BR112016029201A2 - vírus do oeste do nilo/dengue quiméricos e métodos de uso - Google Patents
vírus do oeste do nilo/dengue quiméricos e métodos de usoInfo
- Publication number
- BR112016029201A2 BR112016029201A2 BR112016029201A BR112016029201A BR112016029201A2 BR 112016029201 A2 BR112016029201 A2 BR 112016029201A2 BR 112016029201 A BR112016029201 A BR 112016029201A BR 112016029201 A BR112016029201 A BR 112016029201A BR 112016029201 A2 BR112016029201 A2 BR 112016029201A2
- Authority
- BR
- Brazil
- Prior art keywords
- denv
- serotype
- chimera
- methods
- immune response
- Prior art date
Links
- 241000725619 Dengue virus Species 0.000 title abstract 2
- 241000710886 West Nile virus Species 0.000 title 1
- 230000028993 immune response Effects 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 2
- 241000710831 Flavivirus Species 0.000 abstract 1
- 108700026244 Open Reading Frames Proteins 0.000 abstract 1
- 101710172711 Structural protein Proteins 0.000 abstract 1
- 229940031551 inactivated vaccine Drugs 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229960000856 protein c Drugs 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24161—Methods of inactivation or attenuation
- C12N2770/24162—Methods of inactivation or attenuation by genetic engineering
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
estão descritos aqui flavivírus quiméricos que incluem regiões não codificadoras, proteínas não estruturais e pelo menos uma porção de uma proteína c do vírus nilo (wnv) e uma proteína prm e uma proteína e do vírus da dengue (denv). o denv pode ser do sorotipo den1, sorotipo den2, sorotipo den3 ou sorotipo den4. também estão descritas aqui composições e métodos para desencadear uma resposta imune em um indivíduo tal como uma resposta imune a um ou mais sorotipos de denv. em modalidades particulares, as composições incluem um ou mais vírus inativados que incluem um ácido nucleico quimérico de wn/denv (tal como uma vacina inativada tetravalente que inclui uma quimera de wn/den1, uma quimera de wn/den2, uma quimera de wn/den3 e uma quimera de wn/den4). as composições podem ser administradas a um indivíduo para desencadear uma resposta imune.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462015265P | 2014-06-20 | 2014-06-20 | |
US62/015,265 | 2014-06-20 | ||
PCT/US2015/036728 WO2015196094A1 (en) | 2014-06-20 | 2015-06-19 | Chimeric west nile/dengue viruses and methods of use |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112016029201A2 true BR112016029201A2 (pt) | 2017-10-17 |
BR112016029201B1 BR112016029201B1 (pt) | 2023-11-14 |
BR112016029201B8 BR112016029201B8 (pt) | 2023-12-05 |
Family
ID=53524961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016029201A BR112016029201B8 (pt) | 2014-06-20 | 2015-06-19 | Quimera de ácido nucleico, composição imunogênica, uso de um ou mais vírus inativados compreendendo a quimera de ácido nucleico e método para inativar um vírus |
Country Status (6)
Country | Link |
---|---|
US (1) | US10428313B2 (pt) |
EP (1) | EP3158061B1 (pt) |
CN (1) | CN106574271B (pt) |
AU (1) | AU2015276929B2 (pt) |
BR (1) | BR112016029201B8 (pt) |
WO (1) | WO2015196094A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10632185B2 (en) | 2016-07-08 | 2020-04-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric west nile/zika viruses and methods of use |
US11344615B2 (en) | 2016-07-08 | 2022-05-31 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nucleic acids encoding chimeric dengue/Zika viruses optimized for growth and stability in vero cells |
US11634459B2 (en) | 2017-08-18 | 2023-04-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric reporter West Nile/dengue viruses and their use |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5939254A (en) | 1997-04-28 | 1999-08-17 | University Of Massachusetts | Methods and reagents for rapid diagnosis of dengue virus infection |
US6793488B1 (en) | 1999-04-16 | 2004-09-21 | U.S. Army Medical Research & Materiel Command | Flavivirus detection and quantification assay |
ES2554254T3 (es) * | 2000-02-16 | 2015-12-17 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Quimeras del virus del dengue 2 inmunógenas |
BR0210907A (pt) | 2001-06-01 | 2004-12-21 | Acambis Inc | Vetores de flavivìrus quiméricos |
US20030180329A1 (en) | 2002-01-15 | 2003-09-25 | Monath Thomas P. | Viral vaccine production method |
US8124397B2 (en) | 2005-08-08 | 2012-02-28 | Oregon Health & Science University | Inactivating pathogens with oxidizing agents for vaccine production |
EA201591888A1 (ru) | 2008-03-14 | 2016-05-31 | Санофи Пастер Байолоджикс Ко. | Репликационно-дефектные вакцины и вакцинные векторы против флавивирусов |
US8715689B2 (en) * | 2008-04-30 | 2014-05-06 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Chimeric west nile/dengue viruses |
-
2015
- 2015-06-19 AU AU2015276929A patent/AU2015276929B2/en active Active
- 2015-06-19 EP EP15734770.9A patent/EP3158061B1/en active Active
- 2015-06-19 US US15/318,334 patent/US10428313B2/en active Active
- 2015-06-19 WO PCT/US2015/036728 patent/WO2015196094A1/en active Application Filing
- 2015-06-19 CN CN201580036215.1A patent/CN106574271B/zh active Active
- 2015-06-19 BR BR112016029201A patent/BR112016029201B8/pt active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
BR112016029201B1 (pt) | 2023-11-14 |
CN106574271B (zh) | 2020-06-16 |
EP3158061A1 (en) | 2017-04-26 |
AU2015276929B2 (en) | 2021-04-08 |
EP3158061B1 (en) | 2019-08-07 |
WO2015196094A1 (en) | 2015-12-23 |
US10428313B2 (en) | 2019-10-01 |
CN106574271A (zh) | 2017-04-19 |
AU2015276929A1 (en) | 2016-12-22 |
US20170114330A1 (en) | 2017-04-27 |
BR112016029201B8 (pt) | 2023-12-05 |
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Legal Events
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 19/06/2015, OBSERVADAS AS CONDICOES LEGAIS |
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Free format text: REFERENTE A RPI 2758 DE14/11/2023, QUANTO AO ITEM (54) TITULO. |