CY1121717T1 - Συνθεσεις και μεθοδοι για τη μειωση της αναπαραγωγικης ικανοτητας θηλυκων αρουραιων - Google Patents
Συνθεσεις και μεθοδοι για τη μειωση της αναπαραγωγικης ικανοτητας θηλυκων αρουραιωνInfo
- Publication number
- CY1121717T1 CY1121717T1 CY20191100612T CY191100612T CY1121717T1 CY 1121717 T1 CY1121717 T1 CY 1121717T1 CY 20191100612 T CY20191100612 T CY 20191100612T CY 191100612 T CY191100612 T CY 191100612T CY 1121717 T1 CY1121717 T1 CY 1121717T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compositions
- methods
- reducing
- female rats
- reproductive ability
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000001850 reproductive effect Effects 0.000 title abstract 2
- 241000700159 Rattus Species 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 3
- 210000002394 ovarian follicle Anatomy 0.000 abstract 2
- DFBIRQPKNDILPW-CIVMWXNOSA-N Triptolide Chemical group O=C1OCC([C@@H]2C3)=C1CC[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1(C(C)C)[C@@H](O)[C@]21[C@H]3O1 DFBIRQPKNDILPW-CIVMWXNOSA-N 0.000 abstract 1
- -1 diterpenoid epoxide Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/02—Breeding vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N45/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds having three or more carbocyclic rings condensed among themselves, at least one ring not being a six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/20—Animals treated with compounds which are neither proteins nor nucleic acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Wood Science & Technology (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gynecology & Obstetrics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Peptides Or Proteins (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Παρέχονται συνθέσεις και μέθοδοι για τη μείωση της αναπαραγωγικής ικανότητας των θηλαστικών. Οι συνθέσεις και μέθοδοι περιλαμβάνουν τη χρήση και τη χορήγηση (a) ενός εποξειδίου διτερπενοειδούς που περιλαμβάνει έναν σκελετό τριπτολίδης και που προκαλεί εξάντληση των ωοθυλακίων των ωοθηκών στα θηλυκά θηλαστικά και (b) ένα οργανικό διεποξείδιο που προκαλεί εξάντληση των ωοθυλακίων των ωοθηκών στα θηλυκά θηλαστικά.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261692624P | 2012-08-23 | 2012-08-23 | |
PCT/US2013/056428 WO2014031979A1 (en) | 2012-08-23 | 2013-08-23 | Reducing the reproductive capacity of mammals |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1121717T1 true CY1121717T1 (el) | 2020-07-31 |
Family
ID=50150408
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191100612T CY1121717T1 (el) | 2012-08-23 | 2019-06-12 | Συνθεσεις και μεθοδοι για τη μειωση της αναπαραγωγικης ικανοτητας θηλυκων αρουραιων |
CY20211100909T CY1124743T1 (el) | 2012-08-23 | 2021-10-19 | Μειωση της αναπαραγωγικης ικανοτητας των θηλαστικων |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100909T CY1124743T1 (el) | 2012-08-23 | 2021-10-19 | Μειωση της αναπαραγωγικης ικανοτητας των θηλαστικων |
Country Status (21)
Country | Link |
---|---|
US (2) | US9956235B2 (el) |
EP (2) | EP2871941B1 (el) |
JP (1) | JP6309522B2 (el) |
KR (2) | KR20150059746A (el) |
AU (1) | AU2013305584B2 (el) |
BR (1) | BR112015003702B1 (el) |
CA (1) | CA2882875C (el) |
CY (2) | CY1121717T1 (el) |
DK (2) | DK2871941T3 (el) |
ES (2) | ES2902651T3 (el) |
HR (2) | HRP20211366T1 (el) |
HU (2) | HUE056663T2 (el) |
LT (2) | LT3510860T (el) |
MX (1) | MX368417B (el) |
PL (2) | PL3510860T3 (el) |
PT (2) | PT3510860T (el) |
RS (2) | RS62315B1 (el) |
RU (1) | RU2669350C2 (el) |
SI (2) | SI3510860T1 (el) |
TR (1) | TR201907272T4 (el) |
WO (1) | WO2014031979A1 (el) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT3510860T (lt) | 2012-08-23 | 2021-10-25 | Senestech, Inc. | Žinduolių reprodukcinio pajėgumo sumažinimas |
CN104542484A (zh) * | 2015-02-03 | 2015-04-29 | 何寒 | 一种富硒肉猪的饲养方法 |
CN104839092B (zh) * | 2015-06-09 | 2017-05-17 | 重庆市药物种植研究所 | 一种人工取麝香的方法 |
CN109601474A (zh) * | 2018-12-11 | 2019-04-12 | 中国农业科学院北京畜牧兽医研究所 | 一种新型高繁育性能种羊的育种方法 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5663335A (en) * | 1996-03-01 | 1997-09-02 | Pharmagenesis, Inc. | Immunosuppressive compounds and methods |
US6004999A (en) | 1997-05-23 | 1999-12-21 | Hoechst Marion Roussel, Inc. | Triptolide derivatives useful in the treatment of autoimmune diseases |
DE69909633T2 (de) | 1998-09-02 | 2004-05-13 | Pharmagenesis, Inc., Palo Alto | Gut wasserlösliche triptolid-prodrugs |
US6548537B1 (en) | 1998-09-02 | 2003-04-15 | Pharmagenesis, Inc. | Triptolide prodrugs having high aqueous solubility |
US6294546B1 (en) | 1999-08-30 | 2001-09-25 | The Broad Of Trustees Of The Leland Stanford Junior University | Uses of diterpenoid triepoxides as an anti-proliferative agent |
US20020077350A1 (en) | 2000-08-01 | 2002-06-20 | Ashni Naturaceuticals, Inc. | Compositions exhibiting synergistic inhibition of the expression and/or activity of clyclooxygenase-2 |
CN1179647C (zh) * | 2001-04-03 | 2004-12-15 | 上海莘城科技有限公司 | 雄性不育灭鼠剂及其制备方法 |
AU2003262950B2 (en) * | 2002-08-29 | 2008-12-18 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Animal model for perimenopause and menopause and methods of inducing ovarian failure |
CN1223595C (zh) | 2002-12-27 | 2005-10-19 | 中国科学院上海药物研究所 | 雷公藤内酯醇衍生物及其应用 |
US20090088471A1 (en) * | 2007-09-28 | 2009-04-02 | Min Wang | Chemical sterilant for adult male dog population control with concomitant reduction in human dog-bite acquired rabies |
WO2010051498A1 (en) | 2008-11-03 | 2010-05-06 | Arizona Board Of Regents On Behalf Of Northern Arizona University | Biotechnology relating to mammalian reproduction |
WO2010091193A2 (en) | 2009-02-05 | 2010-08-12 | Pharmagenesis, Inc. | Triptolide c-ring derivatives as anticancer agents and immune modulators |
CA2760953C (en) * | 2009-05-07 | 2017-05-30 | Regents Of The University Of Minnesota | Triptolide prodrugs |
LT3510860T (lt) | 2012-08-23 | 2021-10-25 | Senestech, Inc. | Žinduolių reprodukcinio pajėgumo sumažinimas |
-
2013
- 2013-08-23 LT LTEP19156299.0T patent/LT3510860T/lt unknown
- 2013-08-23 WO PCT/US2013/056428 patent/WO2014031979A1/en active Application Filing
- 2013-08-23 AU AU2013305584A patent/AU2013305584B2/en active Active
- 2013-08-23 KR KR1020157007143A patent/KR20150059746A/ko active Application Filing
- 2013-08-23 DK DK13831276.4T patent/DK2871941T3/da active
- 2013-08-23 PL PL19156299T patent/PL3510860T3/pl unknown
- 2013-08-23 ES ES19156299T patent/ES2902651T3/es active Active
- 2013-08-23 HU HUE19156299A patent/HUE056663T2/hu unknown
- 2013-08-23 SI SI201331925T patent/SI3510860T1/sl unknown
- 2013-08-23 LT LTEP13831276.4T patent/LT2871941T/lt unknown
- 2013-08-23 JP JP2015528693A patent/JP6309522B2/ja not_active Expired - Fee Related
- 2013-08-23 RS RS20211072A patent/RS62315B1/sr unknown
- 2013-08-23 US US14/423,245 patent/US9956235B2/en active Active
- 2013-08-23 TR TR2019/07272T patent/TR201907272T4/tr unknown
- 2013-08-23 PL PL13831276T patent/PL2871941T3/pl unknown
- 2013-08-23 SI SI201331420T patent/SI2871941T1/sl unknown
- 2013-08-23 HR HRP20211366TT patent/HRP20211366T1/hr unknown
- 2013-08-23 MX MX2015002281A patent/MX368417B/es active IP Right Grant
- 2013-08-23 DK DK19156299.0T patent/DK3510860T3/da active
- 2013-08-23 PT PT191562990T patent/PT3510860T/pt unknown
- 2013-08-23 CA CA2882875A patent/CA2882875C/en active Active
- 2013-08-23 EP EP13831276.4A patent/EP2871941B1/en active Active
- 2013-08-23 ES ES13831276T patent/ES2730408T3/es active Active
- 2013-08-23 KR KR1020207036709A patent/KR102238442B1/ko active IP Right Grant
- 2013-08-23 PT PT13831276T patent/PT2871941T/pt unknown
- 2013-08-23 HU HUE13831276A patent/HUE044036T2/hu unknown
- 2013-08-23 RS RS20190493A patent/RS58781B1/sr unknown
- 2013-08-23 BR BR112015003702-0A patent/BR112015003702B1/pt active IP Right Grant
- 2013-08-23 EP EP19156299.0A patent/EP3510860B1/en active Active
- 2013-08-23 RU RU2015110047A patent/RU2669350C2/ru active
-
2018
- 2018-02-22 US US15/902,622 patent/US10646501B2/en active Active
-
2019
- 2019-04-16 HR HRP20190719TT patent/HRP20190719T1/hr unknown
- 2019-06-12 CY CY20191100612T patent/CY1121717T1/el unknown
-
2021
- 2021-10-19 CY CY20211100909T patent/CY1124743T1/el unknown
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