ES2747967T3 - Procedimientos y composiciones para generar progenitores pancreáticos y células beta funcionales a partir de hPSC - Google Patents
Procedimientos y composiciones para generar progenitores pancreáticos y células beta funcionales a partir de hPSC Download PDFInfo
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- ES2747967T3 ES2747967T3 ES13784648T ES13784648T ES2747967T3 ES 2747967 T3 ES2747967 T3 ES 2747967T3 ES 13784648 T ES13784648 T ES 13784648T ES 13784648 T ES13784648 T ES 13784648T ES 2747967 T3 ES2747967 T3 ES 2747967T3
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US201261640366P | 2012-04-30 | 2012-04-30 | |
| PCT/CA2013/000432 WO2013163739A1 (en) | 2012-04-30 | 2013-04-30 | METHODS AND COMPOSITIONS FOR GENERATING PANCREATIC PROGENITORS AND FUNCTIONAL BETA CELLS FROM hPSCs |
Publications (1)
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| ES2747967T3 true ES2747967T3 (es) | 2020-03-12 |
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| ES13784648T Active ES2747967T3 (es) | 2012-04-30 | 2013-04-30 | Procedimientos y composiciones para generar progenitores pancreáticos y células beta funcionales a partir de hPSC |
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Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2014165663A1 (en) * | 2013-04-03 | 2014-10-09 | Cellular Dynamics International, Inc. | Methods and compositions for culturing endoderm progenitor cells in suspension |
| US10472610B2 (en) | 2014-05-21 | 2019-11-12 | Kyoto University | Method for generating pancreatic bud cells and therapeutic agent for pancreatic disease containing pancreatic bud cells |
| JP6954711B2 (ja) | 2015-04-24 | 2021-10-27 | ユニバーシティ オブ コペンハーゲン | 真正膵臓前駆細胞の単離 |
| DK3285572T3 (da) * | 2015-04-24 | 2021-03-01 | Univ Copenhagen | Fremgangsmåde til fremstilling af insulinproducerende celler |
| WO2017019702A1 (en) * | 2015-07-27 | 2017-02-02 | The Regents Of The University Of California | Methods and compositions for producing pancreatic beta cells |
| CN106554936B (zh) * | 2015-09-30 | 2020-05-05 | 海门雨霖细胞科技有限责任公司 | 诱导人干细胞向肝细胞定向分化的新方法 |
| MA45747A (fr) * | 2016-02-24 | 2019-01-02 | Novo Nordisk As | Génération de cellules bêta fonctionnelles à partir de progéniteurs endocrines dérivés de cellules souhes pluripotentes humaines |
| ES3002713T3 (en) * | 2016-04-08 | 2025-03-07 | Univ California | Production of fully functional mature beta cells from human pancreatic progenitors |
| JP7065517B2 (ja) * | 2016-07-26 | 2022-05-12 | 国立大学法人京都大学 | Ｐｔｆ１ａ陽性細胞の製造方法 |
| EP3591040A4 (en) * | 2017-03-03 | 2020-11-11 | Kyoto University | METHOD OF PRODUCTION OF PANCREATIC PROGENITOR CELLS |
| EP4488363A3 (en) * | 2017-07-21 | 2025-03-26 | Vertex Pharmaceuticals Incorporated | Re-aggregation of stem cell-derived pancreatic beta cells |
| CA2983845C (en) | 2017-10-26 | 2024-01-30 | University Of Copenhagen | Generation of glucose-responsive beta cells |
| AU2018370029B2 (en) | 2017-11-15 | 2024-11-07 | Vertex Pharmaceuticals Incorporated | Islet cell manufacturing compositions and methods of use |
| ES2958118T3 (es) | 2018-01-18 | 2024-02-01 | Daiichi Sankyo Co Ltd | Derivado de dihidroindolizinona |
| CA3101021A1 (en) | 2018-05-31 | 2019-12-05 | University Health Network | Methods and compositions comprising tankyrase inhibitors for generating insulin producing cells |
| WO2020033879A1 (en) | 2018-08-10 | 2020-02-13 | Semma Therapeutics, Inc. | Stem cell derived islet differentiation |
| AU2018439389A1 (en) | 2018-08-30 | 2021-02-18 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| CN111875674B (zh) * | 2018-09-03 | 2021-12-10 | 内蒙古创润生物科技有限公司 | 表皮干细胞向胰腺细胞分化的改进方法 |
| DK3868870T3 (en) * | 2018-10-15 | 2026-02-23 | Evia Life Sciences Inc | Method for producing stem/precursor cells, by using low molecular weight compound, from cells derived from endodermal tissue or organ |
| JP7385244B2 (ja) * | 2019-06-27 | 2023-11-22 | 国立大学法人 東京大学 | 膵前駆細胞の分離方法 |
| WO2021051256A1 (en) * | 2019-09-17 | 2021-03-25 | Center For Excellence In Molecular Cell Science, Chinese Academy Of Sciences | Pancreatic pro-endocrine progenitor cells and use thereof |
| US20240093154A1 (en) * | 2021-02-01 | 2024-03-21 | Cedars-Sinai Medical Center | Generation of functional human ipsc-derived pancreatic islets in co-culture with isogenic ipsc-derived vascular endothelial cells |
| CN113234664B (zh) * | 2021-05-11 | 2024-05-10 | 澳门大学 | 一种胰腺祖细胞的制备方法及其应用 |
| CN114634904B (zh) * | 2022-05-17 | 2022-09-13 | 天津外泌体科技有限公司 | 高纯度胰腺祖细胞的产生方法 |
| CN118345030B (zh) * | 2024-06-20 | 2024-08-16 | 羽铂精制生物技术(成都)有限公司 | iPSC诱导分化成为胰腺祖细胞修复胰腺的方法及应用 |
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| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5994619A (en) | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| US5945577A (en) | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| US7033831B2 (en) * | 2001-12-07 | 2006-04-25 | Geron Corporation | Islet cells from human embryonic stem cells |
| CA2576872C (en) | 2004-08-13 | 2013-11-12 | University Of Georgia Research Foundation, Inc. | Compositions and methods for self-renewal and differentiation in human embryonic stem cells |
| EP1999253B1 (en) | 2006-03-02 | 2019-05-22 | Viacyte, Inc. | Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production |
| US7989204B2 (en) | 2006-04-28 | 2011-08-02 | Viacyte, Inc. | Hepatocyte lineage cells |
| US20080063628A1 (en) * | 2006-09-11 | 2008-03-13 | Davis Janet E | Methods to promote cell differentiation |
| US7695963B2 (en) | 2007-09-24 | 2010-04-13 | Cythera, Inc. | Methods for increasing definitive endoderm production |
| US8338170B2 (en) * | 2008-04-21 | 2012-12-25 | Viacyte, Inc. | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| GB201111244D0 (en) * | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| CA2784415C (en) * | 2009-12-23 | 2019-06-18 | Jean Xu | Differentiation of human embryonic stem cells |
| WO2012070014A2 (en) * | 2010-11-26 | 2012-05-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells |
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| PL2844739T3 (pl) | 2019-12-31 |
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