SI2167095T1 - Fenotiazinske spojine za zdravljenje blage kognitivne motnje - Google Patents
Fenotiazinske spojine za zdravljenje blage kognitivne motnjeInfo
- Publication number
- SI2167095T1 SI2167095T1 SI200832080T SI200832080T SI2167095T1 SI 2167095 T1 SI2167095 T1 SI 2167095T1 SI 200832080 T SI200832080 T SI 200832080T SI 200832080 T SI200832080 T SI 200832080T SI 2167095 T1 SI2167095 T1 SI 2167095T1
- Authority
- SI
- Slovenia
- Prior art keywords
- cognitive impairment
- mild cognitive
- treating mild
- phenothiazine compounds
- phenothiazine
- Prior art date
Links
- 208000010877 cognitive disease Diseases 0.000 title 1
- 208000027061 mild cognitive impairment Diseases 0.000 title 1
- 125000001484 phenothiazinyl group Chemical class C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94500607P | 2007-06-19 | 2007-06-19 | |
| PCT/GB2008/002066 WO2008155533A2 (en) | 2007-06-19 | 2008-06-17 | Phenothiazine compounds for treating mild cognitive impairment |
| EP08762390.6A EP2167095B1 (en) | 2007-06-19 | 2008-06-17 | Phenothiazine compounds for treating mild cognitive impairment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2167095T1 true SI2167095T1 (sl) | 2019-09-30 |
Family
ID=39943003
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200832080T SI2167095T1 (sl) | 2007-06-19 | 2008-06-17 | Fenotiazinske spojine za zdravljenje blage kognitivne motnje |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9211294B2 (enExample) |
| EP (1) | EP2167095B1 (enExample) |
| JP (1) | JP5725605B2 (enExample) |
| CN (1) | CN101820884B (enExample) |
| AU (1) | AU2008265045B2 (enExample) |
| BR (1) | BRPI0813670A2 (enExample) |
| CA (1) | CA2690746C (enExample) |
| DK (1) | DK2167095T3 (enExample) |
| ES (1) | ES2739546T3 (enExample) |
| HR (1) | HRP20191513T1 (enExample) |
| HU (1) | HUE045460T2 (enExample) |
| MY (1) | MY177001A (enExample) |
| PL (1) | PL2167095T3 (enExample) |
| PT (1) | PT2167095T (enExample) |
| SI (1) | SI2167095T1 (enExample) |
| WO (1) | WO2008155533A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007231124B2 (en) | 2006-03-29 | 2013-02-21 | TauRx Therapeutics Management Ltd | 3,7-diamino-10H-phenothiazine salts and their use |
| EP2205245B1 (en) * | 2007-10-03 | 2015-06-24 | WisTa Laboratories Ltd. | Therapeutic use of diaminophenothiazines |
| EP2585073B1 (en) | 2010-04-30 | 2016-04-27 | Prosetta Antiviral Inc. | Antiviral compounds |
| AU2011358840B2 (en) * | 2011-02-11 | 2017-05-04 | TauRx Therapeutics Management Ltd | Phenothiazine diaminium salts and their use |
| WO2012145567A1 (en) | 2011-04-20 | 2012-10-26 | Prosetta Antiviral Inc. | Antiviral compounds |
| EP2951149B1 (en) * | 2013-01-30 | 2018-10-10 | Ecolab USA Inc. | Hydrogen sulfide scavengers |
| US10304006B2 (en) * | 2013-02-15 | 2019-05-28 | The Charles Stark Draper Laboratory, Inc. | Method for integrating and fusing heterogeneous data types to perform predictive analysis |
| US10472340B2 (en) * | 2015-02-17 | 2019-11-12 | Arizona Board Of Regents On Behalf Of Arizona State University | Substituted phenothiazines as mitochondrial agents |
| KR20230058533A (ko) * | 2016-07-25 | 2023-05-03 | 위스타 레보레이토리스 리미티드 | 디아미노페노티아진 (diaminophenothiazines)의 투여 및 투여량 (dosage) |
| GB201614834D0 (en) * | 2016-09-01 | 2016-10-19 | Wista Lab Ltd | Treatment of dementia |
| DK4364801T3 (da) | 2018-07-26 | 2025-12-22 | Taurx Therapeutics Man Ltd | Optimeret dosering af diaminophenothiaziner i populationer |
| MY209608A (en) * | 2019-04-10 | 2025-07-24 | Genting Taurx Diagnostic Centre Sdn Bhd | Adaptive neurological testing method |
| GB201909454D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Enhancers |
| GB201909493D0 (en) | 2019-07-01 | 2019-08-14 | Wista Lab Ltd | Therapeutic interactions |
| GB201909506D0 (en) | 2019-07-02 | 2019-08-14 | Wista Lab Ltd | Synaptopathies |
| AU2023279800A1 (en) | 2022-05-31 | 2024-12-19 | TauRx Therapeutics Management Ltd | Treatment of neurodegenerative disorders utilising methylthioninium (mt)-containing compounds |
| WO2024184146A1 (en) | 2023-03-03 | 2024-09-12 | Wista Laboratories Ltd. | Diaminophenothiazine for the treatment of microvascular brain disease disease |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9506197D0 (en) * | 1995-03-27 | 1995-05-17 | Hoffmann La Roche | Inhibition of tau-tau association. |
| GB0017060D0 (en) * | 2000-07-11 | 2000-08-30 | Hunter Fleming Ltd | Production, stabilisation and use of reduced forms of pharmaceutical compounds |
| GB0101049D0 (en) | 2001-01-15 | 2001-02-28 | Univ Aberdeen | Materials and methods relating to protein aggregation in neurodegenerative disease |
| AU2004226876A1 (en) * | 2003-04-03 | 2004-10-14 | Prana Biotechnology Ltd | Treatment of neurological conditions |
| JP5186212B2 (ja) * | 2004-09-23 | 2013-04-17 | ウィスタ ラボラトリーズ リミテッド | メチルチオニニウム塩化物（ｍｔｃ）などのジアミノフェノチアジニウム化合物を化学合成および精製する方法 |
| EP3564223A1 (en) * | 2004-09-23 | 2019-11-06 | WisTa Laboratories Ltd. | Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (mtc) |
| WO2006091728A2 (en) * | 2005-02-24 | 2006-08-31 | The Trustees Of The University Of Pennsylvania | Microtubule stabilizing compounds and methods of their use |
| DK2853293T3 (en) * | 2006-03-29 | 2018-01-22 | Wista Lab Ltd | Thioninium compounds and their use |
| CN101460157B (zh) * | 2006-03-29 | 2015-09-02 | 维斯塔实验室有限公司 | 蛋白聚集抑制剂 |
| AU2007231124B2 (en) * | 2006-03-29 | 2013-02-21 | TauRx Therapeutics Management Ltd | 3,7-diamino-10H-phenothiazine salts and their use |
| SI2457904T1 (sl) | 2006-07-11 | 2015-02-27 | Wista Laboratories Ltd. | Postopki sinteze in/ali čiščenje diaminofenotiazinijevih spojin |
-
2008
- 2008-06-17 AU AU2008265045A patent/AU2008265045B2/en active Active
- 2008-06-17 HR HRP20191513 patent/HRP20191513T1/hr unknown
- 2008-06-17 WO PCT/GB2008/002066 patent/WO2008155533A2/en not_active Ceased
- 2008-06-17 JP JP2010512761A patent/JP5725605B2/ja active Active
- 2008-06-17 HU HUE08762390A patent/HUE045460T2/hu unknown
- 2008-06-17 SI SI200832080T patent/SI2167095T1/sl unknown
- 2008-06-17 ES ES08762390T patent/ES2739546T3/es active Active
- 2008-06-17 PL PL08762390T patent/PL2167095T3/pl unknown
- 2008-06-17 EP EP08762390.6A patent/EP2167095B1/en active Active
- 2008-06-17 US US12/665,608 patent/US9211294B2/en active Active
- 2008-06-17 PT PT08762390T patent/PT2167095T/pt unknown
- 2008-06-17 CN CN2008801031955A patent/CN101820884B/zh active Active
- 2008-06-17 BR BRPI0813670-0A2A patent/BRPI0813670A2/pt not_active Application Discontinuation
- 2008-06-17 CA CA2690746A patent/CA2690746C/en active Active
- 2008-06-17 MY MYPI20095255A patent/MY177001A/en unknown
- 2008-06-17 DK DK08762390.6T patent/DK2167095T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| MY177001A (en) | 2020-09-01 |
| WO2008155533A3 (en) | 2009-02-19 |
| EP2167095B1 (en) | 2019-05-29 |
| CA2690746C (en) | 2018-01-02 |
| CN101820884B (zh) | 2013-08-28 |
| AU2008265045A1 (en) | 2008-12-24 |
| DK2167095T3 (da) | 2019-07-29 |
| CA2690746A1 (en) | 2008-12-24 |
| PT2167095T (pt) | 2019-08-06 |
| EP2167095A2 (en) | 2010-03-31 |
| JP5725605B2 (ja) | 2015-05-27 |
| PL2167095T3 (pl) | 2019-11-29 |
| US9211294B2 (en) | 2015-12-15 |
| CN101820884A (zh) | 2010-09-01 |
| WO2008155533A2 (en) | 2008-12-24 |
| US20100184752A1 (en) | 2010-07-22 |
| AU2008265045B2 (en) | 2014-02-27 |
| HUE045460T2 (hu) | 2019-12-30 |
| JP2010530403A (ja) | 2010-09-09 |
| BRPI0813670A2 (pt) | 2014-12-30 |
| HRP20191513T1 (hr) | 2019-11-29 |
| ES2739546T3 (es) | 2020-01-31 |
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