HRP20151029T1 - Prolijekovi tetrahidrokanabinola, pripravci koji sadržavaju prolijekove tetrahidrokanabinola postupci za njihovu uporabu - Google Patents

Prolijekovi tetrahidrokanabinola, pripravci koji sadržavaju prolijekove tetrahidrokanabinola postupci za njihovu uporabu Download PDF

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HRP20151029T1
HRP20151029T1 HRP20151029TT HRP20151029T HRP20151029T1 HR P20151029 T1 HRP20151029 T1 HR P20151029T1 HR P20151029T T HRP20151029T T HR P20151029TT HR P20151029 T HRP20151029 T HR P20151029T HR P20151029 T1 HRP20151029 T1 HR P20151029T1
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Croatia
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dermatitis
mammals
compound according
group
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HRP20151029TT
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Audra Lynn Stinchcomb
Miroslaw Jerzy Golinski
Dana Carmel Hammell
Jeffry Lynn Howard
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Zynerba Pharmaceuticals, Inc.
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Publication of HRP20151029T1 publication Critical patent/HRP20151029T1/hr

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Claims (8)

1. Spoj koji ima formulu: [image] naznačen time, da je R1 odabran iz skupine koju čine pegilirani ester, hidroksilirani ester, razgranani hidroksilirani ester i pegilirani ester pomiješan s oksalnom kiselinom.
2. Spoj u skladu s patentnim zahtjevom 1, naznačen time, da je odabran iz skupine koju čine: [image] [image] [image]
3. Farmaceutski pripravak, naznačen time, da sadržava: (a) spoj kao što je opisano u patentnom zahtjevu 1 i (b) farmaceutski prihvatljivo pomoćno sredstvo.
4. Farmaceutski pripravak, naznačen time, da sadržava: (a) spoj u skladu s patentnim zahtjevom 1 odabran iz skupine koja se sastoji od: [image] [image] [image] i [image] i (b) farmaceutsku pomoćnu tvar.
5. Uporaba spoja u skladu s patentnim zahtjevom 1, naznačena time, da se koristi za pripravu lijeka za liječenje medicinskog stanja kod sisavaca, a medicinsko stanje odabrano je iz skupine koju čine: anoreksija, mučnina, povraćanje, gubitak tjelesne mase, gubitak tjelesne mase uzrokovan virusom HIV-a, mučnina uzrokovana kemoterapijom i povraćanje, poremećaji uzrokovani uporabom alkohola, antitumorni učinci, amiotrofična lateralna skleroza, multiformni glioblastom, gliom, povećani intraokularni tlak, glaukom, poremećaji uzrokovani kanabisom, Touretteov sindrom, distonija, multipla skleroza, upalne crijevne bolesti, artritis, dermatitis, reumatoidni artritis, sistemski eritemski lupus, protuupalni, antikonvulzantni, antipsihotički, antioksidativni, neuroprotektivni, protukarcinomni i imunomodulacijski učinci, periferna neuropatska bol, neuropatsku bol povezana s post-herpetičkom neuralgijom, dijabetska neuropatija, crvenilo, opekline, aktinične keratoze, usne šupljine čireve i čireva, post- epiziotomijska bol, psorijaza, svrbež, kontaktni dermatitis, ekcem, dermatitis herpetiformis, eksfolijativni dermatitis, mycosis fungoides, pemfigus, teški polimorfni eritem (npr. Stevens- Johnsonov sindrom), seboreični dermatitis, ankilozantni spondilitis, psorijatični artritis, Reiterov sindrom, giht, hondrokalcinoze, bol u zglobovima uslijed dismenoreje, fibromialgija, muskuloskeletalna bol, neuropatske postoperativne komplikacije, polimiozitis, akutni nespecifični tenosinovitis, bursitis, epikondilitis, posttraumatski osteoartritis, sinovitis i juvenilni reumatoidni artritis, naznačen time, da se spoj primjenjuje transdermalno.
6. Upotreba spoja u skladu s patentnim zahtjevom 1 odabranog iz skupine koju čine: [image] [image] [image] i [image] naznačena time, da je namijenjena za pripravu lijeka za liječenje medicinskog stanja odabranog iz skupine koju čine: anoreksija, mučnina, povraćanje, gubitak tjelesne mase, gubitak tjelesne mase uzrokovan virusom HIV-a, mučnina uzrokovana kemoterapijom i povraćanje, poremećaji uzrokovani uporabom alkohola, antitumorni učinci, amiotrofična lateralna skleroza, multiformni glioblastom, gliom, povećani intraokularni tlak, glaukom, poremećaji uzrokovani kanabisom, Touretteov sindrom, distonija, multipla skleroza, upalne crijevne bolesti, artritis, dermatitis, reumatoidni artritis, sistemski eritemski lupus, protuupalni, antikonvulzantni, antipsihotički, antioksidativni, neuroprotektivni, protukarcinomni i imunomodulacijski učinci, periferna neuropatska bol, neuropatsku bol povezana s post-herpetičkom neuralgijom, dijabetska neuropatija, crvenilo, opekline, aktinične keratoze, usne šupljine čireve i čireva, post- epiziotomijska bol, psorijaza, svrbež, kontaktni dermatitis, ekcem, dermatitis herpetiformis, eksfolijativni dermatitis, mycosis fungoides, pemfigus, teški polimorfni eritem (npr. Stevens- Johnsonov sindrom), seboreični dermatitis, ankilozantni spondilitis, psorijatični artritis, Reiterov sindrom, giht, hondrokalcinoze, bol u zglobovima uslijed dismenoreje, fibromialgija, muskuloskeletalna bol, neuropatske postoperativne komplikacije, polimiozitis, akutni nespecifični tenosinovitis, bursitis, epikondilitis, posttraumatski osteoartritis, sinovitis i juvenilni reumatoidni artritis, pri čemu se spoj primjenjuje transdermalno.
7. Upotreba spoja u skladu s patentnim zahtjevom 1, namijenjena za pripremu lijeka za primjenu kod sisavaca, naznačena time, da obuhvaća korake: (a) kombiniranje spoja u skladu s patentnim zahtjevom 1 s farmaceutskim ekscipijentom kako bi se dobilo farmaceutski pripravak; (b) izrada oblika za doziranje iz farmaceutskog pripravka koji je pogodan za primjenu kod sisavaca i (c) primjena oblika za doziranja kod sisavaca, pri čemu se farmaceutski pripravak primjenjuje transdermalno.
8. Upotreba spoja za proizvodnju lijeka za primjenu kod sisavaca naznačena time, da obuhvaća korake: (a) kombiniranje spoja u skladu s patentnim zahtjevom 1, koji se odabire iz skupine koju čine: [image] [image] [image] [image] i [image] s farmaceutskom pomoćnom tvari kako bi se dobilo farmaceutski pripravak; (b) stvaranje oblika za doziranja iz farmaceutskog pripravka koji je pogodan za primjenu kod sisavaca; i (c) primjena oblika za doziranja kod sisavaca, pri čemu se farmaceutski pripravak primjenjuje transdermalno.
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