HRP20192334T1 - Makrociklički inhibitori kinaze rip2 - Google Patents
Makrociklički inhibitori kinaze rip2 Download PDFInfo
- Publication number
- HRP20192334T1 HRP20192334T1 HRP20192334TT HRP20192334T HRP20192334T1 HR P20192334 T1 HRP20192334 T1 HR P20192334T1 HR P20192334T T HRP20192334T T HR P20192334TT HR P20192334 T HRP20192334 T HR P20192334T HR P20192334 T1 HRP20192334 T1 HR P20192334T1
- Authority
- HR
- Croatia
- Prior art keywords
- 6alkyl
- halogen
- optionally
- independently substituted
- substituents
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14185130 | 2014-09-17 | ||
| EP15766800.5A EP3194407B1 (en) | 2014-09-17 | 2015-09-17 | Macrocyclic rip2 kinase inhibitors |
| PCT/EP2015/071347 WO2016042087A1 (en) | 2014-09-17 | 2015-09-17 | Macrocyclic rip2 kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20192334T1 true HRP20192334T1 (hr) | 2020-03-20 |
Family
ID=51687776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20192334TT HRP20192334T1 (hr) | 2014-09-17 | 2015-09-17 | Makrociklički inhibitori kinaze rip2 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10676486B2 (https=) |
| EP (1) | EP3194407B1 (https=) |
| JP (1) | JP6736545B2 (https=) |
| KR (1) | KR102563829B1 (https=) |
| CN (1) | CN106687464B (https=) |
| AU (1) | AU2015316799B2 (https=) |
| BR (1) | BR112017004035B1 (https=) |
| CA (1) | CA2958782C (https=) |
| DK (1) | DK3194407T3 (https=) |
| EA (1) | EA032872B1 (https=) |
| ES (1) | ES2763344T3 (https=) |
| HR (1) | HRP20192334T1 (https=) |
| HU (1) | HUE048518T2 (https=) |
| IL (1) | IL250544B (https=) |
| LT (1) | LT3194407T (https=) |
| MX (1) | MX376087B (https=) |
| MY (1) | MY186523A (https=) |
| PL (1) | PL3194407T3 (https=) |
| PT (1) | PT3194407T (https=) |
| SA (1) | SA517381087B1 (https=) |
| SG (1) | SG11201701116XA (https=) |
| SI (1) | SI3194407T1 (https=) |
| TW (1) | TWI709563B (https=) |
| UA (1) | UA121315C2 (https=) |
| WO (1) | WO2016042087A1 (https=) |
| ZA (1) | ZA201701331B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102719387B1 (ko) * | 2017-01-26 | 2024-10-21 | 한미약품 주식회사 | 이미다조피리다진 화합물 |
| UA129879C2 (uk) | 2020-01-31 | 2025-08-27 | Онкодизайн Пресіжн Медісін (Опм) | Макроциклічні інгібітори rip2-кінази |
| JP2025532532A (ja) * | 2022-09-07 | 2025-10-01 | 蘇州朗睿生物医薬有限公司 | 大環状イミダゾ［１，２－ｂ］ピリダジン誘導体並びにその調製方法及び用途 |
| WO2024146541A1 (en) * | 2023-01-03 | 2024-07-11 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Macrocyclic compounds as usp1 inhibitors |
| WO2025212514A2 (en) * | 2024-04-02 | 2025-10-09 | Interline Therapeutics, Inc. | Methods of treating inflammatory diseases |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| SK283569B6 (sk) | 1993-10-01 | 2003-09-11 | Astra Aktiebolag | Spôsob spracovania jemne deleného práškového liečiva, zariadenie na vykonávanie tohto spôsobu a aglomeráty vyrobené týmto spôsobom |
| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| BRPI0718029A2 (pt) * | 2006-11-06 | 2013-11-26 | Supergen Inc | Derivados de imidazo(1,2-b)piridazina e pirazolo(1,5-a)pirimidina e seu uso como inibidores da proteína cinase |
| AR077468A1 (es) * | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| NZ604708A (en) * | 2010-05-20 | 2015-05-29 | Array Biopharma Inc | Macrocyclic compounds as trk kinase inhibitors |
| WO2013001310A1 (en) * | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Macrocyclic compounds and their use as cdk8 inhibitors |
| TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| CA2849999A1 (en) | 2011-09-30 | 2013-04-04 | Oncodesign S.A. | Macrocyclic flt3 kinase inhibitors |
| BR112014007654A8 (pt) | 2011-09-30 | 2018-06-12 | Ipsen Pharma | Inibidores de lrrk2 quinase macrocíclicos. |
-
2015
- 2015-09-17 CN CN201580050163.3A patent/CN106687464B/zh active Active
- 2015-09-17 PL PL15766800T patent/PL3194407T3/pl unknown
- 2015-09-17 US US15/505,976 patent/US10676486B2/en active Active
- 2015-09-17 JP JP2017514486A patent/JP6736545B2/ja active Active
- 2015-09-17 SG SG11201701116XA patent/SG11201701116XA/en unknown
- 2015-09-17 KR KR1020177010128A patent/KR102563829B1/ko active Active
- 2015-09-17 TW TW104130751A patent/TWI709563B/zh active
- 2015-09-17 HU HUE15766800A patent/HUE048518T2/hu unknown
- 2015-09-17 DK DK15766800.5T patent/DK3194407T3/da active
- 2015-09-17 AU AU2015316799A patent/AU2015316799B2/en active Active
- 2015-09-17 EA EA201790609A patent/EA032872B1/ru unknown
- 2015-09-17 MX MX2017003469A patent/MX376087B/es active IP Right Grant
- 2015-09-17 PT PT157668005T patent/PT3194407T/pt unknown
- 2015-09-17 WO PCT/EP2015/071347 patent/WO2016042087A1/en not_active Ceased
- 2015-09-17 CA CA2958782A patent/CA2958782C/en active Active
- 2015-09-17 BR BR112017004035-2A patent/BR112017004035B1/pt active IP Right Grant
- 2015-09-17 MY MYPI2017700447A patent/MY186523A/en unknown
- 2015-09-17 LT LTEP15766800.5T patent/LT3194407T/lt unknown
- 2015-09-17 UA UAA201703558A patent/UA121315C2/uk unknown
- 2015-09-17 EP EP15766800.5A patent/EP3194407B1/en active Active
- 2015-09-17 SI SI201531050T patent/SI3194407T1/sl unknown
- 2015-09-17 ES ES15766800T patent/ES2763344T3/es active Active
- 2015-09-17 HR HRP20192334TT patent/HRP20192334T1/hr unknown
-
2017
- 2017-02-09 IL IL250544A patent/IL250544B/en active IP Right Grant
- 2017-02-22 ZA ZA2017/01331A patent/ZA201701331B/en unknown
- 2017-03-14 SA SA517381087A patent/SA517381087B1/ar unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20192334T1 (hr) | Makrociklički inhibitori kinaze rip2 | |
| ES2684517T3 (es) | Compuestos de heterociclilo como inhibidores de MEK | |
| AR068538A1 (es) | Compuesto heterociclico de 5 miembros con actividad supresora de la secrecion de acido | |
| EP4458348A3 (en) | Pharmaceutical compositions containing substituted polycyclic pyridone derivatives and prodrug thereof | |
| GEAP202115066A (en) | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | |
| AR103064A1 (es) | Compuestos moduladores de fxr (nr1h4) | |
| ES2855732T3 (es) | Compuestos y composiciones para tratar afecciones asociadas con la actividad de NLRP | |
| MY169179A (en) | Novel piperidine compound or salt thereof | |
| AR107061A1 (es) | Heteroarilhidroxipirimidinonas como agonistas del receptor de apj | |
| IN2014MN02331A (https=) | ||
| WO2013076316A3 (en) | Substituted n-(tetrazol-5-yl)- and n-(triazol-5-yl)hetarylcarboxamide compounds and their use as herbicides | |
| CY1112679T1 (el) | Κινολινες και θεραπευτικη χρηση αυτων | |
| AR113811A1 (es) | Sulfonas y sulfóxidos bicíclicos y métodos de uso de los mismos | |
| PH12017501652A1 (en) | Kv1.3 inhibitors and their medical application | |
| ES2639407T3 (es) | Derivados de cianoquinolina | |
| MX2019014406A (es) | Compuesto heterociclico y composicion que contiene el mismo. | |
| JP2017529365A5 (https=) | ||
| JP2017528481A5 (https=) | ||
| MX2016017371A (es) | Sal de compuesto heterociclico sustituido con halogeno. | |
| AR073741A1 (es) | Derivados heterociclicos de hidantoina, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades inflamatorias, tales como psoriasis o artritis | |
| NZ735032A (en) | Novel heterocyclic compound, method for preparing the same, and pharmaceutical composition comprising the same | |
| AR125365A1 (es) | Derivados de 1h-pirazol como ligandos sigma | |
| AR113991A1 (es) | Compuestos de fluoralquenilo, proceso de preparación y uso de los mismos | |
| NO20092804L (no) | Kondensert, substituert aminopyrrolidinderivat | |
| SA118390677B1 (ar) | مشتقات ثنائي هيدرو بيريميدينون |