HRP20191607T1 - Biomarkeri za inaktivaciju kolateralnih gena i ciljevi za terapiju raka - Google Patents

Biomarkeri za inaktivaciju kolateralnih gena i ciljevi za terapiju raka Download PDF

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Publication number
HRP20191607T1
HRP20191607T1 HRP20191607T HRP20191607T1 HR P20191607 T1 HRP20191607 T1 HR P20191607T1 HR P20191607 T HRP20191607 T HR P20191607T HR P20191607 T1 HRP20191607 T1 HR P20191607T1
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Croatia
Prior art keywords
redundant
homolog
host gene
redundant homolog
cancer
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English (en)
Croatian (hr)
Inventor
Florian L Muller
Eliot Fletcher-Sananikone
Simona Colla
Elisa Aquilanti
Ronald Depinho
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Univ Texas
Dana Farber Cancer Inst Inc
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Application filed by Univ Texas, Dana Farber Cancer Inst Inc filed Critical Univ Texas
Publication of HRP20191607T1 publication Critical patent/HRP20191607T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/191—Carboxylic acids, e.g. valproic acid having two or more hydroxy groups, e.g. gluconic acid
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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HRP20191607 2011-12-14 2012-12-14 Biomarkeri za inaktivaciju kolateralnih gena i ciljevi za terapiju raka HRP20191607T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161570366P 2011-12-14 2011-12-14
US201261652738P 2012-05-29 2012-05-29
EP12858619.5A EP2790738B1 (en) 2011-12-14 2012-12-14 Collateral gene inactivation biomarkers and targets for cancer therapy
PCT/US2012/069767 WO2013090732A2 (en) 2011-12-14 2012-12-14 Collateral gene inactivation biomarkers and targets for cancer therapy

Publications (1)

Publication Number Publication Date
HRP20191607T1 true HRP20191607T1 (hr) 2019-12-13

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Application Number Title Priority Date Filing Date
HRP20191607 HRP20191607T1 (hr) 2011-12-14 2012-12-14 Biomarkeri za inaktivaciju kolateralnih gena i ciljevi za terapiju raka

Country Status (11)

Country Link
US (1) US9452182B2 (Direct)
EP (2) EP3603678A3 (Direct)
JP (2) JP6820653B2 (Direct)
KR (2) KR102144452B1 (Direct)
CN (3) CN115177727A (Direct)
DK (1) DK2790738T3 (Direct)
ES (1) ES2746058T3 (Direct)
HR (1) HRP20191607T1 (Direct)
HU (1) HUE045359T2 (Direct)
IN (1) IN2014DN05803A (Direct)
WO (1) WO2013090732A2 (Direct)

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CN112336851A (zh) 2014-01-13 2021-02-09 博格有限责任公司 烯醇酶1(eno1)组合物及其用途
CN104894229A (zh) * 2014-03-04 2015-09-09 中南大学 己糖激酶2作为鼻咽癌放疗预后预测的生物标志物
ES2823798T3 (es) * 2014-12-31 2021-05-10 Dev Ct Biotechnology Anticuerpos humanizados específicos de alfa-enolasa y procedimientos de usos en la terapia del cáncer
WO2016145113A1 (en) 2015-03-09 2016-09-15 Board Of Regents, The University Of Texas System Enolase inhibitors and methods of treatment therewith
EP3368687B1 (en) 2015-10-27 2021-09-29 The Broad Institute, Inc. Compositions and methods for targeting cancer-specific sequence variations
CA2937896A1 (en) * 2016-08-02 2018-02-02 Universite De Montreal Use of mubritinib for the treatment of poor prognosis acute myeloid leukemia
CN107217054B (zh) * 2017-04-25 2020-08-14 中山大学肿瘤防治中心 G6pd基因及其表达产物在治疗结直肠癌中的应用
CN107460250B (zh) * 2017-09-28 2020-07-28 郑州大学第一附属医院 基于kif14、kif15和kif20a基因的透明细胞肾癌诊断试剂盒及其使用方法
JP2022522602A (ja) * 2019-02-26 2022-04-20 ノボキュア ゲーエムベーハー 標的がん細胞の電気特性に基づくｔｔフィールド治療のための周波数の決定
CN113766955A (zh) * 2019-03-29 2021-12-07 得克萨斯大学体系董事会 对携带her2外显子21插入的癌细胞具有抗肿瘤活性的化合物
US20220244263A1 (en) * 2019-05-28 2022-08-04 The Regents Of The University Of California Methods for treating small cell neuroendocrine and related cancers
US20230075965A1 (en) * 2020-01-24 2023-03-09 Constantine S. Mitsiades Uses of biomarkers for improving immunotherapy
CN113567675B (zh) * 2020-04-28 2023-09-22 苏州浚惠生物科技有限公司 用于肿瘤的己糖激酶2抑制剂液体活检伴随诊断和试剂盒
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