EA201790609A1 - Макроциклические ингибиторы rip2-киназы - Google Patents

Макроциклические ингибиторы rip2-киназы

Info

Publication number
EA201790609A1
EA201790609A1 EA201790609A EA201790609A EA201790609A1 EA 201790609 A1 EA201790609 A1 EA 201790609A1 EA 201790609 A EA201790609 A EA 201790609A EA 201790609 A EA201790609 A EA 201790609A EA 201790609 A1 EA201790609 A1 EA 201790609A1
Authority
EA
Eurasian Patent Office
Prior art keywords
rip2
kinase
inhibitors
macro cyclic
cyclic inhibitors
Prior art date
Application number
EA201790609A
Other languages
English (en)
Other versions
EA032872B1 (ru
Inventor
Ян Хофлак
Петра Блом
Паскаль Бендериттер
Original Assignee
Онкодизайн С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Онкодизайн С.А. filed Critical Онкодизайн С.А.
Publication of EA201790609A1 publication Critical patent/EA201790609A1/ru
Publication of EA032872B1 publication Critical patent/EA032872B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к макроциклическим соединениям и композициям, содержащим указанные соединения, действующие в качестве ингибиторов киназ, в частности в качестве ингибиторов RIP2 и/или ее мутантов, для применения при диагностике, предупреждении и/или лечении ассоциированных с RIP2-киназой заболеваний. Более того, в настоящем изобретении предусмотрены способы применения указанных соединений, например, в качестве лекарственного препарата или диагностического средства.
EA201790609A 2014-09-17 2015-09-17 Макроциклические ингибиторы rip2-киназы EA032872B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14185130 2014-09-17
PCT/EP2015/071347 WO2016042087A1 (en) 2014-09-17 2015-09-17 Macrocyclic rip2 kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201790609A1 true EA201790609A1 (ru) 2017-07-31
EA032872B1 EA032872B1 (ru) 2019-07-31

Family

ID=51687776

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790609A EA032872B1 (ru) 2014-09-17 2015-09-17 Макроциклические ингибиторы rip2-киназы

Country Status (26)

Country Link
US (1) US10676486B2 (ru)
EP (1) EP3194407B1 (ru)
JP (1) JP6736545B2 (ru)
KR (1) KR102563829B1 (ru)
CN (1) CN106687464B (ru)
AU (1) AU2015316799B2 (ru)
BR (1) BR112017004035B1 (ru)
CA (1) CA2958782C (ru)
DK (1) DK3194407T3 (ru)
EA (1) EA032872B1 (ru)
ES (1) ES2763344T3 (ru)
HR (1) HRP20192334T1 (ru)
HU (1) HUE048518T2 (ru)
IL (1) IL250544B (ru)
LT (1) LT3194407T (ru)
MX (1) MX2017003469A (ru)
MY (1) MY186523A (ru)
PL (1) PL3194407T3 (ru)
PT (1) PT3194407T (ru)
SA (1) SA517381087B1 (ru)
SG (1) SG11201701116XA (ru)
SI (1) SI3194407T1 (ru)
TW (1) TWI709563B (ru)
UA (1) UA121315C2 (ru)
WO (1) WO2016042087A1 (ru)
ZA (1) ZA201701331B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180088113A (ko) * 2017-01-26 2018-08-03 한미약품 주식회사 이미다조피리다진 화합물
US20230126352A1 (en) 2020-01-31 2023-04-27 Oncodesign Sa Macrocyclic rip2-kinase inhibitors
CN117659043A (zh) * 2022-09-07 2024-03-08 苏州朗睿生物医药有限公司 一种大环咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
WO1995009615A1 (en) 1993-10-01 1995-04-13 Astra Aktiebolag Process i
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
MX2009004700A (es) * 2006-11-06 2009-05-15 Supergen Inc Derivados de imidazo[1,2-b]piridazin y pirazolo[1,5-a] pirimidina y su uso como inhibidores de proteina cinasa.
AR077468A1 (es) * 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
SG10201506591TA (en) * 2010-05-20 2015-09-29 Array Biopharma Inc Macrocyclic compounds as trk kinase inhibitors
WO2013001310A1 (en) * 2011-06-30 2013-01-03 Centro Nacional De Investigaciones Oncológicas (Cnio) Macrocyclic compounds and their use as cdk8 inhibitors
TWI547494B (zh) * 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之胺基喹唑啉類
UA113186C2 (xx) 2011-09-30 2016-12-26 Макроциклічні інгібітори lrrk2 кінази
HUE027318T2 (en) * 2011-09-30 2016-10-28 Oncodesign Sa Macrocyclic FLT3 kinase inhibitors

Also Published As

Publication number Publication date
AU2015316799B2 (en) 2019-07-11
KR20170048596A (ko) 2017-05-08
SG11201701116XA (en) 2017-03-30
CA2958782A1 (en) 2016-03-24
US20190127390A1 (en) 2019-05-02
ZA201701331B (en) 2020-07-29
MY186523A (en) 2021-07-24
PT3194407T (pt) 2020-01-20
JP2017528481A (ja) 2017-09-28
EA032872B1 (ru) 2019-07-31
PL3194407T3 (pl) 2020-04-30
KR102563829B1 (ko) 2023-08-03
WO2016042087A1 (en) 2016-03-24
NZ730758A (en) 2023-09-29
MX2017003469A (es) 2017-05-08
BR112017004035B1 (pt) 2023-11-14
IL250544B (en) 2020-06-30
BR112017004035A8 (pt) 2023-05-09
SA517381087B1 (ar) 2021-02-09
EP3194407B1 (en) 2019-10-23
TWI709563B (zh) 2020-11-11
US10676486B2 (en) 2020-06-09
EP3194407A1 (en) 2017-07-26
BR112017004035A2 (pt) 2017-12-05
TW201619168A (zh) 2016-06-01
HUE048518T2 (hu) 2020-07-28
HRP20192334T1 (hr) 2020-03-20
CN106687464B (zh) 2020-03-03
JP6736545B2 (ja) 2020-08-05
IL250544A0 (en) 2017-03-30
ES2763344T3 (es) 2020-05-28
CA2958782C (en) 2024-01-09
UA121315C2 (uk) 2020-05-12
LT3194407T (lt) 2020-01-27
AU2015316799A1 (en) 2017-04-27
SI3194407T1 (sl) 2020-03-31
DK3194407T3 (da) 2020-01-27
CN106687464A (zh) 2017-05-17

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