HRP20191677T1 - POSTUPCI I SASTAVI ZA GENERIRANJE PANKREASNIH PROGENITORA I FUNKCIONALNIH BETA STANICA IZ hPSC - Google Patents
POSTUPCI I SASTAVI ZA GENERIRANJE PANKREASNIH PROGENITORA I FUNKCIONALNIH BETA STANICA IZ hPSC Download PDFInfo
- Publication number
- HRP20191677T1 HRP20191677T1 HRP20191677T HRP20191677T1 HR P20191677 T1 HRP20191677 T1 HR P20191677T1 HR P20191677 T HRP20191677 T HR P20191677T HR P20191677 T1 HRP20191677 T1 HR P20191677T1
- Authority
- HR
- Croatia
- Prior art keywords
- cells
- egf
- growth factor
- population
- epidermal growth
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Developmental Biology & Embryology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261640366P | 2012-04-30 | 2012-04-30 | |
| EP13784648.1A EP2844739B1 (en) | 2012-04-30 | 2013-04-30 | METHODS AND COMPOSITIONS FOR GENERATING PANCREATIC PROGENITORS AND FUNCTIONAL BETA CELLS FROM hPSCs |
| PCT/CA2013/000432 WO2013163739A1 (en) | 2012-04-30 | 2013-04-30 | METHODS AND COMPOSITIONS FOR GENERATING PANCREATIC PROGENITORS AND FUNCTIONAL BETA CELLS FROM hPSCs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191677T1 true HRP20191677T1 (hr) | 2019-12-13 |
Family
ID=49514141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191677 HRP20191677T1 (hr) | 2012-04-30 | 2013-04-30 | POSTUPCI I SASTAVI ZA GENERIRANJE PANKREASNIH PROGENITORA I FUNKCIONALNIH BETA STANICA IZ hPSC |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20150104430A1 (enExample) |
| EP (2) | EP2844739B1 (enExample) |
| JP (2) | JP6397397B2 (enExample) |
| CN (2) | CN104411815B (enExample) |
| AU (1) | AU2013255031C1 (enExample) |
| CA (1) | CA2871795C (enExample) |
| CY (1) | CY1122058T1 (enExample) |
| DK (1) | DK2844739T3 (enExample) |
| ES (1) | ES2747967T3 (enExample) |
| HR (1) | HRP20191677T1 (enExample) |
| HU (1) | HUE046271T2 (enExample) |
| IN (1) | IN2014DN10053A (enExample) |
| LT (1) | LT2844739T (enExample) |
| PL (1) | PL2844739T3 (enExample) |
| PT (1) | PT2844739T (enExample) |
| SI (1) | SI2844739T1 (enExample) |
| WO (1) | WO2013163739A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10266807B2 (en) | 2013-04-03 | 2019-04-23 | FUJIFILM Cellular Dynamics, Inc. | Methods and compositions for culturing endoderm progenitor cells in suspension |
| CN106536718B (zh) * | 2014-05-21 | 2021-04-27 | 国立大学法人京都大学 | 胰芽细胞的制造方法及含有胰芽细胞的胰疾病治疗剂 |
| PL3285572T3 (pl) * | 2015-04-24 | 2021-06-28 | University Of Copenhagen | Sposób wytwarzania komórek produkujących insulinę |
| PT3286300T (pt) | 2015-04-24 | 2020-12-28 | Univ Copenhagen | Isolamento de células progenitoras pancreáticas genuínas |
| EP3328404A4 (en) * | 2015-07-27 | 2018-12-26 | The Regents of The University of California | Methods and compositions for producing pancreatic beta cells |
| CN106554936B (zh) * | 2015-09-30 | 2020-05-05 | 海门雨霖细胞科技有限责任公司 | 诱导人干细胞向肝细胞定向分化的新方法 |
| US11274280B2 (en) | 2016-02-24 | 2022-03-15 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| WO2017177163A1 (en) * | 2016-04-08 | 2017-10-12 | The Regents Of The University Of California | Production of fully functional mature beta cells from human pancreatic progenitors |
| JP7065517B2 (ja) * | 2016-07-26 | 2022-05-12 | 国立大学法人京都大学 | Ｐｔｆ１ａ陽性細胞の製造方法 |
| WO2018159805A1 (ja) * | 2017-03-03 | 2018-09-07 | 国立大学法人京都大学 | 膵前駆細胞の製造方法 |
| JP2020527956A (ja) * | 2017-07-21 | 2020-09-17 | センマ・セラピューティクス・インコーポレーテッド | 幹細胞由来の膵臓ベータ細胞の再凝集 |
| CA2983845C (en) | 2017-10-26 | 2024-01-30 | University Of Copenhagen | Generation of glucose-responsive beta cells |
| CN118497104A (zh) | 2017-11-15 | 2024-08-16 | 沃泰克斯药物股份有限公司 | 胰岛细胞制备性组合物和使用方法 |
| SG11202006837XA (en) | 2018-01-18 | 2020-08-28 | Daiichi Sankyo Co Ltd | Dihydroindolizinone derivative |
| WO2019227198A1 (en) | 2018-05-31 | 2019-12-05 | University Health Network (Uhn) | Methods and compositions comprising tankyrase inhibitors for generating insulin producing cells |
| EP3833365A4 (en) | 2018-08-10 | 2022-05-11 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| CA3110932A1 (en) | 2018-08-30 | 2020-03-05 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| CN111875674B (zh) * | 2018-09-03 | 2021-12-10 | 内蒙古创润生物科技有限公司 | 表皮干细胞向胰腺细胞分化的改进方法 |
| AU2019360857B2 (en) * | 2018-10-15 | 2026-02-19 | Evia Life Sciences Inc. | Method for producing stem/precursor cells, by using low molecular weight compound, from cells derived from endodermal tissue or organ |
| JP7385244B2 (ja) * | 2019-06-27 | 2023-11-22 | 国立大学法人 東京大学 | 膵前駆細胞の分離方法 |
| WO2021051256A1 (en) | 2019-09-17 | 2021-03-25 | Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences | Pancreatic pro-endocrine progenitor cells and use thereof |
| JP2024506850A (ja) * | 2021-02-01 | 2024-02-15 | シーダーズ－サイナイ メディカル センター | 同質遺伝子型ｉＰＳＣ由来血管内皮細胞との共培養における機能的なヒトｉＰＳＣ由来膵島の作製 |
| CN113234664B (zh) * | 2021-05-11 | 2024-05-10 | 澳门大学 | 一种胰腺祖细胞的制备方法及其应用 |
| CN114634904B (zh) * | 2022-05-17 | 2022-09-13 | 天津外泌体科技有限公司 | 高纯度胰腺祖细胞的产生方法 |
| CN118345030B (zh) * | 2024-06-20 | 2024-08-16 | 羽铂精制生物技术(成都)有限公司 | iPSC诱导分化成为胰腺祖细胞修复胰腺的方法及应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| CN101240262A (zh) * | 2001-12-07 | 2008-08-13 | 杰龙公司 | 源自人胚胎干细胞的胰岛细胞 |
| JP5102030B2 (ja) | 2004-08-13 | 2012-12-19 | ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド | ヒト胚性幹細胞における自己再生および分化のための組成物および方法 |
| DK2650359T3 (da) * | 2006-03-02 | 2022-06-13 | Viacyte Inc | Endokrine prekursorceller, pancreatiske hormon-udtrykkende celler og fremstillingsfremgangsmåder |
| WO2007127454A2 (en) | 2006-04-28 | 2007-11-08 | Cythera, Inc. | Hepatocyte lineage cells |
| US20080063628A1 (en) * | 2006-09-11 | 2008-03-13 | Davis Janet E | Methods to promote cell differentiation |
| US7695963B2 (en) | 2007-09-24 | 2010-04-13 | Cythera, Inc. | Methods for increasing definitive endoderm production |
| US8338170B2 (en) * | 2008-04-21 | 2012-12-25 | Viacyte, Inc. | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| GB201111244D0 (en) * | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| AU2010333839C1 (en) * | 2009-12-23 | 2016-07-21 | Janssen Biotech Inc. | Differentiation of human embryonic stem cells |
| WO2012070014A2 (en) * | 2010-11-26 | 2012-05-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells |
-
2013
- 2013-04-30 CN CN201380035022.5A patent/CN104411815B/zh active Active
- 2013-04-30 PL PL13784648T patent/PL2844739T3/pl unknown
- 2013-04-30 PT PT137846481T patent/PT2844739T/pt unknown
- 2013-04-30 AU AU2013255031A patent/AU2013255031C1/en active Active
- 2013-04-30 DK DK13784648.1T patent/DK2844739T3/da active
- 2013-04-30 SI SI201331572T patent/SI2844739T1/sl unknown
- 2013-04-30 LT LTEP13784648.1T patent/LT2844739T/lt unknown
- 2013-04-30 IN IN10053DEN2014 patent/IN2014DN10053A/en unknown
- 2013-04-30 HU HUE13784648A patent/HUE046271T2/hu unknown
- 2013-04-30 JP JP2015509270A patent/JP6397397B2/ja active Active
- 2013-04-30 CN CN201711013526.3A patent/CN108004199B/zh active Active
- 2013-04-30 EP EP13784648.1A patent/EP2844739B1/en active Active
- 2013-04-30 ES ES13784648T patent/ES2747967T3/es active Active
- 2013-04-30 HR HRP20191677 patent/HRP20191677T1/hr unknown
- 2013-04-30 WO PCT/CA2013/000432 patent/WO2013163739A1/en not_active Ceased
- 2013-04-30 EP EP19181059.7A patent/EP3594323A1/en active Pending
- 2013-04-30 CA CA2871795A patent/CA2871795C/en active Active
- 2013-04-30 US US14/397,657 patent/US20150104430A1/en active Pending
-
2018
- 2018-08-30 JP JP2018162002A patent/JP6759293B2/ja active Active
-
2019
- 2019-09-13 CY CY20191100960T patent/CY1122058T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3594323A1 (en) | 2020-01-15 |
| WO2013163739A1 (en) | 2013-11-07 |
| CN104411815A (zh) | 2015-03-11 |
| ES2747967T3 (es) | 2020-03-12 |
| CA2871795C (en) | 2023-03-14 |
| HK1254968A1 (zh) | 2019-08-02 |
| EP2844739B1 (en) | 2019-06-19 |
| PL2844739T3 (pl) | 2019-12-31 |
| CN104411815B (zh) | 2017-11-28 |
| AU2013255031C1 (en) | 2018-12-06 |
| CN108004199B (zh) | 2022-03-18 |
| IN2014DN10053A (enExample) | 2015-08-14 |
| JP6397397B2 (ja) | 2018-09-26 |
| JP2015519048A (ja) | 2015-07-09 |
| AU2013255031B2 (en) | 2018-09-06 |
| EP2844739A4 (en) | 2015-12-02 |
| JP6759293B2 (ja) | 2020-09-23 |
| JP2018198620A (ja) | 2018-12-20 |
| HK1208047A1 (en) | 2016-02-19 |
| AU2013255031A1 (en) | 2014-12-04 |
| SI2844739T1 (sl) | 2019-11-29 |
| CY1122058T1 (el) | 2020-11-25 |
| US20150104430A1 (en) | 2015-04-16 |
| LT2844739T (lt) | 2019-10-10 |
| PT2844739T (pt) | 2019-10-01 |
| CA2871795A1 (en) | 2013-11-07 |
| DK2844739T3 (da) | 2019-09-30 |
| HUE046271T2 (hu) | 2020-02-28 |
| CN108004199A (zh) | 2018-05-08 |
| EP2844739A1 (en) | 2015-03-11 |
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