CO2018010874A2 - Vacuna de virus de zika atenuado vivo - Google Patents

Vacuna de virus de zika atenuado vivo

Info

Publication number
CO2018010874A2
CO2018010874A2 CONC2018/0010874A CO2018010874A CO2018010874A2 CO 2018010874 A2 CO2018010874 A2 CO 2018010874A2 CO 2018010874 A CO2018010874 A CO 2018010874A CO 2018010874 A2 CO2018010874 A2 CO 2018010874A2
Authority
CO
Colombia
Prior art keywords
attenuated
immunogenic
zikv
vaccines
zika
Prior art date
Application number
CONC2018/0010874A
Other languages
English (en)
Inventor
Stephen S Whitehead
Anna P Durbin
Sara E Woodson
Alexander G Pletnev
Konstantin A Tsetsarkin
Original Assignee
Univ Johns Hopkins
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201662307170P priority Critical
Priority to PCT/US2017/021989 priority patent/WO2017156511A1/en
Application filed by Univ Johns Hopkins, Us Health filed Critical Univ Johns Hopkins
Publication of CO2018010874A2 publication Critical patent/CO2018010874A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses positive-sense
    • C12N2770/00011MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses positive-sense ssRNA Viruses positive-sense
    • C12N2770/24011Flaviviridae
    • C12N2770/24111Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses positive-sense
    • C12N2770/00011MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses positive-sense ssRNA Viruses positive-sense
    • C12N2770/24011Flaviviridae
    • C12N2770/24111Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses positive-sense
    • C12N2770/00011MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses positive-sense ssRNA Viruses positive-sense
    • C12N2770/24011Flaviviridae
    • C12N2770/24111Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24141Use of virus, viral particle or viral elements as a vector
    • C12N2770/24144Chimeric viral vector comprising heterologous viral elements for production of another viral vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses positive-sense
    • C12N2770/00011MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses positive-sense ssRNA Viruses positive-sense
    • C12N2770/24011Flaviviridae
    • C12N2770/24111Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24161Methods of inactivation or attenuation
    • C12N2770/24162Methods of inactivation or attenuation by genetic engineering
    • Y02A50/386
    • Y02A50/388
    • Y02A50/39
    • Y02A50/392
    • Y02A50/394
    • Y02A50/396

Abstract

La presente divulgación se relaciona con virus y vacunas de Zika atenuado, virus y vacunas de Zika quimérico atenuado, y composiciones inmunogénicas multivalentes que comprenden vacunas de Zika y vacunas para otros flavivirus. Los virus de Zika quimérico incluyen una primera secuencia de nucleótido que codifica por lo menos una proteína estructural de un virus Zika (ZIKV), una segunda secuencia de nucleótido que codifica por lo menos una proteína no estructura de un primer flavivirus, y una tercera secuencia de nucleótido de una región (3’) sin trasladar de un segundo flavivirus. Las composiciones inmunogénicas multivalentes comprenden una vacuna de ZIKV atenuado o una vacuna de ZIKV quimérico sin atenuar (o su combinación) junto con uno o más de un primer virus atenuado que es inmunogénico contra el serotipo (1) de dengue, un segundo virus atenuado que es inmunogénico contra el serotipo (2) de dengue, un tercer virus atenuado que es inmunogénico contra el serotipo (3) de dengue, y un cuarto virus atenuado que es inmunogénico contra el serotipo (4) de dengue. La presente divulgación además se relaciona con métodos para inducir respuestas inmunes, así como prevenir o tratar infecciones de ZIKV, y en ciertas modalidades, la prevención combinada con tratamiento de ZIKV y otros flavivirus, por ejemplo, virus de dengue.
CONC2018/0010874A 2016-03-11 2018-10-10 Vacuna de virus de zika atenuado vivo CO2018010874A2 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US201662307170P true 2016-03-11 2016-03-11
PCT/US2017/021989 WO2017156511A1 (en) 2016-03-11 2017-03-11 Live attenuated zika virus vaccine

Publications (1)

Publication Number Publication Date
CO2018010874A2 true CO2018010874A2 (es) 2018-10-22

Family

ID=58428363

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0010874A CO2018010874A2 (es) 2016-03-11 2018-10-10 Vacuna de virus de zika atenuado vivo

Country Status (11)

Country Link
US (1) US20190194260A1 (es)
EP (1) EP3426292A1 (es)
JP (1) JP2019511221A (es)
KR (1) KR20180127397A (es)
CN (1) CN109152828A (es)
AU (1) AU2017230112A1 (es)
BR (1) BR112018068342A2 (es)
CA (1) CA3016697A1 (es)
CO (1) CO2018010874A2 (es)
MX (1) MX2018010958A (es)
WO (1) WO2017156511A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018129160A1 (en) 2017-01-06 2018-07-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Live attenuated flavivirus vaccines and methods of using and making same
EP3710046A1 (en) * 2017-11-10 2020-09-23 The Research Institute at Nationwide Children's Hospital Recombinant vectors encoding zika virus protein subunits

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001238156B2 (en) 2000-02-10 2006-08-31 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Full-length infectious cDNA clones of tick borne flavivirus
BRPI0209943B8 (pt) * 2001-05-22 2021-05-25 Joseph E Blaney Jr desenvolvimento de mutações úteis para atenuar vírus da dengue e vírus da dengue quiméricos
JP4580650B2 (ja) 2002-01-10 2010-11-17 アメリカ合衆国 西ナイルウイルスにより引き起こされる疾患を予防するために生ウイルスワクチン中に用いるための西ナイルウイルスおよびデングウイルスキメラの構築
CA2483653C (en) 2002-05-03 2014-10-28 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dengue tetravalent vaccine containing a common 30 nucleotide deletion in the 3'-utr of dengue types 1,2,3, and 4, or antigenic chimeric dengue viruses 1,2,3, and 4
CA2548808C (en) 2003-12-08 2015-07-07 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monoclonal antibodies that bind or neutralize dengue virus
EP1761277A1 (en) 2004-06-14 2007-03-14 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES West nile viruses with mutations in the 3' terminal stem and loop secondary structure for use as live virus vaccines
SI2589602T1 (sl) * 2006-08-15 2016-08-31 The Government of the U.S.A., as repr. by the Secretary, Dept. of Health & Human Services, the Nat. Inst. of Health Office of Technology Transfer Development of Dengue Virus Ingredient Ingredients
US20100316670A1 (en) 2007-06-14 2010-12-16 Blaney Joseph E Chimeric sle/dengue type 4 antigenic viruses
WO2012065105A2 (en) * 2010-11-12 2012-05-18 Thomas Monath Chimeric flavivirus vaccines

Also Published As

Publication number Publication date
MX2018010958A (es) 2019-02-07
EP3426292A1 (en) 2019-01-16
CN109152828A (zh) 2019-01-04
AU2017230112A1 (en) 2018-10-04
BR112018068342A2 (pt) 2019-01-15
WO2017156511A1 (en) 2017-09-14
WO2017156511A8 (en) 2018-09-27
JP2019511221A (ja) 2019-04-25
US20190194260A1 (en) 2019-06-27
CA3016697A1 (en) 2017-09-14
KR20180127397A (ko) 2018-11-28

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