ATE334969T1 - Triptolid-prodrugs mit hoher wasserlöslichkeit - Google Patents
Triptolid-prodrugs mit hoher wasserlöslichkeitInfo
- Publication number
- ATE334969T1 ATE334969T1 AT03016090T AT03016090T ATE334969T1 AT E334969 T1 ATE334969 T1 AT E334969T1 AT 03016090 T AT03016090 T AT 03016090T AT 03016090 T AT03016090 T AT 03016090T AT E334969 T1 ATE334969 T1 AT E334969T1
- Authority
- AT
- Austria
- Prior art keywords
- water solubility
- high water
- triptolide
- triptolide prodrugs
- prodrugs
- Prior art date
Links
- DFBIRQPKNDILPW-CIVMWXNOSA-N Triptolide Chemical compound O=C1OCC([C@@H]2C3)=C1CC[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1(C(C)C)[C@@H](O)[C@]21[C@H]3O1 DFBIRQPKNDILPW-CIVMWXNOSA-N 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- YKUJZZHGTWVWHA-UHFFFAOYSA-N triptolide Natural products COC12CC3OC3(C(C)C)C(O)C14OC4CC5C6=C(CCC25C)C(=O)OC6 YKUJZZHGTWVWHA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9880998P | 1998-09-02 | 1998-09-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE334969T1 true ATE334969T1 (de) | 2006-08-15 |
Family
ID=22270998
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03016090T ATE334969T1 (de) | 1998-09-02 | 1999-09-02 | Triptolid-prodrugs mit hoher wasserlöslichkeit |
| AT99949582T ATE245145T1 (de) | 1998-09-02 | 1999-09-02 | Gut wasserlösliche triptolid-prodrugs |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99949582T ATE245145T1 (de) | 1998-09-02 | 1999-09-02 | Gut wasserlösliche triptolid-prodrugs |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6150539A (de) |
| EP (1) | EP1109789B1 (de) |
| JP (1) | JP2002523495A (de) |
| CN (1) | CN1316997A (de) |
| AT (2) | ATE334969T1 (de) |
| AU (1) | AU764123B2 (de) |
| CA (1) | CA2342901A1 (de) |
| DE (2) | DE69932649T2 (de) |
| WO (1) | WO2000012483A1 (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6548537B1 (en) * | 1998-09-02 | 2003-04-15 | Pharmagenesis, Inc. | Triptolide prodrugs having high aqueous solubility |
| GB2367492A (en) * | 1999-06-02 | 2002-04-10 | Oxford Natural Products Plc | Combination of glucosamine with herbal extracts of triptergium, ligustrum and erycibe |
| US6620843B2 (en) * | 2001-01-19 | 2003-09-16 | Pharmagenesis | Anticancer treatment using triptolide prodrugs |
| US6569893B2 (en) | 2001-03-15 | 2003-05-27 | Pharmagenesis, Inc. | Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents |
| JP4680589B2 (ja) * | 2002-05-31 | 2011-05-11 | ファーマジェネシス， インコーポレイテッド | アポトーシスおよび免疫抑制の調節のためのトリプトリド誘導体 |
| CN100398544C (zh) * | 2002-09-18 | 2008-07-02 | 成都达远药物有限公司 | 高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用 |
| JP2006513209A (ja) * | 2002-12-17 | 2006-04-20 | ファーマジェネシス， インコーポレイテッド | 免疫調節因子および抗癌剤としてのトリプトライド誘導体 |
| US6943259B2 (en) * | 2003-02-25 | 2005-09-13 | Pharmagenesis, Inc. | Halogenated triptolide derivatives as immunomodulators and anticancer agents |
| CN100408583C (zh) * | 2003-02-25 | 2008-08-06 | 美国泛华医药公司 | 用作免疫调节剂和抗癌药的卤代雷公藤内酯醇衍生物 |
| WO2005020887A2 (en) * | 2003-06-27 | 2005-03-10 | Pharmagenesis, Inc. | Method for treatment of severe acute respiratory syndrome |
| US7820834B2 (en) * | 2003-12-24 | 2010-10-26 | Pharmagenesis, Inc. | Triptolide 5,6-derivatives as immunomodulators and anticancer agents |
| EP1722806A4 (de) | 2004-02-09 | 2009-09-16 | Pharmagenesis Inc | Verfahren zur isolierung von triptolid-verbindungen aus tripterygium wilfordii |
| ES2385716T3 (es) * | 2004-03-02 | 2012-07-30 | Pharmagenesis, Inc. | Derivados en el anillo de lactona de triptolida como inmunomoduladores y agentes anticáncer |
| WO2006012204A2 (en) * | 2004-06-25 | 2006-02-02 | Pharmagenesis, Inc. | Method for treatment of inflammatory disorders using triptolide compounds |
| US8617906B2 (en) | 2004-10-13 | 2013-12-31 | Pharmagenesis, Inc. | Identification and screening of triptolide target molecules |
| AU2010210594B2 (en) * | 2009-02-05 | 2015-02-12 | Pharmagenesis, Inc. | Triptolide C-ring derivatives as anticancer agents and immune modulators |
| MY160392A (en) * | 2009-05-07 | 2017-03-15 | Univ Minnesota | Triptolide prodrugs |
| US9150600B2 (en) | 2009-05-07 | 2015-10-06 | Regents Of The University Of Minnesota | Triptolide prodrugs |
| MX368417B (es) | 2012-08-23 | 2019-10-02 | Senestech Inc | Reduccion de la capacidad reproductiva de mamiferos. |
| WO2014167581A2 (en) * | 2013-04-01 | 2014-10-16 | Laurus Labs Private Limited | An improved process for the preparation of triptolide prodrugs |
| WO2015127011A1 (en) | 2014-02-21 | 2015-08-27 | Institute Of Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | C-myc as a biomarker for tumor sensitivity to treatment with rna polymerase ii inhibition |
| CN106659700B (zh) * | 2014-06-06 | 2020-07-10 | 斯克里普斯研究所 | 氟化硫(vi)化合物及其制备方法 |
| CN106883284B (zh) * | 2017-03-03 | 2018-10-16 | 广东省中医院 | 雷公藤内酯三醇的快速安全制备方法 |
| CN106995450B (zh) * | 2017-05-19 | 2019-04-02 | 湖北大学 | 一种雷公藤甲素衍生物及其制备方法和用途 |
| CN110759929B (zh) * | 2018-07-27 | 2022-05-03 | 上海医药集团股份有限公司 | (5r)-5-羟基雷公藤内酯醇的制备方法 |
| US11660285B2 (en) * | 2019-12-30 | 2023-05-30 | Guangdong Provincial Hospital of TCM | Triptolide acrylate, preparation method therefor and use thereof |
| EP4200022A1 (de) | 2020-08-21 | 2023-06-28 | Reyoung Corporation | Triptolidkonjugate und verwendungen davon |
| WO2023143330A1 (zh) * | 2022-01-25 | 2023-08-03 | 杭州卫本医药科技有限公司 | 具有杀伤myc阳性细胞功能雷公藤二萜类环氧化合物、及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1027371C (zh) * | 1989-09-08 | 1995-01-11 | 中国医学科学院皮肤病研究所 | 二萜内酯化合物的合成方法 |
| US5663335A (en) * | 1996-03-01 | 1997-09-02 | Pharmagenesis, Inc. | Immunosuppressive compounds and methods |
| UA57757C2 (uk) * | 1996-12-20 | 2003-07-15 | Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) | Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція |
| US5972998A (en) * | 1997-05-23 | 1999-10-26 | Hoechst Marion Roussel, Inc. | Triptolide derivatives useful in the treatment of autoimmune diseases |
-
1999
- 1999-09-02 DE DE69932649T patent/DE69932649T2/de not_active Expired - Fee Related
- 1999-09-02 AU AU62425/99A patent/AU764123B2/en not_active Ceased
- 1999-09-02 EP EP99949582A patent/EP1109789B1/de not_active Expired - Lifetime
- 1999-09-02 WO PCT/US1999/020150 patent/WO2000012483A1/en not_active Ceased
- 1999-09-02 AT AT03016090T patent/ATE334969T1/de not_active IP Right Cessation
- 1999-09-02 JP JP2000567513A patent/JP2002523495A/ja active Pending
- 1999-09-02 AT AT99949582T patent/ATE245145T1/de not_active IP Right Cessation
- 1999-09-02 DE DE69909633T patent/DE69909633T2/de not_active Expired - Fee Related
- 1999-09-02 CA CA002342901A patent/CA2342901A1/en not_active Abandoned
- 1999-09-02 US US09/389,769 patent/US6150539A/en not_active Expired - Fee Related
- 1999-09-02 CN CN99810578A patent/CN1316997A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU764123B2 (en) | 2003-08-07 |
| DE69909633D1 (de) | 2003-08-21 |
| EP1109789A4 (de) | 2002-01-02 |
| DE69932649T2 (de) | 2007-08-09 |
| CA2342901A1 (en) | 2000-03-09 |
| EP1109789B1 (de) | 2003-07-16 |
| CN1316997A (zh) | 2001-10-10 |
| US6150539A (en) | 2000-11-21 |
| EP1109789A1 (de) | 2001-06-27 |
| AU6242599A (en) | 2000-03-21 |
| JP2002523495A (ja) | 2002-07-30 |
| DE69932649D1 (de) | 2006-09-14 |
| ATE245145T1 (de) | 2003-08-15 |
| DE69909633T2 (de) | 2004-05-13 |
| WO2000012483A1 (en) | 2000-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |