HRP20170513T1 - Postupci i pripravci za žive oslabljene viruse - Google Patents

Postupci i pripravci za žive oslabljene viruse Download PDF

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HRP20170513T1
HRP20170513T1 HRP20170513TT HRP20170513T HRP20170513T1 HR P20170513 T1 HRP20170513 T1 HR P20170513T1 HR P20170513T T HRP20170513T T HR P20170513TT HR P20170513 T HRP20170513 T HR P20170513T HR P20170513 T1 HRP20170513 T1 HR P20170513T1
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Croatia
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preparation
live
agents
block copolymers
virus
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HRP20170513TT
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Dan T. Stinchcomb
Jorge E. Osorio
O'neil Wiggan
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Takeda Vaccines, Inc.
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Application filed by Takeda Vaccines, Inc. filed Critical Takeda Vaccines, Inc.
Publication of HRP20170513T1 publication Critical patent/HRP20170513T1/hr

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Claims (15)

1. Pripravak živog oslabljenog virusa, naznačen time što sadrži: jedan ili više živih, oslabljenih virusa; jedan ili više polioksietilen-polioksipropilenskih (EO-PO) blok-kopolimera, gdje jedan ili više EO-PO blok-kopolimera uključuju poloksamer 407 (Pluronic F127®); jedno ili više proteinskih sredstava, gdje su jedno ili više proteinskih sredstava jedan ili više albumina; i jedno ili više ugljikohidratnih sredstava, gdje jedno ili više ugljikohidratnih sredstava uključuju trehalozu, gdje pripravak može smanjivati inaktiviranje živog oslabljenog virusa.
2. Pripravak u skladu s patentnim zahtjevom 1, naznačen time što žive, oslabljene viruse se bira iz skupine koju čine porodice Flavivirus, Togavirus, Coronavirus, Rhabdovirus, Filovirus, Paramyxovirus, Orthomyxovirus, Bunyavirus, Arenavirus, Retrovirus, Hepadnavirus, Herpesvirus, Poxvirus i njihove kombinacije.
3. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 2, naznačen time što su živi, oslabljeni virusi flavivirusi.
4. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 3, naznačen time što je pripravak prilagođen da bude djelomično ili potpuno dehidriran.
5. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačen time što su jedan ili više albumina seralbumini dobiveni iz vrste kralježnjaka.
6. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 5, naznačen time što je jedan ili više EO-PO blok-kopolimera poloksamer 407, jedno ili više proteinskih sredstava je seralbumin, a jedno ili više ugljikohidratnih sredstava je trehaloza.
7. Pripravak u skladu s patentnim zahtjevom 6, naznačen time što se koncentracija poloksamera 407 (Pluronic F127®) kreće od 0,1 do 4% (tež./vol.), koncentracija seralbumina se kreće od 0,001 do 3% (tež./vol.), a koncentracija trehaloze se kreće od 5 do 50% (tež./vol.).
8. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 7, naznačen time što se jedan ili više albumina bira iz skupine koju čine goveđi seralbumin i ljudski seralbumin.
9. Postupak smanjivanja inaktiviranje pripravka živog, oslabljenog virusa, naznačen time što se sastoji u kombiniranju jednog ili više živih, oslabljenih virusa s pripravkom koji sadrži jedan ili više polioksietilen-polioksipropilenskih (EO-PO) blok-kopolimera, gdje jedan ili više EO-PO blok-kopolimera uključuju poloksamer 407 (Pluronic F127®), jedno ili više proteinskih sredstava, gdje su jedno ili više proteinskih sredstava jedan ili više albumina; i jedno ili više ugljikohidratnih sredstava, gdje jedno ili više ugljikohidratnih sredstava uključuju trehalozu, gdje pripravak može smanjivati inaktiviranje živog, oslabljenog virusa.
10. Postupak u skladu s patentnim zahtjevom 9, naznačen time što se žive, oslabljene viruse bira iz skupine koju čine porodice Flavivirus, Togavirus, Coronavirus, Rhabdovirus, Filovirus, Paramyxovirus, Orthomyxovirus, Bunyavirus, Arenavirus, Retrovirus, Hepadnavirus, Herpesvirus, Poxvirus i njihove kombinacije.
11. Postupak u skladu s patentnim zahtjevom 9, naznačen time što se produljuje rok skladištenja virusnog pripravka kada se pripravak drži na sobnoj ili nižoj temperaturi u usporedbi s kontrolnim pripravkom.
12. Postupak u skladu s patentnim zahtjevom 9, naznačen time što pripravak smanjuje inaktiviranje vodene suspenzije živog, oslabljenog virusa tijekom jedan ili više ciklusa smrzavanja i odmrzavanja u usporedbi s kontrolnim pripravkom.
13. Komplet za smanjivanje inaktiviranja pripravka živog, oslabljenog virusa, naznačen time što sadrži: najmanje jedan spremnik; i pripravak koji sadrži jedno ili više proteinskih sredstava, gdje su jedno ili više proteinskih sredstava jedan ili više albumina; jedno ili više ugljikohidratnih sredstava, gdje jedno ili više ugljikohidratnih sredstava uključuju trehalozu; i jedan ili više polioksietilen-polioksipropilenskih (EO-PO) blok-kopolimera, gdje jedan ili više EO-PO blok-kopolimera uključuju poloksamer 407 (Pluronic F127®), gdje pripravak smanjuje inaktiviranje živog oslabljenog virusa.
14. Pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 8, naznačen time što je namijenjen upotrebi u postupku smanjivanja početka ili sprječavanja zdravstvenog stanja.
15. Pripravak u skladu s patentnim zahtjevom 14, naznačen time što se zdravstveno stanje bira iz skupine koju čine zaraza virusom zapadnog Nila, groznica denga, japanski encefalitis, groznica iz šume Kyasanur, australski encefalitis, St. Louis encefalitis, krpeljni encefalitis, žuta groznica i zaraza virusom hepatitisa C.
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