CO6440541A2 - Virus de diarrea viral bovina con una proteina erns modificada - Google Patents

Virus de diarrea viral bovina con una proteina erns modificada

Info

Publication number
CO6440541A2
CO6440541A2 CO11068897A CO11068897A CO6440541A2 CO 6440541 A2 CO6440541 A2 CO 6440541A2 CO 11068897 A CO11068897 A CO 11068897A CO 11068897 A CO11068897 A CO 11068897A CO 6440541 A2 CO6440541 A2 CO 6440541A2
Authority
CO
Colombia
Prior art keywords
virus
bovine viral
diarrea
erns protein
modified
Prior art date
Application number
CO11068897A
Other languages
English (en)
Inventor
Robert Gerard Ankenbauer
Yugang Luo
Siao-Kun Wan Welch
Ying Yuan
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41665513&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6440541(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer filed Critical Pfizer
Publication of CO6440541A2 publication Critical patent/CO6440541A2/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24361—Methods of inactivation or attenuation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Communicable Diseases (AREA)

Abstract

La presente invención se refiere a pestivirus quiméricos que tienen utilidad como composiciones inmunogénicas y vacunas. También se describen en el presente documento procedimientos y kits para tratar o evitar la dispersión de infección con virus de la diarrea viral bovina, así como procedimientos y kits para diferenciar entre animales vacunados y animales infectados con virus de tipo silvestre.
CO11068897A 2008-12-03 2011-06-02 Virus de diarrea viral bovina con una proteina erns modificada CO6440541A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11959408P 2008-12-03 2008-12-03
US17336309P 2009-04-28 2009-04-28

Publications (1)

Publication Number Publication Date
CO6440541A2 true CO6440541A2 (es) 2012-05-15

Family

ID=41665513

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11068897A CO6440541A2 (es) 2008-12-03 2011-06-02 Virus de diarrea viral bovina con una proteina erns modificada

Country Status (20)

Country Link
US (2) US9567375B2 (es)
EP (1) EP2373785B1 (es)
JP (1) JP5744748B2 (es)
KR (1) KR101453146B1 (es)
CN (1) CN102239251B (es)
AR (1) AR075484A1 (es)
AU (1) AU2009323784B2 (es)
BR (1) BRPI0920982A8 (es)
CA (1) CA2744750C (es)
CL (1) CL2011001343A1 (es)
CO (1) CO6440541A2 (es)
ES (1) ES2681685T3 (es)
ME (1) ME01140B (es)
MX (1) MX2011005820A (es)
NZ (1) NZ592979A (es)
RU (2) RU2524426C2 (es)
TW (1) TWI485248B (es)
UY (1) UY32274A (es)
WO (1) WO2010064164A1 (es)
ZA (1) ZA201104508B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2606605T3 (es) * 2010-09-21 2017-03-24 Intervet International B.V. Vacuna para el BVDV
RS56579B1 (sr) * 2011-08-24 2018-02-28 Zoetis Services Llc Poboljšano dijagnostikovanje vakcina
BR112017012484B1 (pt) * 2014-12-19 2024-02-06 Intervet International B.V Vacina para combater tremor congênito (ct) do grupo a-ii em porcos
BR112018013400A2 (pt) * 2015-12-30 2018-12-18 Intervet Int Bv vacina marcadora de pestivírus
DE102018110208A1 (de) * 2018-04-27 2019-10-31 Stiftung Tierärztliche Hochschule Hannover Gentechnisch veränderte Pestiviren und deren Verwendung als Markerimpfstoff
GB201910730D0 (en) * 2019-07-26 2019-09-11 Randox Teoranta Bovine Pathogen Array
CN111057132B (zh) * 2019-10-16 2022-01-07 四川农业大学 牛病毒性腹泻病毒e0蛋白氨基酸及制备方法
CN110665002B (zh) * 2019-10-29 2023-01-24 信阳市动物疫病预防控制中心 一种用于防治牛病毒性腹泻的抗体制剂及其制备方法
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
CN112961224B (zh) * 2021-03-26 2022-09-27 中国农业大学 牛病毒性腹泻病毒1型病毒样颗粒的制备及应用
CN114773438B (zh) * 2022-05-24 2023-06-13 中国农业科学院兰州兽医研究所 一种牛病毒性腹泻病毒e0截短蛋白、制备方法及应用

Family Cites Families (11)

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US5593873A (en) 1986-01-27 1997-01-14 Syntro Corporation Recombinant infectious bovine rhinotracheitis virus
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5709865A (en) * 1994-11-10 1998-01-20 Biostar Inc. Immunogenic composition against Bovine Viral Diarrhea Virus II glycoprotein 53 (BVDV-II gp53)
US6001613A (en) * 1996-05-24 1999-12-14 Board Of Regents Of University Of Nebraska Plasmid bearing a cDNA copy of the genome of bovine viral diarrhea virus, chimeric derivatives thereof, and method of producing an infectious bovine viral diarrhea virus using said plasmid
US6060457A (en) 1996-06-20 2000-05-09 Universite De Montreal DNA plasmid vaccine for immunization of animals against BVDV
EP0982402A1 (en) 1998-08-14 2000-03-01 Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) Pestivirus vaccination
RU2158306C2 (ru) * 1999-01-19 2000-10-27 Институт экспериментальной ветеринарии Сибири и Дальнего Востока СО РАСХН Способ выявления вируса вирусной диареи (болезни слизистых оболочек) крупного рогатого скота с помощью специфических олигонуклеотидных праймеров в полимеразной цепной реакции
EP1170367A1 (en) * 2000-06-27 2002-01-09 Bayer Ag BVDV virus-like particles
DE10143813A1 (de) * 2001-09-06 2003-04-10 Boehringer Ingelheim Vetmed Infektiöser Rindervirusdiarrhoe-Virusklon
US7361357B2 (en) * 2003-07-29 2008-04-22 Pfizer Inc. Safe mutant viral vaccines
UY29915A1 (es) * 2005-11-15 2007-06-29 Boehringer Ingelheim Vetmed Vacuna combinada que comprende un virus atenuado de la diarrea viral bovina

Also Published As

Publication number Publication date
AU2009323784A1 (en) 2010-06-10
CL2011001343A1 (es) 2012-03-23
EP2373785A1 (en) 2011-10-12
TW201024416A (en) 2010-07-01
NZ592979A (en) 2012-08-31
RU2524426C2 (ru) 2014-07-27
RU2011121044A (ru) 2013-01-10
TWI485248B (zh) 2015-05-21
EP2373785B1 (en) 2018-06-27
ZA201104508B (en) 2012-11-28
AU2009323784B2 (en) 2013-08-15
US9567375B2 (en) 2017-02-14
KR101453146B1 (ko) 2014-10-27
ES2681685T3 (es) 2018-09-14
JP2012510285A (ja) 2012-05-10
ME01140B (me) 2013-03-20
CA2744750C (en) 2018-10-09
US20170151321A1 (en) 2017-06-01
CN102239251A (zh) 2011-11-09
US20100136055A1 (en) 2010-06-03
JP5744748B2 (ja) 2015-07-08
UY32274A (es) 2010-06-30
MX2011005820A (es) 2011-06-21
AR075484A1 (es) 2011-04-06
CN102239251B (zh) 2014-04-23
CA2744750A1 (en) 2010-06-10
BRPI0920982A2 (pt) 2016-10-04
WO2010064164A1 (en) 2010-06-10
BRPI0920982A8 (pt) 2017-09-19
KR20110091579A (ko) 2011-08-11
RU2013141044A (ru) 2015-03-20

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