HRP20170571T1 - Tableta koja sadrži 5-hidroksi-1h-imidazol-4-karboksamid - Google Patents
Tableta koja sadrži 5-hidroksi-1h-imidazol-4-karboksamid Download PDFInfo
- Publication number
- HRP20170571T1 HRP20170571T1 HRP20170571TT HRP20170571T HRP20170571T1 HR P20170571 T1 HRP20170571 T1 HR P20170571T1 HR P20170571T T HRP20170571T T HR P20170571TT HR P20170571 T HRP20170571 T HR P20170571T HR P20170571 T1 HRP20170571 T1 HR P20170571T1
- Authority
- HR
- Croatia
- Prior art keywords
- tablet according
- tablet
- silicon dioxide
- carmellose
- carboxamide
- Prior art date
Links
- UEWSIIBPZOBMBL-UHFFFAOYSA-N 5-hydroxyimidazole-4-carboxamide Chemical compound NC(=O)C1=C([O-])[NH2+]C=N1 UEWSIIBPZOBMBL-UHFFFAOYSA-N 0.000 title claims 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 14
- 235000012239 silicon dioxide Nutrition 0.000 claims 8
- 239000000377 silicon dioxide Substances 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 4
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 4
- 229950008138 carmellose Drugs 0.000 claims 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 3
- 229920000881 Modified starch Polymers 0.000 claims 3
- 239000000654 additive Substances 0.000 claims 3
- 230000000996 additive effect Effects 0.000 claims 3
- 239000011575 calcium Substances 0.000 claims 3
- 229910052791 calcium Inorganic materials 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 2
- 238000005550 wet granulation Methods 0.000 claims 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 229960005069 calcium Drugs 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 1
- 229960001681 croscarmellose sodium Drugs 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 1
- 238000005469 granulation Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 235000019426 modified starch Nutrition 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000000741 silica gel Substances 0.000 claims 1
- 229910002027 silica gel Inorganic materials 0.000 claims 1
- 239000010703 silicon Substances 0.000 claims 1
- 229910052710 silicon Inorganic materials 0.000 claims 1
- -1 silicon anhydride Chemical class 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 229940083542 sodium Drugs 0.000 claims 1
- 235000015424 sodium Nutrition 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (13)
1. Tableta koja sadrži (1) 5-hidroksi-1H-imidazol-4-karboksamid ili njegovu sol, ili njegov hidrat, i (2) silicij dioksid.
2. Tableta prema patentnom zahtjevu 1, koja dalje sadrži aditiv.
3. Tableta prema patentnom zahtjevu 2, gdje se aditiv sastoji od aditiva koji sadrži agens za dezintegraciju.
4. Tableta prema bilo kojem od patentnih zahtjeva 1 do 3, gdje se silicij dioksid sastoji od jednog ili više odabranog od silika gela, anhidrida silicija, koloidnog silicij dioksida, lake nehidrirane silicij kiseline, i hidriranog silicij dioksida.
5. Tableta prema bilo kojem od patentnih zahtjeva 1 do 3, gdje se silicij dioksid sastoji od jednog ili više odabranog od lake nehidrirane silicij kiseline i hidriranog silicij dioksida.
6. Tableta prema bilo kojem od patentnih zahtjeva 1 do 5, gdje je sadržaj silicij dioksida 0.1 do 20% mase tablete.
7. Tableta prema patentnom zahtjevu 3, gdje se agens za dezintegraciju sastoji od jednog ili više odabranog od derivata celuloze, derivata škroba, i derivata polivinilpirolidona.
8. Tableta prema patentnom zahtjevu 3, gdje se agens za dezintegraciju sastoji od jednog ili više odabranog od karmeloze kalcij, karmeloze, nisko-supstituirane hidroksipropilceluloze, kroskarmeloza natrija, natrij karboksimetil škroba, djelomično preželatiniziranog škroba, i krospovidona.
9. Tableta prema patentnom zahtjevu 3, gdje se agens za dezintegraciju sastoji od jednog ili više odabranog od karmeloze kalcij, nisko-supstituirane hidroksipropilceluloze, i djelomično preželatiniziranog škroba.
10. Tableta prema patentnom zahtjevu 3, gdje je agens za dezintegraciju karmeloza kalcij.
11. Tableta prema bilo kojem od patentnih zahtjeva 1 do 10, gdje sadržaj 5-hidroksi-1H-imidazol-4-karboksamida ili njegove soli, ili njegovog hidrata je 0.3 do 95% mase tablete.
12. Metoda za proizvodnju tablete prema bilo kojem od patentnih zahtjeva 1 do 11, gdje je tableta napravljena korištenjem granuliranog praha proizvedenog pomoću metode vlažne granulacije.
13. Metoda za proizvodnju prema patentnom zahtjevu 12, gdje metoda vlažne granulacije je metoda “fluidized bed” granulacije.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013004995 | 2013-01-15 | ||
| PCT/JP2014/050591 WO2014112530A1 (ja) | 2013-01-15 | 2014-01-15 | ５－ヒドロキシ－１ｈ－イミダゾール－４－カルボキサミドを含有する錠剤 |
| EP14740552.6A EP2946780B1 (en) | 2013-01-15 | 2014-01-15 | Tablet containing 5-hydroxy-1h-imidazole-4-carboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170571T1 true HRP20170571T1 (hr) | 2017-08-11 |
Family
ID=51209619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170571TT HRP20170571T1 (hr) | 2013-01-15 | 2017-04-11 | Tableta koja sadrži 5-hidroksi-1h-imidazol-4-karboksamid |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9248102B2 (hr) |
| EP (1) | EP2946780B1 (hr) |
| JP (1) | JP5805891B2 (hr) |
| CN (1) | CN104271134B (hr) |
| BR (1) | BR112014027231A2 (hr) |
| CY (1) | CY1119159T1 (hr) |
| DK (1) | DK2946780T3 (hr) |
| ES (1) | ES2622568T3 (hr) |
| HK (1) | HK1205463A1 (hr) |
| HR (1) | HRP20170571T1 (hr) |
| LT (1) | LT2946780T (hr) |
| PL (1) | PL2946780T3 (hr) |
| PT (1) | PT2946780T (hr) |
| RS (1) | RS56032B1 (hr) |
| RU (1) | RU2654703C2 (hr) |
| SI (1) | SI2946780T1 (hr) |
| WO (1) | WO2014112530A1 (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
| WO2018051971A1 (ja) * | 2016-09-13 | 2018-03-22 | 富士フイルム株式会社 | Ｍｌｌ関連白血病の予防または治療のための医薬、方法、使用及び化合物 |
| JP6896093B2 (ja) * | 2017-10-27 | 2021-06-30 | 富士フイルム株式会社 | ５−ヒドロキシ−１ｈ−イミダゾール−４−カルボキサミド・３／４水和物の製造方法 |
| RU2018134165A (ru) * | 2018-09-03 | 2020-04-01 | Фуджифилм Корпорэйшн | Комбинированное фармацевтическое, профилактическое или супрессивное средство для подавления резистентности к пиримидиновому антиметаболиту и способ лечения заболевания |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS604802B2 (ja) | 1976-09-07 | 1985-02-06 | 住友化学工業株式会社 | 制癌剤 |
| US4181731A (en) * | 1976-09-07 | 1980-01-01 | Sumitomo Chemical Company, Limited | Novel therapeutic application of 4-carbamoyl-5-hydroxyimidazole |
| JPS5824569A (ja) | 1981-08-05 | 1983-02-14 | Sumitomo Chem Co Ltd | イミダゾ−ル誘導体の精製方法 |
| JPS60185727A (ja) | 1984-03-05 | 1985-09-21 | Sumitomo Chem Co Ltd | ４−カルバモイルイミダゾリウム−５−オレ−ト製剤の安定化法 |
| JPH048468A (ja) * | 1990-04-27 | 1992-01-13 | Sanshin:Kk | ワーク研摩機 |
| JPH09208468A (ja) * | 1996-02-02 | 1997-08-12 | Dainippon Pharmaceut Co Ltd | ｐ−クロロ−Ｎ−（２−モルホリノエチル）ベンズアミドを含有する錠剤 |
| MX2007004973A (es) * | 2004-10-25 | 2007-06-14 | Japan Tobacco Inc | Formulacion solida con solubilidad y estabilidad mejoradas y metodo para producir la formulacion. |
| JP5021210B2 (ja) * | 2006-01-16 | 2012-09-05 | エスエス製薬株式会社 | 圧縮成型製剤 |
| FR2903695B1 (fr) * | 2006-07-13 | 2008-10-24 | Merck Sante Soc Par Actions Si | Utilisation de derives d'imidazole activateurs de l'ampk, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP5266010B2 (ja) | 2007-09-14 | 2013-08-21 | 富士フイルム株式会社 | ４−カルバモイル−５−ヒドロキシ−イミダゾール誘導体のスルホン酸塩化合物 |
| JP5583659B2 (ja) * | 2009-03-13 | 2014-09-03 | 富山化学工業株式会社 | ６−フルオロ−３−ヒドロキシ−２−ピラジンカルボキサミド含有錠剤および造粒末 |
-
2014
- 2014-01-15 DK DK14740552.6T patent/DK2946780T3/en active
- 2014-01-15 PT PT147405526T patent/PT2946780T/pt unknown
- 2014-01-15 LT LTEP14740552.6T patent/LT2946780T/lt unknown
- 2014-01-15 EP EP14740552.6A patent/EP2946780B1/en active Active
- 2014-01-15 BR BR112014027231A patent/BR112014027231A2/pt not_active Application Discontinuation
- 2014-01-15 ES ES14740552.6T patent/ES2622568T3/es active Active
- 2014-01-15 RU RU2014143976A patent/RU2654703C2/ru not_active IP Right Cessation
- 2014-01-15 WO PCT/JP2014/050591 patent/WO2014112530A1/ja active Application Filing
- 2014-01-15 CN CN201480001101.9A patent/CN104271134B/zh not_active Expired - Fee Related
- 2014-01-15 SI SI201430172A patent/SI2946780T1/sl unknown
- 2014-01-15 RS RS20170377A patent/RS56032B1/sr unknown
- 2014-01-15 PL PL14740552T patent/PL2946780T3/pl unknown
- 2014-01-15 JP JP2014557486A patent/JP5805891B2/ja active Active
- 2014-10-30 US US14/528,768 patent/US9248102B2/en active Active
-
2015
- 2015-06-26 HK HK15106090.9A patent/HK1205463A1/zh not_active IP Right Cessation
-
2017
- 2017-04-11 CY CY20171100434T patent/CY1119159T1/el unknown
- 2017-04-11 HR HRP20170571TT patent/HRP20170571T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN104271134B (zh) | 2016-06-29 |
| RS56032B1 (sr) | 2017-09-29 |
| WO2014112530A1 (ja) | 2014-07-24 |
| SI2946780T1 (sl) | 2017-05-31 |
| PT2946780T (pt) | 2017-04-26 |
| US9248102B2 (en) | 2016-02-02 |
| PL2946780T3 (pl) | 2017-07-31 |
| RU2654703C2 (ru) | 2018-05-22 |
| JPWO2014112530A1 (ja) | 2017-01-19 |
| US20150057324A1 (en) | 2015-02-26 |
| CN104271134A (zh) | 2015-01-07 |
| BR112014027231A2 (pt) | 2017-06-27 |
| HK1205463A1 (zh) | 2015-12-18 |
| EP2946780A1 (en) | 2015-11-25 |
| CY1119159T1 (el) | 2018-02-14 |
| ES2622568T3 (es) | 2017-07-06 |
| JP5805891B2 (ja) | 2015-11-10 |
| LT2946780T (lt) | 2017-06-12 |
| DK2946780T3 (en) | 2017-05-08 |
| EP2946780B1 (en) | 2017-03-01 |
| EP2946780A4 (en) | 2016-06-08 |
| RU2014143976A (ru) | 2016-05-27 |
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