LT2280721T - Indolamino 2,3-dioksigenazės pagrindo imunoterapija - Google Patents

Indolamino 2,3-dioksigenazės pagrindo imunoterapija

Info

Publication number
LT2280721T
LT2280721T LTEP09753556.1T LT09753556T LT2280721T LT 2280721 T LT2280721 T LT 2280721T LT 09753556 T LT09753556 T LT 09753556T LT 2280721 T LT2280721 T LT 2280721T
Authority
LT
Lithuania
Prior art keywords
indoleamine
based immunotherapy
dioxygenase
dioxygenase based
immunotherapy
Prior art date
Application number
LTEP09753556.1T
Other languages
English (en)
Inventor
Mads Hald Andersen
Per Thor Straten
Original Assignee
Io Biotech Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Io Biotech Aps filed Critical Io Biotech Aps
Publication of LT2280721T publication Critical patent/LT2280721T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001154—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
    • C12Y113/11—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of two atoms of oxygen (1.13.11)
    • C12Y113/11052—Indoleamine 2,3-dioxygenase (1.13.11.52), i.e. indoleamine 2,3-dioxygenase 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
LTEP09753556.1T 2008-04-17 2009-04-17 Indolamino 2,3-dioksigenazės pagrindo imunoterapija LT2280721T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200800565 2008-04-17
PCT/DK2009/000095 WO2009143843A1 (en) 2008-04-17 2009-04-17 Indoleamine 2, 3-dioxygenase based immunotherapy

Publications (1)

Publication Number Publication Date
LT2280721T true LT2280721T (lt) 2018-02-12

Family

ID=40873320

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP17194619.7T LT3320912T (lt) 2008-04-17 2009-04-17 Indolamino 2,3-dioksigenaze grindžiama imunoterapija
LTEP09753556.1T LT2280721T (lt) 2008-04-17 2009-04-17 Indolamino 2,3-dioksigenazės pagrindo imunoterapija

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTEP17194619.7T LT3320912T (lt) 2008-04-17 2009-04-17 Indolamino 2,3-dioksigenaze grindžiama imunoterapija

Country Status (20)

Country Link
US (6) US9433666B2 (lt)
EP (3) EP3915570A1 (lt)
JP (2) JP2011520783A (lt)
CN (2) CN104056261B (lt)
AU (1) AU2009253539B2 (lt)
CA (1) CA2721150C (lt)
CY (2) CY1120352T1 (lt)
DK (2) DK2280721T3 (lt)
ES (2) ES2657963T3 (lt)
HR (2) HRP20180282T1 (lt)
HU (2) HUE037973T2 (lt)
IL (1) IL208781A (lt)
LT (2) LT3320912T (lt)
NO (1) NO2280721T3 (lt)
NZ (1) NZ588757A (lt)
PL (2) PL2280721T3 (lt)
PT (2) PT3320912T (lt)
SI (2) SI2280721T1 (lt)
WO (1) WO2009143843A1 (lt)
ZA (1) ZA201008056B (lt)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2721150C (en) * 2008-04-17 2017-09-26 Herlev Hospital Indoleamine 2,3-dioxygenase based immunotherapy
EP2425830A1 (en) * 2010-09-03 2012-03-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Synergistic drug combination for the treatment of cancer
GB201315946D0 (en) * 2013-09-06 2013-10-23 Immune Targeting Systems Its Ltd Oncology vaccine
AU2015265975B2 (en) * 2014-05-29 2020-05-28 Ventana Medical Systems, Inc. Anti- indoleamine 2,3-dioxygenase 1 antibodies and diagnostic uses thereof
NZ730708A (en) * 2014-09-17 2024-01-26 Io Biotech Aps Vaccine compositions comprising tryptophan 2,3-dioxygenase or fragments thereof
CN106148276A (zh) * 2015-04-16 2016-11-23 中国科学院上海生命科学研究院 间充质干细胞在制备治疗神经退行性疾病的药物中的应用
JP6654207B2 (ja) 2015-06-29 2020-02-26 オーエスイー・イミュノセラピューティクス 短鎖ペプチド抗腫瘍ワクチンを用いて早期のｔメモリー応答を誘発する方法。
CN116333088A (zh) 2015-09-16 2023-06-27 Io生物技术公司 包含c-c基序趋化因子22（ccl22）或其片段的疫苗组合物
HRP20240052T1 (hr) * 2016-03-04 2024-03-29 Io Biotech Aps Kombinirana terapija protiv raka
AU2017276498A1 (en) 2016-06-10 2019-01-03 Io Biotech Aps CALR and JAK2 vaccine compositions
WO2018067660A1 (en) * 2016-10-04 2018-04-12 University Of Florida Research Foundation, Inc. Targeted effector proteins and uses thereof
EP3526347B1 (en) * 2016-10-14 2021-01-13 Universität Zürich Indoleamine-2,3-dioxygenase assay for prostate cancer diagnosis and prognosis
AR110857A1 (es) 2017-01-27 2019-05-08 Immatics Biotechnologies Gmbh Péptidos y combinaciones de péptidos para el uso en la inmunoterapia contra el cáncer de ovario y otros tipos de cáncer
SG11201906198PA (en) * 2017-01-27 2019-08-27 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
MA47367B1 (fr) * 2017-01-27 2023-06-28 Immatics Biotechnologies Gmbh Nouveaux peptides et combinaison de peptides à utiliser en immunothérapie contre le cancer de l'ovaire et d'autres cancers
WO2019075062A1 (en) 2017-10-11 2019-04-18 University Of Florida Research Foundation MODIFIED GAL-1 PROTEINS AND USES THEREOF
CA3081774A1 (en) 2017-11-27 2019-05-31 Ose Immunotherapeutics Improved treatment of cancer
CN109758467B (zh) * 2019-03-08 2020-12-25 中国农业科学院兰州兽医研究所 一种吉西他滨在制备预防口蹄疫病毒感染的药物中的应用
WO2021077175A1 (en) * 2019-10-23 2021-04-29 The Council Of The Queensland Institute Of Medical Research Adoptive immunotherapy
CN112881269A (zh) * 2021-02-23 2021-06-01 浙江正熙生物技术股份有限公司 一种流式荧光检测试剂的质量检测方法
GB202103673D0 (en) 2021-03-17 2021-04-28 Io Biotech Aps Combination therapy for cancer
WO2023161350A1 (en) 2022-02-24 2023-08-31 Io Biotech Aps Nucleotide delivery of cancer therapy
CN114657158B (zh) * 2022-05-25 2022-10-21 深圳吉诺因生物科技有限公司 Ido1相关疫苗及其应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US58767A (en) 1866-10-16 John brougjbton
US5554372A (en) 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
AU6180096A (en) * 1995-06-20 1997-01-22 Merck & Co., Inc. Conversion of indene to (1s)-amino-(2r)-indanol free of any stereoisomer, by combination of dioxygenase bioconversion and chemical steps
US6096313A (en) 1996-02-09 2000-08-01 Ludwig Institute For Cancer Research Compositions containing immunogenic molecules and granulocyte-macrophage colony stimulating factor, as an adjuvant
WO1997047271A2 (en) 1996-06-12 1997-12-18 Yajun Guo Cellular vaccines and immunotherapeutics and methods for their preparation
CN1223688A (zh) * 1996-06-27 1999-07-21 纳幕尔杜邦公司 对羟基苯丙酮酸双加氧酶的植物基因
DE19730066A1 (de) * 1997-07-14 1999-01-21 Basf Ag DNA-Sequenz codierend für eine Hydroxyphenylpyruvatdioxygenase und deren Überproduktion in Pflanzen
AU1628599A (en) 1997-12-05 1999-06-28 Medical College Of Georgia Research Institute, Inc. Regulation of t cell-mediated immunity by tryptophan
AU4697600A (en) 1999-05-03 2000-11-17 Ludwig Institute For Cancer Research Methods for increasing t cell proliferation
AU2002245317A1 (en) 2001-01-24 2002-08-06 Protein Design Labs Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer
AU2002258518A1 (en) 2001-03-14 2002-09-24 Millennium Pharmaceuticals, Inc. Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
AU2002318944A1 (en) 2001-08-01 2003-02-17 Coley Pharmaceutical Gmbh Methods and compositions relating to plasmacytoid dendritic cells
AU2002361468A1 (en) 2001-08-14 2003-03-18 The Government Of The United States Of America As Represented By The Secretary Of Health And Human S Method for rapid generation of mature dendritic cells
US20060292618A1 (en) 2002-04-12 2006-12-28 Mellor Andrew L Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance
AU2002307243B2 (en) * 2002-04-12 2008-01-03 Medical College Of Georgia Research Institute, Inc. Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance
DE10229872A1 (de) * 2002-07-03 2004-01-29 Curevac Gmbh Immunstimulation durch chemisch modifizierte RNA
AU2003298786A1 (en) 2002-11-26 2004-06-18 Protein Design Labs, Inc. Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators
AU2003302820A1 (en) 2002-12-05 2004-06-30 Diadexus, Inc. Compositions, splice variants and methods relating to breast specific genes and proteins
EP1569690B1 (en) 2002-12-13 2011-07-27 Mitra Medical Technology AB Antilymphoma targeting agents with effector and affinity functions linked by a trifunctional reagent
DE10261223A1 (de) 2002-12-20 2004-07-08 MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH Steigerung der Immunantwort durch Substanzen, welche die Funktion von Natürlichen Killerzellen beeinflussen
US8008281B2 (en) 2003-03-27 2011-08-30 Lankenau Institute For Medical Research Methods for the treatment of cancer
US20050186289A1 (en) 2003-04-01 2005-08-25 Medical College Of Georgia Research Institute, Inc. Regulation of T cell-mediated immunity by D isomers of inhibitors of indoleamine-2,3-dioxygenase
US7598287B2 (en) 2003-04-01 2009-10-06 Medical College Of Georgia Research Institute, Inc. Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other therapeutic modalities
WO2005017163A2 (en) 2003-08-15 2005-02-24 Imperial College Innovations Limited Phenotypic knockout of cell-surface proteins
WO2005036127A2 (en) 2003-10-02 2005-04-21 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for identifying target cell cytolytic lymphocytes in a sample
CA2581674A1 (en) * 2004-07-13 2006-01-19 The University Of British Columbia Indoleamine 2,3-dioxygenase (ido) inhibitors
WO2006056304A2 (en) 2004-11-23 2006-06-01 Institut Pasteur Control of indoleamine 2,3 deoxygenase expression and activity
MX2007009219A (es) 2005-02-04 2008-01-16 Survac Aps Vacuna de peptido de survivina.
EP2559690B1 (en) 2005-05-10 2016-03-30 Incyte Holdings Corporation Modulators of indoleamine 2,3-dioxygenase and methods of using the same
US7468186B2 (en) 2005-07-22 2008-12-23 City Of Hope Polyomavirus cellular epitopes and uses therefor
GB0519303D0 (en) 2005-09-21 2005-11-02 Oxford Biomedica Ltd Chemo-immunotherapy method
CN107723274B (zh) * 2005-09-23 2021-05-07 塞勒里克斯有限公司 具有免疫调节活性的细胞群及其分离方法和用途
WO2007095050A2 (en) 2006-02-09 2007-08-23 Incyte Corporation N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase
WO2007115068A2 (en) 2006-03-30 2007-10-11 Indiana University Research And Technology Corporation Genetic variants in the indoleamine 2,3-dioxygenase gene
WO2008143668A2 (en) * 2006-05-18 2008-11-27 Lankenau Institute For Medical Research Indoleamine-2, 3-dioxygenase-2
WO2008085828A2 (en) * 2007-01-03 2008-07-17 The Johns Hopkins University Peptide modulators of angiogenesis and use thereof
CA2721150C (en) * 2008-04-17 2017-09-26 Herlev Hospital Indoleamine 2,3-dioxygenase based immunotherapy

Also Published As

Publication number Publication date
EP3915570A1 (en) 2021-12-01
PT3320912T (pt) 2021-05-24
US20220202922A1 (en) 2022-06-30
SI2280721T1 (en) 2018-02-28
ZA201008056B (en) 2011-07-27
HUE055338T2 (hu) 2021-11-29
US10258678B2 (en) 2019-04-16
US11648302B2 (en) 2023-05-16
IL208781A (en) 2017-09-28
JP2015129182A (ja) 2015-07-16
PL2280721T3 (pl) 2018-04-30
JP6016966B2 (ja) 2016-10-26
EP3320912B1 (en) 2021-03-31
NZ588757A (en) 2012-05-25
HRP20180282T1 (hr) 2018-03-23
US9433666B2 (en) 2016-09-06
DK2280721T3 (da) 2018-01-29
ES2870596T3 (es) 2021-10-27
US20230233657A1 (en) 2023-07-27
WO2009143843A1 (en) 2009-12-03
DK3320912T3 (da) 2021-05-31
CN102088994B (zh) 2014-06-25
CA2721150A1 (en) 2009-12-03
HRP20210766T1 (hr) 2021-07-23
US20170049868A1 (en) 2017-02-23
ES2657963T3 (es) 2018-03-07
HUE037973T2 (hu) 2018-09-28
US20110318372A1 (en) 2011-12-29
SI3320912T1 (sl) 2021-08-31
AU2009253539B2 (en) 2014-03-20
AU2009253539A1 (en) 2009-12-03
NO2280721T3 (lt) 2018-04-14
CY1120352T1 (el) 2019-07-10
EP2280721B1 (en) 2017-11-15
IL208781A0 (en) 2010-12-30
CN104056261A (zh) 2014-09-24
US20190201512A1 (en) 2019-07-04
EP2280721A1 (en) 2011-02-09
US20220249641A1 (en) 2022-08-11
PL3320912T3 (pl) 2021-10-25
EP3320912A1 (en) 2018-05-16
LT3320912T (lt) 2021-07-12
JP2011520783A (ja) 2011-07-21
CN102088994A (zh) 2011-06-08
CN104056261B (zh) 2017-01-11
PT2280721T (pt) 2018-02-16
US11324813B2 (en) 2022-05-10
CY1124279T1 (el) 2022-07-22
CA2721150C (en) 2017-09-26

Similar Documents

Publication Publication Date Title
ZA201008056B (en) Indoleamine 2,3-dioxygenase based immunotherapy
HRP20180662T1 (hr) 1,2,5-oksadiazoli kao inhibitori indolamin 2,3-dioksigenaze
ZA201205788B (en) 1,2,4-triazine-4-amine derivatives
SI2384326T1 (sl) Pirolo(2,3-d)pirimidinske spojine
EP2361902A4 (en) 4,6-DIAMINONICOTINSÄUREAMIDVERBINDUNG
EP2376105A4 (en) NKG2D-FC FOR IMMUNOTHERAPY
EP2377874A4 (en) Antioxidant
EP2351732A4 (en) NEW RAMALINE CONNECTION AND ITS USE
ZA201008657B (en) 4,5-dihydro-oxazol-2-yl derivatives
MY165626A (en) 1,2,4,-triazolone derivative
PL2234635T3 (pl) Immunoterapia oparta na białkach rhoc
SI2266990T1 (sl) Spojina 3-fenilpirazolo(5,1-b)tiazola
EP2377875A4 (en) ANTIOXIDANTS
HK1162032A1 (en) 1,1,1-trifluoro-2-hydroxypropyl compounds 111--2-
AP2011005562A0 (en) Phenanthrenone compounds, compositions and methods
HK1161684A1 (en) 5,6-dihydro-1h-pyridin-2-one compounds 56- -1h--2-
GB2461167B (en) Novel amidoxime derivatives