HRP20180282T1 - Imunoterapija na bazi indoleamin 2, 3-dioksigenaze - Google Patents

Imunoterapija na bazi indoleamin 2, 3-dioksigenaze Download PDF

Info

Publication number
HRP20180282T1
HRP20180282T1 HRP20180282TT HRP20180282T HRP20180282T1 HR P20180282 T1 HRP20180282 T1 HR P20180282T1 HR P20180282T T HRP20180282T T HR P20180282TT HR P20180282 T HRP20180282 T HR P20180282T HR P20180282 T1 HRP20180282 T1 HR P20180282T1
Authority
HR
Croatia
Prior art keywords
adjuvant
seq
use according
vaccine preparation
peptide
Prior art date
Application number
HRP20180282TT
Other languages
English (en)
Croatian (hr)
Inventor
Mads Hald Andersen
Per Thor Straten
Original Assignee
Io Biotech Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Io Biotech Aps filed Critical Io Biotech Aps
Publication of HRP20180282T1 publication Critical patent/HRP20180282T1/hr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/193Colony stimulating factors [CSF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2013IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001154Enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0069Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y113/00Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
    • C12Y113/11Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of two atoms of oxygen (1.13.11)
    • C12Y113/11052Indoleamine 2,3-dioxygenase (1.13.11.52), i.e. indoleamine 2,3-dioxygenase 1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5158Antigen-pulsed cells, e.g. T-cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HRP20180282TT 2008-04-17 2009-04-17 Imunoterapija na bazi indoleamin 2, 3-dioksigenaze HRP20180282T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200800565 2008-04-17
EP09753556.1A EP2280721B1 (en) 2008-04-17 2009-04-17 Indoleamine 2, 3-dioxygenase based immunotherapy
PCT/DK2009/000095 WO2009143843A1 (en) 2008-04-17 2009-04-17 Indoleamine 2, 3-dioxygenase based immunotherapy

Publications (1)

Publication Number Publication Date
HRP20180282T1 true HRP20180282T1 (hr) 2018-03-23

Family

ID=40873320

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20180282TT HRP20180282T1 (hr) 2008-04-17 2009-04-17 Imunoterapija na bazi indoleamin 2, 3-dioksigenaze
HRP20210766TT HRP20210766T1 (hr) 2008-04-17 2021-05-13 Imunoterapija na bazi indoleamin 2, 3-dioksigenaze

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20210766TT HRP20210766T1 (hr) 2008-04-17 2021-05-13 Imunoterapija na bazi indoleamin 2, 3-dioksigenaze

Country Status (20)

Country Link
US (7) US9433666B2 (OSRAM)
EP (3) EP3915570A1 (OSRAM)
JP (2) JP2011520783A (OSRAM)
CN (2) CN104056261B (OSRAM)
AU (1) AU2009253539B2 (OSRAM)
CA (1) CA2721150C (OSRAM)
CY (2) CY1120352T1 (OSRAM)
DK (2) DK2280721T3 (OSRAM)
ES (2) ES2870596T3 (OSRAM)
HR (2) HRP20180282T1 (OSRAM)
HU (2) HUE037973T2 (OSRAM)
IL (1) IL208781A (OSRAM)
LT (2) LT3320912T (OSRAM)
NO (1) NO2280721T3 (OSRAM)
NZ (1) NZ588757A (OSRAM)
PL (2) PL2280721T3 (OSRAM)
PT (2) PT2280721T (OSRAM)
SI (2) SI2280721T1 (OSRAM)
WO (1) WO2009143843A1 (OSRAM)
ZA (1) ZA201008056B (OSRAM)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2280721T1 (en) * 2008-04-17 2018-02-28 Io Biotech Aps C/O Cobis Indoleamine 2, 3-dioxygenase based immunotherapy
EP2425830A1 (en) * 2010-09-03 2012-03-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Synergistic drug combination for the treatment of cancer
GB201315946D0 (en) * 2013-09-06 2013-10-23 Immune Targeting Systems Its Ltd Oncology vaccine
CA2947650C (en) * 2014-05-29 2021-04-27 Spring Bioscience Corporation Anti- indoleamine 2,3-dioxygenase 1 antibodies and diagnostic uses thereof
US10736950B2 (en) 2014-09-17 2020-08-11 Herlev Hospital Vaccine compositions comprising tryptophan 2,3-dioxygenase or fragments thereof
CN106148276A (zh) * 2015-04-16 2016-11-23 中国科学院上海生命科学研究院 间充质干细胞在制备治疗神经退行性疾病的药物中的应用
EP3313431B1 (en) 2015-06-29 2023-11-15 OSE Immunotherapeutics Method for inducing early t memory response with short peptides anti-tumor vaccine
EP3349785A1 (en) 2015-09-16 2018-07-25 Herlev Hospital Vaccine compositions comprising c-c motif chemokine 22 (ccl22) or fragments thereof
WO2017149150A1 (en) 2016-03-04 2017-09-08 Io Biotech Aps Combination therapy against cancer
US20190328857A1 (en) 2016-06-10 2019-10-31 Io Biotech Aps Calr and jak2 vaccine compositions
WO2018067660A1 (en) * 2016-10-04 2018-04-12 University Of Florida Research Foundation, Inc. Targeted effector proteins and uses thereof
DK3526347T3 (da) * 2016-10-14 2021-02-15 Univ Zuerich Indolamin-2,3-dioxygenase-analyse til diagnose og prognose af prostatacancer
KR20250067948A (ko) * 2017-01-20 2025-05-15 아타라 바이오테라퓨틱스 인크. 자가 t 세포를 사용하여 다발성 경화증을 치료하는 방법
CR20210128A (es) 2017-01-27 2021-04-26 Immatics Biotechnologies Gmbh Nuevos péptidos y nuevas combinaciones de péptidos para el uso en la inmunoterapia contra el cáncer de ovario y otros tipos de cancer (divisional exp. 2019-388)
TWI796314B (zh) * 2017-01-27 2023-03-21 德商英麥提克生物技術股份有限公司 用於卵巢癌和其他癌症免疫治療的新型肽和肽組合物
US10738100B2 (en) 2017-01-27 2020-08-11 Immatics Biotechnologies Gmbh Peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
US11407797B2 (en) 2017-10-11 2022-08-09 University Of Florida Research Foundation, Incorporated Modified gal-1 proteins and uses thereof
MX2020005454A (es) 2017-11-27 2020-08-27 Ose Immunotherapeutics Tratamiento de cancer mejorado.
CN109758467B (zh) * 2019-03-08 2020-12-25 中国农业科学院兰州兽医研究所 一种吉西他滨在制备预防口蹄疫病毒感染的药物中的应用
AU2020371562A1 (en) * 2019-10-23 2022-06-09 The Council Of The Queensland Institute Of Medical Research Adoptive immunotherapy
US20230173056A1 (en) * 2020-07-02 2023-06-08 The Regents Of The University Of California Persistent memory t-cell responses to cancer and infectious-disease antigens by manipulation of amino acid-catabolism pathways
CN112881269A (zh) * 2021-02-23 2021-06-01 浙江正熙生物技术股份有限公司 一种流式荧光检测试剂的质量检测方法
GB202103673D0 (en) 2021-03-17 2021-04-28 Io Biotech Aps Combination therapy for cancer
WO2023161350A1 (en) 2022-02-24 2023-08-31 Io Biotech Aps Nucleotide delivery of cancer therapy
CN114657158B (zh) * 2022-05-25 2022-10-21 深圳吉诺因生物科技有限公司 Ido1相关疫苗及其应用
EP4651896A1 (en) * 2023-01-17 2025-11-26 Regeneron Pharmaceuticals, Inc. Inositol polyphosphate multikinase (ipmk) therapeutic agents or indoleamine 2,3-dioxygenase 2 (ido2) agonists for use in treating b27-negative uveitis
WO2024178160A2 (en) * 2023-02-21 2024-08-29 Salvitus, Inc. Recombinant phage, probiotic vaccines and therapeutics, related compositions and methods of use
WO2025093541A1 (en) 2023-10-31 2025-05-08 Ose Immunotherapeutics Combination of interleukin 7 and tumour associated antigen vaccine

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US58767A (en) 1866-10-16 John brougjbton
US5554372A (en) 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
WO1997000966A1 (en) * 1995-06-20 1997-01-09 Merck & Co., Inc. Conversion of indene to (1s)-amino-(2r)-indanol free of any stereoisomer, by combination of dioxygenase bioconversion and chemical steps
US6096313A (en) 1996-02-09 2000-08-01 Ludwig Institute For Cancer Research Compositions containing immunogenic molecules and granulocyte-macrophage colony stimulating factor, as an adjuvant
JP3676380B2 (ja) 1996-06-12 2005-07-27 シャンハイ・シーピー・グオジャン・ファーマシューティカル・カンパニー・リミテッド 細胞性ワクチンおよび免疫療法薬ならびにそれらの製造方法
CN1223688A (zh) * 1996-06-27 1999-07-21 纳幕尔杜邦公司 对羟基苯丙酮酸双加氧酶的植物基因
DE19730066A1 (de) * 1997-07-14 1999-01-21 Basf Ag DNA-Sequenz codierend für eine Hydroxyphenylpyruvatdioxygenase und deren Überproduktion in Pflanzen
WO1999029852A1 (en) 1997-12-05 1999-06-17 Medical College Of Georgia Research Institute, Inc. High-affinity tryptophan transporter
WO2000066764A1 (en) 1999-05-03 2000-11-09 Ludwig Institute For Cancer Research Methods for increasing t cell proliferation
MXPA03006617A (es) 2001-01-24 2004-12-02 Protein Design Labs Inc Metodos de diagnostico de cancer de pecho, composiciones y metodos de rastreo de moduladores de cancer de pecho.
US20030087250A1 (en) 2001-03-14 2003-05-08 Millennium Pharmaceuticals, Inc. Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
AU2002318944A1 (en) 2001-08-01 2003-02-17 Coley Pharmaceutical Gmbh Methods and compositions relating to plasmacytoid dendritic cells
US7354909B2 (en) 2001-08-14 2008-04-08 The United States Of America As Represented By Secretary Of The Department Of Health And Human Services Method for rapid generation of mature dendritic cells
WO2003087347A1 (en) 2002-04-12 2003-10-23 Medical College Of Georgia Research Institute, Inc. Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance
US7763251B2 (en) 2002-04-12 2010-07-27 Medical College Of Georgia Research Institute, Inc. Kits to assess the risk of tumor progression
DE10229872A1 (de) * 2002-07-03 2004-01-29 Curevac Gmbh Immunstimulation durch chemisch modifizierte RNA
US20040253606A1 (en) 2002-11-26 2004-12-16 Protein Design Labs, Inc. Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators
US20060205934A1 (en) 2002-12-05 2006-09-14 Macina Roberto A Compositions, splice variants and methods relating to breast specific genes and proteins
WO2004054615A1 (en) 2002-12-13 2004-07-01 Mitra Medical Technology Ab Antilymphoma targeting agents with effector and affinity functions linked by a trifunctional reagent
DE10261223A1 (de) 2002-12-20 2004-07-08 MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH Steigerung der Immunantwort durch Substanzen, welche die Funktion von Natürlichen Killerzellen beeinflussen
CA2520586C (en) 2003-03-27 2011-06-14 Lankenau Institute For Medical Research Novel ido inhibitors and methods of use
US20050186289A1 (en) 2003-04-01 2005-08-25 Medical College Of Georgia Research Institute, Inc. Regulation of T cell-mediated immunity by D isomers of inhibitors of indoleamine-2,3-dioxygenase
US7598287B2 (en) 2003-04-01 2009-10-06 Medical College Of Georgia Research Institute, Inc. Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other therapeutic modalities
WO2005017163A2 (en) 2003-08-15 2005-02-24 Imperial College Innovations Limited Phenotypic knockout of cell-surface proteins
WO2005036127A2 (en) 2003-10-02 2005-04-21 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for identifying target cell cytolytic lymphocytes in a sample
WO2006005185A1 (en) * 2004-07-13 2006-01-19 The University Of British Columbia Indoleamine 2,3-dioxygenase (ido) inhibitors
US20060110371A1 (en) 2004-11-23 2006-05-25 Institut Pasteur Control of indoleamine 2,3 deoxygenase expression and activity
ES2523172T3 (es) 2005-02-04 2014-11-21 Survac Aps Vacuna de péptido de survivina
BR122020016659B8 (pt) 2005-05-10 2021-07-27 Incyte Holdings Corp moduladores de 2,3-dioxigenase de indolamina e métodos de modulação de atividade de inibição e de imunossupressão
US7468186B2 (en) 2005-07-22 2008-12-23 City Of Hope Polyomavirus cellular epitopes and uses therefor
GB0519303D0 (en) 2005-09-21 2005-11-02 Oxford Biomedica Ltd Chemo-immunotherapy method
DK1926813T4 (da) * 2005-09-23 2019-08-19 Tigenix S A U Cellepopulationer med immunregulatorisk aktivitet, fremgangsmåde til isolering og anvendelser
WO2007095050A2 (en) 2006-02-09 2007-08-23 Incyte Corporation N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase
WO2007115068A2 (en) 2006-03-30 2007-10-11 Indiana University Research And Technology Corporation Genetic variants in the indoleamine 2,3-dioxygenase gene
WO2008143668A2 (en) * 2006-05-18 2008-11-27 Lankenau Institute For Medical Research Indoleamine-2, 3-dioxygenase-2
WO2008085828A2 (en) * 2007-01-03 2008-07-17 The Johns Hopkins University Peptide modulators of angiogenesis and use thereof
SI2280721T1 (en) 2008-04-17 2018-02-28 Io Biotech Aps C/O Cobis Indoleamine 2, 3-dioxygenase based immunotherapy

Also Published As

Publication number Publication date
HUE055338T2 (hu) 2021-11-29
PT3320912T (pt) 2021-05-24
DK2280721T3 (da) 2018-01-29
JP2015129182A (ja) 2015-07-16
US20110318372A1 (en) 2011-12-29
US20220249641A1 (en) 2022-08-11
US10258678B2 (en) 2019-04-16
DK3320912T3 (da) 2021-05-31
EP2280721B1 (en) 2017-11-15
ES2870596T3 (es) 2021-10-27
CY1124279T1 (el) 2022-07-22
CY1120352T1 (el) 2019-07-10
US20170049868A1 (en) 2017-02-23
US20220202922A1 (en) 2022-06-30
CN102088994A (zh) 2011-06-08
IL208781A0 (en) 2010-12-30
US20230233657A1 (en) 2023-07-27
CN102088994B (zh) 2014-06-25
PL3320912T3 (pl) 2021-10-25
WO2009143843A1 (en) 2009-12-03
NZ588757A (en) 2012-05-25
HRP20210766T1 (hr) 2021-07-23
HUE037973T2 (hu) 2018-09-28
EP3320912A1 (en) 2018-05-16
NO2280721T3 (OSRAM) 2018-04-14
US12233103B2 (en) 2025-02-25
US20250319159A1 (en) 2025-10-16
SI3320912T1 (sl) 2021-08-31
PL2280721T3 (pl) 2018-04-30
US11648302B2 (en) 2023-05-16
US9433666B2 (en) 2016-09-06
EP3915570A1 (en) 2021-12-01
EP3320912B1 (en) 2021-03-31
ES2657963T3 (es) 2018-03-07
AU2009253539B2 (en) 2014-03-20
ZA201008056B (en) 2011-07-27
PT2280721T (pt) 2018-02-16
US11324813B2 (en) 2022-05-10
CA2721150C (en) 2017-09-26
AU2009253539A1 (en) 2009-12-03
SI2280721T1 (en) 2018-02-28
US20190201512A1 (en) 2019-07-04
JP2011520783A (ja) 2011-07-21
CN104056261A (zh) 2014-09-24
EP2280721A1 (en) 2011-02-09
CA2721150A1 (en) 2009-12-03
CN104056261B (zh) 2017-01-11
JP6016966B2 (ja) 2016-10-26
LT3320912T (lt) 2021-07-12
LT2280721T (lt) 2018-02-12
IL208781A (en) 2017-09-28

Similar Documents

Publication Publication Date Title
HRP20180282T1 (hr) Imunoterapija na bazi indoleamin 2, 3-dioksigenaze
US12168050B2 (en) Compositions comprising a norovirus nucleic acid and methods of use thereof
HRP20220924T1 (hr) Imunoterapija zasnovana na pd-l1
JP2014534202A5 (OSRAM)
AR086078A1 (es) Proteinas de fusion y vacunas de combinacion
AR107020A2 (es) Vacuna de pcsk9 (proteína convertasa subtilisina-kexina tipo 9)
NZ570553A (en) Immunogenic peptide sequences from influenza A and B and uses thereof for vaccines
MX340014B (es) Composicion farmaceutica para el tratamiento y/o prevencion del cancer.
MX340015B (es) Composicion farmaceutica para el tratamiento y/o prevencion del cancer.
MX342291B (es) Composicion farmaceutica para el tratamiento y/o prevencion del cancer.
MX340016B (es) Composicion farmaceutica para el tratamiento y/o prevencion del cancer.
WO2015149944A3 (en) Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant
BRPI0815578B8 (pt) Peptídeo de cdca1, seu uso e composição imunogênica compreendendo o mesmo para induzir imunidade, tratar e/ou prevenir o câncer, bem como método in vitro para induzir uma célula apresentadora de antígeno e uma célula t citotóxica (killer)
MX358725B (es) Antigenos prostaticos de consenso, molecula de acido nucleico que los codifica y vacuna y usos que los comprenden.
AR065076A1 (es) Vacuna contra el papilomavirus
CL2012000447A1 (es) Composición o vacuna que comprende un vector viral de un paramixovirus aviar 8 (apmv-8) recombinante; método para producir dicho vector; y uso para preparar medicamento útil para inducir una respuesta inmunológica.
AR083839A1 (es) Virus del sindrome reproductivo y respiratorio porcino (prrs) de los estados unidos y sus usos
WO2016100328A8 (en) Novel tilapia virus and uses thereof
WO2014205579A4 (en) Modified matrix proteins of vesicular stomatitis virus
AR080111A1 (es) Metodos y composiciones de inmunizacion
BRPI0816134A2 (pt) Herpesvírus, sequência de dna, vetor, célula, vírus, método para produção de partículas infecciosas, partículas infecciosas, vacina, uso de herpesvírus ou da sequência de dna ou do vetor ou das partículas infecciosas, e, método para o tratamento preventivo e/ou terapêutico de uma doença.
RU2015102027A (ru) Проникающие в клетку пептиды и способы идентификации проникающих в клетку пептидов
AR094725A1 (es) Parvovirus 5a porcino, métodos de uso y vacuna
EP4353256A3 (en) Induction of cross-reactive cellular response against rhinovirus antigens
RU2009129531A (ru) Вакцины на основе пептида foxp3