HRP20190652T1 - Fuzijski proteini od prirodnih ljudskih proteinskih fragmenata za proizvodnju pravilno multimeriziranih fc-sastava imunoglobulina - Google Patents
Fuzijski proteini od prirodnih ljudskih proteinskih fragmenata za proizvodnju pravilno multimeriziranih fc-sastava imunoglobulina Download PDFInfo
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- HRP20190652T1 HRP20190652T1 HRP20190652TT HRP20190652T HRP20190652T1 HR P20190652 T1 HRP20190652 T1 HR P20190652T1 HR P20190652T T HRP20190652T T HR P20190652TT HR P20190652 T HRP20190652 T HR P20190652T HR P20190652 T1 HRP20190652 T1 HR P20190652T1
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- Prior art keywords
- polypeptide
- biomimetic compound
- disease
- seq
- biomimetic
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- 239000000203 mixture Substances 0.000 title claims 4
- 102000003839 Human Proteins Human genes 0.000 title 1
- 108090000144 Human Proteins Proteins 0.000 title 1
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 239000012634 fragment Substances 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 230000003592 biomimetic effect Effects 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 2
- 239000000539 dimer Substances 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 208000012657 Atopic disease Diseases 0.000 claims 1
- 208000035143 Bacterial infection Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 1
- 206010036105 Polyneuropathy Diseases 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 1
- 201000004982 autoimmune uveitis Diseases 0.000 claims 1
- 208000022362 bacterial infectious disease Diseases 0.000 claims 1
- 230000000903 blocking effect Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 230000009871 nonspecific binding Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000007824 polyneuropathy Effects 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (10)
1. Polipeptid, naznačen time, da obuhvaća SEQ ID NO: 4.
2. Polipeptid prema zahtjevu 1, naznačen time, da je vodeća sekvenca rascijepljena.
3. Sastav, naznačen time, da obuhvaća multimere dimera od polipeptida iz zahtjeva 1 ili 2, pri čemu su multimeri prisutni u postotku od najmanje oko 45%, ili najmanje oko 55%, ili najmanje oko 65%, ili najmanje oko 70%, ili najmanje oko 73% od ukupnog sastava.
4. Spoj biomimetika, naznačen time, da obuhvaća najmanje dva dimera od polipeptida iz zahtjeva 1 ili zahtjeva 2.
5. Spoj biomimetika prema zahtjevu 4, naznačen time, da se upotrebljava u postupku prilagođavanja imunološkog odgovora ili liječenja upalne bolesti kod pojedinca, pri čemu taj postupak obuhvaća davanje pojedincu učinkovite količine spoja biomimetika.
6. Spoj biomimetika za uporabu prema zahtjevu 5, naznačen time, da se kod upalne bolesti radi o bolesti koja je odabrana od sljedećih: artritis, multipla skleroza, dijabetes tipa I, autoimuni tiroiditis, idiopatska trombocitopenijska purpura, kronična upalna polineuropatija, skleroderma, autoimuni uveitis, sustavna lupus eritematoza, miastenija gravis i atopijski dermatitis, ili bolest povezana s transplantacijom organa od davatelja za primatelja; ili zarazna bolest s bakterijskom infekcijom ili virusnom infekcijom.
7. Postupak blokiranja nespecifičnog vezanja protutijela u testiranju in vitro ili ex vivo, naznačen time, da obuhvaća inkubaciju ciljanog tkiva ili ciljanih stanica sa sastavom koji obuhvaća učinkovitu količinu spoja biomimetika prema zahtjevu 4.
8. Postupak proizvodnje spoja biomimetika, naznačen time, da obuhvaća ekspresiju SEQ ID NO: 4 u domaćinu.
9. Postupak prema zahtjevu 8, naznačen time, da nadalje obuhvaća sljedeće:
(a) kloniranje DNK koja kodira polipeptid od SEQ ID NO: 4 u vektor ekspresije;
(b) transfekciju vektora ekspresije u bakterijskog domaćina;
(c) izolaciju plazmida DNK koji sadrži kloniranu DNK iz bakterijske kulture;
(d) lineariziranje plazmida DNK koji sadrži kloniranu DNK;
(e) transfekciju linearizirane DNK u stanice sisavca;
(f) ekspandiranje pozitivno transfektiranih stanica za dobivanje raspoložive zalihe stabilno transfektiranih stanica;
(g) prikupljanje polipeptida iz medija; i
(h) pročišćavanje polipeptida, pri čemu polipeptid ne sadrži tuđinske sekvence.
10. Postupak prema zahtjevu 9, naznačen time, da se vodeća sekvenca rascijepljuje.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36846510P | 2010-07-28 | 2010-07-28 | |
PCT/US2011/045768 WO2012016073A2 (en) | 2010-07-28 | 2011-07-28 | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions |
EP11813204.2A EP2598533B1 (en) | 2010-07-28 | 2011-07-28 | Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20190652T1 true HRP20190652T1 (hr) | 2019-05-31 |
Family
ID=45530725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20190652TT HRP20190652T1 (hr) | 2010-07-28 | 2019-04-05 | Fuzijski proteini od prirodnih ljudskih proteinskih fragmenata za proizvodnju pravilno multimeriziranih fc-sastava imunoglobulina |
Country Status (21)
Country | Link |
---|---|
US (3) | US20130156765A1 (hr) |
EP (2) | EP2598533B1 (hr) |
JP (2) | JP5826270B2 (hr) |
KR (3) | KR102148265B1 (hr) |
CN (2) | CN103154036B (hr) |
AR (1) | AR082404A1 (hr) |
AU (1) | AU2011282579B2 (hr) |
BR (1) | BR112013002074B1 (hr) |
CA (2) | CA2804512C (hr) |
DK (1) | DK2598533T3 (hr) |
ES (1) | ES2719623T3 (hr) |
HR (1) | HRP20190652T1 (hr) |
HU (1) | HUE044869T2 (hr) |
IL (3) | IL224427A (hr) |
MX (3) | MX368531B (hr) |
PL (1) | PL2598533T3 (hr) |
PT (1) | PT2598533T (hr) |
SI (1) | SI2598533T1 (hr) |
TR (1) | TR201906652T4 (hr) |
TW (2) | TWI542597B (hr) |
WO (1) | WO2012016073A2 (hr) |
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US20100143353A1 (en) * | 2008-12-04 | 2010-06-10 | Mosser David M | POLYPEPTIDES COMPRISING Fc FRAGMENTS OF IMMUNOGLOBULIN G (lgG) AND METHODS OF USING THE SAME |
TR201906652T4 (tr) | 2010-07-28 | 2019-05-21 | Gliknik Inc | Kademeli multimerize immünoglobülin fc bileşimleri oluşturmak için doğal insan protein fragmanları içeren füzyon proteinleri. |
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
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CN104870055A (zh) * | 2012-10-17 | 2015-08-26 | 利物浦热带医学院 | 免疫调节蛋白 |
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US20170007685A1 (en) * | 2013-11-05 | 2017-01-12 | The Board Of Regents Of The University Of Texas System | TUMORS EXPRESSING IgG1 Fc INDUCE ROBUST CD8 T CELL RESPONSES |
EP3071599A4 (en) * | 2013-11-18 | 2017-07-12 | University of Maryland, Baltimore | Hyper-glycosylated antibodies with selective fc receptor binding |
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