HRP20191513T1 - Fenotiazinski spojevi za liječenje blagog kognitivnog poremećaja - Google Patents
Fenotiazinski spojevi za liječenje blagog kognitivnog poremećaja Download PDFInfo
- Publication number
- HRP20191513T1 HRP20191513T1 HRP20191513T HRP20191513T1 HR P20191513 T1 HRP20191513 T1 HR P20191513T1 HR P20191513 T HRP20191513 T HR P20191513T HR P20191513 T1 HRP20191513 T1 HR P20191513T1
- Authority
- HR
- Croatia
- Prior art keywords
- unsubstituted
- substituted
- carboaryl
- aliphatic
- independently selected
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94500607P | 2007-06-19 | 2007-06-19 | |
| PCT/GB2008/002066 WO2008155533A2 (en) | 2007-06-19 | 2008-06-17 | Phenothiazine compounds for treating mild cognitive impairment |
| EP08762390.6A EP2167095B1 (en) | 2007-06-19 | 2008-06-17 | Phenothiazine compounds for treating mild cognitive impairment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191513T1 true HRP20191513T1 (hr) | 2019-11-29 |
Family
ID=39943003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191513 HRP20191513T1 (hr) | 2007-06-19 | 2008-06-17 | Fenotiazinski spojevi za liječenje blagog kognitivnog poremećaja |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9211294B2 (enExample) |
| EP (1) | EP2167095B1 (enExample) |
| JP (1) | JP5725605B2 (enExample) |
| CN (1) | CN101820884B (enExample) |
| AU (1) | AU2008265045B2 (enExample) |
| BR (1) | BRPI0813670A2 (enExample) |
| CA (1) | CA2690746C (enExample) |
| DK (1) | DK2167095T3 (enExample) |
| ES (1) | ES2739546T3 (enExample) |
| HR (1) | HRP20191513T1 (enExample) |
| HU (1) | HUE045460T2 (enExample) |
| MY (1) | MY177001A (enExample) |
| PL (1) | PL2167095T3 (enExample) |
| PT (1) | PT2167095T (enExample) |
| SI (1) | SI2167095T1 (enExample) |
| WO (1) | WO2008155533A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602007008550D1 (de) | 2006-03-29 | 2010-09-30 | Wista Lab Ltd | 3,7-diamino-10h-phenothiazinsalze und ihre verwendung |
| SI2954932T1 (sl) * | 2007-10-03 | 2019-01-31 | Wista Laboratories Ltd. | Terapevtska uporaba diaminofenotiazinov |
| SG185094A1 (en) | 2010-04-30 | 2012-12-28 | Prostetta Antiviral Inc | Antiviral compounds |
| SI2673266T1 (sl) * | 2011-02-11 | 2016-11-30 | Wista Laboratories Ltd. | Fenotiazin diaminijeve soli in njihova uporaba |
| WO2012145567A1 (en) | 2011-04-20 | 2012-10-26 | Prosetta Antiviral Inc. | Antiviral compounds |
| EP3686181B1 (en) * | 2013-01-30 | 2024-07-17 | Ecolab USA Inc. | Hydrogen sulfide scavengers |
| US10304006B2 (en) * | 2013-02-15 | 2019-05-28 | The Charles Stark Draper Laboratory, Inc. | Method for integrating and fusing heterogeneous data types to perform predictive analysis |
| AU2016220096B2 (en) | 2015-02-17 | 2020-01-30 | Arizona Board Of Regents On Behalf Of Arizona State University | Phenothiazine analogues as mitochondrial therapeutic agents |
| SI4335517T1 (sl) * | 2016-07-25 | 2025-11-28 | Taurx Therapeutics Management Ltd. | Dajanje in odmerek diaminofenotiazinov |
| GB201614834D0 (en) * | 2016-09-01 | 2016-10-19 | Wista Lab Ltd | Treatment of dementia |
| EP4385512B1 (en) * | 2018-07-26 | 2025-12-03 | TauRx Therapeutics Management Ltd. | Optimised dosage of diaminophenothiazines in populations |
| MY209608A (en) * | 2019-04-10 | 2025-07-24 | Genting Taurx Diagnostic Centre Sdn Bhd | Adaptive neurological testing method |
| GB201909454D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Enhancers |
| GB201909493D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Therapeutic interactions |
| GB201909506D0 (en) | 2019-07-02 | 2019-08-14 | Wista Lab Ltd | Synaptopathies |
| CA3257856A1 (en) | 2022-05-31 | 2023-12-07 | Wista Laboratories Ltd. | TREATMENT OF NEURODEGENERATIVE DISORDERS USING COMPOUNDS CONTAINING METHYLTHIONINIUM (MT) |
| KR20250154422A (ko) | 2023-03-03 | 2025-10-28 | 타우알엑스 쎄라퓨틱스 매니지먼트 리미티드 | 미세혈관 뇌질환 치료를 위한 디아미노페노티아진 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9506197D0 (en) | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| GB0017060D0 (en) * | 2000-07-11 | 2000-08-30 | Hunter Fleming Ltd | Production, stabilisation and use of reduced forms of pharmaceutical compounds |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| EP1617844A4 (en) * | 2003-04-03 | 2009-07-22 | Prana Biotechnology Ltd | TREATMENT OF NEUROLOGICAL DISEASES |
| WO2006032879A2 (en) * | 2004-09-23 | 2006-03-30 | Wista Laboratories Ltd. | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc) |
| CN101084204B (zh) * | 2004-09-23 | 2012-12-05 | 卫思道制药有限公司 | 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法 |
| WO2006091728A2 (en) * | 2005-02-24 | 2006-08-31 | The Trustees Of The University Of Pennsylvania | Microtubule stabilizing compounds and methods of their use |
| EP2001556B1 (en) * | 2006-03-29 | 2014-10-01 | Wista Laboratories Ltd. | Thioninium compounds and their use |
| DE602007008550D1 (de) | 2006-03-29 | 2010-09-30 | Wista Lab Ltd | 3,7-diamino-10h-phenothiazinsalze und ihre verwendung |
| WO2007110629A1 (en) | 2006-03-29 | 2007-10-04 | Wista Laboratories Ltd | Inhibitors of protein aggregation |
| SI2457905T1 (sl) | 2006-07-11 | 2016-12-30 | Wista Laboratories Ltd. | Postopki sinteze in/ali čiščenja diaminofenotiazinijevih spojin |
-
2008
- 2008-06-17 DK DK08762390.6T patent/DK2167095T3/da active
- 2008-06-17 BR BRPI0813670-0A2A patent/BRPI0813670A2/pt not_active Application Discontinuation
- 2008-06-17 US US12/665,608 patent/US9211294B2/en active Active
- 2008-06-17 ES ES08762390T patent/ES2739546T3/es active Active
- 2008-06-17 JP JP2010512761A patent/JP5725605B2/ja active Active
- 2008-06-17 HU HUE08762390A patent/HUE045460T2/hu unknown
- 2008-06-17 PT PT08762390T patent/PT2167095T/pt unknown
- 2008-06-17 WO PCT/GB2008/002066 patent/WO2008155533A2/en not_active Ceased
- 2008-06-17 PL PL08762390T patent/PL2167095T3/pl unknown
- 2008-06-17 CN CN2008801031955A patent/CN101820884B/zh active Active
- 2008-06-17 SI SI200832080T patent/SI2167095T1/sl unknown
- 2008-06-17 AU AU2008265045A patent/AU2008265045B2/en active Active
- 2008-06-17 CA CA2690746A patent/CA2690746C/en active Active
- 2008-06-17 MY MYPI20095255A patent/MY177001A/en unknown
- 2008-06-17 EP EP08762390.6A patent/EP2167095B1/en active Active
- 2008-06-17 HR HRP20191513 patent/HRP20191513T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008265045B2 (en) | 2014-02-27 |
| BRPI0813670A2 (pt) | 2014-12-30 |
| JP5725605B2 (ja) | 2015-05-27 |
| HUE045460T2 (hu) | 2019-12-30 |
| US20100184752A1 (en) | 2010-07-22 |
| ES2739546T3 (es) | 2020-01-31 |
| CN101820884B (zh) | 2013-08-28 |
| EP2167095B1 (en) | 2019-05-29 |
| AU2008265045A1 (en) | 2008-12-24 |
| DK2167095T3 (da) | 2019-07-29 |
| CA2690746C (en) | 2018-01-02 |
| SI2167095T1 (sl) | 2019-09-30 |
| US9211294B2 (en) | 2015-12-15 |
| MY177001A (en) | 2020-09-01 |
| CA2690746A1 (en) | 2008-12-24 |
| WO2008155533A3 (en) | 2009-02-19 |
| PT2167095T (pt) | 2019-08-06 |
| PL2167095T3 (pl) | 2019-11-29 |
| WO2008155533A2 (en) | 2008-12-24 |
| CN101820884A (zh) | 2010-09-01 |
| JP2010530403A (ja) | 2010-09-09 |
| EP2167095A2 (en) | 2010-03-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20191513T1 (hr) | Fenotiazinski spojevi za liječenje blagog kognitivnog poremećaja | |
| SI2004155T1 (en) | Protein aggregation inhibitors | |
| TWI798470B (zh) | 作為神經激肽－１受體拮抗劑的化合物及其用途 | |
| CN101801942B (zh) | 杂环化合物和作为抗癌剂的用途 | |
| ES2701089T3 (es) | Uso terapéutico de las diaminofenotiazinas | |
| WO2018075993A1 (en) | Compounds and methods to sensitize cancer cells to tyrosine kinase inhibitors | |
| CN103796654B (zh) | 氘富集化4-羟基-5-甲氧基-n,1-二甲基-2-氧代-n-[(4-三氟-甲基)苯基]-1,2-二氢喹啉-3-甲酰胺 | |
| EP3684772B1 (en) | Cyclic iminopyrimidine derivatives as kinase inhibitors | |
| ES2632471T3 (es) | Novedosa sal de abexinostat, forma cristalina asociada, su procedimiento de preparación y las composiciones farmacéuticas que las contienen | |
| JP2013528600A5 (enExample) | ||
| JP2010530403A5 (enExample) | ||
| EP2586780A4 (en) | 2-ARYL-IMIDAZO- [1,2-A] -PYRIDINE-3-ACETAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE | |
| Su et al. | The development of bis (hydroxymethyl) pyrrole analogs as bifunctional DNA cross-linking agents and their chemotherapeutic potential | |
| HRP20181027T1 (hr) | Derivati fuzioniranog triazola kao inhibitori fosfodiesteraze 10a | |
| WO2003062240A1 (de) | Pteridinderivate, verfahren zu deren herstellung und ihre verwendung | |
| JP2014514288A5 (enExample) | ||
| JP5733839B2 (ja) | 神経変性疾患治療薬 | |
| Basavarajaiah et al. | Pharmacological Activities of Some 5-Substituted-3-phenyl-Nβ-(substituted-2-oxo-2H-pyrano [2, 3-b] quinoline-3-carbonyl)-1H-indole-2-carboxyhydrazides | |
| ES2847229T3 (es) | Compuestos intermedios utilizables en la síntesis de (-)-huperzina y proceso para obtener uno de estos compuestos intermedios | |
| ES3012496T3 (en) | Synthesis of a thiosulfonic acid by a step of periodate mediated oxidative coupling of a thiosulfonic acid with an aniline | |
| CN105813643A (zh) | 利用含有噻吩并三唑二氮杂*化合物的药物制剂治疗非小细胞肺癌的方法 | |
| PE20250745A1 (es) | Polimorfos cristalinos de (s)-2-etil-8-metil-1-tia-4,8-diazaspiro[4.5]decan-3-ona como agonista del receptor muscarinico de acetilcolina | |
| KR20080056221A (ko) | 베타 아밀로이드 응집의 나프틸 유도체 억제제 | |
| WO2016187377A1 (en) | Compounds and methods for modulating serotonin receptors in the periphery | |
| WO2017180723A1 (en) | Ataxia telengiectasia and rad3-related (atr) inhibitors and methods of their use |