapone
ES2886088T3 (es) 2017-02-13 2021-12-16 Bayer Animal Health Gmbh Composición líquida que contiene pradofloxacina
WO2019129120A1 (en) * 2017-12-28 2019-07-04 Rpxds Co., Ltd Tolcapone for prevention and/or treatment of obesity and related metabolic diseases
EP3768263B1 (en) * 2018-03-23 2025-10-29 LobSor Pharmaceuticals Aktiebolag Continuous administration of pharmaceutical composition for treatment of neurodegenerative disorders
EP3593819A1 (en) * 2018-07-10 2020-01-15 Medday Pharmaceuticals Compositions for therapeutic uses containing 5-htp and carbidopa
MX368750B (es) * 2018-08-31 2019-10-15 Cell Therapy And Tech S A De C V Composiciones farmaceuticas semisolidas de base oleosa conteniendo pirfenidona para su aplicacion en la reparacion tisular.
JP2022514659A (ja) * 2018-12-18 2022-02-14 イーライ リリー アンド カンパニー ドーパミン作動性cns障害の治療におけるly3154207の使用のための用量レジメン
JP7506371B2 (ja) * 2020-01-20 2024-06-26 国立大学法人浜松医科大学 ドーパミン減少抑制剤
CN115335036A (zh) * 2020-03-13 2022-11-11 巴尔-波特拉及康邦亚股份有限公司 微粉化的奥匹卡朋
CN111643493B (zh) * 2020-05-26 2023-01-10 上海京新生物医药有限公司 一种高浓度左旋多巴制剂及其制备方法及其应用
SI4200280T1 (sl) 2020-10-07 2024-04-30 Eli Lilly And Company Derivati fenil-3,4-dihidroizokvinolin-2(1H)-il-etan-1-ona kot pozitivni alosterični modulatorji dopamin D1 receptorja
WO2022158991A1 (en) * 2021-01-20 2022-07-28 Bial-Portela & Ca., S.A. Treatment of pain associated with parkinson's disease with opicapone in combination with levodopa
WO2025162373A1 (en) * 2024-01-30 2025-08-07 National Institute Of Biological Sciences, Beijing Electrophile-containing catechol-o-methyltransferase (comt) inhibitors for targeting the keap1/nrf2 pathway

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GB9004348D0 (en) 1990-02-27 1990-04-25 Orion Yhtymae Oy New use of catechol derivatives and their physiologically acceptable salts and esters
SE9203594D0 (sv) 1992-11-30 1992-11-30 Christer Nystroem Laekemedel i dispersa system
HK1041441A1 (zh) * 1998-11-10 2002-07-12 Teva Pharmaceutical Industries, Ltd. 包含l-多巴乙酯的可分散组合物
FI109453B (fi) 1999-06-30 2002-08-15 Orion Yhtymae Oyj Farmaseuttinen koostumus
US20100221321A1 (en) 2003-02-27 2010-09-02 Innercap Technologies, Inc. Apparatus And Methods For Delivering A Plurality Of Medicaments For Management Of Co-Morbid Diseases, Illnesses Or Conditions
ATE495739T1 (de) 2003-08-29 2011-02-15 Transform Pharmaceuticals Inc Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa
ES2360759T3 (es) * 2003-08-29 2011-06-08 Centocor Ortho Biotech Inc. Composiciones farmacéuticas y procedimiento de utilización de la levodopa y de la carbidopa.
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ATE510537T1 (de) * 2008-02-06 2011-06-15 Wockhardt Research Center Pharmazeutische zusammensetzungen von entacapon, levodopa und carbidopa mit verbesserter bioverfügbarkeit
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SE538425C2 (en) 2014-09-04 2016-06-21 Lobsor Pharmaceuticals Ab Pharmaceutical compositions comprising levodopa, carbidopa and a comt inhibitor and method of administration thereof
WO2016036308A1 (en) 2014-09-04 2016-03-10 Lobsor Pharmaceuticals Aktiebolag Pharmaceutical compositions comprising levodopa, a dopamine decarboxylase inhibitor and a comt inhibitor and method of administration thereof
WO2017039525A1 (en) 2015-09-04 2017-03-09 Lobsor Pharmaceuticals Aktiebolag Method of treating a dopamine related disorder in a subject by administering levodopa, in combination with a dopamine decarboxylase inhibitor and a catechol-o-methyltransferase inhibitor

Also Published As

Publication number Publication date
US10071069B2 (en) 2018-09-11
US20220362193A1 (en) 2022-11-17
CA2959307A1 (en) 2016-03-10
US12156858B2 (en) 2024-12-03
JP6622310B2 (ja) 2019-12-18
HRP20240314T1 (hr) 2024-05-24
US20180338944A1 (en) 2018-11-29
EP3782617B1 (en) 2024-01-03
JP6889231B2 (ja) 2021-06-18
CA2959307C (en) 2023-03-28
AU2020239682A1 (en) 2020-10-15
AU2022200291B2 (en) 2024-01-25
CN107072973A (zh) 2017-08-18
AU2022200291A1 (en) 2022-02-10
US20170231937A1 (en) 2017-08-17
HUE052857T2 (hu) 2021-05-28
ES2973289T3 (es) 2024-06-19
AU2015312430B2 (en) 2020-06-25
ES2844500T3 (es) 2021-07-22
HUE066097T2 (hu) 2024-07-28
AU2020239682B2 (en) 2021-12-23
EP4356907A1 (en) 2024-04-24
DK3782617T3 (da) 2024-03-04
CA3175785A1 (en) 2016-03-10
EP3782617A1 (en) 2021-02-24
PT3782617T (pt) 2024-02-29
FI3782617T3 (fi) 2024-03-13
PL3188725T3 (pl) 2021-08-02
EP3188725B1 (en) 2020-10-28
PT3188725T (pt) 2021-01-27
US10786472B2 (en) 2020-09-29
WO2016036308A1 (en) 2016-03-10
EP3188725A1 (en) 2017-07-12
US20250041257A1 (en) 2025-02-06
JP2017527623A (ja) 2017-09-21
DK3188725T3 (da) 2021-01-18
RS65337B1 (sr) 2024-04-30
PL3782617T3 (pl) 2024-06-24
US20210023033A1 (en) 2021-01-28
SI3188725T1 (sl) 2021-04-30
SI3782617T1 (sl) 2024-04-30
US11413262B2 (en) 2022-08-16
AU2015312430A1 (en) 2017-03-30
EP3188725A4 (en) 2018-04-25
JP2020045353A (ja) 2020-03-26

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