TWI709563B - 巨環ｒｉｐ２激酶抑制劑 - Google Patents
巨環ｒｉｐ２激酶抑制劑 Download PDFInfo
- Publication number
- TWI709563B TWI709563B TW104130751A TW104130751A TWI709563B TW I709563 B TWI709563 B TW I709563B TW 104130751 A TW104130751 A TW 104130751A TW 104130751 A TW104130751 A TW 104130751A TW I709563 B TWI709563 B TW I709563B
- Authority
- TW
- Taiwan
- Prior art keywords
- alkyl
- het
- halo
- cycloalkyl
- optionally
- Prior art date
Links
- 0 *CCN1C(**c(cc[n]2nc3)nc2c3Br)CCC1 Chemical compound *CCN1C(**c(cc[n]2nc3)nc2c3Br)CCC1 0.000 description 2
- RPIKHRLOOAVQRY-UHFFFAOYSA-N C(C1)CN(CCO2)C1CNc(cc[n]1nc3)nc1c3-c1cccc2c1 Chemical compound C(C1)CN(CCO2)C1CNc(cc[n]1nc3)nc1c3-c1cccc2c1 RPIKHRLOOAVQRY-UHFFFAOYSA-N 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N C1CCCCC1 Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- QCPPNQBVOQVJTE-UHFFFAOYSA-N CN(CC(CCC1)N1CCO1)c(cc[n]2nc3)nc2c3-c2cccc1c2 Chemical compound CN(CC(CCC1)N1CCO1)c(cc[n]2nc3)nc2c3-c2cccc1c2 QCPPNQBVOQVJTE-UHFFFAOYSA-N 0.000 description 1
- MENPYAFXUZUAKV-MRXNPFEDSA-N Clc1cc(OCCCN(CCC2)[C@H]2CNc2nc3c-4cn[n]3cc2)cc-4c1 Chemical compound Clc1cc(OCCCN(CCC2)[C@H]2CNc2nc3c-4cn[n]3cc2)cc-4c1 MENPYAFXUZUAKV-MRXNPFEDSA-N 0.000 description 1
- ASSLKTYURCITCF-HNNXBMFYSA-N Clc1cc(OCCN(CCC2)[C@@H]2CNc2nc3c-4cn[n]3cc2)cc-4c1 Chemical compound Clc1cc(OCCN(CCC2)[C@@H]2CNc2nc3c-4cn[n]3cc2)cc-4c1 ASSLKTYURCITCF-HNNXBMFYSA-N 0.000 description 1
- NWIWCNPHEKBKHL-HNNXBMFYSA-N Fc1cc(-c(cn[n]2cc3)c2nc3NC[C@H](CCC2)N2CCO2)cc2c1 Chemical compound Fc1cc(-c(cn[n]2cc3)c2nc3NC[C@H](CCC2)N2CCO2)cc2c1 NWIWCNPHEKBKHL-HNNXBMFYSA-N 0.000 description 1
- KLHLBYYXDWZTGO-MRXNPFEDSA-N Fc1cc(OCCCN(CCC2)[C@H]2CNc2nc3c-4cn[n]3cc2)cc-4c1 Chemical compound Fc1cc(OCCCN(CCC2)[C@H]2CNc2nc3c-4cn[n]3cc2)cc-4c1 KLHLBYYXDWZTGO-MRXNPFEDSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14185130.3 | 2014-09-17 | ||
| EP14185130 | 2014-09-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201619168A TW201619168A (zh) | 2016-06-01 |
| TWI709563B true TWI709563B (zh) | 2020-11-11 |
Family
ID=51687776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW104130751A TWI709563B (zh) | 2014-09-17 | 2015-09-17 | 巨環ｒｉｐ２激酶抑制劑 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10676486B2 (https=) |
| EP (1) | EP3194407B1 (https=) |
| JP (1) | JP6736545B2 (https=) |
| KR (1) | KR102563829B1 (https=) |
| CN (1) | CN106687464B (https=) |
| AU (1) | AU2015316799B2 (https=) |
| BR (1) | BR112017004035B1 (https=) |
| CA (1) | CA2958782C (https=) |
| DK (1) | DK3194407T3 (https=) |
| EA (1) | EA032872B1 (https=) |
| ES (1) | ES2763344T3 (https=) |
| HR (1) | HRP20192334T1 (https=) |
| HU (1) | HUE048518T2 (https=) |
| IL (1) | IL250544B (https=) |
| LT (1) | LT3194407T (https=) |
| MX (1) | MX376087B (https=) |
| MY (1) | MY186523A (https=) |
| PL (1) | PL3194407T3 (https=) |
| PT (1) | PT3194407T (https=) |
| SA (1) | SA517381087B1 (https=) |
| SG (1) | SG11201701116XA (https=) |
| SI (1) | SI3194407T1 (https=) |
| TW (1) | TWI709563B (https=) |
| UA (1) | UA121315C2 (https=) |
| WO (1) | WO2016042087A1 (https=) |
| ZA (1) | ZA201701331B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102719387B1 (ko) * | 2017-01-26 | 2024-10-21 | 한미약품 주식회사 | 이미다조피리다진 화합물 |
| UA129879C2 (uk) | 2020-01-31 | 2025-08-27 | Онкодизайн Пресіжн Медісін (Опм) | Макроциклічні інгібітори rip2-кінази |
| JP2025532532A (ja) * | 2022-09-07 | 2025-10-01 | 蘇州朗睿生物医薬有限公司 | 大環状イミダゾ［１，２－ｂ］ピリダジン誘導体並びにその調製方法及び用途 |
| WO2024146541A1 (en) * | 2023-01-03 | 2024-07-11 | Guangdong Newopp Biopharmaceuticals Co., Ltd. | Macrocyclic compounds as usp1 inhibitors |
| WO2025212514A2 (en) * | 2024-04-02 | 2025-10-09 | Interline Therapeutics, Inc. | Methods of treating inflammatory diseases |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013001310A1 (en) * | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Macrocyclic compounds and their use as cdk8 inhibitors |
| CN103930427A (zh) * | 2011-09-30 | 2014-07-16 | 昂科迪塞恩股份有限公司 | 大环flt3 激酶抑制剂 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| SK283569B6 (sk) | 1993-10-01 | 2003-09-11 | Astra Aktiebolag | Spôsob spracovania jemne deleného práškového liečiva, zariadenie na vykonávanie tohto spôsobu a aglomeráty vyrobené týmto spôsobom |
| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| BRPI0718029A2 (pt) * | 2006-11-06 | 2013-11-26 | Supergen Inc | Derivados de imidazo(1,2-b)piridazina e pirazolo(1,5-a)pirimidina e seu uso como inibidores da proteína cinase |
| AR077468A1 (es) * | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
| NZ604708A (en) * | 2010-05-20 | 2015-05-29 | Array Biopharma Inc | Macrocyclic compounds as trk kinase inhibitors |
| TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
| BR112014007654A8 (pt) | 2011-09-30 | 2018-06-12 | Ipsen Pharma | Inibidores de lrrk2 quinase macrocíclicos. |
-
2015
- 2015-09-17 CN CN201580050163.3A patent/CN106687464B/zh active Active
- 2015-09-17 PL PL15766800T patent/PL3194407T3/pl unknown
- 2015-09-17 US US15/505,976 patent/US10676486B2/en active Active
- 2015-09-17 JP JP2017514486A patent/JP6736545B2/ja active Active
- 2015-09-17 SG SG11201701116XA patent/SG11201701116XA/en unknown
- 2015-09-17 KR KR1020177010128A patent/KR102563829B1/ko active Active
- 2015-09-17 TW TW104130751A patent/TWI709563B/zh active
- 2015-09-17 HU HUE15766800A patent/HUE048518T2/hu unknown
- 2015-09-17 DK DK15766800.5T patent/DK3194407T3/da active
- 2015-09-17 AU AU2015316799A patent/AU2015316799B2/en active Active
- 2015-09-17 EA EA201790609A patent/EA032872B1/ru unknown
- 2015-09-17 MX MX2017003469A patent/MX376087B/es active IP Right Grant
- 2015-09-17 PT PT157668005T patent/PT3194407T/pt unknown
- 2015-09-17 WO PCT/EP2015/071347 patent/WO2016042087A1/en not_active Ceased
- 2015-09-17 CA CA2958782A patent/CA2958782C/en active Active
- 2015-09-17 BR BR112017004035-2A patent/BR112017004035B1/pt active IP Right Grant
- 2015-09-17 MY MYPI2017700447A patent/MY186523A/en unknown
- 2015-09-17 LT LTEP15766800.5T patent/LT3194407T/lt unknown
- 2015-09-17 UA UAA201703558A patent/UA121315C2/uk unknown
- 2015-09-17 EP EP15766800.5A patent/EP3194407B1/en active Active
- 2015-09-17 SI SI201531050T patent/SI3194407T1/sl unknown
- 2015-09-17 ES ES15766800T patent/ES2763344T3/es active Active
- 2015-09-17 HR HRP20192334TT patent/HRP20192334T1/hr unknown
-
2017
- 2017-02-09 IL IL250544A patent/IL250544B/en active IP Right Grant
- 2017-02-22 ZA ZA2017/01331A patent/ZA201701331B/en unknown
- 2017-03-14 SA SA517381087A patent/SA517381087B1/ar unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013001310A1 (en) * | 2011-06-30 | 2013-01-03 | Centro Nacional De Investigaciones Oncológicas (Cnio) | Macrocyclic compounds and their use as cdk8 inhibitors |
| CN103930427A (zh) * | 2011-09-30 | 2014-07-16 | 昂科迪塞恩股份有限公司 | 大环flt3 激酶抑制剂 |
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