HRP20200610T1 - Rekombinantni mycobacterium kao cjepivo za uporabu kod ljudi - Google Patents
Rekombinantni mycobacterium kao cjepivo za uporabu kod ljudi Download PDFInfo
- Publication number
- HRP20200610T1 HRP20200610T1 HRP20200610TT HRP20200610T HRP20200610T1 HR P20200610 T1 HRP20200610 T1 HR P20200610T1 HR P20200610T T HRP20200610T T HR P20200610TT HR P20200610 T HRP20200610 T HR P20200610T HR P20200610 T1 HRP20200610 T1 HR P20200610T1
- Authority
- HR
- Croatia
- Prior art keywords
- mycobacterium bovis
- recombinant
- recombinant mycobacterium
- bovis cell
- cell
- Prior art date
Links
- 241000186359 Mycobacterium Species 0.000 title claims 4
- 229960005486 vaccine Drugs 0.000 title claims 2
- 241000186366 Mycobacterium bovis Species 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- YQYJSBFKSSDGFO-UHFFFAOYSA-N Epihygromycin Natural products OC1C(O)C(C(=O)C)OC1OC(C(=C1)O)=CC=C1C=C(C)C(=O)NC1C(O)C(O)C2OCOC2C1O YQYJSBFKSSDGFO-UHFFFAOYSA-N 0.000 claims 1
- 108010046334 Urease Proteins 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (7)
1. Rekombinantni Mycobacterium bovis soj stanica danskog podtipa Prag što je oskudan ureazom i koji sadrži rekombinantnu molekulu nukleinske kiseline koja kodira fuzijski polipeptid kako je prikazano u SEQ ID NO: 1, naznačen time što sadrži:
(a) Mycobacterium antigen koji sadrži aminokiselinsku sekvencu kodiranu nukleotidima 121-153 iz SEQ ID NO: 1 i
(b) fagolizosomalnu domenu bijega koja sadrži aminokiselinsku sekvencu kodiranu nukleotidima 211-1722 iz SEQ ID NO: 1.
2. Rekombinantna Mycobacterium bovis stanica iz zahtjeva 1, naznačena time što rekombinantna Mycobacterium bovis stanica nosi gen za rezistenciju na antibiotike, npr. gen za otpornost na higromicin.
3. Rekombinantna Mycobacterium bovis stanica iz zahtjeva 1, naznačena time što rekombinantna Mycobacterium bovis stanica ne nosi gen za rezistenciju na antibiotike.
4. Rekombinantna Mycobacterium bovis stanica iz zahtjeva 1 ili 2, koja je okarakterizirana kao rBCG ΔUrec :: Hly+ :: Hyg+.
5. Rekombinantna Mycobacterium bovis stanica iz bilo kojeg od zahtjeva 1-4, za uporabu kao cjepivo na ljudskim ispitanicima.
6. Rekombinantna Mycobacterium bovis stanica za uporabu prema zahtjevu 5, naznačena time što ljudski ispitanik je ispitanik koji prethodno nije bio izložen Mycobacterium, npr. novorođenče.
7. Rekombinantna Mycobacterium bovis stanica za uporabu prema zahtjevu 5, naznačena time što ljudski ispitanik je ispitanik prethodno izložen Mycobacteriumu.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38437510P | 2010-09-20 | 2010-09-20 | |
| EP18161921.4A EP3360569B1 (en) | 2010-09-20 | 2011-09-16 | Recombinant mycobacterium as vaccine for use in humans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20200610T1 true HRP20200610T1 (hr) | 2020-10-02 |
Family
ID=44645725
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20181387TT HRP20181387T1 (hr) | 2010-09-20 | 2018-08-29 | Rekombinantna mikobakterija kao cjepivo za korištenje na ljudima |
| HRP20200610TT HRP20200610T1 (hr) | 2010-09-20 | 2020-04-09 | Rekombinantni mycobacterium kao cjepivo za uporabu kod ljudi |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20181387TT HRP20181387T1 (hr) | 2010-09-20 | 2018-08-29 | Rekombinantna mikobakterija kao cjepivo za korištenje na ljudima |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9084749B2 (hr) |
| EP (2) | EP3360569B1 (hr) |
| JP (1) | JP5919276B2 (hr) |
| KR (1) | KR101907222B1 (hr) |
| CN (1) | CN103118703A (hr) |
| AU (1) | AU2011304385B2 (hr) |
| BR (1) | BR112013006245A2 (hr) |
| CA (1) | CA2811158C (hr) |
| CU (1) | CU24182B1 (hr) |
| CY (2) | CY1120748T1 (hr) |
| DK (2) | DK2618837T3 (hr) |
| EA (1) | EA026661B1 (hr) |
| ES (2) | ES2685928T3 (hr) |
| HK (1) | HK1258603A1 (hr) |
| HR (2) | HRP20181387T1 (hr) |
| HU (2) | HUE039038T2 (hr) |
| LT (2) | LT3360569T (hr) |
| MX (1) | MX346708B (hr) |
| PL (2) | PL2618837T3 (hr) |
| PT (2) | PT3360569T (hr) |
| RS (2) | RS60146B1 (hr) |
| SG (1) | SG188595A1 (hr) |
| SI (2) | SI2618837T1 (hr) |
| UA (1) | UA112297C2 (hr) |
| WO (1) | WO2012038348A1 (hr) |
| ZA (1) | ZA201301187B (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2654783T3 (pl) | 2010-12-21 | 2017-08-31 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Rekombinowane Mycobacterium jako szczepionka |
| EP3090757A1 (en) | 2015-05-04 | 2016-11-09 | Vakzine Projekt Management GmbH | Recombinant mycobacterium as an immunotherapeutic agent for the treatment of cancer |
| KR102338845B1 (ko) | 2020-05-22 | 2021-12-13 | 서울대학교산학협력단 | 플랩 구동 장치 및 회전익기의 블레이드 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5733151A (en) | 1996-08-23 | 1998-03-31 | Edsall; David | Electrical clamping connection device |
| AUPO761697A0 (en) | 1997-06-30 | 1997-07-24 | Cardiac Crc Nominees Pty Limited | Process for the purification of polyethers |
| EP0902086A1 (en) * | 1997-08-22 | 1999-03-17 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Tuberculosis vaccine |
| CN1513551A (zh) * | 2002-09-09 | 2004-07-21 | 丛繁滋 | 复合生物制品组合物及其制备方法 |
| ATE473238T1 (de) | 2003-04-23 | 2010-07-15 | Max Planck Gesellschaft | Tuberkulose vaccine mit verbesserter effizienz |
| EP1649869A1 (en) | 2004-10-21 | 2006-04-26 | Vakzine Projekt Management GmbH | Combination of a recombinant mycobacterium and a biologically active agent as a vaccine |
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2011
- 2011-09-16 AU AU2011304385A patent/AU2011304385B2/en active Active
- 2011-09-16 CU CUP2013000041A patent/CU24182B1/es active IP Right Grant
- 2011-09-16 KR KR1020137006766A patent/KR101907222B1/ko active IP Right Grant
- 2011-09-16 US US13/822,706 patent/US9084749B2/en active Active
- 2011-09-16 UA UAA201303087A patent/UA112297C2/uk unknown
- 2011-09-16 LT LTEP18161921.4T patent/LT3360569T/lt unknown
- 2011-09-16 SG SG2013020102A patent/SG188595A1/en unknown
- 2011-09-16 PT PT181619214T patent/PT3360569T/pt unknown
- 2011-09-16 HU HUE11755362A patent/HUE039038T2/hu unknown
- 2011-09-16 RS RS20200356A patent/RS60146B1/sr unknown
- 2011-09-16 BR BR112013006245A patent/BR112013006245A2/pt not_active Application Discontinuation
- 2011-09-16 LT LTEP11755362.8T patent/LT2618837T/lt unknown
- 2011-09-16 SI SI201131557T patent/SI2618837T1/sl unknown
- 2011-09-16 PL PL11755362T patent/PL2618837T3/pl unknown
- 2011-09-16 MX MX2013002989A patent/MX346708B/es active IP Right Grant
- 2011-09-16 HU HUE18161921A patent/HUE048774T2/hu unknown
- 2011-09-16 PT PT11755362T patent/PT2618837T/pt unknown
- 2011-09-16 SI SI201131865T patent/SI3360569T1/sl unknown
- 2011-09-16 EP EP18161921.4A patent/EP3360569B1/en active Active
- 2011-09-16 ES ES11755362.8T patent/ES2685928T3/es active Active
- 2011-09-16 CN CN2011800450826A patent/CN103118703A/zh active Pending
- 2011-09-16 CA CA2811158A patent/CA2811158C/en active Active
- 2011-09-16 JP JP2013528689A patent/JP5919276B2/ja active Active
- 2011-09-16 EA EA201300380A patent/EA026661B1/ru not_active IP Right Cessation
- 2011-09-16 WO PCT/EP2011/066131 patent/WO2012038348A1/en active Application Filing
- 2011-09-16 ES ES18161921T patent/ES2784451T3/es active Active
- 2011-09-16 DK DK11755362.8T patent/DK2618837T3/en active
- 2011-09-16 PL PL18161921T patent/PL3360569T3/pl unknown
- 2011-09-16 DK DK18161921.4T patent/DK3360569T3/da active
- 2011-09-16 EP EP11755362.8A patent/EP2618837B1/en active Active
- 2011-09-16 RS RS20180978A patent/RS57574B1/sr unknown
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2013
- 2013-02-15 ZA ZA2013/01187A patent/ZA201301187B/en unknown
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2018
- 2018-08-29 HR HRP20181387TT patent/HRP20181387T1/hr unknown
- 2018-09-04 CY CY181100918T patent/CY1120748T1/el unknown
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2019
- 2019-01-18 HK HK19100962.3A patent/HK1258603A1/zh unknown
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2020
- 2020-04-07 CY CY20201100331T patent/CY1123049T1/el unknown
- 2020-04-09 HR HRP20200610TT patent/HRP20200610T1/hr unknown
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