HRP20190719T1 - Sastavi i postupci za smanjenje reproduktivnog kapaciteta ženskih štakora - Google Patents
Sastavi i postupci za smanjenje reproduktivnog kapaciteta ženskih štakora Download PDFInfo
- Publication number
- HRP20190719T1 HRP20190719T1 HRP20190719TT HRP20190719T HRP20190719T1 HR P20190719 T1 HRP20190719 T1 HR P20190719T1 HR P20190719T T HRP20190719T T HR P20190719TT HR P20190719 T HRP20190719 T HR P20190719T HR P20190719 T1 HRP20190719 T1 HR P20190719T1
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- Prior art keywords
- composition according
- alkyl
- group
- diepoxide
- composition
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims 21
- 241000700159 Rattus Species 0.000 title claims 8
- 230000001850 reproductive effect Effects 0.000 title claims 4
- -1 diterpenoid epoxide Chemical class 0.000 claims 8
- OECTYKWYRCHAKR-UHFFFAOYSA-N 4-vinylcyclohexene dioxide Chemical compound C1OC1C1CC2OC2CC1 OECTYKWYRCHAKR-UHFFFAOYSA-N 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- DFBIRQPKNDILPW-CIVMWXNOSA-N Triptolide Chemical group O=C1OCC([C@@H]2C3)=C1CC[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1(C(C)C)[C@@H](O)[C@]21[C@H]3O1 DFBIRQPKNDILPW-CIVMWXNOSA-N 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- YKUJZZHGTWVWHA-UHFFFAOYSA-N triptolide Natural products COC12CC3OC3(C(C)C)C(O)C14OC4CC5C6=C(CCC25C)C(=O)OC6 YKUJZZHGTWVWHA-UHFFFAOYSA-N 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- IVIDDMGBRCPGLJ-UHFFFAOYSA-N 2,3-bis(oxiran-2-ylmethoxy)propan-1-ol Chemical compound C1OC1COC(CO)COCC1CO1 IVIDDMGBRCPGLJ-UHFFFAOYSA-N 0.000 claims 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- 229910003827 NRaRb Chemical group 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- UWFRVQVNYNPBEF-UHFFFAOYSA-N 1-(2,4-dimethylphenyl)propan-1-one Chemical compound CCC(=O)C1=CC=C(C)C=C1C UWFRVQVNYNPBEF-UHFFFAOYSA-N 0.000 claims 1
- YQMXOIAIYXXXEE-UHFFFAOYSA-N 1-benzylpyrrolidin-3-ol Chemical compound C1C(O)CCN1CC1=CC=CC=C1 YQMXOIAIYXXXEE-UHFFFAOYSA-N 0.000 claims 1
- HPTCYMNPHWXVLA-UBBHAYRHSA-N 16-hydroxytriptolide Chemical compound O=C1OCC([C@@H]2C3)=C1CC[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1([C@H](CO)C)[C@@H](O)[C@]21[C@H]3O1 HPTCYMNPHWXVLA-UBBHAYRHSA-N 0.000 claims 1
- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical compound C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 claims 1
- ORTMHVMCRHIAHL-UHFFFAOYSA-N 4-methyl-5-(7-oxabicyclo[4.1.0]heptan-4-yl)-7-oxabicyclo[4.1.0]heptane-4-carboxylic acid Chemical compound C1CC2OC2CC1C1C2OC2CCC1(C)C(O)=O ORTMHVMCRHIAHL-UHFFFAOYSA-N 0.000 claims 1
- QHWOFMXDKFORMO-UHFFFAOYSA-N Deltaalphabetadihydropiperine Natural products C=1C=C2OCOC2=CC=1CCC=CC(=O)N1CCCCC1 QHWOFMXDKFORMO-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- QHWOFMXDKFORMO-XVNBXDOJSA-N Piperanine Chemical compound C=1C=C2OCOC2=CC=1CC/C=C/C(=O)N1CCCCC1 QHWOFMXDKFORMO-XVNBXDOJSA-N 0.000 claims 1
- PUJWFVBVNFXCHZ-SQEQANQOSA-N Tripdiolide Chemical compound O=C1OCC([C@@H]2C3)=C1[C@@H](O)C[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1(C(C)C)[C@@H](O)[C@]21[C@H]3O1 PUJWFVBVNFXCHZ-SQEQANQOSA-N 0.000 claims 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 210000002394 ovarian follicle Anatomy 0.000 claims 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical group C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims 1
- SWOVVKGLGOOUKI-ZHGGVEMFSA-N triptonide Chemical compound O=C1OCC([C@@H]2C3)=C1CC[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1(C(C)C)C(=O)[C@]21[C@H]3O1 SWOVVKGLGOOUKI-ZHGGVEMFSA-N 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/02—Breeding vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N45/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/20—Animals treated with compounds which are neither proteins nor nucleic acids
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Claims (16)
1. Sastav prikladan za smanjenje reproduktivnog kapaciteta ženskih štakora, koji sadrži:
(a) diterpenoid epoksid ili njegovu sol koji sadrži kostur triptolida predstavljen sljedećom strukturom:
te koji uzrokuje depleciju folikula jajnika u ženskim sisavcima, i
(b) organski diepoksid odabran iz skupine koja se sastoji od 4-vinilcikloheksen diepoksida (VCD), glicerol diglicidil etera (GDE), 1,4-butandiol diglicidil etera (BDE), 1,4-cikloheksandimetanol diglicidil etera (CHDE), 3,4-epoksi-cikloheksil-metil-3,4-epoksicikloheksil karboksilata (ERL 4221) i etilen glikol diglicidil etera (Quetol).
2. Sastav prema zahtjevu 1, naznačen time što je (a) predstavljen formulom (I):
pri čemu
X1 je H, R1, OH ili OR1,
X2 je H, R1, OH, OR1 =O ili Y,
X3 je H ili OH,
X4 je H, OH ili OR1,
R1 je C1-4 alkil skupina,
Y je (CR2R3O)nP(O)(O-Z+)2,
svaki R2 je, nezavisno, H, C1-6 alkil, aril-C1-6 alkil-, C3-6 cikloalkil ili aril,
svaki R3 je, nezavisno, H, C1-6 alkil, aril-C1-6 alkil-, C3-6 cikloalkil ili aril,
ili R2 i R3, zajedno s atomom ugljika na koji su vezani tvore C3-7 cikloalkil skupinu,
pri čemu svaka alkil ili cikloalkil skupina u R2 ili R3 može izborno biti supstituirana jednim do pet supstituenata odabranih iz skupine koja se sastoji od halo, C1-6 alkoksi i NRaRb,
pri čemu svaka aril skupina u R2 ili R3 može izborno biti supstituirana jednim do pet supstituenata odabranih iz skupine koja se sastoji od C1-6 alkila, C1-6 alkoksi, NRaRb, nitro i cijano,
n je 1, 2 ili 3,
svaki Z je H,
Ra i Rb su svaki, nezavisno, H, C1-6 alkil, C3-6 cikloalkil ili aril,
ili Ra i Rb, zajedno s atomom dušika na koji su vezani, tvore pirolidin, piperidin, piperanin, azetidin, morfolin, ili tiomorfolin skupinu,
ili njegova sol.
3. Sastav prema zahtjevu 2, naznačen time što X1 je H, CH3, OH ili OCH3.
4. Sastav prema zahtjevu 2, naznačen time što X2 je H, CH3, OH, OCH3 ili =O.
5. Sastav prema zahtjevu 2, naznačen time što X2 je Y.
6. Sastav prema zahtjevu 2, naznačen time što X3 je H.
7. Sastav prema zahtjevu 2, naznačen time što X4 je H, OH ili OCH3.
8. Sastav prema zahtjevu 1, naznačen time što diterpenoid epoksid (a) je triptolid, tripdiolid, 16-hidroksitriptolid, triptonid ili minelid ili njihova sol.
9. Sastav prema zahtjevu 1, naznačen time što diterpenoid epoksid (a) je triptolid.
10. Sastav prema zahtjevu 1, naznačen time što organski diepoksid (b) je 4-vinilcikloheksen diepoksid (VCD).
11. Sastav prema zahtjevu 1, naznačen time što diterpenoid epoksid (a) je triptolid i organski diepoksid (b) je 4-vinilcikloheksen diepoksid (VCD).
12. Sastav prema zahtjevu 1, naznačen time što koncentracija diterpenoid epoksida (a) u sastavu je oko 1 nM do oko 10 mM i koncentracija organskog diepoksida (b) u sastavu je oko 1 mM do oko 750 mM.
13. Sastav prema zahtjevu 1, naznačen time što molarni omjer diterpenoid epoksida (a) naspram organskog diepoksida (b) je od 1/5 do 1/75,000.
14. Sastav prema zahtjevu 1, naznačen time što molarni omjer diterpenoid epoksida (a) naspram organskog diepoksida (b) je od 1/2 do 1/50,000.
15. Sastav prema zahtjevu 1, naznačen time što molarni omjer diterpenoid epoksida (a) naspram organskog diepoksida (b) je od 1/5 do 1/500.
16. Postupak smanjenja reproduktivnog kapaciteta ženskih štakora u populaciji štakora koja sadrži muške i ženske štakore, koji sadrži hranjenje populacije štakora efikasnom količinom sastava prema bilo kojem od zahtjeva 1 i 8 do 15, naznačen time što
sastav konzumiraju i muški i ženski štakori, te
sastav smanjuje reproduktivni kapacitet ženskih štakora.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261692624P | 2012-08-23 | 2012-08-23 | |
| EP13831276.4A EP2871941B1 (en) | 2012-08-23 | 2013-08-23 | Compositions and methods for reducing the reproductive capacity of female rats |
| PCT/US2013/056428 WO2014031979A1 (en) | 2012-08-23 | 2013-08-23 | Reducing the reproductive capacity of mammals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20190719T1 true HRP20190719T1 (hr) | 2019-08-09 |
Family
ID=50150408
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20211366TT HRP20211366T1 (hr) | 2012-08-23 | 2013-08-23 | Metoda kontrole veličine populacije nehumanih sisavaca |
| HRP20190719TT HRP20190719T1 (hr) | 2012-08-23 | 2019-04-16 | Sastavi i postupci za smanjenje reproduktivnog kapaciteta ženskih štakora |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20211366TT HRP20211366T1 (hr) | 2012-08-23 | 2013-08-23 | Metoda kontrole veličine populacije nehumanih sisavaca |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9956235B2 (hr) |
| EP (2) | EP2871941B1 (hr) |
| JP (1) | JP6309522B2 (hr) |
| KR (2) | KR20150059746A (hr) |
| AU (1) | AU2013305584B2 (hr) |
| BR (1) | BR112015003702B1 (hr) |
| CA (1) | CA2882875C (hr) |
| CY (2) | CY1121717T1 (hr) |
| DK (2) | DK3510860T3 (hr) |
| ES (2) | ES2730408T3 (hr) |
| HR (2) | HRP20211366T1 (hr) |
| HU (2) | HUE044036T2 (hr) |
| LT (2) | LT3510860T (hr) |
| MX (1) | MX368417B (hr) |
| PL (2) | PL3510860T3 (hr) |
| PT (2) | PT2871941T (hr) |
| RS (2) | RS62315B1 (hr) |
| RU (1) | RU2669350C2 (hr) |
| SI (2) | SI2871941T1 (hr) |
| TR (1) | TR201907272T4 (hr) |
| WO (1) | WO2014031979A1 (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX368417B (es) | 2012-08-23 | 2019-10-02 | Senestech Inc | Reduccion de la capacidad reproductiva de mamiferos. |
| CN104542484A (zh) * | 2015-02-03 | 2015-04-29 | 何寒 | 一种富硒肉猪的饲养方法 |
| CN104839092B (zh) * | 2015-06-09 | 2017-05-17 | 重庆市药物种植研究所 | 一种人工取麝香的方法 |
| CN109601474A (zh) * | 2018-12-11 | 2019-04-12 | 中国农业科学院北京畜牧兽医研究所 | 一种新型高繁育性能种羊的育种方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5663335A (en) | 1996-03-01 | 1997-09-02 | Pharmagenesis, Inc. | Immunosuppressive compounds and methods |
| US6004999A (en) | 1997-05-23 | 1999-12-21 | Hoechst Marion Roussel, Inc. | Triptolide derivatives useful in the treatment of autoimmune diseases |
| ATE334969T1 (de) | 1998-09-02 | 2006-08-15 | Pharmagenesis Inc | Triptolid-prodrugs mit hoher wasserlöslichkeit |
| US6548537B1 (en) | 1998-09-02 | 2003-04-15 | Pharmagenesis, Inc. | Triptolide prodrugs having high aqueous solubility |
| US6294546B1 (en) | 1999-08-30 | 2001-09-25 | The Broad Of Trustees Of The Leland Stanford Junior University | Uses of diterpenoid triepoxides as an anti-proliferative agent |
| US20020077350A1 (en) | 2000-08-01 | 2002-06-20 | Ashni Naturaceuticals, Inc. | Compositions exhibiting synergistic inhibition of the expression and/or activity of clyclooxygenase-2 |
| CN1179647C (zh) * | 2001-04-03 | 2004-12-15 | 上海莘城科技有限公司 | 雄性不育灭鼠剂及其制备方法 |
| EP1545195B1 (en) | 2002-08-29 | 2011-08-17 | The Arizona Board of Regents on behalf of the University of Arizona | Mouse model for perimenopause and menopause and methods of preparation |
| CN1223595C (zh) | 2002-12-27 | 2005-10-19 | 中国科学院上海药物研究所 | 雷公藤内酯醇衍生物及其应用 |
| US20090088471A1 (en) * | 2007-09-28 | 2009-04-02 | Min Wang | Chemical sterilant for adult male dog population control with concomitant reduction in human dog-bite acquired rabies |
| WO2010051498A1 (en) * | 2008-11-03 | 2010-05-06 | Arizona Board Of Regents On Behalf Of Northern Arizona University | Biotechnology relating to mammalian reproduction |
| EP2393818A4 (en) | 2009-02-05 | 2013-09-04 | Pharmagenesis Inc | TRIPTOLID C-RING DERIVATIVES AS ANTITUMULAR AGENTS AND IMMUNOMODULATORS |
| DK2427467T3 (en) | 2009-05-07 | 2015-11-09 | Univ Minnesota | Triptolid prodrugs |
| MX368417B (es) | 2012-08-23 | 2019-10-02 | Senestech Inc | Reduccion de la capacidad reproductiva de mamiferos. |
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2013
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