CY1122058T1 - Μεθοδοι και συνθεσεις για την παραγωγη παγκρεατικων προγονικων και λειτουργικων βητα κυτταρων απο hpscs - Google Patents
Μεθοδοι και συνθεσεις για την παραγωγη παγκρεατικων προγονικων και λειτουργικων βητα κυτταρων απο hpscsInfo
- Publication number
- CY1122058T1 CY1122058T1 CY20191100960T CY191100960T CY1122058T1 CY 1122058 T1 CY1122058 T1 CY 1122058T1 CY 20191100960 T CY20191100960 T CY 20191100960T CY 191100960 T CY191100960 T CY 191100960T CY 1122058 T1 CY1122058 T1 CY 1122058T1
- Authority
- CY
- Cyprus
- Prior art keywords
- component
- pancreatic progenitor
- compositions
- methods
- hpscs
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 4
- 102100028098 Homeobox protein Nkx-6.1 Human genes 0.000 abstract 2
- 101000578254 Homo sapiens Homeobox protein Nkx-6.1 Proteins 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 229960003966 nicotinamide Drugs 0.000 abstract 2
- 235000005152 nicotinamide Nutrition 0.000 abstract 2
- 239000011570 nicotinamide Substances 0.000 abstract 2
- 210000000130 stem cell Anatomy 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/11—Epidermal growth factor [EGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Developmental Biology & Embryology (AREA)
- Endocrinology (AREA)
- Physiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261640366P | 2012-04-30 | 2012-04-30 | |
| PCT/CA2013/000432 WO2013163739A1 (en) | 2012-04-30 | 2013-04-30 | METHODS AND COMPOSITIONS FOR GENERATING PANCREATIC PROGENITORS AND FUNCTIONAL BETA CELLS FROM hPSCs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1122058T1 true CY1122058T1 (el) | 2020-11-25 |
Family
ID=49514141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191100960T CY1122058T1 (el) | 2012-04-30 | 2019-09-13 | Μεθοδοι και συνθεσεις για την παραγωγη παγκρεατικων προγονικων και λειτουργικων βητα κυτταρων απο hpscs |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20150104430A1 (enExample) |
| EP (2) | EP2844739B1 (enExample) |
| JP (2) | JP6397397B2 (enExample) |
| CN (2) | CN104411815B (enExample) |
| AU (1) | AU2013255031C1 (enExample) |
| CA (1) | CA2871795C (enExample) |
| CY (1) | CY1122058T1 (enExample) |
| DK (1) | DK2844739T3 (enExample) |
| ES (1) | ES2747967T3 (enExample) |
| HR (1) | HRP20191677T1 (enExample) |
| HU (1) | HUE046271T2 (enExample) |
| IN (1) | IN2014DN10053A (enExample) |
| LT (1) | LT2844739T (enExample) |
| PL (1) | PL2844739T3 (enExample) |
| PT (1) | PT2844739T (enExample) |
| SI (1) | SI2844739T1 (enExample) |
| WO (1) | WO2013163739A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10266807B2 (en) | 2013-04-03 | 2019-04-23 | FUJIFILM Cellular Dynamics, Inc. | Methods and compositions for culturing endoderm progenitor cells in suspension |
| WO2015178431A1 (ja) * | 2014-05-21 | 2015-11-26 | 国立大学法人京都大学 | 膵芽細胞の製造方法および膵芽細胞を含む膵疾患治療剤 |
| US10494608B2 (en) | 2015-04-24 | 2019-12-03 | University Of Copenhagen | Isolation of bona fide pancreatic progenitor cells |
| US20180119105A1 (en) * | 2015-04-24 | 2018-05-03 | University Of Copenhagen | Method for production of insulin-producing cells |
| WO2017019702A1 (en) * | 2015-07-27 | 2017-02-02 | The Regents Of The University Of California | Methods and compositions for producing pancreatic beta cells |
| CN106554936B (zh) * | 2015-09-30 | 2020-05-05 | 海门雨霖细胞科技有限责任公司 | 诱导人干细胞向肝细胞定向分化的新方法 |
| ES2967942T3 (es) | 2016-02-24 | 2024-05-06 | Novo Nordisk As | Generación de células beta funcionales a partir de progenitoras endocrinas derivadas de células madre pluripotentes humanas |
| MA45329A (fr) * | 2016-04-08 | 2019-02-13 | Univ California | Production de cellules bêta matures pleinement fonctionnelles à partir de progénitrices pancréatiques humaines |
| JP7065517B2 (ja) * | 2016-07-26 | 2022-05-12 | 国立大学法人京都大学 | Ｐｔｆ１ａ陽性細胞の製造方法 |
| WO2018159805A1 (ja) * | 2017-03-03 | 2018-09-07 | 国立大学法人京都大学 | 膵前駆細胞の製造方法 |
| EP4488363A3 (en) * | 2017-07-21 | 2025-03-26 | Vertex Pharmaceuticals Incorporated | Re-aggregation of stem cell-derived pancreatic beta cells |
| CA2983845C (en) | 2017-10-26 | 2024-01-30 | University Of Copenhagen | Generation of glucose-responsive beta cells |
| AU2018370029B2 (en) | 2017-11-15 | 2024-11-07 | Vertex Pharmaceuticals Incorporated | Islet cell manufacturing compositions and methods of use |
| KR20200110338A (ko) | 2018-01-18 | 2020-09-23 | 다이이찌 산쿄 가부시키가이샤 | 디하이드로인돌리지논 유도체 |
| JP2021525094A (ja) * | 2018-05-31 | 2021-09-24 | ユニバーシティー ヘルス ネットワーク | インスリン産生細胞を生成する、タンキラーゼ阻害剤を含む方法及び組成物 |
| EP3833365A4 (en) | 2018-08-10 | 2022-05-11 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| CA3110932A1 (en) | 2018-08-30 | 2020-03-05 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| CN111875674B (zh) * | 2018-09-03 | 2021-12-10 | 内蒙古创润生物科技有限公司 | 表皮干细胞向胰腺细胞分化的改进方法 |
| AU2019360857A1 (en) * | 2018-10-15 | 2021-06-03 | Evia Life Sciences Inc. | Method for producing stem/precursor cells, by using low molecular weight compound, from cells derived from endodermal tissue or organ |
| JP7385244B2 (ja) * | 2019-06-27 | 2023-11-22 | 国立大学法人 東京大学 | 膵前駆細胞の分離方法 |
| WO2021051256A1 (en) * | 2019-09-17 | 2021-03-25 | Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences | Pancreatic pro-endocrine progenitor cells and use thereof |
| JP2024506850A (ja) * | 2021-02-01 | 2024-02-15 | シーダーズ－サイナイ メディカル センター | 同質遺伝子型ｉＰＳＣ由来血管内皮細胞との共培養における機能的なヒトｉＰＳＣ由来膵島の作製 |
| CN113234664B (zh) * | 2021-05-11 | 2024-05-10 | 澳门大学 | 一种胰腺祖细胞的制备方法及其应用 |
| CN114634904B (zh) * | 2022-05-17 | 2022-09-13 | 天津外泌体科技有限公司 | 高纯度胰腺祖细胞的产生方法 |
| CN118345030B (zh) * | 2024-06-20 | 2024-08-16 | 羽铂精制生物技术(成都)有限公司 | iPSC诱导分化成为胰腺祖细胞修复胰腺的方法及应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| GB2399823B (en) * | 2001-12-07 | 2006-02-15 | Geron Corp | Islet cells from primate pluripotent stem cells |
| EP1791952A4 (en) | 2004-08-13 | 2008-06-11 | Univ Georgia Res Found | COMPOSITIONS AND METHODS OF SELF-RENEWAL AND DIFFERENTIATION IN HUMAN EMBRYONAL STEM CELLS |
| CA2644468C (en) | 2006-03-02 | 2022-02-01 | Cythera, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
| US7989204B2 (en) | 2006-04-28 | 2011-08-02 | Viacyte, Inc. | Hepatocyte lineage cells |
| US20080063628A1 (en) * | 2006-09-11 | 2008-03-13 | Davis Janet E | Methods to promote cell differentiation |
| US7695963B2 (en) | 2007-09-24 | 2010-04-13 | Cythera, Inc. | Methods for increasing definitive endoderm production |
| US8338170B2 (en) * | 2008-04-21 | 2012-12-25 | Viacyte, Inc. | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| GB201111244D0 (en) * | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| BR112012017761A2 (pt) * | 2009-12-23 | 2015-09-15 | Centocor Ortho Biotech Inc | diferenciação das células-tronco embrionárias humanas |
| WO2012070014A2 (en) * | 2010-11-26 | 2012-05-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells |
-
2013
- 2013-04-30 HU HUE13784648A patent/HUE046271T2/hu unknown
- 2013-04-30 IN IN10053DEN2014 patent/IN2014DN10053A/en unknown
- 2013-04-30 SI SI201331572T patent/SI2844739T1/sl unknown
- 2013-04-30 CA CA2871795A patent/CA2871795C/en active Active
- 2013-04-30 HR HRP20191677 patent/HRP20191677T1/hr unknown
- 2013-04-30 LT LTEP13784648.1T patent/LT2844739T/lt unknown
- 2013-04-30 CN CN201380035022.5A patent/CN104411815B/zh active Active
- 2013-04-30 CN CN201711013526.3A patent/CN108004199B/zh active Active
- 2013-04-30 JP JP2015509270A patent/JP6397397B2/ja active Active
- 2013-04-30 ES ES13784648T patent/ES2747967T3/es active Active
- 2013-04-30 EP EP13784648.1A patent/EP2844739B1/en active Active
- 2013-04-30 PL PL13784648T patent/PL2844739T3/pl unknown
- 2013-04-30 US US14/397,657 patent/US20150104430A1/en active Pending
- 2013-04-30 PT PT137846481T patent/PT2844739T/pt unknown
- 2013-04-30 EP EP19181059.7A patent/EP3594323A1/en active Pending
- 2013-04-30 AU AU2013255031A patent/AU2013255031C1/en active Active
- 2013-04-30 WO PCT/CA2013/000432 patent/WO2013163739A1/en not_active Ceased
- 2013-04-30 DK DK13784648.1T patent/DK2844739T3/da active
-
2018
- 2018-08-30 JP JP2018162002A patent/JP6759293B2/ja active Active
-
2019
- 2019-09-13 CY CY20191100960T patent/CY1122058T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3594323A1 (en) | 2020-01-15 |
| CA2871795A1 (en) | 2013-11-07 |
| LT2844739T (lt) | 2019-10-10 |
| EP2844739A1 (en) | 2015-03-11 |
| CN108004199A (zh) | 2018-05-08 |
| AU2013255031C1 (en) | 2018-12-06 |
| CN104411815A (zh) | 2015-03-11 |
| CA2871795C (en) | 2023-03-14 |
| HUE046271T2 (hu) | 2020-02-28 |
| US20150104430A1 (en) | 2015-04-16 |
| SI2844739T1 (sl) | 2019-11-29 |
| IN2014DN10053A (enExample) | 2015-08-14 |
| HRP20191677T1 (hr) | 2019-12-13 |
| JP6759293B2 (ja) | 2020-09-23 |
| PT2844739T (pt) | 2019-10-01 |
| HK1254968A1 (zh) | 2019-08-02 |
| CN104411815B (zh) | 2017-11-28 |
| JP2018198620A (ja) | 2018-12-20 |
| EP2844739A4 (en) | 2015-12-02 |
| PL2844739T3 (pl) | 2019-12-31 |
| CN108004199B (zh) | 2022-03-18 |
| WO2013163739A1 (en) | 2013-11-07 |
| AU2013255031A1 (en) | 2014-12-04 |
| AU2013255031B2 (en) | 2018-09-06 |
| HK1208047A1 (en) | 2016-02-19 |
| JP6397397B2 (ja) | 2018-09-26 |
| EP2844739B1 (en) | 2019-06-19 |
| JP2015519048A (ja) | 2015-07-09 |
| ES2747967T3 (es) | 2020-03-12 |
| DK2844739T3 (da) | 2019-09-30 |
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